Y Tintut

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation
    Y Tintut
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 274:28875-9. 1999
  2. ncbi request reprint 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway
    Yin Tintut
    Department of Medicine, School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 277:14221-6. 2002
  3. ncbi request reprint Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    Y Tintut
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 102:2636-42. 2000
  4. ncbi request reprint Leptin enhances the calcification of vascular cells: artery wall as a target of leptin
    F Parhami
    Departments of Medicine, University of California, Los Angeles, USA
    Circ Res 88:954-60. 2001
  5. ncbi request reprint Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients
    F Parhami
    Department of Medicine, University of California, Los Angeles School of Medicine, USA
    Arterioscler Thromb Vasc Biol 17:680-7. 1997
  6. ncbi request reprint Recent advances in multifactorial regulation of vascular calcification
    Y Tintut
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095-1679, USA
    Curr Opin Lipidol 12:555-60. 2001
  7. ncbi request reprint Atherogenic high-fat diet reduces bone mineralization in mice
    F Parhami
    Division of Cardiology, University of California, Los Angeles School of Medicine, 90095-1679, USA
    J Bone Miner Res 16:182-8. 2001
  8. ncbi request reprint Regulation of vascular calcification in atherosclerosis
    F Parhami
    Division of Cardiology, UCLA School of Medicine, Center for the Health Sciences, 47 123, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Z Kardiol 90:27-30. 2001
  9. ncbi request reprint N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways
    M Abedin
    Department of Medicine, University of California, Los Angeles, CA, USA
    Circ Res 98:727-9. 2006
  10. ncbi request reprint HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells
    K Bostrom
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Cell Biochem 78:210-21. 2000

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation
    Y Tintut
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 274:28875-9. 1999
    ..These results suggest that suppression of osteoblastic function by the cAMP pathway is through proteolytic degradation of Cbfa1 involving a ubiquitin/proteasome-dependent mechanism...
  2. ncbi request reprint 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway
    Yin Tintut
    Department of Medicine, School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 277:14221-6. 2002
    ..These data suggest that isoPGE2 enhances osteoclastic differentiation of marrow preosteoclasts and that this regulation occurs via the cAMP-dependent protein kinase pathway...
  3. ncbi request reprint Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    Y Tintut
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 102:2636-42. 2000
    ..Because tumor necrosis factor-alpha (TNF-alpha), a pleiotropic cytokine found in atherosclerotic lesions, is also a regulator of bone formation, we investigated the role of TNF-alpha in in vitro vascular calcification...
  4. ncbi request reprint Leptin enhances the calcification of vascular cells: artery wall as a target of leptin
    F Parhami
    Departments of Medicine, University of California, Los Angeles, USA
    Circ Res 88:954-60. 2001
    ..Taken together, these results suggest that leptin regulates the osteoblastic differentiation and calcification of vascular cells and that the artery wall may be an important peripheral tissue target of leptin action...
  5. ncbi request reprint Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients
    F Parhami
    Department of Medicine, University of California, Los Angeles School of Medicine, USA
    Arterioscler Thromb Vasc Biol 17:680-7. 1997
    ..These results suggest that specific oxidized lipids may be the common factors underlying the pathogenesis of both atherosclerotic calcification and osteoporosis...
  6. ncbi request reprint Recent advances in multifactorial regulation of vascular calcification
    Y Tintut
    Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095-1679, USA
    Curr Opin Lipidol 12:555-60. 2001
    ....
  7. ncbi request reprint Atherogenic high-fat diet reduces bone mineralization in mice
    F Parhami
    Division of Cardiology, University of California, Los Angeles School of Medicine, 90095-1679, USA
    J Bone Miner Res 16:182-8. 2001
    ..Osteocalcin expression was reduced in the marrow of high fat-fed C57BL/6 mice. These findings suggest that an atherogenic diet inhibits bone formation by blocking differentiation of osteoblast progenitor cells...
  8. ncbi request reprint Regulation of vascular calcification in atherosclerosis
    F Parhami
    Division of Cardiology, UCLA School of Medicine, Center for the Health Sciences, 47 123, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Z Kardiol 90:27-30. 2001
    ..This article will focus on four important mediators of vascular calcification: 1) calcifying vascular cells, 2) oxidized lipids, 3) cytokines, and 4) leptin...
  9. ncbi request reprint N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways
    M Abedin
    Department of Medicine, University of California, Los Angeles, CA, USA
    Circ Res 98:727-9. 2006
    ..Together, these results suggest that N-3 fatty acids directly inhibit vascular calcification, and that the inhibitory effects are mediated by the p38-MAPK and PPAR-gamma pathways...
  10. ncbi request reprint HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells
    K Bostrom
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Cell Biochem 78:210-21. 2000
    ..These findings suggest that HOXB7 plays a role in expansion of immature cell populations or dedifferentiation of mature cells...
  11. ncbi request reprint Vascular calcification
    Y Tintut
    Department of Medicine, UCLA, Los Angeles, CA 90095 1679, USA
    J Musculoskelet Neuronal Interact 7:346. 2007
  12. ncbi request reprint Regulation of RANKL-induced osteoclastic differentiation by vascular cells
    Yin Tintut
    Department of Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    J Mol Cell Cardiol 39:389-93. 2005
    ..These results suggest that vascular cells inhibit osteoclastic differentiation, and that CVC have greater inhibitory effects than BASMC...
  13. ncbi request reprint Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification
    Yin Tintut
    Department of Medicine, University of California, Los Angeles, Los Angels, CA, USA
    J Investig Med 54:395-401. 2006
    ....
  14. ncbi request reprint Mineralocorticoid receptor activation promotes vascular cell calcification
    Iris Z Jaffe
    Tufts University School of Medicine, New England Medical Center, Molecular Cardiology Research Institute, 750 Washington St, Box 80, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:799-805. 2007
    ..This study examines the effects of MR activation by aldosterone on the process of in vitro vascular calcification...
  15. ncbi request reprint A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells"
    Linda L Demer
    Department of Medicine, Physiology and Biomedical Engineering, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Free Radic Biol Med 44:504-5. 2008
  16. pmc Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice
    Sean Morony
    Department of Molecular Cellular and Integrative Physiology, University of California, Los Angeles, USA
    Circulation 117:411-20. 2008
    ..However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification...
  17. doi request reprint Vascular calcification: pathobiology of a multifaceted disease
    Linda L Demer
    Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 117:2938-48. 2008
  18. doi request reprint Vitamin D and osteogenic differentiation in the artery wall
    Jeffrey J Hsu
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1679, USA
    Clin J Am Soc Nephrol 3:1542-7. 2008
    ..These findings raise interesting questions regarding the effects of vitamin D intake on atherosclerotic calcification and cardiovascular risk...
  19. pmc Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification
    Michael S Huang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Center for the Health Sciences BH 307, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    Biochem Biophys Res Commun 374:553-8. 2008
    ..These results suggest that phosphate is necessary for PKA-induced calcification of vascular cells and that the extent of PKA-induced calcification is controlled by feedback induction of the inhibitor, pyrophosphate...
  20. ncbi request reprint Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways
    Kristen Radcliff
    Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Circ Res 96:398-400. 2005
    ..These results suggest that IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of vascular cells via both ERK and PI3K pathways...
  21. ncbi request reprint Mesenchymal stem cells and the artery wall
    Moeen Abedin
    Department of Medicine, The David Geffen School of Medicine at University of California at Los Angeles, CA 90095 1679, USA
    Circ Res 95:671-6. 2004
    ..A greater understanding of how mesenchymal stem cells from the bone marrow or artery wall bring about vascular regeneration and repair may lead to novel cell-based treatments for cardiovascular disease...
  22. ncbi request reprint Vascular calcification and its relation to bone calcification: possible underlying mechanisms
    Nilam Mody
    Departments of Medicine and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, Calif 90095 1679, USA
    J Nucl Cardiol 10:177-83. 2003
  23. ncbi request reprint Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture
    Linda L Demer
    Department of Medicine, The David Geffen School of Medicine at University of California Los Angeles, 90095 1679, USA
    Arterioscler Thromb Vasc Biol 23:1739-43. 2003
    ..The review closes with a mention of therapeutic possibilities and an evolutionary paradigm to explain the reciprocal responses of vascular and bone mineralization to inflammation...
  24. ncbi request reprint Multilineage potential of cells from the artery wall
    Yin Tintut
    Department of Medicine, David Geffen School of Medicine, UCLA, 10833 LeConte Ave, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2505-10. 2003
    ..We now show that CVC have the potential to differentiate along other mesenchymal lineages...
  25. ncbi request reprint Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo
    Yin Tintut
    Department of Medicine, The David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:e6-10. 2004
    ..To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice...
  26. ncbi request reprint High-density lipoprotein regulates calcification of vascular cells
    Farhad Parhami
    Department of Medicine, University of California, Los Angeles 90095, USA
    Circ Res 91:570-6. 2002
    ..Taken together, these results suggest that HDL regulates the osteoblastic differentiation and calcification of vascular cells and that vascular calcification may be another target of HDL action in the artery wall...
  27. ncbi request reprint Novel mechanisms in accelerated vascular calcification in renal disease patients
    Linda L Demer
    Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Curr Opin Nephrol Hypertens 11:437-43. 2002
    ..It is a regulated biological process following many of the cellular and molecular programs in osteogenesis. This review summarizes some of the regulatory mechanisms that may explain its severity in renal patients...
  28. ncbi request reprint Vascular calcification: mechanisms and clinical ramifications
    Moeen Abedin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1161-70. 2004
    ..Further understanding of processes governing vascular calcification may yield new therapeutic options for vascular disease...
  29. ncbi request reprint Monocyte/macrophage regulation of vascular calcification in vitro
    Yin Tintut
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Circulation 105:650-5. 2002
    ..Calcification is a common complication of atherosclerosis and other chronic inflammatory processes that involves infiltration of monocytes and accumulation of macrophages...
  30. pmc Pattern formation by vascular mesenchymal cells
    Alan Garfinkel
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Proc Natl Acad Sci U S A 101:9247-50. 2004
    ..Thus, reaction-diffusion principles may play a significant role in morphogenetic processes in adult mesenchymal cells...
  31. ncbi request reprint Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells
    Farhad Parhami
    Department of Medicine, University of California at Los Angeles, 90095, USA
    J Bone Miner Res 17:1997-2003. 2002
    ..Identification of those molecules may provide new therapeutic approaches to prevent the decline in osteoblastic activity in osteoporosis and aging...
  32. ncbi request reprint Murine models of atherosclerotic calcification
    Jeffrey J Hsu
    Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Drug Targets 9:224-8. 2008
    ..The aim is to briefly review current understanding of the molecular basis for atherosclerotic calcification and to discuss some murine models that may be useful in advancing knowledge of its mechanisms...
  33. pmc Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts
    Michael S Huang
    Department of Medicine, University of California at Los Angeles, California 90095, USA
    J Biol Chem 282:21237-43. 2007
    ..These results suggest that atherogenic lipids inhibit osteogenic signaling induced by BMP-2 and PTH, raising the possibility that hyperlipidemia and atherogenic phospholipids may interfere with anabolic therapy...
  34. ncbi request reprint Mechanical response of a calcified plaque model to fluid shear force
    Tiantian C Lin
    Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, 90089, USA
    Ann Biomed Eng 34:1535-41. 2006
    ..This model may represent the first in vitro model of mechanical rupture of atherosclerotic plaque...
  35. ncbi request reprint Pitting phosphate transport inhibitors against vascular calcification
    Linda L Demer
    Circ Res 98:857-9. 2006
  36. ncbi request reprint Return to ectopia: stem cells in the artery wall
    Linda L Demer
    Arterioscler Thromb Vasc Biol 25:1307-8. 2005
  37. doi request reprint Nanoscale architecture in atherosclerotic calcification
    Linda L Demer
    Arterioscler Thromb Vasc Biol 28:1882-4. 2008