Research Topics
Genomes and Genes
Species | Hemant K TiwariSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
COGA phenotypes and linkages on chromosome 2Howard W Wiener
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
BMC Genet 6:S125. 2005..A region on chromosome 2 at 250 cM was found to be linked to both of these derived phenotypes. Further examination of the SNPs in this region identified several haplotypes strongly associated with these derived phenotypes...- Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?Hemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
Nutr Rev 63:315-9. 2005..Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity... - New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random samplingHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Genet Epidemiol 28:48-57. 2005..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance... - Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principlesHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 66:67-86. 2008.... - A clustering analysis of lipoprotein diameters in the metabolic syndromeAlexis C Frazier-Wood
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, USA
Lipids Health Dis 10:237. 2011.... - Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network StudyMarguerite R Irvin
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Pharmacogenet Genomics 22:367-72. 2012..Given significant interindividual variations in the TG response, we investigated the association of PPARA rare variants with treatment response in the Genetics of Lipid-Lowering Drugs and Diet Network study... - Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive familiesDonna K Arnett
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 220E, 1530 3rd Ave South, Birmingham, AL 35294 0022, USA
Circ Res 108:279-83. 2011..Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive individuals... - Preliminary evidence for an association between LRP-1 genotype and body mass index in humansAlexis C Frazier-Wood
Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, Alabama, United States of America
PLoS ONE 7:e30732. 2012.... - Association between family risk of stroke and myocardial infarction with prevalent risk factors and coexisting diseasesRichard E Kennedy
DRPH, Professor and Chair, Department of Biostatistics, School of Public Health, 1665 University Boulevard, University of Alabama at Birmingham, Birmingham, AL 35294 0022
Stroke 43:974-9. 2012..We examined relationships between family risk of stroke and MI with risk factors for these phenotypes... - Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrateAlexis C Frazier-Wood
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Pharmacogenet Genomics 22:750-7. 2012..Individual responses to fenofibrate vary, and we conducted a genome-wide association study to identify genetic differences that could contribute to such differences... - A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet NetworkStella Aslibekyan
Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Alabama, USA
Pharmacogenet Genomics 22:191-7. 2012..This study provides the first genome-wide examination of fenofibrate effects on systemic inflammation... - Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN studyMarguerite R Irvin
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 6:e24052. 2011.... - Detection of gene x gene interactions in genome-wide association studies of human population dataSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 63:67-84. 2007..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data... - Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear modelDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Genet 2:e137. 2006.... - Characterization of autosomal copy-number variation in African Americans: the HyperGEN StudyNathan E Wineinger
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Eur J Hum Genet 19:1271-5. 2011..We identified 1541 unique copy-number variable regions, 309 of which did not overlap with the Database of Genomic Variants. These results provide further insight into the distribution of CNV in African Americans... - Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetSAlexis C Wood
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, Alabama, USA
Lipids Health Dis 10:143. 2011.... - Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to FenofibrateStella Aslibekyan
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 7:e48663. 2012..In conclusion, we present evidence linking several novel and biologically relevant genetic polymorphisms to lipid lowering drug response, as well as suggesting novel gene-gene interactions in fenofibrate pharmacogenetics... - Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN studyNathan E Wineinger
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
BMC Med Genomics 4:4. 2011..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects... - Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT StudyMarguerite R Irvin
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Hypertens 28:2076-83. 2010..Several clinical studies report increased risk of diabetes mellitus with pharmacologic treatment for hypertension (HTN). HTN genes may modify glycemic response to antihypertensive treatment... - Similarity-based multimarker association tests for continuous traitsWan Yu Lin
Department of Biostatistics, University of Alabama at Birmingham, USA
Ann Hum Genet 76:246-60. 2012..3). Our SIMp test outperforms other tests when the causal variant was introduced at common haplotypes (the maximum frequency of risk haplotypes >0.4). We also applied our two tests to an adiposity data set to show their utility... - Relative efficiency and sample size for cluster randomized trials with variable cluster sizesZhiying You
Department of Medicine, School of Medicine, University of Alabama, Birmingham, AL, USA
Clin Trials 8:27-36. 2011.... - Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected menMarguerite Ryan Irvin
Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA
Pharmacogenet Genomics 21:798-807. 2011..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)... - Statistical issues in the analysis of DNA Copy Number VariationsNathan E Wineinger
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Int J Comput Biol Drug Des 1:368-95. 2008..We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis... - Definition of phenotypeMary K Wojczynski
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Adv Genet 60:75-105. 2008..We show that the power of a study depends heavily on the phenotype measured and that misclassification or measurement error can dramatically reduce the power. We also suggest some possible responses to these challenges... - A new estimate of family disease history providing improved prediction of disease risksRui Feng
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Med 28:1269-83. 2009..The results show that assessing family history can improve the prediction of disease risks and the SLFS has strongest positive associations with both myocardial infarction and stroke... - An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African AmericansJames M Kelley
University of Alabama at Birmingham, Birmingham, AL, USA
PLoS Genet 5:e1000424. 2009..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations... - Association test of multiallelic gene copy numbers in family triosSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Genet Epidemiol 34:2-6. 2010..We present theoretical derivation of the statistics and results of simulation studies that show robustness of our approach and power under several genetic models... - Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjectsMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Exp Gerontol 46:60-4. 2011..Future studies are warranted to replicate these findings in independent and larger populations and to investigate whether rs659822 is the causal variant responsible for the observed associations... - X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairsHoward Wiener
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Ala 35294 0022, USA
Hum Hered 55:97-107. 2003..Simulation results are presented to describe the power of this technique for a theoretical best case scenario... - The impact of errors in copy number variation detection algorithms on association resultsNathan E Wineinger
Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Birmingham, Alabama, United States of America
PLoS ONE 7:e32396. 2012..It is our recommendation that CNV researchers use intensity measurements as an alternative to CNV calls in these scenarios... - Imputation of incident events in longitudinal cohort studiesGeorge Howard
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Ryals Building, Room 327D, 1665 University Boulevard, Birmingham, AL 35294 0022, USA
Am J Epidemiol 174:718-26. 2011.... - Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) StudyMarguerite R Irvin
Department of Epidemiology, University of Alabama at Birmingham, USA
Circ Cardiovasc Genet 3:462-7. 2010..Although much is known about the effect of Apolipoprotein E (APOE) alleles on fasting lipid concentrations, less is known about the effect of APOE alleles on postprandial triglyceridemia or the triglyceride response to fenofibrate... - Do allelic variants of SLC6A14 predispose to obesity?Hemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, 35294, USA
J Clin Invest 112:1633-6. 2003.... - Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's diseaseJian Li
Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Psychosom Med 69:551-9. 2007..To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD)... - Structural equation model-based genome scan for the metabolic syndromeCatherine M Stein
Department of Epidemiology and Biostatistics, Case Western Reserve University 2500 MetroHealth Dr, R258 Rammelkamp Building, Cleveland, Ohio, USA
BMC Genet 4:S99. 2003..Because these traits cluster, there are likely common genetic factors involved... - Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypesJennifer Wessel
Center for Human Genetics and Genomics, University of California San Diego, La Jolla, CA, USA
Genet Epidemiol 31:789-96. 2007.... - Problems with genome-wide association studiesDaniel Shriner
Science 316:1840-2. 2007 - A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26Ram S Puranam
Department of Medicine (Neurology, Duke University, Durham, NC 27710, USA
Ann Neurol 58:449-58. 2005..000065). Fine mapping of the locus defined an interval of 4.45Mb. These findings identify a novel locus for GTCS on 10q25-q26 and support the idea that distinct loci underlie distinct seizure types within an epilepsy syndrome such as JME... - Heritability analysis of cytokines as intermediate phenotypes of tuberculosisCatherine M Stein
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
J Infect Dis 187:1679-85. 2003..This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci for TB and demonstrates that this area deserves further research...
Research Grants
- Frontiers in Statistical Genetics for NIAMS ResearchersHemant Tiwari; Fiscal Year: 2005..abstract_text> ..