Kim Tieu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc A guide to neurotoxic animal models of Parkinson's disease
    Kim Tieu
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14625, USA
    Cold Spring Harb Perspect Med 1:a009316. 2011
  2. pmc Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
    Phillip M Rappold
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:20766-71. 2011
  3. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
  4. pmc Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin
    Youngnam N Jin
    Departmentsof Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e57932. 2013
  5. pmc Neurosteroid transport by the organic solute transporter OSTα-OSTβ
    Fang Fang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurochem 115:220-33. 2010
  6. pmc Astrocytes and therapeutics for Parkinson's disease
    Phillip M Rappold
    Department of Neurology, Center for Translational Neuromedicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Neurotherapeutics 7:413-23. 2010
  7. pmc Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1
    Mei Cui
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 285:11740-52. 2010
  8. pmc D-β-hydroxybutyrate is protective in mouse models of Huntington's disease
    Soyeon Lim
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e24620. 2011
  9. pmc Cultured astrocytes do not release adenosine during hypoxic conditions
    Takumi Fujita
    Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:e1-7. 2012
  10. pmc The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
    Mei Cui
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:8043-8. 2009

Research Grants

Collaborators

  • Maiken Nedergaard
  • Takahiro Takano
  • Wei Liu
  • Gail V W Johnson
  • Yisang Yoon
  • Fang Fang
  • David Blum
  • Phillip M Rappold
  • Mei Cui
  • Youngnam N Jin
  • Ditte Lovatt
  • Nathan A Smith
  • Takumi Fujita
  • Jonathan C Grima
  • Soyeon Lim
  • Adrianne S Chesser
  • Jonathan A Javitch
  • Serge Przedborski
  • Whitney V Christian
  • Soner Gundemir
  • Chulman Jo
  • Yanxun V Yu
  • Tina K Jensen
  • Erika K Williams
  • Jurgen Schnermann
  • Qiwu Xu
  • Namita Sen
  • Lihua Duan
  • Jacqueline Tibbett
  • Xiangna Tang
  • Vernice Jackson-Lewis
  • Mamata Hatwar
  • Radha Aras
  • Joseph Panza
  • Nazzareno Ballatori

Detail Information

Publications10

  1. pmc A guide to neurotoxic animal models of Parkinson's disease
    Kim Tieu
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14625, USA
    Cold Spring Harb Perspect Med 1:a009316. 2011
    ..And second, to provide an overview of basic technical requirements for assessing the pathology, structure, and function of the nigrostriatal pathway...
  2. pmc Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3
    Phillip M Rappold
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:20766-71. 2011
    ..This study provides a mechanism by which DAT and Oct3 modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling...
  3. pmc Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity
    Ditte Lovatt
    Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:6265-70. 2012
    ..This study shows that adenosine-mediated synaptic depression is not a consequence of astrocytic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmission during prolonged activity...
  4. pmc Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin
    Youngnam N Jin
    Departmentsof Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e57932. 2013
    ..These results suggest that mHtt disrupts Nrf2 signaling which contributes to impaired mitochondrial dynamics and may enhance susceptibility to oxidative stress in STHdh(Q111/Q111) cells...
  5. pmc Neurosteroid transport by the organic solute transporter OSTα-OSTβ
    Fang Fang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurochem 115:220-33. 2010
    ..These results demonstrate that OSTα-OSTβ is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action...
  6. pmc Astrocytes and therapeutics for Parkinson's disease
    Phillip M Rappold
    Department of Neurology, Center for Translational Neuromedicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Neurotherapeutics 7:413-23. 2010
    ..These emerging roles of astrocytes in the pathogenesis of Parkinson's disease constitute an exciting development with promising novel therapeutic targets...
  7. pmc Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1
    Mei Cui
    Department of Neurology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 285:11740-52. 2010
    ....
  8. pmc D-β-hydroxybutyrate is protective in mouse models of Huntington's disease
    Soyeon Lim
    Department of Neurology in the Center for Translational Neuromedicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e24620. 2011
    ..These pre-clinical findings suggest that by simultaneously targeting the mitochondrial and the epigenetic abnormalities associated with mutant huntingtin, DβHB may be a valuable therapeutic agent for HD...
  9. pmc Cultured astrocytes do not release adenosine during hypoxic conditions
    Takumi Fujita
    Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    J Cereb Blood Flow Metab 32:e1-7. 2012
    ..These results show that cultured astrocytes do not release adenosine during mild hypoxia, an observation consistent with their high resistance to hypoxia...
  10. pmc The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
    Mei Cui
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:8043-8. 2009
    ..These results may have far-reaching implications for our understanding of the mechanism of cell death in a wide range of neurodegenerative diseases and may open new avenues for neuroprotective intervention...

Research Grants6

  1. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2007
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..
  2. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2010
    ..In addition, these studies may provide significant insights into a novel mechanism that contributes to the pattern of cell death as seen in neurodegenerative disorders such as sporadic Parkinson's disease. ..