STEPHEN LLOYD TILLEY

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, and the Center of Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e24947. 2011
  2. pmc Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation
    Steven J Budd
    Protochips, Raleigh, NC, USA
    Respir Res 13:56. 2012
  3. pmc Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 8033 Burnett Womack, Chapel Hill, NC 27599 7219, USA
    J Pharmacol Exp Ther 344:426-35. 2013
  4. pmc Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection
    Ilona Jaspers
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Part Fibre Toxicol 6:22. 2009
  5. ncbi request reprint Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 178:3208-18. 2007
  6. doi request reprint Therapeutic applications
    Stephen Tilley
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC, 29799, USA
    Subcell Biochem 55:235-76. 2011
  7. ncbi request reprint Methylxanthines in asthma
    Stephen L Tilley
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Handb Exp Pharmacol 200:439-56. 2011
  8. pmc Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy
    Xiaoyang Hua
    Pulmonary Division, Department of Medicine, CB 7219, Burnett Womack Bldg, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Appl Physiol (1985) 108:189-96. 2010
  9. pmc Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice
    Joshua G McCaskill
    Department of Medicine, Division of Pulmonary Diseases and Cricital Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7219, USA
    Am J Respir Cell Mol Biol 35:347-56. 2006
  10. ncbi request reprint Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 171:331-7. 2003

Research Grants

  1. Role of propionibacteria in sarcoidosis
    Stephen Tilley; Fiscal Year: 2005
  2. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2004
  3. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2009
  4. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2009
  5. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2007
  6. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2006
  7. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2005
  8. ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
    Stephen Tilley; Fiscal Year: 2004
  9. Role of Adenosine in Allergic Lung Disease
    STEPHEN LLOYD TILLEY; Fiscal Year: 2010

Collaborators

Detail Information

Publications14

  1. pmc IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, and the Center of Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e24947. 2011
    ..These results suggest that Th2 cytokines in the asthmatic lung may alter adenosine receptor expression on airway mast cells to promote increased responsiveness to adenosine...
  2. pmc Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation
    Steven J Budd
    Protochips, Raleigh, NC, USA
    Respir Res 13:56. 2012
    ..We investigated mannose binding (MBL) during cold ischemia and in tissue samples from explanted lungs with BOS, and assessed MBL and complement proteins in plasma post-lung transplantation relative to BOS staging...
  3. pmc Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 8033 Burnett Womack, Chapel Hill, NC 27599 7219, USA
    J Pharmacol Exp Ther 344:426-35. 2013
    ..We identify A(2B) as the primary receptor limiting mast cell degranulation, whereas the combined activity of A(2A) and A(2B) is required for the inhibition of cytokine synthesis...
  4. pmc Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection
    Ilona Jaspers
    Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Part Fibre Toxicol 6:22. 2009
    ..abstract:..
  5. ncbi request reprint Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 178:3208-18. 2007
    ..These data reveal a critical role for RORgamma in the regulation of Ig production and Th1/Th2 balance in adaptive immunity...
  6. doi request reprint Therapeutic applications
    Stephen Tilley
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC, 29799, USA
    Subcell Biochem 55:235-76. 2011
    ..We use the information acquired in the previous chapters on purinergic signaling and lung functions to scrutinize the preclinical and clinical data, and to realign the efforts of the pharmaceutical industry...
  7. ncbi request reprint Methylxanthines in asthma
    Stephen L Tilley
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Handb Exp Pharmacol 200:439-56. 2011
    ....
  8. pmc Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy
    Xiaoyang Hua
    Pulmonary Division, Department of Medicine, CB 7219, Burnett Womack Bldg, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Appl Physiol (1985) 108:189-96. 2010
    ..It provides more comprehensive evaluation on nasal MCC rather than assessing a single component of the MCC apparatus in isolation...
  9. pmc Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice
    Joshua G McCaskill
    Department of Medicine, Division of Pulmonary Diseases and Cricital Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7219, USA
    Am J Respir Cell Mol Biol 35:347-56. 2006
    ....
  10. ncbi request reprint Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 171:331-7. 2003
    ..Finally, our findings indicate that adenosine exposure can result in A(3)-dependent airway inflammation, as reflected in neutrophil recruitment, as well as alterations in airway function...
  11. pmc Enhanced mast cell activation in mice deficient in the A2b adenosine receptor
    Xiaoyang Hua
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Exp Med 204:117-28. 2007
    ....
  12. doi request reprint Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 122:107-13, 113.e1-7. 2008
    ..Adenosine levels are high in the lungs of patients with asthma, but a role for adenosine in the development of this cardinal feature of asthma has not been previously reported...
  13. ncbi request reprint Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7219, USA
    Am J Physiol Lung Cell Mol Physiol 293:L25-32. 2007
    ..Further examination of this response using pharmacologically, surgically, and genetically manipulated mice supports a model in which adenosine-induced bronchoconstriction occurs indirectly through the activation of sensory neurons...
  14. ncbi request reprint Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003
    ..This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma...

Research Grants10

  1. Role of propionibacteria in sarcoidosis
    Stephen Tilley; Fiscal Year: 2005
    ..Future directions will include a placebo-controlled trial of tetracyclines for sarcoidosis if Propionibacteria are identified. ..
  2. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2004
    ..abstract_text> ..
  3. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2009
    ..A better understanding of the inflammatory mediators involved in this disease, such as adenosine, will help identify new avenues of therapy, leading to better treatments for asthma. ..
  4. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2009
    ..A better understanding of the inflammatory mediators involved in this disease, such as adenosine, will help identify new avenues of therapy, leading to better treatments for asthma. ..
  5. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2007
    ..abstract_text> ..
  6. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2006
    ..abstract_text> ..
  7. Role of Adenosine in Allergic Lung Disease
    Stephen Tilley; Fiscal Year: 2005
    ..abstract_text> ..
  8. ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
    Stephen Tilley; Fiscal Year: 2004
    ..abstract_text> ..
  9. Role of Adenosine in Allergic Lung Disease
    STEPHEN LLOYD TILLEY; Fiscal Year: 2010
    ..A better understanding of the inflammatory mediators involved in this disease, such as adenosine, will help identify new avenues of therapy, leading to better treatments for asthma. ..