Guo Feng Tian

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Drug Deliv Rev 58:773-87. 2006
  2. ncbi Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
  3. ncbi Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
  4. ncbi Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
  6. ncbi Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury
    Chunlan Huang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 32:3333-8. 2012
  7. ncbi Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
    Weiguo Peng
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:12489-93. 2009
  8. ncbi Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
  9. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
  10. ncbi Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin
    Elisabeth Schultke
    Departments of Anatomy and Cell Biology, and Surgery, Division of Neurosurgery, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    J Neurotrauma 22:1475-84. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Drug Deliv Rev 58:773-87. 2006
    ....
  2. ncbi Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor
    Lane Bekar
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    Nat Med 14:75-80. 2008
    ....
  3. ncbi Loss of astrocytic domain organization in the epileptic brain
    Nancy Ann Oberheim
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:3264-76. 2008
    ..Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain...
  4. ncbi Cortical spreading depression causes and coincides with tissue hypoxia
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, New York 14642, USA
    Nat Neurosci 10:754-62. 2007
    ..Increasing O2 availability shortens the duration of CSD and improves local redox state. Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply...
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..These observations implicate astrocytes in the control of local microcirculation and suggest that one of their physiological roles is to mediate vasodilation in response to increased neural activity...
  6. ncbi Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury
    Chunlan Huang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 32:3333-8. 2012
    ..Connexins may thereby constitute a new therapeutic target in spinal cord injury...
  7. ncbi Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
    Weiguo Peng
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:12489-93. 2009
    ..1), which crosses the blood-brain barrier. Systemic administration of BBG may thus comprise a readily feasible approach by which to treat traumatic SCI in humans...
  8. ncbi Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  9. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  10. ncbi Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin
    Elisabeth Schultke
    Departments of Anatomy and Cell Biology, and Surgery, Division of Neurosurgery, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    J Neurotrauma 22:1475-84. 2005
    ..Quercetin significantly prevented decrease of glutathione levels and decreased myeloperoxidase activity. We conclude that this dietary flavonoid has therapeutic potential following brain trauma...
  11. ncbi An astrocytic basis of epilepsy
    Guo-Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    ..Our results show an unanticipated key role for astrocytes in seizure activity. As such, these findings identify astrocytes as a proximal target for the treatment of epileptic disorders...
  12. ncbi Protective effect of high glucose against ischemia-induced synaptic transmission damage in rat hippocampal slices
    Guo Feng Tian
    Traumatic Brain Injury Laboratory, Cara Phelan Centre for Trauma Research and Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8 Canada
    J Neurophysiol 88:236-48. 2002
    ..These results indicate that high glucose in ACSF during the period before and after ischemia significantly protects CA1 synaptic transmission against in vitro ischemia-induced damage through postponing the occurrence of ID...