Research Topics
| P E ThorpeSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Cytotoxicity of VEGF(121)/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2Khalid A Mohamedali
Departments of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
BMC Cancer 11:358. 2011..In this study, we examined the basis for the specific toxicity of this construct and assessed its intracellular effects in vitro and in vivo...
Mapping zip codes in human vasculatureP E Thorpe
University of Texas Southwestern, Simon's Cancer Center, Dallas, 75390, USA
Pharmacogenomics J 2:205-6. 2002- Vascular targeting agents as cancer therapeuticsPhilip E Thorpe
Department of Pharmacology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Clin Cancer Res 10:415-27. 2004..Because efficacy is expected when the agents are used with conventional chemotherapeutic drugs or radiation, the results of Phase II combination studies are eagerly awaited... - The first international conference on vascular targeting: meeting overviewPhilip E Thorpe
Department of Pharmacology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cancer Res 63:1144-7. 2003..These agents are now being evaluated in combined modality studies to see whether the impressive results obtained in experimental models can be translated into humans... - Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonanceX Huang
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235, USA
Biochem Biophys Res Commun 252:643-8. 1998..Heparin was not required for the binding of VEGF to sFlk-1 in this assay. The obtained values will serve as baseline parameters for the design of improved versions of recombinant soluble VEGF receptor... - Increased exposure of anionic phospholipids on the surface of tumor blood vesselsSophia Ran
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390-8594, USA
Cancer Res 62:6132-40. 2002..Anionic phospholipids on tumor vessels could potentially provide markers for tumor vessel targeting and imaging... - Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapySophia Ran
Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8594, USA
Int J Radiat Oncol Biol Phys 54:1479-84. 2002..2) To determine whether PS exposure can be induced on viable endothelial cells in tissue culture by conditions present in the tumor microenvironment... - Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiologyRalph P Mason
Department of Radiology, U T Southwestern Medical Center, Dallas, Texas, USA
J Cell Biochem Suppl 39:45-53. 2002.... - Heparin-steroid conjugates lacking glucocorticoid or mineralocorticoid activities inhibit the proliferation of vascular endothelial cellsE J Derbyshire
Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
Biochim Biophys Acta 1310:86-96. 1996.... - Plasma protein beta-2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cellsTroy A Luster
Simmons Comprehensive Cancer Center, Hamon Center for Therapeutic Oncology Research, the Department of Pharmacology and the Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 281:29863-71. 2006..Together, these data indicate that 3G4 targets tumor EC by increasing the avidity of beta2GP1 for anionic phospholipids through formation of multivalent 3G4-beta2GP1 complexes... - Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarctionRalph P Mason
Department of Radiology, U.T. Southwestern Medical Center, Dallas, TX 75390, USA
Adv Exp Med Biol 530:197-204. 2003..This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction... - Generation and characterization of recombinant vascular targeting agents from hybridoma cell linesC Gottstein
University of Texas Southwestern Medical Center, Dallas, TX, USA
Biotechniques 30:190-4, 196, 198 passim. 2001..The fusion proteins exhibited similar functional activity to analogous biochemical constructs. This is the first report to describe the generation and characterization of recombinant coaguligands... - A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer modelWei Zhang
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8594, USA
Angiogenesis 5:35-44. 2002..These findings suggest that 2C3 is a candidate for treating primary cancer and for preventing the outgrowth of tumor metastases in cancer patients... - Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipidsJin He
Simmons Comprehensive Cancer Center, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
Clin Cancer Res 13:5211-8. 2007..Here we tested the hypothesis that radiation therapy can increase phosphatidylserine exposure on lung tumor vasculature, thereby enhancing the antitumor properties of the anti-phosphatidylserine antibody 2aG4... - Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in miceSophia Ran
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 2201 Inwood Road NC7.304, Dallas, TX 75390, USA
Clin Cancer Res 11:1551-62. 2005..CONCLUSIONS: 3G4 localizes specifically to complexes of anionic phospholipids and serum proteins on the surface of vascular endothelial cells in tumors in mice. This results in damage to tumor vasculature and suppression of tumor growth... - Anti-tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate-specific membrane antigenXianming Huang
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 2201 Inwood, Road, Dallas, Texas, USA
Prostate 61:1-11. 2004.... - Evaluation of novel antimouse VEGFR2 antibodies as potential antiangiogenic or vascular targeting agents for tumor therapySophia Ran
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8594, USA
Neoplasia 5:297-307. 2003..Vascular damage was not observed in normal organs, including kidneys and pancreas. These studies demonstrate that anti-VEGFR2 antibodies have potential for vascular targeting and imaging of tumors in vivo... 
Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cellsAndrei Marconescu
Department of Pharmacology and Simmons and Hamon Cancer Centers, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Biochim Biophys Acta 1778:2217-24. 2008..We conclude that APLs and PE coincidently appear on the external leaflet of the plasma membrane of cells after irradiation. Probably, this is because PE and the major APL, PS, share common regulatory mechanisms of translocation...- Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastomaJin He
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
Clin Cancer Res 15:6871-80. 2009..Here, we determined whether treatment with the murine equivalent of bavituximab, 2aG4, combined with irradiation can suppress tumor growth in a rat model of glioblastoma... - Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in miceAdam W Beck
Simmons Comprehensive Cancer Center and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA
Int J Cancer 118:2639-43. 2006..In conclusion, 3G4 enhanced the anti-tumor and anti-metastatic activity of gemcitabine without contributing to toxicity... - The vascular-ablative agent VEGF(121)/rGel inhibits pulmonary metastases of MDA-MB-231 breast tumorsSophia Ran
Simmons Comprehensive Cancer Center and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Neoplasia 7:486-96. 2005..Thus, the antitumor vascular-ablative effect of VEGF(121)/rGel may be utilized not only for treating primary tumors but also for inhibiting metastatic spread and vascularization of metastases... - A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in miceXianming Huang
Department of Pharmacology and Simmons and Hamon Cancer Centers, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8594, USA
Cancer Res 65:4408-16. 2005..The combination therapy was no more toxic to the mice than was docetaxel alone. These results indicate that, as an adjuvant therapy, 3G4 could enhance the therapeutic efficacy of docetaxel in breast cancer patients... - The vascular-targeting fusion toxin VEGF121/rGel inhibits the growth of orthotopic human bladder carcinoma tumorsKhalid A Mohamedali
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Neoplasia 7:912-20. 2005..Thus, VEGF121/rGel inhibits the growth of human bladder cancer by cytotoxic effects directed against the tumor vascular supply and has significant potential as a novel antiangiogenic therapeutic against human bladder cancer... - Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserineMarc Jennewein
Institute of Nuclear Chemistry, Johannes Gutenberg University of Mainz, Mainz, Germany
Clin Cancer Res 14:1377-85. 2008..In the present study, we tested the hypothesis that a chimeric monoclonal antibody that binds phosphatidylserine could be labeled with radioactive arsenic isotopes and used for molecular imaging of solid tumors in rats... - Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivoDana M Brantley
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, TN 37232, USA
Oncogene 21:7011-26. 2002..These data provide the first functional evidence for Eph A class receptor regulation of pathogenic angiogenesis induced by tumors and support the function of A class Eph receptors in tumor progression... - Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancerSusann Stephan
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 10:6993-7000. 2004.... - A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasmaJohn M L Ebos
Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, S 217, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Mol Cancer Res 2:315-26. 2004....
Research Grants
- Novel Anti-Viral Agents for Treating Lassa FeverPhilip Thorpe; Fiscal Year: 2007..The information generated by these studies may also extend to other viruses that could be used for bioterrorism purposes. ..