David W Threadgill

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The collaborative cross: a recombinant inbred mouse population for the systems genetic era
    David W Threadgill
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    ILAR J 52:24-31. 2011
  2. ncbi request reprint Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor
    Daekee Lee
    Department of Genetics, University of North Carolina School of Medicine, CB 7264, Chapel Hill, North Carolina, 27599, USA
    Mamm Genome 15:525-36. 2004
  3. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
  4. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
  5. ncbi request reprint Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort
    David W Threadgill
    Department of Genetics, CB 7264, Lineberger Comprehensive Cancer Center, Rm 11 109, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mamm Genome 13:175-8. 2002
  6. ncbi request reprint Meeting report for the 4th annual Complex Trait Consortium meeting: from QTLs to systems genetics
    David W Threadgill
    Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 17:2-4. 2006
  7. pmc Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned
    Karen E Strunk
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37221, USA
    Genetics 167:1821-32. 2004
  8. pmc Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
    Cordelia J Barrick
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    Am J Physiol Heart Circ Physiol 297:H65-75. 2009
  9. pmc Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat
    Michele La Merrill
    Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Endocrinol Metab 296:E203-10. 2009
  10. pmc Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross
    Chevonne D Eversley
    Department of Genetics, Center for Gastrointestinal Biology and Disease, and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    G3 (Bethesda) 2:1577-84. 2012

Research Grants

  1. Integrative Genetics of Cancer Susceptibility
    David Threadgill; Fiscal Year: 2007

Collaborators

Detail Information

Publications63

  1. ncbi request reprint The collaborative cross: a recombinant inbred mouse population for the systems genetic era
    David W Threadgill
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    ILAR J 52:24-31. 2011
    ..The CC supports data integration across environmental and biological perturbations and across space (different labs) and time...
  2. ncbi request reprint Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor
    Daekee Lee
    Department of Genetics, University of North Carolina School of Medicine, CB 7264, Chapel Hill, North Carolina, 27599, USA
    Mamm Genome 15:525-36. 2004
    ..In vitro characterization shows that the antimorphic property of Egfr Wa5 is caused by a kinase-dead receptor acting as a dominant negative...
  3. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  4. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  5. ncbi request reprint Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort
    David W Threadgill
    Department of Genetics, CB 7264, Lineberger Comprehensive Cancer Center, Rm 11 109, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mamm Genome 13:175-8. 2002
  6. ncbi request reprint Meeting report for the 4th annual Complex Trait Consortium meeting: from QTLs to systems genetics
    David W Threadgill
    Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 17:2-4. 2006
    ....
  7. pmc Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned
    Karen E Strunk
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37221, USA
    Genetics 167:1821-32. 2004
    ..This method should be generally useful to partition heterogeneity contributing to other complex traits...
  8. pmc Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
    Cordelia J Barrick
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    Am J Physiol Heart Circ Physiol 297:H65-75. 2009
    ..These studies provide a novel model of aortic sclerosis and stenosis and suggest that long-term inhibition of EGFR signaling for cancer therapy may have unexpected consequences on aortic valves in susceptible individuals...
  9. pmc Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat
    Michele La Merrill
    Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Endocrinol Metab 296:E203-10. 2009
    ..Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise...
  10. pmc Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross
    Chevonne D Eversley
    Department of Genetics, Center for Gastrointestinal Biology and Disease, and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    G3 (Bethesda) 2:1577-84. 2012
    ..Furthermore, this work provides the foundation for large population-level epistatic interaction tests to identify combinations of low effect alleles that may have large effects on CRC susceptibility...
  11. doi request reprint Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor
    Tang Cheng Lee
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genesis 47:85-92. 2009
    ..This new mouse model should have wide utility to inactivate Egfr conditionally for functional analysis of EGFR in adult tissues and disease states...
  12. pmc Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials
    Erica S Rinella
    Department of Genetics, Curriculum in Genetics and Molecular Biology, Lineberger Cancer Center, Center for Gastrointestinal Biology and Disease, and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e39552. 2012
    ..Better-designed preclinical studies should lead to more accurate predictions of therapeutic response in the clinic...
  13. pmc Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles
    Jennifer Dackor
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 183:207-18. 2009
    ....
  14. pmc Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice
    Blair U Bradford
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 120:206-17. 2011
    ..These studies provide better understanding of the mechanisms of TCE-induced toxicity anchored on metabolism and genotype-phenotype correlations that may define susceptibility or resistance...
  15. pmc Architecture of energy balance traits in emerging lines of the Collaborative Cross
    Wendy Foulds Mathes
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Endocrinol Metab 300:E1124-34. 2011
    ..These results suggest that the CC will be a powerful, high-precision tool for examining the genetic architecture of complex traits such as those involved in regulation of energy balance...
  16. pmc Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
    Alison H Harrill
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genome Res 19:1507-15. 2009
    ..These studies demonstrate that a diverse mouse population can be used to understand and predict adverse toxicity in heterogeneous human populations through guided resequencing...
  17. doi request reprint Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Exp Metastasis 27:279-93. 2010
    ....
  18. pmc Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer
    Erica S Rinella
    Department of Genetics, Curriculum in Genetics and Molecular Biology, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA
    Cancer Biol Ther 13:130-7. 2012
    ..Unexpectedly, the combined use of dietary calcium supplementation and EGFR inhibitors also resulted in elevated toxicity suggesting that careful consideration be given when combining dietary supplements with prescribed cancer therapies...
  19. pmc Replication and narrowing of gene expression quantitative trait loci using inbred mice
    Daniel M Gatti
    Department of Environmental Sciences and Engineering, University of North Carolina, CB 7431, Chapel Hill, NC 27599, USA
    Mamm Genome 20:437-46. 2009
    ....
  20. ncbi request reprint Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet
    Anika Bissahoyo
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, 27599, USA
    Toxicol Sci 88:340-5. 2005
    ..These results provide experimental support for a standardized AOM treatment and for the importance of controlling both genetic and non-genetic factors when using this model...
  21. pmc Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
    Daekee Lee
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2702-13. 2009
    ..These results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ERBB3 may be a promising target for the treatment of colorectal cancers...
  22. pmc Parent-of-origin effects on cardiac response to pressure overload in mice
    Cordelia J Barrick
    Curriculum in Toxicology, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Physiol Heart Circ Physiol 297:H1003-9. 2009
    ..Our results suggest that susceptibility to LVH is more complex than simple Mendelian inheritance and that parental origin effects strongly impact the LV response to TAC in these commonly used inbred strains...
  23. pmc MicroRNA expression in the livers of inbred mice
    Daniel M Gatti
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Mutat Res 714:126-33. 2011
    ....
  24. pmc Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage
    Daekee Lee
    Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 24:8907-16. 2004
    ..However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium...
  25. pmc Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome
    Hanwen Huang
    Department of Biostatistics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Genetics 176:2529-40. 2007
    ..The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer...
  26. doi request reprint Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor
    Jennifer Dackor
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 20:339-49. 2009
    ..In addition, EGFR promotes growth of the placental spongiotrophoblast layer in mice, and EGFR expressed in the uterine stroma may play an underappreciated role in preparation of the uterus for embryo implantation...
  27. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  28. pmc Genome-level analysis of genetic regulation of liver gene expression networks
    Daniel Gatti
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Hepatology 46:548-57. 2007
    ..genenetwork.org) that allows custom data mining, identification of coregulated transcripts and correlated phenotypes, cross-tissue, and cross-species comparisons, as well as testing of a broad array of hypotheses...
  29. ncbi request reprint Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage
    Joshua M Uronis
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Cancer Res 67:11594-600. 2007
    ....
  30. pmc Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors
    Michele La Merrill
    Department of Genetics, Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27695, USA
    Environ Health Perspect 117:1414-9. 2009
    ..Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands...
  31. pmc Toxicogenetics: population-based testing of drug and chemical safety in mouse models
    Ivan Rusyn
    Department of Environmental Sciences and Engineering, 0031 Michael Hooker Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacogenomics 11:1127-36. 2010
    ....
  32. pmc Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
    Michele La Merrill
    Department of Genetics, Center for Environmental and Health Susceptibility, Lineberger Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 118:596-601. 2010
    ....
  33. pmc Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations
    Fei Zou
    Department of Biostatistics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 170:1299-311. 2005
    ....
  34. pmc Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross
    Chevonne D Eversley
    Department of Genetics, Curriculum in Genetics and Molecular Biology, and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Genet 11:98. 2010
    ..Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss...
  35. pmc Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice
    Cordelia J Barrick
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 228:315-25. 2008
    ..Taken together, these data suggest that chronic dietary exposure to TKIs may result in pathological and physiological changes in the heart...
  36. pmc The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics
    Adam Roberts
    Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA
    Mamm Genome 18:473-81. 2007
    ..We conclude that the CC represents a dramatic improvement over existing genetic resources for mammalian systems biology applications...
  37. pmc Status and access to the Collaborative Cross population
    Catherine E Welsh
    Department of Computer Science, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mamm Genome 23:706-12. 2012
    ..Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia...
  38. pmc EGFR signaling promotes TGFβ-dependent renal fibrosis
    Jianchun Chen
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Soc Nephrol 23:215-24. 2012
    ....
  39. pmc Murine models of colorectal cancer
    Joshua M Uronis
    Curriculum in Genetics and Molecular Biology, Department of Genetics, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 20:261-8. 2009
    ..This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of colorectal cancer...
  40. pmc Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel
    Alison H Harrill
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 110:235-43. 2009
    ..Our data demonstrate that a multistrain approach may provide utility for understanding genotype-independent toxicity responses and facilitate identification of novel targets of therapeutic intervention...
  41. doi request reprint Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:179-89. 2008
    ..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations...
  42. pmc Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
    Reade B Roberts
    Department of Cell Biology, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 99:1521-6. 2002
    ..Treatment with EKI-785 produced a dose-dependent reduction in tumor growth, suggesting that Egfr inhibitors may be useful for advanced colorectal cancer treatment...
  43. ncbi request reprint Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies
    Reade B Roberts
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Cell 5:115-20. 2004
    ..Here we review and propose how genetically engineered mouse models can serve as valuable tools to predict targeted therapy toxicity, as well as to identify allelic variants that predispose individuals to side effects...
  44. pmc Modeling host genetic regulation of influenza pathogenesis in the collaborative cross
    Martin T Ferris
    Carolina Vaccine Institute, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 9:e1003196. 2013
    ..We sequenced the coding regions of Mx1 in the eight CC founder strains, and identified a novel Mx1 allele that showed reduced ability to inhibit viral replication, while maintaining protection from weight loss...
  45. doi request reprint The gastrointestinal microbiome: a malleable, third genome of mammals
    Ian M Carroll
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 20:395-403. 2009
    ..The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed...
  46. pmc Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors
    Christine L Powell
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 115:131-9. 2010
    ..Profound changes in alcohol metabolism represent additional important mechanism of the protective effect of methyl donors in ALI...
  47. pmc Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response
    Michelle C Desimone
    Affiliations of authors Department of Genetics, North Carolina State University, Raleigh, NC MCD, DWT Department of Genetics WKR and Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC WKR, DWT
    J Natl Cancer Inst 105:1355-64. 2013
    ....
  48. pmc Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
    James J Crowley
    Department of Genetics, University of North Carolina, Genomic Medicine Building, CB 7264, Chapel Hill, NC 27599 7264, USA
    Mamm Genome 23:322-35. 2012
    ....
  49. ncbi request reprint Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment
    A Deloris Alexander
    Department of Genetics and Center for Gastrointestinal Biology and Disease, University of North Carolina, CB 7264, Chapel Hill, North Carolina 27599, USA
    Mamm Genome 17:1093-104. 2006
    ..Furthermore, cohabitation of different inbred strains maintained most of the interstrain variation in the GI flora, supporting a role of host genetics in determining GI flora composition...
  50. pmc Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia
    Sheryl S Moy
    Carolina Center for Developmental Disabilities, CB 7146, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA
    J Neurodev Disord 1:302-12. 2009
    ..Nrg1+/- pups did not exhibit changes in isolation-induced ultrasonic vocalizations, a measure of emotional reactivity. Overall, these findings provide evidence that social behavior is mediated by NRG1-ERBB signaling...
  51. ncbi request reprint Investigating gene function using mouse models
    Daekee Lee
    Department of Genetics, CB 7264, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Curr Opin Genet Dev 14:246-52. 2004
    ..Furthermore, novel technologies have been developed that can regulate biological information at each level from creating specific modifications in DNA, to inhibiting gene transcription, to regulating protein activity...
  52. ncbi request reprint Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy
    Cordelia J Barrick
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Heart Circ Physiol 292:H2119-30. 2007
    ..These results also imply that genetic background differences can complicate interpretation of TAC studies when using mixed genetic backgrounds...
  53. ncbi request reprint Human epithelial-specific response to pathogenic Campylobacter jejuni
    Erica S Rinella
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    FEMS Microbiol Lett 262:236-43. 2006
    ..This study demonstrates that mouse and human colonic epithelia remain relatively unresponsive to commensal bacterial challenge, while the human pathogen C. jejuni elicits a host-specific response...
  54. ncbi request reprint Enhanced oligonucleotide microarray labeling and hybridization
    Haider Ali Syed
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Biotechniques 41:685-6. 2006
  55. ncbi request reprint Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    Elissa J Chesler
    University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Genet 37:233-42. 2005
    ..We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses...
  56. pmc Genetics of dark skin in mice
    Karen R Fitch
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 17:214-28. 2003
    ....
  57. doi request reprint Down's syndrome: paradox of a tumour repressor
    David W Threadgill
    Nature 451:21-2. 2008
  58. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  59. ncbi request reprint Bayesian hierarchical modeling for time course microarray experiments
    Yueh Yun Chi
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Biometrics 63:496-504. 2007
    ..The methodology is applied to a mouse model time course experiment to correlate temporal changes in azoxymethane-induced gene expression profiles with colorectal cancer susceptibility...
  60. pmc Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation
    Minnie Hsieh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5317, USA
    Mol Cell Biol 27:1914-24. 2007
    ....
  61. ncbi request reprint Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene
    Sybil M Genther Williams
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 65:6534-42. 2005
    ..Through the analysis of these mice, we show a requirement of the epidermal growth factor receptor for the hyperplastic properties of E5...
  62. ncbi request reprint Metastatic potential as a heritable trait
    David W Threadgill
    Nat Genet 37:1026-7. 2005
  63. ncbi request reprint High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
    Nobukazu Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11478-85. 2005
    ..Thus, lung adenocarcinoma cells that depend on EGFR for survival constitutively activate the receptor through a combination of genetic mutations and overexpression of EGFR dimeric partners and their ligands...

Research Grants2

  1. Integrative Genetics of Cancer Susceptibility
    David Threadgill; Fiscal Year: 2007
    ..abstract_text> ..