K Tillisch

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Complementary and alternative medicine for functional gastrointestinal disorders
    K Tillisch
    Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 700, Los Angeles, CA 90095, USA
    Gut 55:593-6. 2006
  2. ncbi request reprint Neuroimaging the microbiome-gut-brain axis
    Kirsten Tillisch
    Division of Digestive Diseases, Department of Medicine, Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, CHS 42 210 MC737818, 957378, Los Angeles, CA, 90095 7378, USA
    Adv Exp Med Biol 817:405-16. 2014
  3. pmc Consumption of fermented milk product with probiotic modulates brain activity
    Kirsten Tillisch
    Oppenheimer Family Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Gastroenterology 144:1394-401, 1401.e1-4. 2013
  4. pmc Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study
    K Tillisch
    Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 35:360-7. 2012
  5. ncbi request reprint Complementary and alternative medicine for gastrointestinal disorders
    Kirsten Tillisch
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Clin Med 7:224-7. 2007
  6. ncbi request reprint Pain perception in irritable bowel syndrome
    Kirsten Tillisch
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    CNS Spectr 10:877-82. 2005
  7. pmc Sex specific alterations in autonomic function among patients with irritable bowel syndrome
    K Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 54:1396-401. 2005
  8. pmc Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
  9. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
  10. ncbi request reprint Traditional Chinese medicine based subgrouping of irritable bowel syndrome patients
    S Tan
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Chin Med 33:365-79. 2005

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Complementary and alternative medicine for functional gastrointestinal disorders
    K Tillisch
    Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 700, Los Angeles, CA 90095, USA
    Gut 55:593-6. 2006
    ..Studies of acupuncture and herbal therapy for functional gastrointestinal disorders in the Western literature have often been limited by poor study design but these interventions may have promise and are discussed here...
  2. ncbi request reprint Neuroimaging the microbiome-gut-brain axis
    Kirsten Tillisch
    Division of Digestive Diseases, Department of Medicine, Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, CHS 42 210 MC737818, 957378, Los Angeles, CA, 90095 7378, USA
    Adv Exp Med Biol 817:405-16. 2014
    ..As we gather knowledge about the way that our microbiota interact with their local environments, there is also increasing interest in their communication with the brain. ..
  3. pmc Consumption of fermented milk product with probiotic modulates brain activity
    Kirsten Tillisch
    Oppenheimer Family Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Gastroenterology 144:1394-401, 1401.e1-4. 2013
    ..We investigated whether consumption of a fermented milk product with probiotic (FMPP) for 4 weeks by healthy women altered brain intrinsic connectivity or responses to emotional attention tasks...
  4. pmc Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study
    K Tillisch
    Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 35:360-7. 2012
    ..The substance P ⁄ neurokinin-1 receptor system is implicated in the regulation of both pain and anxiety, suggesting a potential therapeutic target in IBS...
  5. ncbi request reprint Complementary and alternative medicine for gastrointestinal disorders
    Kirsten Tillisch
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Clin Med 7:224-7. 2007
    ..As we learn more about these CAM modalities, integration of those shown to be effective into our conventional practice and avoidance of those shown to be risky or of little use will be of benefit both to patients and practitioners...
  6. ncbi request reprint Pain perception in irritable bowel syndrome
    Kirsten Tillisch
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    CNS Spectr 10:877-82. 2005
    ..The frequent comorbidity with psychiatric disorders suggests the possibility of shared pathophysiological mechanisms and etiologic factors...
  7. pmc Sex specific alterations in autonomic function among patients with irritable bowel syndrome
    K Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 54:1396-401. 2005
    ..The few studies directly examining ANS measures have been suggestive of alterations in some IBS patients, but no studies to date have examined the potentially critical variables of sex differences or response to visceral stimulation...
  8. pmc Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
    ..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain...
  9. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
    ..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework...
  10. ncbi request reprint Traditional Chinese medicine based subgrouping of irritable bowel syndrome patients
    S Tan
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, USA
    Am J Chin Med 33:365-79. 2005
    ..This pilot study provides preliminary support for a methodology to identify novel subgroups of IBS patients related to the TCM classification, which may differ in underlying pathophysiology and treatment responses...
  11. pmc Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
    Am J Gastroenterol 104:1984-91. 2009
    ..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities...
  12. pmc Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome
    Jennifer S Labus
    Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroimage 47:952-60. 2009
    ....
  13. pmc The brain-gut axis in abdominal pain syndromes
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Annu Rev Med 62:381-96. 2011
    ....
  14. pmc Differences in brain responses between lean and obese women to a sweetened drink
    L Connolly
    Oppenheimer Family Center for Neurobiology of Stress, Los Angeles, CA 90095 7378, USA
    Neurogastroenterol Motil 25:579-e460. 2013
    ....
  15. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  16. ncbi request reprint Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease
    E A Mayer
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 24:919-33. 2006
    ..Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia...
  17. pmc Studying the brain-gut axis with pharmacological imaging
    Kirsten Tillisch
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6949, USA
    Ann N Y Acad Sci 1144:256-64. 2008
    ..This chapter reviews the state of the art in pharmacological imaging studies, both in human subjects and in animal models of brain-gut interactions...
  18. ncbi request reprint Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome
    Kirsten Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Am J Gastroenterol 100:896-904. 2005
    ..Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized...
  19. ncbi request reprint Diagnosis and treatment of irritable bowel syndrome: state of the art
    Kirsten Tillisch
    VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 7:249-56. 2005
    ..Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review...
  20. ncbi request reprint Is lansoprazole effective for the initial management of young patients with dyspepsia?
    Emeran A Mayer
    David Geffen School of Medicine, Suite 700, 100 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Nat Clin Pract Gastroenterol Hepatol 5:200-1. 2008
  21. ncbi request reprint Emerging drugs for irritable bowel syndrome
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, UCLA Division of Digestive Diseases, GLA VA HC Bldg, 115 CURE, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Expert Opin Emerg Drugs 11:293-313. 2006
    ..Advances in clinical trial design will help to evaluate these compounds in different IBS patient populations...

Research Grants2

  1. Central and Peripheral Autonomic Responses in Irritable Bowel Syndrome
    Kirsten Tillisch; Fiscal Year: 2007
    ..The proposed training will provide the candidate with a novel set of skills to use in investigating the potential causes of IBS, and developing new treatment strategies ..