SARAH TISHKOFF

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Exploring genomic studies in Africa
    Scott M Williams
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, 2215 Garland Avenue, Nashville, TN 37232 0700, USA
    Genome Med 3:45. 2011
  2. pmc Genetic adaptation to high altitude in the Ethiopian highlands
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genome Biol 13:R1. 2012
  3. pmc Living the high life: high-altitude adaptation
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Biol 11:133. 2010
  4. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
  5. ncbi History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation
    Sarah A Tishkoff
    Department of Biology, University of Maryland, USA
    Mol Biol Evol 24:2180-95. 2007
  6. ncbi Whole-mtDNA genome sequence analysis of ancient African lineages
    Mary Katherine Gonder
    Department of Biology, University of Maryland, MD, USA
    Mol Biol Evol 24:757-68. 2007
  7. pmc African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping
    Michael C Campbell
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Genomics Hum Genet 9:403-33. 2008
  8. pmc Convergent adaptation of human lactase persistence in Africa and Europe
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 39:31-40. 2007
  9. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
  10. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004

Collaborators

Detail Information

Publications15

  1. pmc Exploring genomic studies in Africa
    Scott M Williams
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, 2215 Garland Avenue, Nashville, TN 37232 0700, USA
    Genome Med 3:45. 2011
    ..A report on the African Society of Human Genetics meeting, Cape Town, South Africa, 6-9 March 2011...
  2. pmc Genetic adaptation to high altitude in the Ethiopian highlands
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genome Biol 13:R1. 2012
    ..We genotyped the Illumina 1M SNP array and employed several genome-wide scans for selection and targeted association with hemoglobin levels to identify genes that play a role in adaptation to high altitude...
  3. pmc Living the high life: high-altitude adaptation
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Biol 11:133. 2010
    ..Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation...
  4. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
    ..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies...
  5. ncbi History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation
    Sarah A Tishkoff
    Department of Biology, University of Maryland, USA
    Mol Biol Evol 24:2180-95. 2007
    ....
  6. ncbi Whole-mtDNA genome sequence analysis of ancient African lineages
    Mary Katherine Gonder
    Department of Biology, University of Maryland, MD, USA
    Mol Biol Evol 24:757-68. 2007
    ..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa...
  7. pmc African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping
    Michael C Campbell
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Genomics Hum Genet 9:403-33. 2008
    ..This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility...
  8. pmc Convergent adaptation of human lactase persistence in Africa and Europe
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 39:31-40. 2007
    ..These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits-animal domestication and adult milk consumption...
  9. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
    ..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution...
  10. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004
    ..Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptive during human evolution...
  11. ncbi Genetic analysis of African populations: human evolution and complex disease
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Genet 3:611-21. 2002
  12. ncbi Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 13:569-75. 2003
    ....
  13. ncbi African human diversity, origins and migrations
    Floyd A Reed
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 16:597-605. 2006
    ..Thus, we have tremendous potential to learn about human variation and evolutionary history and to positively impact human health care from studies of genetic diversity in Africa...
  14. pmc Positive selection can create false hotspots of recombination
    Floyd A Reed
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Genetics 172:2011-4. 2006
    ....
  15. ncbi Implications of biogeography of human populations for 'race' and medicine
    Sarah A Tishkoff
    Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 36:S21-7. 2004
    ..Identifiers based on race will often be insufficient...

Research Grants5

  1. Variation at Malaria Resistance Genes in Africans
    SARAH TISHKOFF; Fiscal Year: 2006
    ..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..
  2. Variation at Malaria Resistance Genes in Africans
    SARAH TISHKOFF; Fiscal Year: 2009
    ..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..
  3. African Odyssey: An Integrative Genomics Analysis of Complex Physiologic Traits
    SARAH TISHKOFF; Fiscal Year: 2009
    ..I will use a systems and evolutionary biology approach to identify genetic and environmental factors that influence complex physiologic traits, incl ..