Seema Tiwari-Woodruff

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination
    Daniel K Crawford
    Multiple Sclerosis Program at UCLA, Department of Neurology, School of Medicine, University of California Los Angeles, 635 Charles E Young Drive, Los Angeles, CA 90095 1769, USA
    Brain 133:2999-3016. 2010
  2. pmc Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis
    Spencer Moore
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA Los Angeles, California
    Brain Behav 3:664-82. 2013
  3. ncbi request reprint K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development
    Seema Tiwari-Woodruff
    UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Am J Physiol Cell Physiol 291:C687-98. 2006
  4. pmc Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice
    Seema Tiwari-Woodruff
    Department of Neurology, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Neurol Sci 286:81-5. 2009
  5. pmc Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    Rhonda R Voskuhl
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 29:11511-22. 2009
  6. pmc Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    Seema Tiwari-Woodruff
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:14813-8. 2007
  7. pmc Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
    Marina O Ziehn
    Interdepartmental Program of Neuroscience, University of California, Los Angeles, CA, USA
    Lab Invest 90:774-86. 2010
  8. ncbi request reprint Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis
    Laurie Beth J Morales
    Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:6823-33. 2006

Collaborators

  • Rhonda Voskuhl
  • A C Charles
  • MICHAEL SOFRONIEW
  • Spencer Moore
  • Rhusheet Patel
  • Marina O Ziehn
  • Daniel K Crawford
  • Laurie Beth J Morales
  • Manda Sasidhar
  • Anna J Khalaj
  • Leonardo Martinez-Torres
  • Liat Hayardeny
  • Timothy Yoo
  • Gemmy Hannsun
  • Jaehee Yoon
  • Sienmi Du
  • Mario Mangiardi
  • Andrea A Avedisian
  • Bingbing Song
  • Cory Peterson
  • Kyi Kyi Loo
  • Hong Biao Liu

Detail Information

Publications8

  1. pmc Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination
    Daniel K Crawford
    Multiple Sclerosis Program at UCLA, Department of Neurology, School of Medicine, University of California Los Angeles, 635 Charles E Young Drive, Los Angeles, CA 90095 1769, USA
    Brain 133:2999-3016. 2010
    ..These findings show a direct neuroprotective effect of oestrogen receptor β ligand treatment on oligodendrocyte differentiation, myelination and axon conduction during experimental autoimmune encephalomyelitis...
  2. pmc Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis
    Spencer Moore
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA Los Angeles, California
    Brain Behav 3:664-82. 2013
    ..Laquinimod (LQ) is an orally administered, central nervous system (CNS)-active immunomodulator with demonstrated efficacy in MS clinical trials and a favorable safety and tolerability profile...
  3. ncbi request reprint K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development
    Seema Tiwari-Woodruff
    UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Am J Physiol Cell Physiol 291:C687-98. 2006
    ..1 K(+) current accounts for a significant component of the total K(+) current in cells of the Olg lineage and, in association with OSP/claudin-11, plays a significant role in OPC proliferation and migration and myelination of axons...
  4. pmc Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice
    Seema Tiwari-Woodruff
    Department of Neurology, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Neurol Sci 286:81-5. 2009
    ..ERbeta ligand treatment should be considered as a potential neuroprotective agent for MS and other neurodegenerative diseases, particularly since breast and uterine cancer are mediated through ERalpha...
  5. pmc Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    Rhonda R Voskuhl
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 29:11511-22. 2009
    ..The findings suggest that loss or disruption of astrocyte functions may underlie or exacerbate the inflammation and pathologies associated with autoimmune diseases of the CNS, including multiple sclerosis...
  6. pmc Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    Seema Tiwari-Woodruff
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:14813-8. 2007
    ....
  7. pmc Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
    Marina O Ziehn
    Interdepartmental Program of Neuroscience, University of California, Los Angeles, CA, USA
    Lab Invest 90:774-86. 2010
    ..This work establishes a preclinical model for assessing treatments targeted toward preventing hippocampal neuropathology and dysfunction in MS...
  8. ncbi request reprint Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis
    Laurie Beth J Morales
    Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:6823-33. 2006
    ..In conclusion, treatment with an ERalpha ligand is highly selective in vivo, mediating both anti-inflammatory and neuroprotective effects in EAE...