P K Tithof

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
  2. doi request reprint Activation of group IVC phospholipase A(2) by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells
    Patricia K Tithof
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4545, USA
    Arch Toxicol 85:623-34. 2011
  3. ncbi request reprint 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells
    P K Tithof
    Department of Comparative Medicine, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996 4500, USA
    Am J Physiol Heart Circ Physiol 281:H1946-54. 2001
  4. ncbi request reprint Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism
    Patricia K Tithof
    Department of Comparative Medicine, The University of Tennessee, Knoxville, Tennessee 37996 4543, USA
    FASEB J 16:1463-4. 2002
  5. pmc Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
    Patricia K Tithof
    The University of Tennessee College of Veterinary Medicine, TN, USA
    Reprod Biol Endocrinol 5:16. 2007
  6. ncbi request reprint Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines
    Y Cakir
    Experimental Oncology Laboratory, Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Oncol 21:153-7. 2002
  7. ncbi request reprint Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds
    P K Tithof
    College of Veterinary Medicine, The University of Tennessee, Knoxville 37996 4500, USA
    Toxicol Sci 53:40-7. 2000
  8. ncbi request reprint Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors
    Jeong Ho Kim
    Department of Pathobiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Toxicol Sci 85:585-93. 2005
  9. ncbi request reprint Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    Peter Mancuso
    Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
    Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004
  10. ncbi request reprint EGR1 is a novel target for AhR agonists in human lung epithelial cells
    Jeanelle M Martinez
    Laboratory of Computational Biology and Risk Analysis, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:429-35. 2004

Collaborators

Detail Information

Publications10

  1. pmc Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production
    James D Godkin
    Department of Animal Science, The University of Tennessee, Knoxville, TN, USA
    Reprod Biol Endocrinol 6:44. 2008
    ..The objectives of this investigation were to evaluate the expression and activities of calcium-dependent group IVA (PLA2G4A) and calcium-independent group VI (PLA2G6) enzymes in the regulation of BEND cell PG production...
  2. doi request reprint Activation of group IVC phospholipase A(2) by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells
    Patricia K Tithof
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4545, USA
    Arch Toxicol 85:623-34. 2011
    ..These data suggest that PAHs induce apoptosis of HCAECs via activation of group IVC PLA(2)...
  3. ncbi request reprint 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells
    P K Tithof
    Department of Comparative Medicine, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37996 4500, USA
    Am J Physiol Heart Circ Physiol 281:H1946-54. 2001
    ..These data suggest that NNK causes EC apoptosis by a mechanism that involves beta1- and beta2-adrenergic receptor-mediated release of AA...
  4. ncbi request reprint Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism
    Patricia K Tithof
    Department of Comparative Medicine, The University of Tennessee, Knoxville, Tennessee 37996 4543, USA
    FASEB J 16:1463-4. 2002
    ..These data suggest that 1-MA, B(a)P and PA induce apoptosis of endothelial cells by a mechanism that involves activation of these three distinct isoforms of PLA2...
  5. pmc Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
    Patricia K Tithof
    The University of Tennessee College of Veterinary Medicine, TN, USA
    Reprod Biol Endocrinol 5:16. 2007
    ....
  6. ncbi request reprint Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines
    Y Cakir
    Experimental Oncology Laboratory, Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Oncol 21:153-7. 2002
    ..Moreover, our findings suggest that cardiovascular disease and adenocarcinomas in a variety of organ systems, including the breast may share common risk factors and benefit from similar preventive and treatment strategies...
  7. ncbi request reprint Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds
    P K Tithof
    College of Veterinary Medicine, The University of Tennessee, Knoxville 37996 4500, USA
    Toxicol Sci 53:40-7. 2000
    ..This suggests that more than one isoform of PLA2 is activated by dieldrin and by lindane, and that one isoform is calcium-dependent...
  8. ncbi request reprint Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors
    Jeong Ho Kim
    Department of Pathobiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Toxicol Sci 85:585-93. 2005
    ..In conclusion, PAHs activate PPAR alpha and PPAR beta/delta, and up-regulate EGR-1 expression in vitro as well as in vivo. These data may provide a diversity of PAH activity in several biological pathways...
  9. ncbi request reprint Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    Peter Mancuso
    Dept of Environmental Health Sciences, Univ of Michigan, 1420 Washington Hts, SPH II, Ann Arbor, MI 48109 2029, USA
    Am J Physiol Lung Cell Mol Physiol 287:L497-502. 2004
    ....
  10. ncbi request reprint EGR1 is a novel target for AhR agonists in human lung epithelial cells
    Jeanelle M Martinez
    Laboratory of Computational Biology and Risk Analysis, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:429-35. 2004
    ..Increased expression of a transcription factor EGR1 with tumorigenic and other biological activities could contribute to the deleterious pulmonary effects of exposure to these environmental agents...