Research Topics
Genomes and Genes | David W ThreadgillSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotypeJessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599-7264, USA
Genetics 174:1229-36. 2006..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
The collaborative cross: a recombinant inbred mouse population for the systems genetic eraDavid W Threadgill
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
ILAR J 52:24-31. 2011..The CC supports data integration across environmental and biological perturbations and across space (different labs) and time...
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems geneticsAdam Roberts
Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA
Mamm Genome 18:473-81. 2007..We conclude that the CC represents a dramatic improvement over existing genetic resources for mammalian systems biology applications...- Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerSergio Kaiser
Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Genome Biol 8:R131. 2007..5-18.5... - Meeting report for the 4th annual Complex Trait Consortium meeting: from QTLs to systems geneticsDavid W Threadgill
Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 17:2-4. 2006.... - Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitionedKaren E Strunk
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37221, USA
Genetics 167:1821-32. 2004..This method should be generally useful to partition heterogeneity contributing to other complex traits... - Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effortDavid W Threadgill
Department of Genetics, CB#7264, Lineberger Comprehensive Cancer Center, Rm 11-109, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mamm Genome 13:175-8. 2002 - Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ miceCordelia J Barrick
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Am J Physiol Heart Circ Physiol 297:H65-75. 2009..These studies provide a novel model of aortic sclerosis and stenosis and suggest that long-term inhibition of EGFR signaling for cancer therapy may have unexpected consequences on aortic valves in susceptible individuals... - Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fatMichele La Merrill
Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Am J Physiol Endocrinol Metab 296:E203-10. 2009..Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise... 
Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptorTang Cheng Lee
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genesis 47:85-92. 2009..This new mouse model should have wide utility to inactivate Egfr conditionally for functional analysis of EGFR in adult tissues and disease states...- Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor allelesJennifer Dackor
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genetics 183:207-18. 2009.... - Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humansAlison H Harrill
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genome Res 19:1507-15. 2009..These studies demonstrate that a diverse mouse population can be used to understand and predict adverse toxicity in heterogeneous human populations through guided resequencing... - Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasisRyan R Gordon
Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Clin Exp Metastasis 27:279-93. 2010.... - Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptorDaekee Lee
Department of Genetics, University of North Carolina School of Medicine, CB 7264, Chapel Hill, North Carolina, 27599, USA
Mamm Genome 15:525-36. 2004..In vitro characterization shows that the antimorphic property of Egfr Wa5 is caused by a kinase-dead receptor acting as a dominant negative... - Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred miceBlair U Bradford
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 120:206-17. 2011..These studies provide better understanding of the mechanisms of TCE-induced toxicity anchored on metabolism and genotype-phenotype correlations that may define susceptibility or resistance... - Architecture of energy balance traits in emerging lines of the Collaborative CrossWendy Foulds Mathes
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Physiol Endocrinol Metab 300:E1124-34. 2011..These results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance... - Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancerErica S Rinella
Department of Genetics, Curriculum in Genetics and Molecular Biology, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA
Cancer Biol Ther 13:130-7. 2012..Unexpectedly, the combined use of dietary calcium supplementation and EGFR inhibitors also resulted in elevated toxicity suggesting that careful consideration be given when combining dietary supplements with prescribed cancer therapies... - Parent-of-origin effects on cardiac response to pressure overload in miceCordelia J Barrick
Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, USA
Am J Physiol Heart Circ Physiol 297:H1003-9. 2009..Our results suggest that susceptibility to LVH is more complex than simple Mendelian inheritance and that parental origin effects strongly impact the LV response to TAC in these commonly used inbred strains... - Replication and narrowing of gene expression quantitative trait loci using inbred miceDaniel M Gatti
Department of Environmental Sciences and Engineering, University of North Carolina, CB 7431, Chapel Hill, NC 27599, USA
Mamm Genome 20:437-46. 2009.... - Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epitheliumDaekee Lee
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Invest 119:2702-13. 2009..These results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ERBB3 may be a promising target for the treatment of colorectal cancers... - Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and dietAnika Bissahoyo
Curriculum in Toxicology, University of North Carolina, Chapel Hill, 27599, USA
Toxicol Sci 88:340-5. 2005..These results provide experimental support for a standardized AOM treatment and for the importance of controlling both genetic and non-genetic factors when using this model... - Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damageDaekee Lee
Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
Mol Cell Biol 24:8907-16. 2004..However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium... - Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptorJennifer Dackor
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 20:339-49. 2009..In addition, EGFR promotes growth of the placental spongiotrophoblast layer in mice, and EGFR expressed in the uterine stroma may play an underappreciated role in preparation of the uterus for embryo implantation... - Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strainsSheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses... - MicroRNA expression in the livers of inbred miceDaniel M Gatti
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
Mutat Res 714:126-33. 2011.... - Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genomeHanwen Huang
Department of Biostatistics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
Genetics 176:2529-40. 2007..The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer... - Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stageJoshua M Uronis
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Cancer Res 67:11594-600. 2007.... - Toxicogenetics: population-based testing of drug and chemical safety in mouse modelsIvan Rusyn
Department of Environmental Sciences and Engineering, 0031 Michael Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Pharmacogenomics 11:1127-36. 2010.... - Genome-level analysis of genetic regulation of liver gene expression networksDaniel Gatti
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Hepatology 46:548-57. 2007..genenetwork.org) that allows custom data mining, identification of coregulated transcripts and correlated phenotypes, cross-tissue, and cross-species comparisons, as well as testing of a broad array of hypotheses... - Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptorsMichele La Merrill
Department of Genetics, Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA
Environ Health Perspect 117:1414-9. 2009..Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands... - Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in miceMichele La Merrill
Department of Genetics, Center for Environmental and Health Susceptibility, Lineberger Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 118:596-601. 2010.... - Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J miceCordelia J Barrick
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 228:315-25. 2008..Taken together, these data suggest that chronic dietary exposure to TKIs may result in pathological and physiological changes in the heart... - Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcrossChevonne D Eversley
Department of Genetics, Curriculum in Genetics and Molecular Biology, and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
BMC Genet 11:98. 2010..Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss... - Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerationsFei Zou
Department of Biostatistics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genetics 170:1299-311. 2005.... - Status and access to the Collaborative Cross populationCatherine E Welsh
Department of Computer Science, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Mamm Genome 23:706-12. 2012..Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia... - EGFR signaling promotes TGFβ-dependent renal fibrosisJianchun Chen
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Am Soc Nephrol 23:215-24. 2012.... - Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapiesReade B Roberts
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Cancer Cell 5:115-20. 2004..Here we review and propose how genetically engineered mouse models can serve as valuable tools to predict targeted therapy toxicity, as well as to identify allelic variants that predispose individuals to side effects... - Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasisRyan R Gordon
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 19:179-89. 2008..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations... - Murine models of colorectal cancerJoshua M Uronis
Curriculum in Genetics and Molecular Biology, Department of Genetics, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 20:261-8. 2009..This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of colorectal cancer... - Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panelAlison H Harrill
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 110:235-43. 2009..Our data demonstrate that a multistrain approach may provide utility for understanding genotype-independent toxicity responses and facilitate identification of novel targets of therapeutic intervention... - Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesisReade B Roberts
Department of Cell Biology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 99:1521-6. 2002..Treatment with EKI-785 produced a dose-dependent reduction in tumor growth, suggesting that Egfr inhibitors may be useful for advanced colorectal cancer treatment... - Mechanism for prevention of alcohol-induced liver injury by dietary methyl donorsChristine L Powell
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 115:131-9. 2010..Profound changes in alcohol metabolism represent additional important mechanism of the protective effect of methyl donors in ALI... - The gastrointestinal microbiome: a malleable, third genome of mammalsIan M Carroll
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 20:395-403. 2009..The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed... - Mapping six new susceptibility to colon cancer (scc) Loci using a mouse interspecific backcrossChevonne D Eversley
Department of Genetics, Center for Gastrointestinal Biology and Disease, and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599
G3 (Bethesda) 2:1577-84. 2012..Furthermore, this work provides the foundation for large population-level epistatic interaction tests to identify combinations of low effect alleles that may have large effects on CRC susceptibility... - Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trialsErica S Rinella
Department of Genetics, Curriculum in Genetics and Molecular Biology, Lineberger Cancer Center, Center for Gastrointestinal Biology and Disease, and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 7:e39552. 2012..Better-designed preclinical studies should lead to more accurate predictions of therapeutic response in the clinic... - Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in miceJames J Crowley
Department of Genetics, University of North Carolina, Genomic Medicine Building, CB 7264, Chapel Hill, NC 27599 7264, USA
Mamm Genome 23:322-35. 2012.... - Investigating gene function using mouse modelsDaekee Lee
Department of Genetics, CB#7264, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Curr Opin Genet Dev 14:246-52. 2004..Furthermore, novel technologies have been developed that can regulate biological information at each level from creating specific modifications in DNA, to inhibiting gene transcription, to regulating protein activity... - Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophreniaSheryl S Moy
Carolina Center for Developmental Disabilities, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA
J Neurodev Disord 1:302-12. 2009..Nrg1+/- pups did not exhibit changes in isolation-induced ultrasonic vocalizations, a measure of emotional reactivity. Overall, these findings provide evidence that social behavior is mediated by NRG1-ERBB signaling... - Human epithelial-specific response to pathogenic Campylobacter jejuniErica S Rinella
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
FEMS Microbiol Lett 262:236-43. 2006..This study demonstrates that mouse and human colonic epithelia remain relatively unresponsive to commensal bacterial challenge, while the human pathogen C. jejuni elicits a host-specific response... - Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironmentA Deloris Alexander
Department of Genetics and Center for Gastrointestinal Biology and Disease, University of North Carolina, CB# 7264, Chapel Hill, North Carolina 27599, USA
Mamm Genome 17:1093-104. 2006..Furthermore, cohabitation of different inbred strains maintained most of the interstrain variation in the GI flora, supporting a role of host genetics in determining GI flora composition... - Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophyCordelia J Barrick
Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Physiol Heart Circ Physiol 292:H2119-30. 2007..These results also imply that genetic background differences can complicate interpretation of TAC studies when using mixed genetic backgrounds... - Enhanced oligonucleotide microarray labeling and hybridizationHaider Ali Syed
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Biotechniques 41:685-6. 2006 - Genetics of dark skin in miceKaren R Fitch
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 17:214-28. 2003.... - Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system functionElissa J Chesler
University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
Nat Genet 37:233-42. 2005..We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses... - Down's syndrome: paradox of a tumour repressorDavid W Threadgill
Nature 451:21-2. 2008 - The nature and identification of quantitative trait loci: a community's viewOduola Abiola
Nat Rev Genet 4:911-6. 2003..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?.. - Bayesian hierarchical modeling for time course microarray experimentsYueh Yun Chi
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
Biometrics 63:496-504. 2007..The methodology is applied to a mouse model time course experiment to correlate temporal changes in azoxymethane-induced gene expression profiles with colorectal cancer susceptibility... - Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulationMinnie Hsieh
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5317, USA
Mol Cell Biol 27:1914-24. 2007.... - Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogeneSybil M Genther Williams
McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Cancer Res 65:6534-42. 2005..Through the analysis of these mice, we show a requirement of the epidermal growth factor receptor for the hyperplastic properties of E5... - Metastatic potential as a heritable traitDavid W Threadgill
Nat Genet 37:1026-7. 2005 - High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptorNobukazu Fujimoto
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer Res 65:11478-85. 2005..Thus, lung adenocarcinoma cells that depend on EGFR for survival constitutively activate the receptor through a combination of genetic mutations and overexpression of EGFR dimeric partners and their ligands...
Research Grants
- Integrative Genetics of Cancer SusceptibilityDavid Threadgill; Fiscal Year: 2007..abstract_text> ..