Stephanie C Tjen-A-Looi

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats
    Stephanie C Tjen-A-Looi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    Am J Physiol Regul Integr Comp Physiol 304:R321-32. 2013
  2. pmc Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid
    Stephanie C Tjen-A-Looi
    School of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 302:R833-44. 2012
  3. ncbi request reprint Nitric oxide modulates sympathoexcitatory cardiac-cardiovascular reflexes elicited by bradykinin
    S C Tjen-A-Looi
    Department of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 281:H2010-7. 2001
  4. ncbi request reprint Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2543-53. 2006
  5. pmc Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA
    Stephanie C Tjen-A-Looi
    School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 106:1793-9. 2009
  6. ncbi request reprint Role of unmyelinated fibers in electroacupuncture cardiovascular responses
    Stephanie C Tjen-A-Looi
    Medical Science 1, Department of Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    Auton Neurosci 118:43-50. 2005
  7. ncbi request reprint Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 293:H3627-35. 2007
  8. pmc Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats
    Stephanie C Tjen-A-Looi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 300:H1003-12. 2011
  9. ncbi request reprint Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints
    Stephanie C Tjen-A-Looi
    Medical Science 1 C240, College of Medicine, Univ of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 287:R852-62. 2004
  10. pmc Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Physiol 543:327-36. 2002

Collaborators

Detail Information

Publications26

  1. pmc Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats
    Stephanie C Tjen-A-Looi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    Am J Physiol Regul Integr Comp Physiol 304:R321-32. 2013
    ..Thus, EA through GABAA receptor mechanisms in the rVLM, cVLM, and NAmb modulates gastric distention-induced reflex sympathoinhibition and vagal excitation...
  2. pmc Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid
    Stephanie C Tjen-A-Looi
    School of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 302:R833-44. 2012
    ..Thus EA at P5-6 decreases PBG evoked hypotension and bradycardia as well as the NAmb PBG-sensitive preganglionic cardiac vagal outflow through opioid and GABA neurotransmitter systems...
  3. ncbi request reprint Nitric oxide modulates sympathoexcitatory cardiac-cardiovascular reflexes elicited by bradykinin
    S C Tjen-A-Looi
    Department of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 281:H2010-7. 2001
    ..05). In conclusion, neuronal NOS facilitates, whereas endothelial NOS modulates, the excitatory cardiovascular reflex elicited by chemical stimulation of sympathetic cardiac afferents...
  4. ncbi request reprint Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2543-53. 2006
    ..We conclude that the inhibitory influence of EA involves vlPAG stimulation, which, in turn, inhibits rVLM neurons in the EA-related attenuation of the cardiovascular excitatory response during visceral afferent stimulation...
  5. pmc Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA
    Stephanie C Tjen-A-Looi
    School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 106:1793-9. 2009
    ..Reduction of GABA release disinhibits vlPAG cells, which, in turn, modulate the activity of rVLM neurons to attenuate the sympathoexcitatory reflex responses...
  6. ncbi request reprint Role of unmyelinated fibers in electroacupuncture cardiovascular responses
    Stephanie C Tjen-A-Looi
    Medical Science 1, Department of Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    Auton Neurosci 118:43-50. 2005
    ..This study demonstrates that the inhibitory effect of EA at P5-P6 on cardiovascular autonomic excitatory reflexes involves unmyelinated group IV fibers of the median nerves...
  7. ncbi request reprint Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 293:H3627-35. 2007
    ..Furthermore, in the rVLM, opioids and GABA, but not nociceptin, participate in the long-term EA-related inhibition of sympathoexcitatory cardiovascular responses...
  8. pmc Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats
    Stephanie C Tjen-A-Looi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 300:H1003-12. 2011
    ..Efferent chronotropic responses involve both increased parasympathetic and reduced sympathetic activity, whereas the decrease in BP is mediated by reduced α-adrenergic tone...
  9. ncbi request reprint Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints
    Stephanie C Tjen-A-Looi
    Medical Science 1 C240, College of Medicine, Univ of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 287:R852-62. 2004
    ....
  10. pmc Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Physiol 543:327-36. 2002
    ..This study demonstrates that ROS generated from the oxidation of purines contribute to the stimulation of ischaemically sensitive cardiac sympathetic afferents, whereas PMNs do not play a major role in this process...
  11. pmc Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture
    Ali Moazzami
    Susan Samueli Center for Integrative Medicine, Department of Medicine, Medical Science 1 C240, School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 108:1336-46. 2010
    ..Thus activation of the NRP, through a mechanism involving serotonergic neurons and 5-HT1A receptors in the rVLM during somatic stimulation with EA, attenuates sympathoexcitatory cardiovascular reflexes...
  12. pmc Long-loop pathways in cardiovascular electroacupuncture responses
    Peng Li
    Department of Medicine, University of California, Irvine, CA, USA
    J Appl Physiol (1985) 106:620-30. 2009
    ..Direct projections from the ARC to the rVLM, which serve as an important source of beta-endorphin, appear also to exist...
  13. pmc Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture
    Peng Li
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1369-76. 2010
    ..These results indicate that EA activates the vlPAG, which excites the NRP to, in turn, inhibit rVLM presympathetic neurons and reflex cardiovascular sympathoexcitatory responses...
  14. ncbi request reprint Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2535-42. 2006
    ..These results suggest that excitatory projections from the ARC to the vlPAG are essential to the EA inhibition of the reflex increase in BP induced by SN or gallbladder visceral afferent stimulation...
  15. ncbi request reprint Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses
    Wei Zhou
    Department of Medicine, College of Medicine, University of California, Irvine, CA 92697, USA
    J Appl Physiol (1985) 98:872-80. 2005
    ..The similarity of the responses to EA and MA and the lack of cardiovascular response to high-frequency EA appear to be largely a function of somatic afferent responses...
  16. ncbi request reprint Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, University of California at Irvine, Irvine, CA 92697 4075, USA
    Auton Neurosci 106:119-31. 2003
    ..Through an opioid mechanism, EA inhibits splanchnic nerve-induced excitatory responses of these rVLM neurons. Many of these neurons receiving convergent visceral and somatic input exhibit long-lasting inhibition by EA...
  17. pmc Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide
    Min Li
    Department of Medicine and Susan Samueli Center of Integrative Medicine, University of California, Irvine, California
    Am J Physiol Regul Integr Comp Physiol 305:R404-13. 2013
    ....
  18. ncbi request reprint Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats
    Wei Zhou
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 291:H1309-18. 2006
    ..These results suggest that glutamate in the rVLM serves as an excitatory neurotransmitter through a baroreflex-independent mechanism and that both NMDA and AMPA receptors mediate the visceral sympathoexcitatory reflex responses...
  19. pmc Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: role of synthase isoforms
    Zhi Ling Guo
    Department of Medicine, School of Medicine, University of California, Susan Samueli Center for Integrative Medicine, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 297:H1478-86. 2009
    ..These data suggest that NO, specifically nNOS, mediates sympathetic cardiac-cardiovascular responses through its action in the rVLM...
  20. ncbi request reprint Effect of electroacupuncture on pressor reflex during gastric distension
    Peng Li
    Department of Internal Medicine, College of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1335-45. 2002
    ....
  21. pmc Repetitive electroacupuncture causes prolonged increased met-enkephalin expression in the rVLM of conscious rats
    Min Li
    Department of Medicine, School of Medicine, University of California, Irvine, 92697 4075, United States
    Auton Neurosci 170:30-5. 2012
    ..Since opioids in the rVLM contribute importantly to the action of EA on sympathetic outflow, this mechanism may contribute to the prolonged action of acupuncture on elevated blood pressure in patients...
  22. pmc An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, United States
    Auton Neurosci 158:13-23. 2010
    ..Thus, a reciprocal excitatory glutamatergic neural circuit between the arcuate and vlPAG contributes to long-lasting EA cardiovascular inhibition. ACh in the arcuate but not in the vlPAG participates in the reciprocal excitation...
  23. ncbi request reprint Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats
    Melissa M Crisostomo
    Medical Science 1, C240, College of Medicine, University of California Irvine, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 98:2056-63. 2005
    ..Thus, in addition to the classical opioid system, nociceptin, through opioid receptor-like-1 receptor stimulation in the rVLM, participates in the modulatory influence of EA on reflex-induced increases in blood pressure...
  24. ncbi request reprint Brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats
    Wei Yi Syuu Zhou
    Department of Medicine, College of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 99:851-60. 2005
    ....
  25. pmc Electroacupuncture enhances preproenkephalin mRNA expression in rostral ventrolateral medulla of rats
    Min Li
    Department of Medicine and Susan Samueli Center of Integrative Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, United States
    Neurosci Lett 477:61-5. 2010
    ....
  26. doi request reprint Mechanism of the inhibitory effect of electroacupuncture on experimental arrhythmias
    Peng Li
    School of Medicine, University of California, Irvine, CA 92697, USA
    J Acupunct Meridian Stud 6:69-81. 2013
    ..These experimental data explore the mechanism of acupuncture's effect on arrhythmias and are useful for clinical application...