Heidi Tissenbaum

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint A gene-centered C. elegans protein-DNA interaction network
    Bart Deplancke
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 125:1193-205. 2006
  2. pmc PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism
    Sri Devi Narasimhan
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 7:e1001377. 2011
  3. pmc Genetics, life span, health span, and the aging process in Caenorhabditis elegans
    Heidi A Tissenbaum
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Gerontol A Biol Sci Med Sci 67:503-10. 2012
  4. ncbi request reprint Model organisms as a guide to mammalian aging
    Heidi A Tissenbaum
    Program in Gene Function and Expression, University of Massachusetts Medical School, New Research Building Suite 604, 364 Plantation Street, Worcester, MA 01605, USA
    Dev Cell 2:9-19. 2002
  5. ncbi request reprint Serotonin's SOS signal
    Heidi A Tissenbaum
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Aaron Lazare Research Building Suite 615, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Cell Metab 4:415-7. 2006
  6. ncbi request reprint Reproduction and longevity: secrets revealed by C. elegans
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA
    Trends Cell Biol 17:65-71. 2007
  7. ncbi request reprint C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
    Yamei Wang
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Mech Ageing Dev 127:741-7. 2006
  8. ncbi request reprint Worming pathways to and from DAF-16/FOXO
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Exp Gerontol 41:928-34. 2006
  9. ncbi request reprint Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
    Yamei Wang
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mech Ageing Dev 127:48-56. 2006
  10. pmc JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    Seung Wook Oh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 102:4494-9. 2005

Research Grants

  1. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2007
  2. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2009
  3. Dissecting complex regulation by C. elegans DAF-16
    Heidi Tissenbaum; Fiscal Year: 2009
  4. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2005
  5. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2006
  6. Dissecting complex regulation by C. elegans DAF-16
    Heidi A Tissenbaum; Fiscal Year: 2010
  7. Life span, fat storage and insulin-like signaling
    Heidi A Tissenbaum; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A gene-centered C. elegans protein-DNA interaction network
    Bart Deplancke
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 125:1193-205. 2006
    ..We provide additional in vivo evidence for multiple PDIs and illustrate how the PDI network provides insights into metazoan differential gene expression at a systems level...
  2. pmc PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism
    Sri Devi Narasimhan
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 7:e1001377. 2011
    ..Our results may provide a new perspective in understanding of the regulation of these pathways under normal conditions and in the context of disease...
  3. pmc Genetics, life span, health span, and the aging process in Caenorhabditis elegans
    Heidi A Tissenbaum
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Gerontol A Biol Sci Med Sci 67:503-10. 2012
    ..I discuss how this connects to the aging process, age-associated disease, and the potential to increase healthy aging in addition to lengthening life span...
  4. ncbi request reprint Model organisms as a guide to mammalian aging
    Heidi A Tissenbaum
    Program in Gene Function and Expression, University of Massachusetts Medical School, New Research Building Suite 604, 364 Plantation Street, Worcester, MA 01605, USA
    Dev Cell 2:9-19. 2002
    ..Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae and highlight general features of the regulation of aging that may have implications for mammals...
  5. ncbi request reprint Serotonin's SOS signal
    Heidi A Tissenbaum
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Aaron Lazare Research Building Suite 615, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Cell Metab 4:415-7. 2006
    ..New work from in this issue of Cell Metabolism reveals that, in C. elegans, serotonin functions during conditions of stress through the well-characterized insulin/IGF-1 signaling pathway, suggesting a mechanism for the stress response...
  6. ncbi request reprint Reproduction and longevity: secrets revealed by C. elegans
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA
    Trends Cell Biol 17:65-71. 2007
    ..Here we discuss recent advances in our understanding of the regulation of life span by reproductive signaling, focusing on studies using Caenorhabditis elegans...
  7. ncbi request reprint C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
    Yamei Wang
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Mech Ageing Dev 127:741-7. 2006
    ..Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO...
  8. ncbi request reprint Worming pathways to and from DAF-16/FOXO
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Exp Gerontol 41:928-34. 2006
    ..Therefore, DAF-16 integrates signals from multiple pathways and regulates its downstream target genes to control diverse processes. Here, we discuss the signals to and from DAF-16, with a focus on life span regulation...
  9. ncbi request reprint Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
    Yamei Wang
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mech Ageing Dev 127:48-56. 2006
    ..Our data defines a central role for C. elegans SIR2 in regulation of life span by caloric restriction and demonstrates that sir-2.1 and daf-16 have both overlapping and distinct functions in regulation of C. elegans life span...
  10. pmc JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    Seung Wook Oh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 102:4494-9. 2005
    ..Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance...
  11. pmc A new DAF-16 isoform regulates longevity
    Eun Soo Kwon
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 466:498-502. 2010
    ..Importantly, in mammals, four FOXO genes have overlapping and different functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-mediated processes in the context of a whole organism...
  12. pmc InAKTivation of insulin/IGF-1 signaling by dephosphorylation
    Sri Devi Narasimhan
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA, USA
    Cell Cycle 8:3878-84. 2009
    ..Understanding the function of B56 subunits may have important consequences in diseases such as Type 2 diabetes and cancer where the balance of Akt phosphorylation is deregulated...
  13. pmc A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation
    Srivatsan Padmanabhan
    University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 136:939-51. 2009
    ..This study reveals a conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation, thereby having widespread implications in cancer and diabetes research...
  14. pmc Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Protoc 3:698-709. 2008
    ..It takes approximately 10-12 d to obtain the worm culture for ChIP; the ChIP procedure is spaced out over a period of 2.5 d with two overnight incubations...
  15. pmc An endocytic pathway as a target of tubby for regulation of fat storage
    Arnab Mukhopadhyay
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    EMBO Rep 8:931-8. 2007
    ..We propose that TUB-1 controls receptor or sensory molecule degradation in neurons by regulating a RAB-7-mediated endocytic pathway...
  16. ncbi request reprint Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    Seung Wook Oh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Genet 38:251-7. 2006
    ..We also demonstrate that DAF-16 is recruited to multiple promoters to coordinate regulation of its downstream targets. The large number of target genes discovered provides insight into how DAF-16 controls diverse biological functions...
  17. ncbi request reprint Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans
    Melissa M Grabowski
    Program in Gene Function and Expression, Program in Molecular Medicine, Aaron Lazare Research Building, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mech Ageing Dev 126:1314-21. 2005
    ..The increased level of genomic instability that leads to him-6(ok412) mutants having a shortened life span...
  18. ncbi request reprint C. elegans tubby regulates life span and fat storage by two independent mechanisms
    Arnab Mukhopadhyay
    Cell Metab 2:35-42. 2005
    ..Taken together, we define a role for tub-1 in regulation of life span and show that tub-1 regulates life span and fat storage by two independent mechanisms...

Research Grants8

  1. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2007
    ..We are confident that understanding the molecular connection between life span, fat storage, and insulin-like signaling will have relevance to mammalian systems because all of the genes and pathways appear conserved. ..
  2. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2009
    ..We are confident that understanding the molecular connection between life span, fat storage, and insulin-like signaling will have relevance to mammalian systems because all of the genes and pathways appear conserved. ..
  3. Dissecting complex regulation by C. elegans DAF-16
    Heidi Tissenbaum; Fiscal Year: 2009
    ..The high degree of conservation between worms and mammals in this pathway indicate that these studies will also undoubtedly have implications for our understanding of the mammalian aging process. ..
  4. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2005
    ..We are confident that understanding the molecular connection between life span, fat storage, and insulin-like signaling will have relevance to mammalian systems because all of the genes and pathways appear conserved. ..
  5. Life span, fat storage and insulin-like signaling
    Heidi Tissenbaum; Fiscal Year: 2006
    ..We are confident that understanding the molecular connection between life span, fat storage, and insulin-like signaling will have relevance to mammalian systems because all of the genes and pathways appear conserved. ..
  6. Dissecting complex regulation by C. elegans DAF-16
    Heidi A Tissenbaum; Fiscal Year: 2010
    ..The high degree of conservation between worms and mammals in this pathway indicate that these studies will also undoubtedly have implications for our understanding of the mammalian aging process. ..
  7. Life span, fat storage and insulin-like signaling
    Heidi A Tissenbaum; Fiscal Year: 2010
    ..In this proposal, we dissect how additional conserved signaling pathways couple with the insulin/IGF-1 signaling pathway to cooperatively regulate life span and fat storage. ..