JENNY PY TING

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    Irving C Allen
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Exp Med 207:1045-56. 2010
  2. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
  3. pmc Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation
    Kelly E Roney
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e24795. 2011
  4. pmc Characterization of NLRP12 during the development of allergic airway disease in mice
    Irving C Allen
    Lineberger Comprehensive Cancer Center, Institute of Inflammatory Diseases and Center for Translational Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e30612. 2012
  5. pmc H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection
    N J Felix
    University of North Carolina Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Exp Med 192:31-40. 2000
  6. ncbi request reprint Genetic control of MHC class II expression
    Jenny Pan Yun Ting
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 109:S21-33. 2002
  7. ncbi request reprint The CATERPILLER family: an ancient family of immune/apoptotic proteins
    Jenny P Y Ting
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Immunol 115:33-7. 2005
  8. ncbi request reprint CATERPILLERs, pyrin and hereditary immunological disorders
    Jenny P Y Ting
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nat Rev Immunol 6:183-95. 2006

Collaborators

Detail Information

Publications8

  1. pmc The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    Irving C Allen
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Exp Med 207:1045-56. 2010
    ..These data suggest that the inflammasome functions as an attenuator of colitis and CAC...
  2. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
  3. pmc Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation
    Kelly E Roney
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e24795. 2011
    ..The data presented here show that Plexin-B2 functions in mouse macrophages as a negative regulator of the GTPases Rac and Cdc42 and as a negative regulator of basal cell motility and wound healing...
  4. pmc Characterization of NLRP12 during the development of allergic airway disease in mice
    Irving C Allen
    Lineberger Comprehensive Cancer Center, Institute of Inflammatory Diseases and Center for Translational Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e30612. 2012
    ..Thus, the allergic airway inflammation models described here should be appropriate for subsequent studies that seek to decipher the contribution of NLRP12 in mediating the host response to agents associated with asthma exacerbation...
  5. pmc H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection
    N J Felix
    University of North Carolina Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Exp Med 192:31-40. 2000
    ..These results demonstrate the significance of peptide rather than just allogeneic MHC, in eliciting graft rejection...
  6. ncbi request reprint Genetic control of MHC class II expression
    Jenny Pan Yun Ting
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 109:S21-33. 2002
    ..The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression...
  7. ncbi request reprint The CATERPILLER family: an ancient family of immune/apoptotic proteins
    Jenny P Y Ting
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Immunol 115:33-7. 2005
    ..Several prominent members including CIITA, CIAS1, and NOD2 are linked to immunologic genetic disorders that are hereditary. This indicates that these genes are ancient and important regulators of the immune system...
  8. ncbi request reprint CATERPILLERs, pyrin and hereditary immunological disorders
    Jenny P Y Ting
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nat Rev Immunol 6:183-95. 2006
    ..Most importantly, they are genetically linked to several human immunological disorders...

Research Grants46

  1. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2005
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  2. MOLECULAR REGULATION OF CLASS II MHC GENES
    Jenny Ting; Fiscal Year: 2001
    ..These goals will further our comprehension of class II gene regulation at the molecular and biologic levels. ..
  3. M Tuberculosis and Host-Defense Mechanisms
    Jenny Ting; Fiscal Year: 2005
    ..Crucial experiments will be reproduced with MDR TB. If ASC alters host response to Mtb, future experiments will be planned to study an ASC-null mouse. ..
  4. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2006
    ..4) Cell lines with reduced ASC will also be tested. Since ASC can overcome the negative regulatory function of Monarch-1 and CIAS, ASC may enhance immune response to Pg to contain the infection. ..
  5. MOLECULAR REGULATION OF CLASS II MHC GENES
    Jenny Ting; Fiscal Year: 2000
    ..These goals will further our comprehension of class II gene regulation at the molecular and biologic levels. ..
  6. M Tuberculosis and Host-Defense Mechanisms
    Jenny Ting; Fiscal Year: 2006
    ..Crucial experiments will be reproduced with MDR TB. If ASC alters host response to Mtb, future experiments will be planned to study an ASC-null mouse. ..
  7. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2001
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  8. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2002
    ..abstract_text> ..
  9. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2003
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..
  10. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2004
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  11. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2005
    ..abstract_text> ..
  12. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2005
    ..4) Cell lines with reduced ASC will also be tested. Since ASC can overcome the negative regulatory function of Monarch-1 and CIAS, ASC may enhance immune response to Pg to contain the infection. ..
  13. COORDINATE CONTROL OF HUMAN HLA-D REGION AND II GENES
    Jenny Ting; Fiscal Year: 2000
    ..Finally, identification of the basic defect in G3A, which leads to the lack of CIITA induction by IFN-gamma will be identified by complementation cloning. ..
  14. COORDINATE CONTROL OF HUMAN IA ANTIGENS AND II CHAIN
    Jenny Ting; Fiscal Year: 1992
    ..This type of functional analysis will definitely determine if class II genes are coordinately regulated due to shared specificity for DNA-binding proteins...
  15. MOLECULAR REGULATION OF CLASS II MHC GENES
    Jenny Ting; Fiscal Year: 1999
    ..These goals will further our comprehension of class II gene regulation at the molecular and biologic levels. ..
  16. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2009
    ..4) Cell lines with reduced ASC will also be tested. Since ASC can overcome the negative regulatory function of Monarch-1 and CIAS, ASC may enhance immune response to Pg to contain the infection. ..
  17. COORDINATE CONTROL OF HUMAN IA ANTIGENS AND II CHAIN
    Jenny Ting; Fiscal Year: 1993
    ..This type of functional analysis will definitely determine if class II genes are coordinately regulated due to shared specificity for DNA-binding proteins...
  18. M Tuberculosis and Host-Defense Mechanisms
    Jenny Ting; Fiscal Year: 2007
    ..Crucial experiments will be reproduced with MDR TB. If ASC alters host response to Mtb, future experiments will be planned to study an ASC-null mouse. ..
  19. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2003
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  20. COORDINATE CONTROL OF HUMAN HLA-D REGION AND II GENES
    Jenny Ting; Fiscal Year: 1999
    ..Finally, identification of the basic defect in G3A, which leads to the lack of CIITA induction by IFN-gamma will be identified by complementation cloning. ..
  21. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2001
    ..abstract_text> ..
  22. Role of Class II MHC Antigens in Neurologic Diseases
    Jenny Ting; Fiscal Year: 2002
    ..4. Identify genes that are activated upon class II MHC engagement. in a microglial-macrophage line by Affy metrix screening, and assess the status of these genes in the cuprizone model. ..
  23. M Tuberculosis and Host-Defense Mechanisms
    Jenny Ting; Fiscal Year: 2009
    ..Crucial experiments will be reproduced with MDR TB. If ASC alters host response to Mtb, future experiments will be planned to study an ASC-null mouse. ..
  24. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2006
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..
  25. Plexin-A1: Regulation by CIITA and immunologic function
    Jenny Ting; Fiscal Year: 2007
    ..abstract_text> ..
  26. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2007
    ..4) Cell lines with reduced ASC will also be tested. Since ASC can overcome the negative regulatory function of Monarch-1 and CIAS, ASC may enhance immune response to Pg to contain the infection. ..
  27. COORDINATE CONTROL OF HUMAN IA ANTIGENS AND II CHAIN
    Jenny Ting; Fiscal Year: 1991
    ..This type of functional analysis will definitely determine if class II genes are coordinately regulated due to shared specificity for DNA-binding proteins...
  28. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2002
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..
  29. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2003
    ..abstract_text> ..
  30. Cordinate Control of Human HLA-D Region and II Genes
    Jenny Ting; Fiscal Year: 2004
    ..abstract_text> ..
  31. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2004
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..
  32. Role of CIITA Isoforms in Graft Rejection
    Jenny Ting; Fiscal Year: 2005
    ..3) What are the biochemical and biophysical natures of these three isoforms? Can this information assist us in the design of small peptides that may block the function of CIITA, and therefore enhance the survival of allogeneic grafts?..