Research Topics
Genomes and Genes
| Tarik TihanSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The prognostic value of histological grading of posterior fossa ependymomas in children: a Children's Oncology Group study and a review of prognostic factorsTarik Tihan
Department of Pathology, University of California, San Francisco, CA 94143 0102, USA
Mod Pathol 21:165-77. 2008....- Astrocytic neoplasms of the central nervous system and orbit: a morphologic perspectiveTarik Tihan
Department of Pathology, University of California, San Francisco, UCSF School of Medicine, California, 94143 0102, USA
Semin Diagn Pathol 27:114-21. 2010..This short review highlights the most pertinent features of neoplasms considered within this diverse family... - Pathologic and epidemiologic findings of intramedullary spinal cord tumorsTarik Tihan
Department of Pathology, University of California, San Francisco, CA 94143, USA
Neurosurg Clin N Am 17:7-11. 2006 - Neural stem cells and their role in the pathology and classification of central nervous system tumorsTarik Tihan
Department of Pathology, University of California San Francisco, San Francisco, USA
Turk Patoloji Derg 27:1-11. 2011..We strongly believe that the ever increasing knowledge in the field of neural and brain tumor stem cells should be influential in the subsequent attempts to classify brain tumors... 
Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional studyTarik Tihan
Department of Pathology, University of California San Francisco, San Francisco, CA, USA
Am J Surg Pathol 36:43-55. 2012..This finding has significant implications given its role in oncogen-induced senescence and possible influence on treatment decisions of subtotally resected tumors...- Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 112:990-6. 2010..The authors present a large series of histologically confirmed SGSs, with follow-up to describe the clinical and radiological presentation, pathological diagnosis, and treatment outcomes... - Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patientsMartin J Rutkowski
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Cancer 118:1628-36. 2012..Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management... - Role of extent of resection in the long-term outcome of low-grade hemispheric gliomasJustin S Smith
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave, Room M 779, San Francisco, CA 94143 0112, USA
J Clin Oncol 26:1338-45. 2008..The prognostic role of extent of resection (EOR) of low-grade gliomas (LGGs) is a major controversy. We designed a retrospective study to assess the influence of EOR on long-term outcomes of LGGs... - Management of recurrent intracranial hemangiopericytomaMartin J Rutkowski
Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Clin Neurosci 18:1500-4. 2011..This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent HPC with adjuvant EBRT should be the first steps in management... - Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumorsMichael W Johnson
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Surg Pathol 34:1783-91. 2010..Further follow-up is needed to more accurately determine the prognosis of intermediate tumors... - Comprehensive management of symptomatic and aggressive vertebral hemangiomasFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco, R505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 19:17-29. 2008..Vertebroplasty is useful for improving pain symptoms, especially when vertebral body compression fracture has occurred in patients without neurological deficit, but is less effective in providing long-term pain relief... - The superiority of conservative resection and adjuvant radiation for craniopharyngiomasAdam Schoenfeld
Department of Radiation Oncology, University of California, San Francisco UCSF, San Francisco, CA 94143 1708, USA
J Neurooncol 108:133-9. 2012..014). In conclusion, for patients with craniopharyngioma, STR + RT may provide superior clinical outcome, achieving better disease control than STR and limiting side effects associated with aggressive surgical resection... - Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomasAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California, USA
World Neurosurg 74:200-5. 2010..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord... - Clinical characteristics and outcomes for a modern series of primary gliosarcoma patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, CA, USA
Cancer 116:1358-66. 2010..In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide... - Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytomaG Evren Keles
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg 105:34-40. 2006.... 
SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization systemAlexander R Pico
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Nucleic Acids Res 37:D803-9. 2009..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data...- Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastomaJames S Waldron
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94123, USA
J Clin Neurosci 17:1543-7. 2010..In addition, our results raise the possibility of combining T-cell based immunotherapy protocols with clinical inhibitors of the PI3K/Akt/mTOR pathway... - Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Neurosci 17:1209-11. 2010..The patient remains recurrence free 4 years after treatment... - Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamicsXi Huang
Howard Hughes Medical Institute, San Francisco, CA 94158, USA
Genes Dev 26:1780-96. 2012.... - SSBP2 variants are associated with survival in glioblastoma patientsYuanyuan Xiao
Department of Epidemiology and Biostatistics, University of California, San Francisco 185 Berry St, Suite 5700, San Francisco, CA 94107, USA
Clin Cancer Res 18:3154-62. 2012..Glioblastoma is a devastating, incurable disease with few known prognostic factors. Here, we present the first genome-wide survival and validation study for glioblastoma... - Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 inductionLouis Chesler
Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
Neoplasia 10:1268-74. 2008.... - DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expressionShichun Zheng
Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
Neuro Oncol 13:280-9. 2011..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications... - Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastomaMatthew C Tate
Departments of Neurological Surgery, University of California San Francisco, California, USA
J Neurosurg Pediatr 4:479-83. 2009..To the authors' knowledge this is the first reported case of reactive changes mimicking metastasis in a single vertebral body following standard therapy for resected primary pineoblastoma... - Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomesIsaac Yang
Department of Neurological Surgery, University of California at Los Angeles, Los Angeles, California, USA
J Clin Neurosci 18:29-33. 2011..Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control... - Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure controlDoris D Wang
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, California 94143, USA
J Neurosurg 118:337-44. 2013..The aim of this study was to characterize seizure control outcomes and prognostic significance of the transmantle sign in FCD epilepsy... - Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biologyIsaac Yang
Department of Neurosurgery, University of California, Los Angeles, California, USA
J Neurosurg 115:505-11. 2011..In this paper the authors demonstrate that characterization of the intratumoral inflammatory infiltrate can distinguish high-grade glioblastoma from low-grade pilocytic astrocytoma... - Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytomaEli E Bar
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neuropathol Exp Neurol 67:878-87. 2008..These data indicate that focal gains at chromosome 7q34 and increased BRAF-MEK-ERK signaling are common findings in sporadic pilocytic astrocytomas... - Pleiotropic role for MYCN in medulloblastomaFredrik J Swartling
University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 24:1059-72. 2010..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis... - Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastomaJohn K Wiencke
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 9:271-9. 2007.... - The next step: innovative molecular targeted therapies for treatment of intracranial chordoma patientsJeffrey J Barry
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA
Neurosurgery 68:231-40; discussion 240-1. 2011..Patients who relapse or cannot undergo a complete en bloc resection generally have a poor prognosis. New agents for postoperative adjuvant treatment of chordomas are needed... - Intratumoral hemorrhage and fibrosis in vestibular schwannoma: a possible mechanism for hearing lossMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, 94143, USA
J Neurosurg 114:386-93. 2011..In this case-control study, the authors investigated the relationship between preoperative hearing loss and histological changes such as intratumoral microhemorrhage and extensive fibrosis... - CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survivalIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94117, USA
J Clin Neurosci 17:1381-5. 2010..006). Thus, CD8+ T-cell infiltrate is associated with prolonged survival. Our data provide the impetus for more sophisticated studies to further elucidate prospectively the specific T-cell subtypes associated with long-term survival... - Biomarkers to predict response to epidermal growth factor receptor inhibitorsDaphne A Haas-Kogan
Department of Radiation Oncology, University of California San Francisco, USA
Cell Cycle 4:1369-72. 2005..Ultimately the goal of these studies is to allow selection of patients who will preferentially respond to EGFR inhibitors... - Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505, Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 98:101-8. 2010..Our data suggests that younger patients with chondroid type cranial chordoma treated with both surgery and radiation may have improved rates of tumor recurrence in the treatment of these tumors... - Evidence of ambiguous differentiation and mTOR pathway dysregulation in subependymal giant cell astrocytomaBrad D Barrows
Department of Pathology, University of California San Francisco, San Francisco, USA
Turk Patoloji Derg 28:95-103. 2012..Inactivation leads to loss of proteins that inhibit mammalian target of rapamycin (mTOR ) disrupting tightly regulated cell functions... - Expression of p75NTR in fetal brain and medulloblastomas: evidence of a precursor cell marker and its persistence in neoplasiaMichael Barnes
Department of Pathology, UCSF Medical Center, San Francisco, CA, USA
J Neurooncol 92:193-201. 2009..The persistence of p75NTR in a small group of medulloblastomas raises the possibility that in such tumors, the receptor could be a potential therapeutic target... - Secondary gliosarcoma: a review of clinical features and pathological diagnosisSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 112:26-32. 2010..In this article the authors review the literature on secondary gliosarcoma, with attention to clinical course and pathological features... - Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibilityMargaret Wrensch
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Nat Genet 41:905-8. 2009..85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases... - High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous systemTheodore Nicolaides
Department of Pediatrics, University of California San Francisco School of Medicine, 505 Parnassus Avenue, M649, Box 0106, San Francisco, CA 94143, USA
J Neurooncol 98:117-23. 2010..Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach... - Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005Melike Pekmezci
Department of Pathology, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 67:1341-9; discussion 1349. 2010..Craniopharyngiomas are rare epithelial tumors that are presumed to arise from the remnants of Rathke's pouch... - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in gliomaAndrew T Parsa
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, California 94143, USA
Nat Med 13:84-8. 2007..These data identify a previously unrecognized mechanism linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part by B7-H1... - Predictors of seizure freedom after surgery for malformations of cortical developmentEdward F Chang
Northern California Comprehensive Epilepsy Center, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 70:151-62. 2011..Our aim was to examine a surgical series of patients with cortical malformations to determine the prognostic factors associated with long-term seizure control... - Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1-deficient BrainWanqiu Chen
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Ave, Box 1363, San Francisco, CA 94110
Arterioscler Thromb Vasc Biol 33:305-10. 2013..We tested the hypothesis that vascular endothelial growth factor impairs vascular integrity in the Alk1-deficient brain through reduction of mural cell coverage... - HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced deliveryJ Andrew MacKay
Joint Graduate Group in Bioengineering, University of California at San Francisco, San Francisco, California, USA
Mol Ther 16:893-900. 2008.... - Temporal fossa hemangiopericytoma: a case seriesMarc A Heiser
Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California 94143 0342, USA
Otol Neurotol 30:985-9. 2009..Review clinical experience with temporal fossa hemangiopericytomas (HPCs)... - Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forestsJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma... - The molecular pathology of central neurocytomasAri J Kane
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
J Clin Neurosci 18:1-6. 2011..Our discussion is expanded to include important and related insights into the cellular origin and classification of central nervous system tumors... - Intracranial dermoid cyst mimicking hemorrhage. Case report and review of the literatureRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, San Francisco 94143, USA
J Neurosurg 105:311-4. 2006..The authors describe their experience and review the literature, emphasizing that a dermoid cyst may have unusual radiographic characteristics indicative of hemorrhage and may contain areas of hemorrhage on histological examination... - Prognostic value of detecting recurrent glioblastoma multiforme in surgical specimens from patients after radiotherapy: should pathology evaluation alter treatment decisions?Tarik Tihan
Department of Pathology, University of California at San Francisco, San Francisco, CA 94143 0511, USA
Hum Pathol 37:272-82. 2006..A comprehensive prospective study with advanced radiologic, pathologic, and molecular analyses may be more useful to determine prognostically valuable parameters... - Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumorRebecca S Swain
Department of Pathology, Neuropathology, University of California, San Francisco, CA 94143 0102, USA
Hum Pathol 39:410-9. 2008..Neither IMT nor IP cases demonstrated HHV-8 expression. We suggest that IMT in the CNS is distinct from the nonneoplastic IP, and distinguishing IMT from nonneoplastic lesions should enable better decisions for patient management... - Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesisMichael Safaee
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
Neuro Oncol 15:255-67. 2013..Improving our understanding of the molecular biology, genetics, and oncogenic pathways associated with this tumor will allow for the development of targeted therapies and improved outcomes for patients with this disease... - Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcomaCynthia Jimenez
Department of Pathology, Neuropathology Unit, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
J Neurooncol 105:317-23. 2011..Studies are under way to determine the significance of chromosome 3 alterations in gliosarcomas... - Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patientsEdward F Chang
Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg Pediatr 5:123-30. 2010..The authors' aim was to identify factors that predict seizure control following excision... - Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspectiveTarik Tihan
Department of Pathology, UCSF School of Medicine, San Francisco, CA 94143 0511, USA
J Neurooncol 76:175-83. 2006..This article presents a critical review of the existing studies and a brief mention of our experience from a pathological perspective... - Genetic aberrations in gliomatosis cerebriMarcus L Ware
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 60:150-8; discussion 158. 2007.... - Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinibDaphne A Haas-Kogan
Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
J Natl Cancer Inst 97:880-7. 2005.... - Solitary fibrous tumors in the central nervous system. A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomasTarik Tihan
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Pathol Lab Med 127:432-9. 2003..In particular, densely cellular regions seen in some SFTs can be indistinguishable from HPC. Little is known about the biological behavior of SFTs, although most seem amenable to total resection... - Intradural extramedullary leptomeningeal hemangioblastomatosis and paraneoplastic limbic encephalitis diagnosed at autopsy: an unlikely pairRageshree Ramachandran
Department of Pathology, University of California at San Francisco School of Medicine, San Francisco, CA, USA
Arch Pathol Lab Med 132:104-8. 2008..To the best of our knowledge, this is the first case of limbic encephalitis occurring in the setting of disseminated hemangioblastomatosis... - Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannomaJames S Waldron
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 59:E939-40; discussion E940. 2006..Although the natural history of SFTs in the CNS is not completely understood, correct diagnosis is important, given the rate of recurrence found in the more common pleural-based SFT and examples of CNS SFTs with malignant features... - Cardiac rupture after intravenous t-PA administration in acute ischemic strokeAmar Dhand
Department of Neurology, University of California San Francisco, 505 Parnassus Avenue, Box 0114, San Francisco, CA 94143 0114, USA
Neurocrit Care 13:261-2. 2010..Although described in MI patients who receive thrombolytic therapy, this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA... - Current treatment strategies and outcomes in the management of symptomatic vertebral hemangiomasFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
Neurosurgery 58:287-95; discussion 287-95. 2006..Treatment included transarterial embolization, embolization followed by surgical decompression or vertebral reconstruction with arthrodesis, and percutaneous vertebroplasty alone... - Clinical management of pituitary carcinomasMichael C Oh
Department of Neurological Surgery, California Center for Pituitary Disorders, University of California, San Francisco, San Francisco, CA 94143, USA
Neurosurg Clin N Am 23:595-606. 2012..Here we review the clinical behavior and pathologic characteristics of pituitary carcinomas and the recent advances in potential therapies for this malignant disease... - Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation ruptureYi Guo
University of California, San Francisco, CA 94110, USA
Stroke 43:1240-6. 2012.... - Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitizationAndrea H Yeung
Departments of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA
Neurosurg Focus 27:E2. 2009..An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors... - Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridizationJoanna J Phillips
Neuropathology Unit, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
Arch Pathol Lab Med 134:1063-9. 2010..This pattern of genetic changes only partially overlaps with the genomic alterations reported in pituitary adenomas. In summary, our data suggest that pituicytomas are a unique subset of tumors of the sellar region... - Management of a sporadic malignant subfrontal peripheral nerve sheath tumorRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, M 779, Box 0112, San Francisco, CA 94143, USA
J Neurooncol 76:165-9. 2006..Our case shows that these rare lesions can present as a malignant variant and thus require aggressive surgical and postoperative management to provide long-term tumor control... - A case of enteroviral meningoencephalitis presenting as rapidly progressive dementiaVictor Valcour
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA94143, USA
Nat Clin Pract Neurol 4:399-403. 2008..He had hypophonic speech and had mildly increased axial tone. He scored 5 out of 30 on the Mini Mental State Examination and was admitted for expedited evaluation... - Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entitySeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
J Neurooncol 96:313-20. 2010..Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy... - Epidemiology and pathology of intraventricular tumorsJames S Waldron
Department of Neurological Surgery, University of California at San Francisco, 513 Parnassus, HSW 511, San Francisco, CA 94143 0511, USA
Neurosurg Clin N Am 14:469-82. 2003..When used in conjunction with clinical and radiologic data, histopathologic features can distinguish among this wide range of possibilities to provide the correct diagnosis for optimal patient management... - The value of tandem CSF/MRI evaluation for predicting disseminated disease in childhood central nervous system neoplasmsJudy Pang
Department of Pathology, UCSF School of Medicine, San Francisco, CA, 94143 0102, USA
J Neurooncol 87:97-102. 2008..Even though the number of cases is limited, our findings suggest that a positive CSF cytology with no other corroborating evidence of tumor spread or recurrence should be interpreted with caution... - Retro-convection enhanced delivery to increase blood to brain transfer of macromoleculesGrace H Huynh
Joint Graduate Group in Bioengineering, University of California, San Francisco and University of California, Berkeley, San Francisco, CA 94143 0446, USA
Brain Res 1128:181-90. 2007.... - Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behavior in 23 patientsCharles G Eberhart
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Pediatr Hematol Oncol 25:198-203. 2003..To review the clinical behavior and histopathologic features of medulloblastomas that metastasize outside the central nervous systems (CNS)... - The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entityEugene P Ceppa
Department of Pathology, University of California, Neuropathology Unit, 513 Parnassus Avenue, HSW 408 Box 0511, San Francisco, CA 94143 0511, USA
J Neurooncol 81:191-6. 2007..More systematic review of such cases will provide a better answer for the origin of PMA, and its relation to PA... - Myxopapillary ependymoma: cytomorphologic characteristics and differential diagnosisPeter Kulesza
The John K. Frost Cytopathology Laboratory, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Diagn Cytopathol 26:247-50. 2002..An accurate preoperative diagnosis of ME on FNA can be achieved based on its distinctive cytomorphologic features... - Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imagingSoonmee Cha
Department of Radiology, University of California-San Francisco, UCSF Medical Center, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA
AJNR Am J Neuroradiol 26:266-73. 2005..Our findings suggest that tumor rCBV(max) derived from DSC MR imaging can be used to distinguish between the two low-grade gliomas... - Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathwayTy W Abel
Department of Pathology, Division of Neuropathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Neuropathol Exp Neurol 64:341-9. 2005..These data support recommendations for genetic testing and screening for CD in patients with LDD and suggest a novel therapy for LDD through pharmacologic inhibition of mTOR... - Combination chemotherapy of BCNU and Didox acts synergystically in 9L glioma cellsZsuzsanna Horvath
Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
Nucleosides Nucleotides Nucleic Acids 23:1531-5. 2004..These results introduce the combination of Didox and BCNU as a viable alternative for the treatment of malignant gliomas... - Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomasRicardo J Komotar
Department of Neurosurgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
Neurosurgery 54:72-9; discussion 79-80. 2004..Increased recognition of these lesions could affect the prognosis and treatment of pediatric astrocytomas... - MR imaging characteristics of pilomyxoid astrocytomasAtilla Arslanoglu
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
AJNR Am J Neuroradiol 24:1906-8. 2003.... - Polilactofate microspheres for Paclitaxel delivery to central nervous system malignanciesKhan W Li
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Clin Cancer Res 9:3441-7. 2003..CONCLUSIONS: Paclimer extends survival in a rodent model of glioma with minimal morbidity and optimal pharmacokinetics... - Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytomaDaniel J Brat
Department of Pathology and Laboratory Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Brain Pathol 17:319-24. 2007..It is solid in architecture, composed of spindle cells and presumably derived from pituicytes. Pituicytomas are indolent tumours, and are designated WHO grade I... - Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymomaMin Wang
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Medical School, Houston, Texas, USA
J Neuropathol Exp Neurol 64:875-81. 2005..Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal... - The hypoxic response of tumors is dependent on their microenvironmentBarbara Blouw
Molecular Biology Section, Division of Biological Sciences, University of California at San Diego, Pacific Hall Room 1212, MC-0366, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cancer Cell 4:133-46. 2003..These results demonstrate that HIF-1alpha has differential roles in tumor progression, which are greatly dependent on the extant microenvironment of the tumor... - Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumorsMark A Watson
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Brain Pathol 14:297-303. 2004..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics... - Desmoplastic noninfantile ganglioglioma: report of a caseIbrahim Qaddoumi
Department of Oncology, King Hussein Cancer Center, Amman, Jordan
Pediatr Dev Pathol 9:462-7. 2006..It is also unclear whether the desmoplastic noninfantile ganglioglioma has characteristics similar to classical ganglioglioma. This rare case highlights the remarkable versatility of glioneuronal tumors in children... - Solitary central nervous system metastasis from acinic cell carcinoma of the parotid glandMaciej S Lesniak
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Otolaryngol 31:38-41. 2002 - Pilomyxoid astrocytoma: diagnosis, prognosis, and managementRicardo J Komotar
Department of Neurosurgery, Columbia University, New York, New York, USA
Neurosurg Focus 18:E7. 2005..To increase awareness of PMA within the neurosurgical community, the authors review the diagnostic criteria, prognostic implications, and current management of this recently described pediatric low-grade astrocytoma... - Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology ConsortiumFaith G Davis
Division of Epidemiology Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA
Cancer Epidemiol Biomarkers Prev 17:484-9. 2008..It is essential that epidemiologists and neuropathologists collaborate to develop appropriate study designs and protocols for specific hypothesis and populations... - Impact of telemedicine on pediatric neuro-oncology in a developing country: the Jordanian-Canadian experienceIbrahim Qaddoumi
Department of Pediatrics, King Hussein Cancer Center KHCC, Amman, Jordan
Pediatr Blood Cancer 48:39-43. 2007..Pediatric neuro-oncology is a complex multidisciplinary discipline that is underserved in most of DC and provides a model to test the feasibility of such tool for twinning purposes... - Pilomyxoid astrocytoma: a reviewRicardo J Komotar
Department of Neurosurgery, Columbia University, New York, USA
MedGenMed 6:42. 2004..Increased recognition of PMA within the medical community has the potential to affect the treatment and prognosis of pediatric low-grade astrocytomas... - Outcome analysis of childhood low-grade astrocytomasPaul G Fisher
Department of Neurology, Stanford University, Palo Alto, California 94305 5826, USA
Pediatr Blood Cancer 51:245-50. 2008..We aimed to determine the long-term natural history of low-grade astrocytomas (LGA) in children, with respect to pathology, and to evaluate influence of treatment on survival... - Pilomyxoid astrocytoma of the spinal cord: report of three casesRicardo J Komotar
Department of Neurosurgery, Columbia University, New York, New York, USA
Neurosurgery 56:191. 2005..We believe that increased recognition of these circumscribed gliomas will help to elucidate their nature and lead to better management decisions... - Growth and regression of arteriovenous malformations in a patient with hereditary hemorrhagic telangiectasia. Case reportRose Du
Department of Neurological Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurosurg 106:470-7. 2007..Histopathological features of the surgical specimen were examined. Active angiogenesis, as indicated by increased endothelial proliferation, might be a part of the underlying pathophysiology of the growth and regression of AVMs... - Recurrent glioependymal cyst of the posterior fossa: an unusual entity containing mixed glial elements. Case reportJames Frazier
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurooncol 68:13-7. 2004..Definitive diagnosis is by microscopic examination of surgically resected specimens. Total extirpation of these cystic lesions is recommended... - Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cellsZsuzsanna Horvath
General Hospital of Vienna, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, 5H Waehringer Guertel 18-20, 1090, Austria
Cancer Chemother Pharmacol 54:139-45. 2004..Further in vivo tests using these two compounds systemically and/or locally at the tumor site might be warranted... - Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology ConsortiumMelissa L Bondy
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 113:1953-68. 2008..In this report, BTEC epidemiologists reviewed the group's consensus on the current state of scientific findings, and they present a consensus on research priorities to identify which important areas the science should move to address...