Research Topics
| SARAH TISHKOFFSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Exploring genomic studies in AfricaScott M Williams
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, 2215 Garland Avenue, Nashville, TN 37232 0700, USA
Genome Med 3:45. 2011..A report on the African Society of Human Genetics meeting, Cape Town, South Africa, 6-9 March 2011...- Genetic adaptation to high altitude in the Ethiopian highlandsLaura B Scheinfeldt
Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Genome Biol 13:R1. 2012..We genotyped the Illumina 1M SNP array and employed several genome-wide scans for selection and targeted association with hemoglobin levels to identify genes that play a role in adaptation to high altitude... - Living the high life: high-altitude adaptationLaura B Scheinfeldt
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
Genome Biol 11:133. 2010..Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation... - The genetic structure and history of Africans and African AmericansSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Science 324:1035-44. 2009..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies... 
History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variationSarah A Tishkoff
Department of Biology, University of Maryland, USA
Mol Biol Evol 24:2180-95. 2007....- Whole-mtDNA genome sequence analysis of ancient African lineagesMary Katherine Gonder
Department of Biology, University of Maryland, MD, USA
Mol Biol Evol 24:757-68. 2007..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa... - African genetic diversity: implications for human demographic history, modern human origins, and complex disease mappingMichael C Campbell
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
Annu Rev Genomics Hum Genet 9:403-33. 2008..This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility... - Convergent adaptation of human lactase persistence in Africa and EuropeSarah A Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nat Genet 39:31-40. 2007..These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits-animal domestication and adult milk consumption... - Evidence for balancing selection from nucleotide sequence analyses of human G6PDBrian C Verrelli
Department of Biology, University of Maryland, College Park, MD 20742, USA
Am J Hum Genet 71:1112-28. 2002..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution... - Signatures of selection and gene conversion associated with human color vision variationBrian C Verrelli
Department of Biology, University of Maryland, College Park 20742, USA
Am J Hum Genet 75:363-75. 2004..Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptive during human evolution... - Genetic analysis of African populations: human evolution and complex diseaseSarah A Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Genet 3:611-21. 2002 - Role of evolutionary history on haplotype block structure in the human genome: implications for disease mappingSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Curr Opin Genet Dev 13:569-75. 2003.... - African human diversity, origins and migrationsFloyd A Reed
Department of Biology, University of Maryland, College Park, MD 20742, USA
Curr Opin Genet Dev 16:597-605. 2006..Thus, we have tremendous potential to learn about human variation and evolutionary history and to positively impact human health care from studies of genetic diversity in Africa... - Positive selection can create false hotspots of recombinationFloyd A Reed
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Genetics 172:2011-4. 2006.... - Implications of biogeography of human populations for 'race' and medicineSarah A Tishkoff
Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
Nat Genet 36:S21-7. 2004..Identifiers based on race will often be insufficient...
Research Grants
- Variation at Malaria Resistance Genes in AfricansSARAH TISHKOFF; Fiscal Year: 2006..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..
- Variation at Malaria Resistance Genes in AfricansSARAH TISHKOFF; Fiscal Year: 2009..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..
- African Odyssey: An Integrative Genomics Analysis of Complex Physiologic TraitsSARAH TISHKOFF; Fiscal Year: 2009..I will use a systems and evolutionary biology approach to identify genetic and environmental factors that influence complex physiologic traits, incl ..