Sarah A Tishkoff

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 13:569-75. 2003
  2. pmc Convergent adaptation of human lactase persistence in Africa and Europe
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 39:31-40. 2007
  3. ncbi request reprint Whole-mtDNA genome sequence analysis of ancient African lineages
    Mary Katherine Gonder
    Department of Biology, University of Maryland, MD, USA
    Mol Biol Evol 24:757-68. 2007
  4. ncbi request reprint History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation
    Sarah A Tishkoff
    Department of Biology, University of Maryland, USA
    Mol Biol Evol 24:2180-95. 2007
  5. ncbi request reprint Implications of biogeography of human populations for 'race' and medicine
    Sarah A Tishkoff
    Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 36:S21-7. 2004
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
  7. doi request reprint Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations
    Holly M Mortensen
    Department of Biology, University of Maryland, College Park, MD, USA
    Pharmacogenomics 12:1545-58. 2011
  8. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004
  9. pmc Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers
    Joseph Lachance
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 150:457-69. 2012
  10. ncbi request reprint African human diversity, origins and migrations
    Floyd A Reed
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 16:597-605. 2006

Research Grants

  1. Variation at Malaria Resistance Genes in Africans
    SARAH TISHKOFF; Fiscal Year: 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 13:569-75. 2003
    ....
  2. pmc Convergent adaptation of human lactase persistence in Africa and Europe
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 39:31-40. 2007
    ..These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits-animal domestication and adult milk consumption...
  3. ncbi request reprint Whole-mtDNA genome sequence analysis of ancient African lineages
    Mary Katherine Gonder
    Department of Biology, University of Maryland, MD, USA
    Mol Biol Evol 24:757-68. 2007
    ..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa...
  4. ncbi request reprint History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation
    Sarah A Tishkoff
    Department of Biology, University of Maryland, USA
    Mol Biol Evol 24:2180-95. 2007
    ....
  5. ncbi request reprint Implications of biogeography of human populations for 'race' and medicine
    Sarah A Tishkoff
    Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 36:S21-7. 2004
    ..Identifiers based on race will often be insufficient...
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
    ..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies...
  7. doi request reprint Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations
    Holly M Mortensen
    Department of Biology, University of Maryland, College Park, MD, USA
    Pharmacogenomics 12:1545-58. 2011
    ..Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution...
  8. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004
    ..Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptive during human evolution...
  9. pmc Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers
    Joseph Lachance
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 150:457-69. 2012
    ..Within the Pygmy population, we identify multiple highly differentiated loci that play a role in growth and anterior pituitary function and are associated with height...
  10. ncbi request reprint African human diversity, origins and migrations
    Floyd A Reed
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 16:597-605. 2006
    ..Thus, we have tremendous potential to learn about human variation and evolutionary history and to positively impact human health care from studies of genetic diversity in Africa...
  11. pmc Positive selection can create false hotspots of recombination
    Floyd A Reed
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Genetics 172:2011-4. 2006
    ....
  12. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
    ..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution...
  13. ncbi request reprint Patterns of human genetic diversity: implications for human evolutionary history and disease
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genomics Hum Genet 4:293-340. 2003
    ..We discuss these differences and their implications for mapping disease genes and for understanding how population and genomic diversity have been important in the evolution, differentiation, and adaptation of humans...
  14. ncbi request reprint Genetic analysis of African populations: human evolution and complex disease
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Genet 3:611-21. 2002
  15. ncbi request reprint Elevated male European and female African contributions to the genomes of African American individuals
    Joanne M Lind
    Laboratory of Genomic Diversity, NCI Frederick, Frederick, MD, USA
    Hum Genet 120:713-22. 2007
    ..mtDNA) to the genomes of African American individuals meaning that admixture-based gene discovery will have the most power for the autosomes and will be more limited for X chromosome analysis...
  16. ncbi request reprint Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1717-20. 2005
    ..It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes...
  17. ncbi request reprint Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees
    Brian C Verrelli
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
    Mol Biol Evol 23:1592-601. 2006
    ..These comparative analyses suggest that the recent signature of positive selection at G6PD in humans is unique...
  18. ncbi request reprint Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variation
    Makoto K Shimada
    Department of Genetics, Rutgers University, NJ, USA
    Mol Biol Evol 24:687-98. 2007
    ..Taken together, these features of hX-that it is much older than other haplotypes and uncommon and patchily distributed throughout Africa, Europe, and Asia-present a cautionary tale for interpretations of human history...
  19. ncbi request reprint Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005
    ..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution...
  20. pmc A high-density admixture map for disease gene discovery in african americans
    Michael W Smith
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
    Am J Hum Genet 74:1001-13. 2004
    ..The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations...
  21. ncbi request reprint Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics
    Giorgio Sirugo
    Medical Research Council Laboratories, Fajara, The Gambia, West Africa
    Hum Genet 123:557-98. 2008
    ..In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease...
  22. pmc Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa
    Brenna M Henn
    Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
    Proc Natl Acad Sci U S A 105:10693-8. 2008
    ..Our Y-chromosomal evidence supports a demic diffusion model of pastoralism from eastern to southern Africa approximately 2,000 years ago...
  23. ncbi request reprint Molecular characterization of G6PD deficiency in Cyprus
    Anthi Drousiotou
    Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Blood Cells Mol Dis 33:25-30. 2004
    ....
  24. pmc Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 2:81-9. 2005
    ....
  25. pmc Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms
    Jianxin Wang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Gene 365:11-20. 2006
    ..Among chromosomes, the density of Alu insertion polymorphisms is positively correlated with the Alu-site availability and is inversely correlated with the densities of older Alu elements and genes...

Research Grants1

  1. Variation at Malaria Resistance Genes in Africans
    SARAH TISHKOFF; Fiscal Year: 2007
    ..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..