Samuel A Tisherman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005
  2. doi request reprint Providing care for critically ill surgical patients: challenges and recommendations
    Samuel A Tisherman
    Departments of Critical Care Medicine and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    JAMA Surg 148:669-74. 2013
  3. doi request reprint Rescue therapies in the surgical patient
    Samuel A Tisherman
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Surg Clin North Am 92:433-9, x. 2012
  4. doi request reprint Clinical practice guideline: penetrating zone II neck trauma
    Samuel A Tisherman
    Departments of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 64:1392-405. 2008
  5. pmc Regulatory challenges for the resuscitation outcomes consortium
    Samuel A Tisherman
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 118:1585-92. 2008
  6. doi request reprint Acute care surgery survey: opinions of surgeons about a new training paradigm
    Samuel A Tisherman
    Department of Critical Care Medicine and Surgery, University of Pittsburgh, PA 15261, USA
    Arch Surg 146:101-6. 2011
  7. pmc Is fibrinogen the answer to coagulopathy after massive transfusions?
    Samuel A Tisherman
    Departments of Critical Care Medicine and Surgery, University of Pittsburgh, 638 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:154. 2010
  8. ncbi request reprint Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs
    Xianren Wu
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 28:302-11. 2008
  9. doi request reprint Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Resuscitation 77:220-8. 2008
  10. ncbi request reprint Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs
    Ala Nozari
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 57:1266-75. 2004

Detail Information

Publications50

  1. ncbi request reprint Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005
    ..The goal of this study was to evaluate the independent association between admission hypothermia and mortality after major trauma, with adjustment for clinical confounders...
  2. doi request reprint Providing care for critically ill surgical patients: challenges and recommendations
    Samuel A Tisherman
    Departments of Critical Care Medicine and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    JAMA Surg 148:669-74. 2013
    ..Support from academic and administrative leadership, as well as national organizations, will be needed. ..
  3. doi request reprint Rescue therapies in the surgical patient
    Samuel A Tisherman
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Surg Clin North Am 92:433-9, x. 2012
    ..Although perioperative complications can be catastrophic, rapid intervention, including rescue therapies when necessary, can improve outcomes...
  4. doi request reprint Clinical practice guideline: penetrating zone II neck trauma
    Samuel A Tisherman
    Departments of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 64:1392-405. 2008
  5. pmc Regulatory challenges for the resuscitation outcomes consortium
    Samuel A Tisherman
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 118:1585-92. 2008
  6. doi request reprint Acute care surgery survey: opinions of surgeons about a new training paradigm
    Samuel A Tisherman
    Department of Critical Care Medicine and Surgery, University of Pittsburgh, PA 15261, USA
    Arch Surg 146:101-6. 2011
    ..We believed that analysis of survey responses about the new training paradigm before its implementation would yield valuable information on current practice patterns and on opinions about the ACS model...
  7. pmc Is fibrinogen the answer to coagulopathy after massive transfusions?
    Samuel A Tisherman
    Departments of Critical Care Medicine and Surgery, University of Pittsburgh, 638 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:154. 2010
    ..Administration of a fibrinogen concentrate along with red blood cells can quickly restore hemostasis in a clinically relevant animal model...
  8. ncbi request reprint Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs
    Xianren Wu
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 28:302-11. 2008
    ....
  9. doi request reprint Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Resuscitation 77:220-8. 2008
    ..1+/-30.3 in D10 groups, respectively (p=0.3). OPC, NDS and HDS were not significantly different between groups. In conclusion, DADLE failed to confer benefit on functional or histological outcome in our model of prolonged rat EPR...
  10. ncbi request reprint Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs
    Ala Nozari
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 57:1266-75. 2004
    ..This study is designed to better mimic the clinical scenario of an exsanguinating trauma victim, for whom suspended animation may buy time for resuscitative surgery and delayed resuscitation...
  11. ncbi request reprint Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs
    Xianren Wu
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 113:1974-82. 2006
    ..Previously, we achieved intact survival of dogs from 2 hours of EPR after rapid hemorrhage. We tested the hypothesis that EPR would achieve good outcome if prolonged hemorrhage preceded cardiac arrest...
  12. ncbi request reprint Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs
    Xianren Wu
    Safar Center for Resuscitation Research, Department of Anesthesiology, University of Pittsburgh, PA 15260, USA
    J Trauma 59:291-9; discussion 299-301. 2005
    ....
  13. doi request reprint Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Ave, Pittsburgh, PA 15260, USA
    Shock 35:67-73. 2011
    ..Our data mirror those seen in piglets and provide additional evidence of difficulty in translating the hypothermia effect of H2S to large animals in a clinically relevant postinsult paradigm...
  14. pmc Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice
    Joseph N Hemerka
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 29:2192-208. 2012
    ..05 at 24 h and 7 days). CA1 cell loss at 21 days was seen only in CCI+HS animals (p<0.05). Brief, severe, pressure-controlled HS after CCI produces robust functional deficits and exacerbates neuropathology versus CCI or HS alone...
  15. ncbi request reprint Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Resuscitation 83:517-26. 2012
    ..This suggests that microglia may not play a pivotal role in mediating neuronal death in prolonged hypothermic CA. This novel strategy provides us with a tool to study the specific effects of microglia in hypothermic CA...
  16. ncbi request reprint Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 72:295-305. 2007
    ..We hypothesized that combining potent antioxidants with a hypertonic solution during UHS would preserve the logistical advantage of small volume resuscitation and improve survival...
  17. ncbi request reprint Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs
    Ala Nozari
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:2110-6. 2004
    ..The effect of cooling during CPCR is not known. We hypothesized that mild to moderate hypothermia during CPCR would increase the rate of neurologically intact survival after prolonged cardiac arrest in dogs...
  18. doi request reprint Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation
    Fei Han
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, United States
    Resuscitation 79:301-10. 2008
    ..We hypothesized that 75 min but not 60 min of EPR would be associated with activation of two potential secondary injury cascades in brain as reflected by protein nitration and poly (ADP-ribose) polymerase (PARP) activation...
  19. pmc Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice
    Erik C Brockman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Cereb Blood Flow Metab 33:1457-64. 2013
    ..68 mm Hg, P<0.001), and lower %BW vs. LR (80.3±0.12 vs. 80.9±0.12%, P=0.003). After TBI+HS, resuscitation with PNPH lowers fluid requirements, improves ICP and CPP, and reduces brain edema vs. LR, supporting its development. ..
  20. doi request reprint Extracorporeal versus conventional cardiopulmonary resuscitation after ventricular fibrillation cardiac arrest in rats: a feasibility trial
    Andreas Janata
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 41:e211-22. 2013
    ..We hypothesized that extracorporeal cardiopulmonary resuscitation is feasible after ventricular fibrillation cardiac arrest in rats and improves outcome versus conventional cardiopulmonary resuscitation...
  21. ncbi request reprint Titrated hypertonic/hyperoncotic solution for hypotensive fluid resuscitation during uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 65:87-95. 2005
    ..v. infusion of HHS, compared to titrated lactated Ringer's solution (LR), for hypotensive fluid resuscitation during uncontrolled HS reduces fluid requirement, does not increase blood loss, and improves survival...
  22. ncbi request reprint Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh, School of Medicine, Pittsburgh PA 15260, USA
    Life Sci 81:543-52. 2007
    ..sham, and no cognitive deficits were seen in either group vs. sham. Future studies with longer DHCA duration will be necessary to provide targets to assess novel preservation strategies...
  23. ncbi request reprint Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Resuscitation 75:114-23. 2007
    ..This model should serve as a screening model both for testing new pharmacological adjuncts to improve survival after exsanguination CA, and for elucidating the underlying mechanisms of ischemia/reperfusion injury...
  24. ncbi request reprint Hypothermia and injury
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 10:512-9. 2004
    ..Therapeutic hypothermia for traumatic brain injury is discussed...
  25. doi request reprint Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation
    Manuella S Lahoud-Rahme
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, United States
    Resuscitation 80:484-8. 2009
    ..The objective of this study was to assess BBB permeability in two EPR models in rats, associated with poor outcome. Rats subjected to traumatic brain injury (TBI) and naïve rats served as positive and negative controls, respectively...
  26. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010
    ..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
  27. ncbi request reprint Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial
    Tomas Drabek
    Safar Center for Resuscitation Research, and the Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Crit Care Med 35:532-7. 2007
    ..Development of a rat EPR model would enable study of the molecular mechanisms of neuronal injury and the screening of novel agents for emergency preservation...
  28. pmc Therapeutic hypothermia: the Safar vision
    Patrick M Kochanek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 26:417-20. 2009
    ..A discussion of future potential uses of this therapy in a variety of applications as part of the Safar vision is also presented...
  29. doi request reprint Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Anesth Analg 109:914-23. 2009
    ..We hypothesized that deep hypothermia and minocycline would attenuate neuronal death and microglial activation and improve outcome after exsanguination CA in rats...
  30. ncbi request reprint Regional TNFα mapping in the brain reveals the striatum as a neuroinflammatory target after ventricular fibrillation cardiac arrest in rats
    Andreas Janata
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Resuscitation 85:694-701. 2014
    ..This study was approved by the University of Pittsburgh IACUC 1002340A-3...
  31. ncbi request reprint Suspended animation for resuscitation from exsanguinating hemorrhage
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:S46-50. 2004
    ..As laboratory studies to optimize suspended animation proceed, clinical trials should be initiated. In addition, devices should be developed to facilitate induction of suspended animation, eventually in the field...
  32. ncbi request reprint Clinical practice guideline: endpoints of resuscitation
    Samuel A Tisherman
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Trauma 57:898-912. 2004
  33. ncbi request reprint After spontaneous hypothermia during hemorrhagic shock, continuing mild hypothermia (34 degrees C) improves early but not late survival in rats
    Xianren Wu
    Department of Anesthesiology, University of Pittsburgh, Pennsylvania, 15260, USA
    J Trauma 55:308-16. 2003
    ..We hypothesized that after spontaneous cooling during HS, continuing mild therapeutic hypothermia during resuscitation is beneficial compared with active rewarming...
  34. ncbi request reprint Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Department of Anesthesiology Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 22:105-17. 2002
    ..The mechanisms involved in this beneficial effect need further clarification...
  35. pmc An early, novel illness severity score to predict outcome after cardiac arrest
    Jon C Rittenberger
    University of Pittsburgh, Department of Emergency Medicine, PA, USA
    Resuscitation 82:1399-404. 2011
    ..We developed an early, novel post-arrest illness severity score to predict survival, good outcome and development of multiple organ failure (MOF) after cardiac arrest...
  36. ncbi request reprint Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats
    Rainer Kentner
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania 15260, USA
    J Trauma 53:968-77. 2002
    ..We hypothesized that the combination of free Tempol with polynitroxylated albumin (PNA)-bound Tempol (which prolongs half-life and decreases toxicity) improves outcome after HS in rats...
  37. pmc Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, United States
    Resuscitation 79:198-204. 2008
    ..We implemented a series of process interventions designed to increase TH use and improve outcomes in patients successfully resuscitated from out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA)...
  38. ncbi request reprint Trauma fluid resuscitation in 2010
    Samuel A Tisherman
    Safar Center for Resuscitation Research, Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    J Trauma 54:S231-4. 2003
  39. ncbi request reprint Management of sepsis
    Gina Howell
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Surg Clin North Am 86:1523-39. 2006
    ..In the future, a better understanding of the pathophysiology of sepsis and clinical studies may further improve outcomes from severe sepsis...
  40. ncbi request reprint Hot or cold? In support of cold
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hosp Med 66:78-80. 2005
  41. ncbi request reprint Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses
    Xianren Wu
    Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA
    Crit Care Med 31:195-202. 2003
    ..To explore the hypothesis that the survival benefit of mild, therapeutic hypothermia during hemorrhagic shock is associated with inhibition of lipid peroxidation and the acute inflammatory response...
  42. ncbi request reprint Systemic hypothermia, but not regional gut hypothermia, improves survival from prolonged hemorrhagic shock in rats
    Xianren Wu
    Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15260, USA
    J Trauma 53:654-62. 2002
    ..We hypothesized that cooling the gut alone could improve survival in a rat HS model and avoid potential deleterious effects of systemic hypothermia...
  43. ncbi request reprint Structure of surgical critical care and trauma fellowships
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA
    Crit Care Med 34:2282-6. 2006
    ..As the American Board of Surgery is considering combining SCC, trauma, and emergency surgery into "acute care surgery" fellowship training, a better understanding of current program structures is needed...
  44. ncbi request reprint Effects of mild hypothermia on survival and serum cytokines in uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research and the Department of Anesthesiology CCM, University of Pittsburgh, Pennsylvania 15260, USA
    Shock 17:521-6. 2002
    ..We conclude that mild hypothermia improves survival time after uncontrolled HS. Uncontrolled HS induces a robust proinflammatory cytokine response. The unexpected increase in TNF-alpha with hypothermia deserves further investigation...
  45. ncbi request reprint Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Departments of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 54:89-98. 2002
    ..There were no arrhythmias. We conclude that in large dogs the induction of mild systemic hypothermia with extracorporeal veno-venous blood shunt cooling is simple and four times more rapid than skin surface cooling...
  46. ncbi request reprint Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Pittsburgh, PA, USA
    Crit Care Med 31:1523-31. 2003
    ....
  47. pmc No sampling technique was superior for the diagnosis of ventilator-associated pneumonia
    Deanna Blisard
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 9:E4. 2005
  48. ncbi request reprint Winning the cold war: inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group
    Ericka L Fink
    Crit Care Med 35:1199-202. 2007
  49. ncbi request reprint Comment on article by Ahmed and Cheng-Robles
    Samuel A Tisherman
    J Trauma 63:455. 2007
  50. ncbi request reprint Hydrogen sulfide: metabolic mediator or toxic gas?
    Samuel A Tisherman
    Pediatr Crit Care Med 9:129-30. 2008