Kim Tieu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc D-β-hydroxybutyrate is protective in mouse models of Huntington's disease
    Soyeon Lim
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e24620. 2011
  2. pmc A guide to neurotoxic animal models of Parkinson's disease
    Kim Tieu
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14625, USA
    Cold Spring Harb Perspect Med 1:a009316. 2011
  3. ncbi request reprint Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice
    Dong Kug Choi
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 25:6594-600. 2005
  4. ncbi request reprint L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 56:51-60. 2004
  5. pmc NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:6145-50. 2003
  6. pmc Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
    Celine Perier
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:19126-31. 2005
  7. pmc D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 112:892-901. 2003
  8. ncbi request reprint Pathogenic role of glial cells in Parkinson's disease
    Peter Teismann
    Neuroscience Research, Movement Disorder Division, Department of Neurology, Columbia University, New York, New York 10032, USA
    Mov Disord 18:121-9. 2003
  9. pmc Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
    Phillip M Rappold
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:20766-71. 2011
  10. ncbi request reprint MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Bioenerg Biomembr 36:375-9. 2004

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc D-β-hydroxybutyrate is protective in mouse models of Huntington's disease
    Soyeon Lim
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e24620. 2011
    ..These pre-clinical findings suggest that by simultaneously targeting the mitochondrial and the epigenetic abnormalities associated with mutant huntingtin, DβHB may be a valuable therapeutic agent for HD...
  2. pmc A guide to neurotoxic animal models of Parkinson's disease
    Kim Tieu
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14625, USA
    Cold Spring Harb Perspect Med 1:a009316. 2011
    ..And second, to provide an overview of basic technical requirements for assessing the pathology, structure, and function of the nigrostriatal pathway...
  3. ncbi request reprint Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice
    Dong Kug Choi
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 25:6594-600. 2005
    ..This study demonstrates that MPO participates in the MPTP neurotoxic process and suggests that inhibitors of MPO may provide a protective benefit in PD...
  4. ncbi request reprint L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 56:51-60. 2004
    ..This study demonstrates that HADH II/ABAD modulates MPTP neurotoxicity and suggests that HADH II/ABAD mimetics may provide protective benefit in the treatment of PD...
  5. pmc NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:6145-50. 2003
    ..This study supports a critical role for NADPH-oxidase in the pathogenesis of PD and suggests that targeting this enzyme or enhancing extracellular antioxidants may provide novel therapies for PD...
  6. pmc Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
    Celine Perier
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:19126-31. 2005
    ..This molecular scenario may have far-reaching implications for the development of effective neuroprotective therapies for these incurable illnesses...
  7. pmc D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 112:892-901. 2003
    ..Because of the safety record of ketone bodies in the treatment of epilepsy and their ability to penetrate the blood-brain barrier, DbetaHB may be a novel neuroprotective therapy for PD...
  8. ncbi request reprint Pathogenic role of glial cells in Parkinson's disease
    Peter Teismann
    Neuroscience Research, Movement Disorder Division, Department of Neurology, Columbia University, New York, New York 10032, USA
    Mov Disord 18:121-9. 2003
    ..We discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how those factors may contribute to the pathogenesis of this disease...
  9. pmc Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
    Phillip M Rappold
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:20766-71. 2011
    ..This study provides a mechanism by which DAT and Oct3 modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling...
  10. ncbi request reprint MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Bioenerg Biomembr 36:375-9. 2004
    ..How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review...
  11. pmc The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
    Mei Cui
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:8043-8. 2009
    ..These results may have far-reaching implications for our understanding of the mechanism of cell death in a wide range of neurodegenerative diseases and may open new avenues for neuroprotective intervention...
  12. pmc Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1
    Mei Cui
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 285:11740-52. 2010
    ....
  13. ncbi request reprint Free radical and nitric oxide toxicity in Parkinson's disease
    Serge Przedborski
    Departments of Neurology and Pathology, Columbia University, New York, New York, USA
    Adv Neurol 91:83-94. 2003
  14. pmc Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
    Peter Teismann
    Neuroscience Research Laboratories of the Movement Disorder Division, Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:5473-8. 2003
    ..Because of the safety record of the COX-2 inhibitors, and their ability to penetrate the blood-brain barrier, these drugs may be therapies for PD...
  15. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
    ..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity...
  16. ncbi request reprint Glial cell response: A pathogenic factor in Parkinson's disease
    Du Chu Wu
    Neuroscience Research, Movement Disorder Division, Department of Neurology, Columbia University, New York, New York, USA
    J Neurovirol 8:551-8. 2002
    ..In this review, the authors discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how these factors may contribute to the pathogenesis of this disease...
  17. ncbi request reprint Nitric oxide and reactive oxygen species in Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    IUBMB Life 55:329-35. 2003
    ..Similar contribution of reactive nitrogen and oxygen species may well underlie the neurodegenerative processes in Parkinson's disease...
  18. pmc Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin
    Youngnam N Jin
    Departmentsof Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e57932. 2013
    ..These results suggest that mHtt disrupts Nrf2 signaling which contributes to impaired mitochondrial dynamics and may enhance susceptibility to oxidative stress in STHdh(Q111/Q111) cells...
  19. pmc Neurosteroid transport by the organic solute transporter OSTα-OSTβ
    Fang Fang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurochem 115:220-33. 2010
    ..These results demonstrate that OSTα-OSTβ is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action...
  20. pmc Astrocytes and therapeutics for Parkinson's disease
    Phillip M Rappold
    Department of Neurology, Center for Translational Neuromedicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Neurotherapeutics 7:413-23. 2010
    ..These emerging roles of astrocytes in the pathogenesis of Parkinson's disease constitute an exciting development with promising novel therapeutic targets...
  21. pmc Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP
    William Dauer
    Department of Neurology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 99:14524-9. 2002
    ....
  22. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
    ..Thus by impairing this process, mutations in either Parkin or PINK1 may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease...
  23. pmc Cultured astrocytes do not release adenosine during hypoxic conditions
    Takumi Fujita
    Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:e1-7. 2012
    ..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia...
  24. ncbi request reprint Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  25. pmc Glutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Biol Chem 390:191-214. 2009
    ..The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases...

Research Grants6

  1. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2006
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
  2. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2007
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
  3. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2007
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
  4. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2009
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
  5. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2010
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..