LISA D TIMMONS

Summary

Affiliation: University of Kansas
Country: USA

Publications

  1. pmc Inducible systemic RNA silencing in Caenorhabditis elegans
    Lisa Timmons
    Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas 66045, USA
    Mol Biol Cell 14:2972-83. 2003
  2. pmc Natural and unanticipated modifiers of RNAi activity in Caenorhabditis elegans
    Nadeem Asad
    Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 7:e50191. 2012
  3. ncbi request reprint Endogenous inhibitors of RNA interference in Caenorhabditis elegans
    Lisa Timmons
    Department of Molecular Biosciences, 1200 Sunnyside Avenue, University of Kansas, Lawrence, Kansas 66045, USA
    Bioessays 26:715-8. 2004
  4. ncbi request reprint ABC transporters and RNAi in Caenorhabditis elegans
    LISA D TIMMONS
    Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 5041 Haworth Hall, Lawrence, KS 66045 7534, USA
    J Bioenerg Biomembr 39:459-63. 2007
  5. pmc Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7
    Prema Sundaram
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    Genetics 178:801-14. 2008
  6. pmc The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments
    Wang Han
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    Genetics 178:1875-93. 2008
  7. pmc ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans
    Prema Sundaram
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Mol Biol Cell 17:3678-88. 2006
  8. ncbi request reprint Delivery methods for RNA interference in C. elegans
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, USA
    Methods Mol Biol 351:119-25. 2006
  9. ncbi request reprint Construction of plasmids for RNA interference and in vitro transcription of double-stranded RNA
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, USA
    Methods Mol Biol 351:109-17. 2006
  10. ncbi request reprint The long and short of siRNAs
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Mol Cell 10:435-7. 2002

Collaborators

Detail Information

Publications11

  1. pmc Inducible systemic RNA silencing in Caenorhabditis elegans
    Lisa Timmons
    Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas 66045, USA
    Mol Biol Cell 14:2972-83. 2003
    ..elegans and can separate mechanisms underlying systemic RNA silencing into tissue-specific components. These data suggest that trafficking of RNA silencing signals in C. elegans is regulated by specific physiological and genetic factors...
  2. pmc Natural and unanticipated modifiers of RNAi activity in Caenorhabditis elegans
    Nadeem Asad
    Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 7:e50191. 2012
    ..These observations highlight the potential for unanticipated mutations, coupled with genetic and environmental phenomena, to enhance or suppress the effects of known mutations and cause variation between wild-type strains...
  3. ncbi request reprint Endogenous inhibitors of RNA interference in Caenorhabditis elegans
    Lisa Timmons
    Department of Molecular Biosciences, 1200 Sunnyside Avenue, University of Kansas, Lawrence, Kansas 66045, USA
    Bioessays 26:715-8. 2004
    ..Since ERI-1 is a conserved protein, development of procedures to enhance RNAi effectiveness in other systems may be possible...
  4. ncbi request reprint ABC transporters and RNAi in Caenorhabditis elegans
    LISA D TIMMONS
    Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 5041 Haworth Hall, Lawrence, KS 66045 7534, USA
    J Bioenerg Biomembr 39:459-63. 2007
    ..We will also describe unique roles for some transporter genes in endogenous RNAi-related processes...
  5. pmc Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7
    Prema Sundaram
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    Genetics 178:801-14. 2008
    ..From our results, we speculate that the coordinated activities of ABC(RNAi) transporters, through their effects on endogenous RNAi-related mechanisms, ultimately affect chromosome function and integrity...
  6. pmc The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments
    Wang Han
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    Genetics 178:1875-93. 2008
    ..Thus, the ultimate functions of rsd-2 and rsd-6 in systemic RNAi are remarkably complex and environmentally responsive...
  7. pmc ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans
    Prema Sundaram
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Mol Biol Cell 17:3678-88. 2006
    ..elegans. Thus, the ability to mount a robust RNAi response to dsRNA depends upon the deployment of two ancient systems that respond to environmental assaults: RNAi mechanisms and membrane transport systems that use ABC proteins...
  8. ncbi request reprint Delivery methods for RNA interference in C. elegans
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, USA
    Methods Mol Biol 351:119-25. 2006
    ..This chapter describes four methods for delivery of double-stranded RNA to Caenorhabditis elegans (injection, feeding, soaking, and in vivo delivery), and suggests schemes that should facilitate detection of specific gene silencing...
  9. ncbi request reprint Construction of plasmids for RNA interference and in vitro transcription of double-stranded RNA
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, USA
    Methods Mol Biol 351:109-17. 2006
    ..In this chapter, we describe how to generate DNAs that can be used as templates for transcription of dsRNA...
  10. ncbi request reprint The long and short of siRNAs
    Lisa Timmons
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Mol Cell 10:435-7. 2002
    ..2002). This class has slower electrophoretic mobility than previously characterized siRNAs and may play an important role in transgene-induced systemic silencing and in methylation of endogenous retroelement DNA...
  11. ncbi request reprint Methods for delivery of double-stranded RNA into Caenorhabditis elegans
    Dawn Hull
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA
    Methods Mol Biol 265:23-58. 2004
    ..elegans, techniques for dsRNA preparation, four basic methods for delivery of dsRNA to C. elegans (injection, soaking, feeding, and in vivo delivery), and we suggest schemes that should facilitate detection of specific gene silencing...

Research Grants1

  1. INBRE: KU-L: PARTITION OF DSRNAS TO DAUGHTER CELLS FOLLOWING MITOSIS/MEIOSIS
    Lisa Timmons; Fiscal Year: 2006
    ..We are using genetics and developmental biology approaches in C. elegans to uncover mechanisms that facilitate silencing in dividing cells of developing organisms. ..