Hemant K Tiwari

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
    Nutr Rev 63:315-9. 2005
  2. pmc Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
    Hemant K Tiwari
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 2:56. 2011
  3. pmc COGA phenotypes and linkages on chromosome 2
    Howard W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Genet 6:S125. 2005
  4. ncbi request reprint New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Epidemiol 28:48-57. 2005
  5. pmc Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 66:67-86. 2008
  6. pmc Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Pharmacogenet Genomics 22:750-7. 2012
  7. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
  8. pmc Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate
    Stella Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e48663. 2012
  9. pmc Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study
    Marguerite R Irvin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Pharmacogenet Genomics 22:367-72. 2012
  10. pmc Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 220E, 1530 3rd Ave South, Birmingham, AL 35294 0022, USA
    Circ Res 108:279-83. 2011

Research Grants

Detail Information

Publications48

  1. ncbi request reprint Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
    Nutr Rev 63:315-9. 2005
    ..Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity...
  2. pmc Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)
    Hemant K Tiwari
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 2:56. 2011
    ..We also observed the significant interaction of rs11643744 by treatment effect on the weight gain...
  3. pmc COGA phenotypes and linkages on chromosome 2
    Howard W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Genet 6:S125. 2005
    ..A region on chromosome 2 at 250 cM was found to be linked to both of these derived phenotypes. Further examination of the SNPs in this region identified several haplotypes strongly associated with these derived phenotypes...
  4. ncbi request reprint New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Epidemiol 28:48-57. 2005
    ..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance...
  5. pmc Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 66:67-86. 2008
    ....
  6. pmc Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Pharmacogenet Genomics 22:750-7. 2012
    ..Individual responses to fenofibrate vary, and we conducted a genome-wide association study to identify genetic differences that could contribute to such differences...
  7. pmc A clustering analysis of lipoprotein diameters in the metabolic syndrome
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
    Lipids Health Dis 10:237. 2011
    ....
  8. pmc Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate
    Stella Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e48663. 2012
    ..In conclusion, we present evidence linking several novel and biologically relevant genetic polymorphisms to lipid lowering drug response, as well as suggesting novel gene-gene interactions in fenofibrate pharmacogenetics...
  9. pmc Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study
    Marguerite R Irvin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Pharmacogenet Genomics 22:367-72. 2012
    ..Given significant interindividual variations in the TG response, we investigated the association of PPARA rare variants with treatment response in the Genetics of Lipid-Lowering Drugs and Diet Network study...
  10. pmc Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 220E, 1530 3rd Ave South, Birmingham, AL 35294 0022, USA
    Circ Res 108:279-83. 2011
    ..Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals...
  11. pmc Preliminary evidence for an association between LRP-1 genotype and body mass index in humans
    Alexis C Frazier-Wood
    Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama, United States of America
    PLoS ONE 7:e30732. 2012
    ....
  12. pmc Association between family risk of stroke and myocardial infarction with prevalent risk factors and coexisting diseases
    Richard E Kennedy
    Department of Biostatistics, School of Public Health, 1665 University Boulevard, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Stroke 43:974-9. 2012
    ..We examined relationships between family risk of stroke and MI with risk factors for these phenotypes...
  13. pmc Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity
    Alexis C Frazier-Wood
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Genet 132:405-13. 2013
    ..As lipoprotein diameters are modifiable, this may lead new strategies to modify lipoprotein profiles during the reduction of IR that are sensitive to race/ethnicity...
  14. pmc A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network
    Stella Aslibekyan
    Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 22:191-7. 2012
    ..This study provides the first genome-wide examination of fenofibrate effects on systemic inflammation...
  15. pmc Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e24052. 2011
    ....
  16. pmc Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study
    Bertha Hidalgo
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL
    Diabetes 63:801-7. 2014
    ..75 × 10(-3) and P = 3.35 × 10(-2), respectively). Our findings suggest that methylation of a CpG site within ABCG1 is associated with fasting insulin and merits further evaluation as a novel disease risk marker. ..
  17. pmc Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Genet 2:e137. 2006
    ....
  18. ncbi request reprint Detection of gene x gene interactions in genome-wide association studies of human population data
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 63:67-84. 2007
    ..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data...
  19. pmc Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study
    Marguerite R Irvin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 9:e99509. 2014
    ..We hypothesized that detailed lipid profiles (eg, sterols and fatty acids) may help elucidate specific genetic and dietary pathways contributing to the PPL response...
  20. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  21. pmc Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study
    Nathan E Wineinger
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Hum Genet 19:1271-5. 2011
    ..We identified 1541 unique copy-number variable regions, 309 of which did not overlap with the Database of Genomic Variants. These results provide further insight into the distribution of CNV in African Americans...
  22. pmc Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS
    Alexis C Wood
    Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
    Lipids Health Dis 10:143. 2011
    ....
  23. pmc Kernel-machine testing coupled with a rank-truncation method for genetic pathway analysis
    Qi Yan
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Genet Epidemiol 38:447-56. 2014
    ..We also apply our proposed methodology to data from a study of the association between bipolar disorder and candidate pathways from Wellcome Trust Case Control Consortium (WTCCC) to show its utility. ..
  24. pmc Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 28:2076-83. 2010
    ..Several clinical studies report increased risk of diabetes mellitus with pharmacologic treatment for hypertension (HTN). HTN genes may modify glycemic response to antihypertensive treatment...
  25. pmc Similarity-based multimarker association tests for continuous traits
    Wan Yu Lin
    Department of Biostatistics, University of Alabama at Birmingham, USA
    Ann Hum Genet 76:246-60. 2012
    ..3). Our SIMp test outperforms other tests when the causal variant was introduced at common haplotypes (the maximum frequency of risk haplotypes >0.4). We also applied our two tests to an adiposity data set to show their utility...
  26. doi request reprint Relative efficiency and sample size for cluster randomized trials with variable cluster sizes
    Zhiying You
    Department of Medicine, School of Medicine, University of Alabama, Birmingham, AL, USA
    Clin Trials 8:27-36. 2011
    ....
  27. pmc Evidence for novel genetic loci associated with metabolic traits in Yup'ik people
    Stella Aslibekyan
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294
    Am J Hum Biol 25:673-80. 2013
    ....
  28. pmc Risk-stratified imputation in survival analysis
    Richard E Kennedy
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Clin Trials 10:530-9. 2013
    ....
  29. pmc The utility of mitochondrial and y chromosome phylogenetic data to improve correction for population stratification
    Robert Makowsky
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 3:301. 2012
    ....
  30. pmc Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men
    Marguerite Ryan Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 21:798-807. 2011
    ..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)...
  31. pmc Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects
    Maria De Luca
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Gerontol 46:60-4. 2011
    ..Future studies are warranted to replicate these findings in independent and larger populations and to investigate whether rs659822 is the causal variant responsible for the observed associations...
  32. ncbi request reprint X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairs
    Howard Wiener
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Ala 35294 0022, USA
    Hum Hered 55:97-107. 2003
    ..Simulation results are presented to describe the power of this technique for a theoretical best case scenario...
  33. doi request reprint Definition of phenotype
    Mary K Wojczynski
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Genet 60:75-105. 2008
    ..We show that the power of a study depends heavily on the phenotype measured and that misclassification or measurement error can dramatically reduce the power. We also suggest some possible responses to these challenges...
  34. pmc A new estimate of family disease history providing improved prediction of disease risks
    Rui Feng
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stat Med 28:1269-83. 2009
    ..The results show that assessing family history can improve the prediction of disease risks and the SLFS has strongest positive associations with both myocardial infarction and stroke...
  35. pmc An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans
    James M Kelley
    University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS Genet 5:e1000424. 2009
    ..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations...
  36. doi request reprint Association test of multiallelic gene copy numbers in family trios
    Sadeep Shrestha
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Genet Epidemiol 34:2-6. 2010
    ..We present theoretical derivation of the statistics and results of simulation studies that show robustness of our approach and power under several genetic models...
  37. pmc Statistical issues in the analysis of DNA Copy Number Variations
    Nathan E Wineinger
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Int J Comput Biol Drug Des 1:368-95. 2008
    ..We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis...
  38. pmc The impact of errors in copy number variation detection algorithms on association results
    Nathan E Wineinger
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Birmingham, Alabama, United States of America
    PLoS ONE 7:e32396. 2012
    ..It is our recommendation that CNV researchers use intensity measurements as an alternative to CNV calls in these scenarios...
  39. pmc Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study
    Marguerite R Irvin
    Department of Epidemiology, University of Alabama at Birmingham, USA
    Circ Cardiovasc Genet 3:462-7. 2010
    ..Although much is known about the effect of Apolipoprotein E (APOE) alleles on fasting lipid concentrations, less is known about the effect of APOE alleles on postprandial triglyceridemia or the triglyceride response to fenofibrate...
  40. pmc Do allelic variants of SLC6A14 predispose to obesity?
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, 35294, USA
    J Clin Invest 112:1633-6. 2003
    ....
  41. pmc Imputation of incident events in longitudinal cohort studies
    George Howard
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Ryals Building, Room 327D, 1665 University Boulevard, Birmingham, AL 35294 0022, USA
    Am J Epidemiol 174:718-26. 2011
    ....
  42. ncbi request reprint Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's disease
    Jian Li
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Psychosom Med 69:551-9. 2007
    ..To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD)...
  43. pmc Structural equation model-based genome scan for the metabolic syndrome
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University 2500 MetroHealth Dr, R258 Rammelkamp Building, Cleveland, Ohio, USA
    BMC Genet 4:S99. 2003
    ..Because these traits cluster, there are likely common genetic factors involved...
  44. ncbi request reprint Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes
    Jennifer Wessel
    Center for Human Genetics and Genomics, University of California San Diego, La Jolla, CA, USA
    Genet Epidemiol 31:789-96. 2007
    ....
  45. ncbi request reprint Problems with genome-wide association studies
    Daniel Shriner
    Science 316:1840-2. 2007
  46. ncbi request reprint A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26
    Ram S Puranam
    Department of Medicine Neurology, Duke University, Durham, NC 27710, USA
    Ann Neurol 58:449-58. 2005
    ..000065). Fine mapping of the locus defined an interval of 4.45Mb. These findings identify a novel locus for GTCS on 10q25-q26 and support the idea that distinct loci underlie distinct seizure types within an epilepsy syndrome such as JME...
  47. pmc Heritability analysis of cytokines as intermediate phenotypes of tuberculosis
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:1679-85. 2003
    ..This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci for TB and demonstrates that this area deserves further research...

Research Grants1

  1. Frontiers in Statistical Genetics for NIAMS Researchers
    Hemant Tiwari; Fiscal Year: 2005
    ..abstract_text> ..