Affiliation: University of California
- Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelinationDaniel K Crawford
Multiple Sclerosis Program at UCLA, Department of Neurology, School of Medicine, University of California Los Angeles, 635 Charles E Young Drive, Los Angeles, CA 90095 1769, USA
Brain 133:2999-3016. 2010..These findings show a direct neuroprotective effect of oestrogen receptor β ligand treatment on oligodendrocyte differentiation, myelination and axon conduction during experimental autoimmune encephalomyelitis...
- Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosisSpencer Moore
Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA Los Angeles, California
Brain Behav 3:664-82. 2013..Laquinimod (LQ) is an orally administered, central nervous system (CNS)-active immunomodulator with demonstrated efficacy in MS clinical trials and a favorable safety and tolerability profile...
- K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte developmentSeema Tiwari-Woodruff
UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Am J Physiol Cell Physiol 291:C687-98. 2006..1 K(+) current accounts for a significant component of the total K(+) current in cells of the Olg lineage and, in association with OSP/claudin-11, plays a significant role in OPC proliferation and migration and myelination of axons...
- Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in miceSeema Tiwari-Woodruff
Department of Neurology, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
J Neurol Sci 286:81-5. 2009..ERbeta ligand treatment should be considered as a potential neuroprotective agent for MS and other neurodegenerative diseases, particularly since breast and uterine cancer are mediated through ERalpha...
- Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNSRhonda R Voskuhl
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 29:11511-22. 2009..The findings suggest that loss or disruption of astrocyte functions may underlie or exacerbate the inflammation and pathologies associated with autoimmune diseases of the CNS, including multiple sclerosis...
- Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatmentSeema Tiwari-Woodruff
Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:14813-8. 2007....
- Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAEMarina O Ziehn
Interdepartmental Program of Neuroscience, University of California, Los Angeles, CA, USA
Lab Invest 90:774-86. 2010..This work establishes a preclinical model for assessing treatments targeted toward preventing hippocampal neuropathology and dysfunction in MS...
- Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitisLaurie Beth J Morales
Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 26:6823-33. 2006..In conclusion, treatment with an ERalpha ligand is highly selective in vivo, mediating both anti-inflammatory and neuroprotective effects in EAE...