Research Topics
Genomes and GenesSpecies | Jide TianSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed miceJide Tian
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e25338. 2011..Given that GABA is safe for human consumption, activators of GABA receptors may be valuable for the prevention of obesity and intervention of T2DM in the clinic...
B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic miceJide Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 90095, USA
J Immunol 176:2654-61. 2006..Conceivably, the modulation of the capacity of B cells to present Ag may provide new interventions for enhancing Ag-based immunotherapy and controlling autoimmune diseases...- Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic miceJ Tian
Department of Molecular and Medical Pharmacology, University of California School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Immunol 167:1081-9. 2001..These findings provide new insights into T-B cell interactions and may aid in the design of new therapies for human T1DM... - Memory and effector T cells modulate subsequently primed immune responses to unrelated antigensJide Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
Cell Immunol 224:74-85. 2003..Thus, immunization with one antigen not only primes immune responses to that antigen, but also influences subsequently primed immune responses to unrelated antigens... - Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes modelJide Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA
J Immunol 173:5298-304. 2004..Potentially, pharmacological modulation of GABAA receptors on T cells may provide a new class of therapies for human T1D as well as other inflammatory diseases... - Long-term monitoring of transplanted islets using positron emission tomographyYuxin Lu
Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA
Mol Ther 14:851-6. 2006..These studies suggest that PET imaging of lentivirus-transduced islets could provide a safe and feasible method for long-term monitoring of islet graft survival... - Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone miceAngelica P Olcott
Department of Molecular and Medical Pharmacology, University of California, School of Medicine, Los Angeles, CA 90095-1735, USA
J Immunol 175:1991-9. 2005..These findings suggest a new strategy for designing more efficacious Ag-based therapeutics for late-stage autoimmune diseases... - Noninvasive imaging of islet grafts using positron-emission tomographyYuxin Lu
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1735, USA
Proc Natl Acad Sci U S A 103:11294-9. 2006..These studies lay a foundation for noninvasive quantitative assessments of islet graft survival using PET... - Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetesJing Yong
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA
Diabetes 60:1383-92. 2011..This should enable the noninvasive imaging of β-cells by charge-coupled device (CCD) and micro-positron emission tomography (PET), as well as the identification of β-cells at the cellular level by fluorescent microscopy... - A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowthLorraine R Washburn
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e18439. 2011..We discuss the involvement of complement proteins in generating sMHCI and new theoretical models of MHCI's biological activities in the nervous system... - Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigensJide Tian
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, USA
Diabetes 58:2843-50. 2009..To study how tolerance to GAD65 affects the development of autoimmunity to other beta-cell autoantigens (beta-CAAs) in GAD65-transgenic (GAD-tg) NOD mice... 
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarizationTina Bilousova
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California Los Angeles, CA 90095 1735, USA
J Neuroimmunol 247:1-8. 2012..Together with the results of others, MHCI appears to differentially modulate neuritogenesis and synaptogenesis...- Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepairZhongqi Phyllis Wu
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
J Neuroimmunol 232:8-16. 2011..These findings complement a growing body of knowledge concerning the neurobiological activities of MHCI and may have potential clinical relevance... - A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejectionAngelica P Olcott
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1735, USA
Diabetes 53:2574-80. 2004..Antioxidants designed to prevent the formation of both cytotoxic reactive oxygen and nitrogen species may effectively protect beta-cells from spontaneous autoimmunity and alloresponses... - Bioluminescent monitoring of islet graft survival after transplantationYuxin Lu
Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA
Mol Ther 9:428-35. 2004..Such imaging technologies may allow earlier detection of graft rejection and the adjustment of therapies to prolong graft survival posttransplantation... - Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nervesZhongqi Phyllis Wu
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
Immunol Lett 135:118-23. 2011..These results suggest that MHCI and MHCI receptors play roles during early stages of PNS development and may provide new targets of therapeutic strategies to promote neuronal outgrowth after PNS injury... - Antigen-based immunotherapy drives the precocious development of autoimmunityJide Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA
J Immunol 169:6564-9. 2002..Such phenomena have not been observed in experimental autoimmune disease models and may have important clinical implications... - Neurons preferentially respond to self-MHC class I allele products regardless of peptide presentedNathalie Escande-Beillard
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90024, USA
J Immunol 184:816-23. 2010..Consistent with this notion, we show that MHC I and MHC I receptors are coexpressed by precursor cells at the earliest stages of retina development, which could enable such coordination... - Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone miceJ Tian
Department of Molecular and Medical Pharmacology, University of California Los Angeles 90095, USA
Nat Med 2:1348-53. 1996..Thus, modulation of autoantigen-specific Th1/Th2 balances may provide a minimally invasive means of downregulating established pathogenic autoimmune responses... - BCG vaccine-induced neuroprotection in a mouse model of Parkinson's diseaseJing Yong
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e16610. 2011..Accordingly, BCG vaccination may provide a new strategy to augment current treatments for a wide range of neuropathological conditions... - The frequency of high avidity T cells determines the hierarchy of determinant spreadingJ Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
J Immunol 166:7144-50. 2001.... - Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD miceJide Tian
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e25337. 2011.... - Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritisJide Tian
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095 1735, USA
Autoimmunity 44:465-70. 2011..Our results suggest that activation of peripheral GABA-Rs may provide a new modality to modulate T cell, B cell, and APC activity and help ameliorate RA and other inflammatory diseases... - Vestibular catch-up saccades in labyrinthine deficiencyJ Tian
Department of Ophthalmology, University of California, Los Angeles 90095 7002, USA
Exp Brain Res 131:448-57. 2000.... - Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetesBangyan L Stiles
Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
Mol Cell Biol 26:2772-81. 2006..Our data demonstrate that PTEN loss in beta cells is not tumorigenic but beneficial. This suggests that modulating the PTEN-controlled signaling pathway is a potential approach for beta-cell protection and regeneration therapies... - The postnatal maternal environment influences diabetes development in nonobese diabetic miceL R Washburn
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California, Los Angeles, CA 90095 1735, USA
J Autoimmun 28:19-23. 2007..The results may be relevant for understanding the increasing incidence of T1D and designing interventions... - Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acidLi Chen
Department of Phytochemistry, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China
J Med Chem 51:4834-8. 2008..Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers...
Research Grants
- Genetic Modification of DCs as Immunotherapy for IDDMJide Tian; Fiscal Year: 2002....
- LYMPHOCYTIC GABAA RECEPTORSJide Tian; Fiscal Year: 2002..Moreover, the results may have potential clinical application for down-regulating inflammatory processes in man. ..
- Genetic Modification of Mouse Islets for TransplantationJide Tian; Fiscal Year: 2003..Our findings may provide the basis for novel immunotherapies for the prevention and inhibition of immunorejection of islet grafts in man. ..
- NOD B Cells in Determinant Spreading of T Cell ImmunityJide Tian; Fiscal Year: 2004..These studies will address fundamental questions concerning the role of B cells in T cell autoimmunity and may provide a basis to develop novel immunotherapies for the intervention of human IDDM. ..
- PDL1-based rAAV-mediated gene therapy for mouse T1DJide Tian; Fiscal Year: 2007..Our findings may provide a basis for the design of specific immunotherapies for T1D patients. ..
- A Derivative of Oleanolic Acid: Anti-Hepatocellular Carcinoma (HCC) ActivityJide Tian; Fiscal Year: 2007..Layperson's abstract: We will center on examining the anti-liver cancer activity of a synthetic chemical compound. Our findings may provide a basis for the design of human liver cancer-specific chemotherapies for human patients. ..