Research Topics
Genomes and GenesSpecies | Sarah A TishkoffSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Role of evolutionary history on haplotype block structure in the human genome: implications for disease mappingSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Curr Opin Genet Dev 13:569-75. 2003....
Convergent adaptation of human lactase persistence in Africa and EuropeSarah A Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nat Genet 39:31-40. 2007..These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits-animal domestication and adult milk consumption...- Whole-mtDNA genome sequence analysis of ancient African lineagesMary Katherine Gonder
Department of Biology, University of Maryland, MD, USA
Mol Biol Evol 24:757-68. 2007..We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa... - History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variationSarah A Tishkoff
Department of Biology, University of Maryland, USA
Mol Biol Evol 24:2180-95. 2007.... - Implications of biogeography of human populations for 'race' and medicineSarah A Tishkoff
Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
Nat Genet 36:S21-7. 2004..Identifiers based on race will often be insufficient... - The genetic structure and history of Africans and African AmericansSarah A Tishkoff
Department of Biology, University of Maryland, College Park, MD 20742, USA
Science 324:1035-44. 2009..This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies... 
Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populationsHolly M Mortensen
Department of Biology, University of Maryland, College Park, MD, USA
Pharmacogenomics 12:1545-58. 2011..Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution...- Signatures of selection and gene conversion associated with human color vision variationBrian C Verrelli
Department of Biology, University of Maryland, College Park 20742, USA
Am J Hum Genet 75:363-75. 2004..Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptive during human evolution... - Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherersJoseph Lachance
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 150:457-69. 2012..Within the Pygmy population, we identify multiple highly differentiated loci that play a role in growth and anterior pituitary function and are associated with height... - African human diversity, origins and migrationsFloyd A Reed
Department of Biology, University of Maryland, College Park, MD 20742, USA
Curr Opin Genet Dev 16:597-605. 2006..Thus, we have tremendous potential to learn about human variation and evolutionary history and to positively impact human health care from studies of genetic diversity in Africa... - Positive selection can create false hotspots of recombinationFloyd A Reed
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Genetics 172:2011-4. 2006.... - Evidence for balancing selection from nucleotide sequence analyses of human G6PDBrian C Verrelli
Department of Biology, University of Maryland, College Park, MD 20742, USA
Am J Hum Genet 71:1112-28. 2002..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution... - Patterns of human genetic diversity: implications for human evolutionary history and diseaseSarah A Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Annu Rev Genomics Hum Genet 4:293-340. 2003..We discuss these differences and their implications for mapping disease genes and for understanding how population and genomic diversity have been important in the evolution, differentiation, and adaptation of humans... - Genetic analysis of African populations: human evolution and complex diseaseSarah A Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Genet 3:611-21. 2002 - Elevated male European and female African contributions to the genomes of African American individualsJoanne M Lind
Laboratory of Genomic Diversity, NCI Frederick, Frederick, MD, USA
Hum Genet 120:713-22. 2007..mtDNA) to the genomes of African American individuals meaning that admixture-based gene discovery will have the most power for the autosomes and will be more limited for X chromosome analysis... - Microcephalin, a gene regulating brain size, continues to evolve adaptively in humansPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1717-20. 2005..It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes... - Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzeesBrian C Verrelli
Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
Mol Biol Evol 23:1592-601. 2006..These comparative analyses suggest that the recent signature of positive selection at G6PD in humans is unique... - Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variationMakoto K Shimada
Department of Genetics, Rutgers University, NJ, USA
Mol Biol Evol 24:687-98. 2007..Taken together, these features of hX-that it is much older than other haplotypes and uncommon and patchily distributed throughout Africa, Europe, and Asia-present a cautionary tale for interpretations of human history... - Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiensNitzan Mekel-Bobrov
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1720-2. 2005..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution... - A high-density admixture map for disease gene discovery in african americansMichael W Smith
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
Am J Hum Genet 74:1001-13. 2004..The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations... - Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeuticsGiorgio Sirugo
Medical Research Council Laboratories, Fajara, The Gambia, West Africa
Hum Genet 123:557-98. 2008..In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease... - Y-chromosomal evidence of a pastoralist migration through Tanzania to southern AfricaBrenna M Henn
Department of Anthropology, Stanford University, Stanford, CA 94035 2117, USA
Proc Natl Acad Sci U S A 105:10693-8. 2008..Our Y-chromosomal evidence supports a demic diffusion model of pastoralism from eastern to southern Africa approximately 2,000 years ago... - Molecular characterization of G6PD deficiency in CyprusAnthi Drousiotou
Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
Blood Cells Mol Dis 33:25-30. 2004.... - Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variationMark D Shriver
Penn State University, University Park, Pennsylvania, USA
Hum Genomics 2:81-9. 2005.... - Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphismsJianxin Wang
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Gene 365:11-20. 2006..Among chromosomes, the density of Alu insertion polymorphisms is positively correlated with the Alu-site availability and is inversely correlated with the densities of older Alu elements and genes...
Research Grants
- Variation at Malaria Resistance Genes in AfricansSARAH TISHKOFF; Fiscal Year: 2007..Lastly, we will have a better understanding of the evolutionary history of malarial infection in humans and the role of natural selection and demography on the prevalence and distribution of genetic disease. ..