Jay W Tichelaar

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Exp Lung Res 33:385-417. 2007
  2. pmc Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    BMC Cancer 5:155. 2005
  3. ncbi request reprint Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia
    Jay W Tichelaar
    University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 125:153S. 2004
  4. pmc Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology
    Michael T Borchers
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Toxicol Sci 105:188-99. 2008
  5. pmc Gene expression changes during the development of acute lung injury: role of transforming growth factor beta
    Scott C Wesselkamper
    Department of Environmental Health, P O Box 670056, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Am J Respir Crit Care Med 172:1399-411. 2005
  6. pmc Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    J Clin Invest 119:636-49. 2009
  7. ncbi request reprint Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
  8. ncbi request reprint Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis
    William D Hardie
    Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004
  9. pmc CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Exp Mol Pathol 83:301-10. 2007
  10. ncbi request reprint SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003

Detail Information

Publications14

  1. ncbi request reprint Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Exp Lung Res 33:385-417. 2007
    ..FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression...
  2. pmc Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies
    Jay W Tichelaar
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    BMC Cancer 5:155. 2005
    ..The acquisition of anti-apoptotic signals is critical for the survival of cancer cells but the pathways involved are incompletely characterized in developing intra-epithelial neoplasia (IEN)...
  3. ncbi request reprint Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia
    Jay W Tichelaar
    University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 125:153S. 2004
  4. pmc Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology
    Michael T Borchers
    Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Toxicol Sci 105:188-99. 2008
    ..These data provide strong evidence that T-cell subpopulations in the lung are major determinants of pulmonary pathology and highlight the advantages of dissecting their effector functions in response to toxicant exposures...
  5. pmc Gene expression changes during the development of acute lung injury: role of transforming growth factor beta
    Scott C Wesselkamper
    Department of Environmental Health, P O Box 670056, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Am J Respir Crit Care Med 172:1399-411. 2005
    ..Acute lung injury can occur from multiple causes, resulting in high mortality. The pathophysiology of nickel-induced acute lung injury in mice is remarkably complex, and the molecular mechanisms are uncertain...
  6. pmc Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    J Clin Invest 119:636-49. 2009
    ..These results demonstrate that aberrant, persistent NKG2D ligand expression in the pulmonary epithelium contributes to the development of COPD pathologies...
  7. ncbi request reprint Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
    ..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis...
  8. ncbi request reprint Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis
    William D Hardie
    Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004
    ..Induction of pulmonary fibrosis by TGF-alpha was independent of inflammation or early activation of TGF-beta...
  9. pmc CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
    Michael T Borchers
    Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Exp Mol Pathol 83:301-10. 2007
    ..In this study, we utilize a mouse model of COPD to examine the contributions of CD8(+) T cells in the persistent macrophage accumulation and airspace enlargement resulting from chronic irritant exposure...
  10. ncbi request reprint SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003
    ..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function...
  11. pmc Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice
    Marshall W Anderson
    Department of Molecular Oncogenesis, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Carcinogenesis 29:1594-600. 2008
    ..Our results suggest a potential role for green tea extracts in preventing the progression of large, aggressive lung adenocarcinomas...
  12. ncbi request reprint Over expression of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of Kerapr-rtTA/FGF7 bitransgenic mice
    Miyuki Hayashi
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267 0527, USA
    Mol Vis 11:201-7. 2005
    ..In the present study, we used a binary inducible transgenic mouse model to examine the role of FGF7 on corneal epithelium proliferation...
  13. ncbi request reprint Conditional gene expression in the respiratory epithelium of the mouse
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Transgenic Res 11:21-9. 2002
    ..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung...
  14. ncbi request reprint Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung
    Urpo Lappalainen
    Goteborg University, Department of Pediatrics, The Queen Silvia Children s Hospital, 41685 Goteborg, Sweden
    Am J Respir Cell Mol Biol 32:311-8. 2005
    ..Chronic production of IL-1beta in respiratory epithelial cells of adult mice causes lung inflammation, enlargement of distal airspaces, mucus metaplasia, and airway fibrosis in the adult mouse...