Research Topics
| Peter ThorneSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Murine pulmonary responses after sub-chronic exposure to aluminum oxide-based nanowhiskersAndrea Adamcakova-Dodd
Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA 52242, USA
Part Fibre Toxicol 9:22. 2012..They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO nanowhisker aerosols...
Safety assessment of inhaled xylitol in mice and healthy volunteersLakshmi Durairaj
Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Respir Res 5:13. 2004..Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers...- Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection modelJong Sung Kim
Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, 52242, USA
Part Fibre Toxicol 8:29. 2011..The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (Cu) NPs using a model of lung inflammation and host defense... - Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation modelLarissa V Stebounova
Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
Part Fibre Toxicol 8:5. 2011..The objective of this study was to determine whether very small commercially available nanosilver induces pulmonary toxicity in mice following inhalation exposure... - An integrated model of environmental factors in adult asthma lung function and disease severity: a cross-sectional studyLaura Trupin
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Environ Health 9:24. 2010..We sought to evaluate the contribution of combined social and physical environmental exposures to adult asthma lung function and disease severity... 
Surface sampling for endotoxin assessment using electrostatic wiping clothsPeter S Thorne
Occupational and Environmental Health, College of Public Health, The University of Iowa, 100 Oakdale Campus, IREH, Iowa City, IA 52242 5000, USA
Ann Occup Hyg 49:401-6. 2005..Thus, we evaluated the feasibility of wipe sampling for endotoxin environmental assessment using electrostatic wipes with or without the use of disposable examination gloves...- Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housingPeter S Thorne
Department of Occupational and Environmental Health, College of Public Health, University of Iowa, 100 Oakdale Campus, 176 IREH, Iowa City, IA 52242 5000, USA
Am J Respir Crit Care Med 172:1371-7. 2005..We assayed 2,552 house dust samples in a representative nationwide sam- ple to explore relationships between endotoxin exposures and risk factors for asthma, asthma symptoms, and medication use... - Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in micePeter S Thorne
The University of Iowa, College of Public Health, 100 Oakdale Campus, IREH Iowa City, IA 52242 5000, USA
Am J Respir Crit Care Med 173:759-68. 2006..Other constituents of in-use metalworking fluids (MWFs) may also contribute to the development of lung disease. We investigated the potential for Mycobacterium immunogenum (MI) in MWFs to induce HP... - Biomonitoring for assessment of organic dust-induced lung inflammationL J Mueller-Anneling
Dept of Occupational and Environmental Health, The University of Iowa, College of Public Health, 100 Oakdale Campus, IREH, Iowa City, IA 52242 5000, USA
Eur Respir J 27:1096-102. 2006..This study demonstrates the efficacy of whole blood assay as a biomarker of inhalation exposure to inflammatory agents and its use for assessing susceptibility to organic dust-induced lung inflammation... - Environmental health impacts of concentrated animal feeding operations: anticipating hazards--searching for solutionsPeter S Thorne
College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
Environ Health Perspect 115:296-7. 2007.... 
Concentrations of bioaerosols, odors, and hydrogen sulfide inside and downwind from two types of swine livestock operationsPeter S Thorne
Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
J Occup Environ Hyg 6:211-20. 2009..Both types of swine operations produced high airborne concentrations of endotoxin, odor, hydrogen sulfide, bacteria, and fungi. Endotoxin and odors were found downwind at concentrations previously associated with adverse health effects...- Predictors of endotoxin levels in U.S. housingPeter S Thorne
Environmental Health Sciences Research Center, College of Public Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
Environ Health Perspect 117:763-71. 2009..However, few studies have evaluated predictors of household endotoxin, and none have done so for multiple locations within homes and on a national scale... - Evaluation of the Limulus amebocyte lysate and recombinant factor C assays for assessment of airborne endotoxinPeter S Thorne
Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA
Appl Environ Microbiol 76:4988-95. 2010..Both methods provided suitable lower limits of detection such that all but 19 of 1,824 samples were quantifiable... - Working Group report 4: exposure assessment for biological agentsPeter S Thorne
College of Public Health, University of Iowa, Iowa City, IA 55242 5000, USA
Am J Ind Med 46:419-22. 2004..Endotoxin exposure assessment using the Limulus amebocyte lysate method is a high priority for harmonization because of its importance as a pulmonary inflammatory agent in many occupational settings... - Evaluation of five extraction protocols for quantification of endotoxin in metalworking fluid aerosolPeter S Thorne
College of Public Health, Department of Occupational and Environmental Health, 100 Oakdale Campus, IREH, The University of Iowa, Iowa City, IA 52242 5000, USA
Ann Occup Hyg 47:31-6. 2003..This study was conducted to generate multiple samples with similar mass and endotoxin loading in order to compare four alternative extraction methods with the ASTM method... - Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammationP S Thorne
Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
Am J Respir Cell Mol Biol 20:1155-64. 1999..These data demonstrate that replication-deficient Ad induce early inflammation and LPS-induced inflammation is not augmented by concurrent treatment with Ad... - Inhalation toxicology models of endotoxin- and bioaerosol-induced inflammationP S Thorne
Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City, IA 52242 5000, USA
Toxicology 152:13-23. 2000..In order to produce reliable data, rigorous exposure chamber design, aerosol generation systems, exposure quantitation and experimental protocols must be utilized... - Indoor and outdoor air quality assessment of four wastewater treatment plantsJoung Ae Lee
Department of Occupational and Environmental Health, The University of Iowa, Iowa City 52242, USA
J Occup Environ Hyg 3:36-43. 2006..The results showed that the factors analyzed affected concentrations of H2S and endotoxin differently. Therefore, different control methods for endotoxin and H2S need to be considered to effectively reduce their concentrations at WWTPs... - Comparison of endotoxin assays using agricultural dustsStephen J Reynolds
College of Public Health, Department of Occupational and Environmental Health, 140 IREH, University of Iowa, Iowa City, IA 52242, USA
AIHA J (Fairfax, Va) 63:430-8. 2002..The results of this study will be useful for standardization of sampling and analysis of airborne endotoxin in agriculture... - Exposure to particulates, microorganisms, beta(1-3)-glucans, and endotoxins during soybean harvestingChad J Roy
The University of Iowa, College of Public Health, Department of Occupational and Environmental Health, Iowa City, IA 52242-5000, USA
AIHA J (Fairfax, Va) 64:487-95. 2003..6 x 10(4) to 4.0 x 10(8) organisms/m(3). These data indicate the potential exists for high exposures to organic dust and bioaerosols during soybean harvesting... - MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation stateSuzana Hadina
Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA 52242 5000, USA
Am J Respir Cell Mol Biol 38:647-54. 2008..Hyporesponsiveness in MD-2-null mice after nasal aspiration of wild-type LOS indicate its essential role in airway responsiveness to endotoxin... - The potential role of concentrated animal feeding operations in infectious disease epidemics and antibiotic resistanceMary J Gilchrist
University Hygienic Laboratory, Iowa City, Iowa 52242, USA
Environ Health Perspect 115:313-6. 2007.... - Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responsesCaroline L S George
Department of Pediatrics, University of Iowa, Iowa City, 52242, USA
Am J Physiol Lung Cell Mol Physiol 291:L512-22. 2006..In conclusion, exposure to a nonhygienic environment did not induce significant airway neutrophilia, yet altered the population of immunologically active cells in the lung and reduced subsequent allergic inflammation... - Asthma and farm exposures in a cohort of rural Iowa childrenJames A Merchant
Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City, Iowa, USA
Environ Health Perspect 113:350-6. 2005.... - A small whole-body exposure chamber for laboratory usePATRICK T O'SHAUGHNESSY
Department of Occupational and Environmental Health, College of Public Health, University of Iowa, 100 Oakdale Campus, 137 IREH, Iowa City, IA 52242 5000, USA
Inhal Toxicol 15:251-63. 2003..8% and 11.0%, respectively. These CV values are comparable to those obtained from similar studies involving other inhalation exposure chambers... - Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxinCaroline L S George
Department of Pediatrics, Division of Pediatric Critical Care, University of Iowa, Iowa City, IA 52242, USA
Am J Physiol Lung Cell Mol Physiol 285:L1337-44. 2003..Furthermore, these alterations in SP-A gene activity and protein metabolism are dependent on an intact endotoxin signaling system... - Exposures to the Kuwait oil fires and their association with asthma and bronchitis among gulf war veteransJeffrey L Lange
Department of Occupational and Environmental Health, College of Public Health, College of Medicine, University of Iowa, Iowa City, Iowa, USA
Environ Health Perspect 110:1141-6. 2002..In contrast, there was no association between the modeled exposure and any of the outcomes. These findings do not support speculation that exposures to oil-fire smoke caused respiratory symptoms among veterans... - Monitoring risks in association with exposure levels among wastewater treatment plant workersJoung Ae Lee
Health Protection Office, The University of Iowa, Iowa City, IA 52246, USA
J Occup Environ Med 49:1235-48. 2007..To investigate the relationship between exposure to hydrogen sulfide and endotoxin during specific job tasks and health symptoms among wastewater treatment plant (WWTP) workers... - Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nmVicki H Grassian
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
Environ Health Perspect 115:397-402. 2007..Nanotechnology offers great promise in many industrial applications. However, little is known about the health effects of manufactured nanoparticles, the building blocks of nanomaterials... - Asthma prevalence and morbidity among rural Iowa schoolchildrenElizabeth Chrischilles
Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
J Allergy Clin Immunol 113:66-71. 2004..Unmeasured risk factors might account for the apparent protective effect in Keokuk County. These findings cast doubt on a protective effect of rural life for the development of childhood asthma... - Community health and socioeconomic issues surrounding concentrated animal feeding operationsKelley J Donham
College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
Environ Health Perspect 115:317-20. 2007.... - Novispirin G10-induced lung toxicity in a Klebsiella pneumoniae infection modelKaren H Bartlett
Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242, USA
Antimicrob Agents Chemother 47:3901-6. 2003..This finding establishes the importance of investigating candidate antimicrobial agents in an in vivo infection model... - Ambient endotoxin concentrations in PM10 from Southern CaliforniaLinda Mueller-Anneling
College of Public Health, The University of Iowa, 100 Oakdale Campus, IREH, Iowa City, IA 52242-5000, USA
Environ Health Perspect 112:583-8. 2004.... - Women in the Gulf War: combat experience, exposures, and subsequent health care useCaroline P Carney
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Mil Med 168:654-61. 2003..If these important differences in exposures and health care use are confirmed in other studies, optimal training and deployment preparedness strategies should be reconsidered... - Reduction in the bactericidal activity of selected cathelicidin peptides by bovine calf serum or exogenous endotoxinKaren H Bartlett
Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, 100 Oakdale Campus, IREH, Iowa City, IA 52242, USA
Int J Antimicrob Agents 23:606-12. 2004..LPS-binding efficiency was not correlated with antimicrobial activity in complex media. Additionally, LPS- and serum-binding may interfere with the antimicrobial activity of peptides in complex media... - Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosisShubha Murthy
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Am J Physiol Lung Cell Mol Physiol 297:L846-55. 2009..For the first time, these results demonstrate that Rac1 plays a crucial role in asbestos-induced pulmonary fibrosis. Moreover, it suggests that a simple intervention may be useful to prevent progression of the disease... - Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposuresJohannes Klösener
Department of Occupational and Environmental Health, High Resolution Mass Spectrometry Facility, and Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, 100 Oakdale Campus, Iowa City, Iowa 52242, USA
Chem Res Toxicol 22:179-86. 2009..Our study is of fundamental importance to the development of xenobiotic tracers for monitoring routes of human exposure to PBDEs and understanding uptake of PBDEs from particles and vapors... - Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixtureXin Hu
Interdisciplinary Graduate Program in Human Toxicology, Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, USA
Environ Sci Technol 44:6893-900. 2010..Selective uptake and elimination led to accumulation of a distinct congener spectrum in tissue. Minimal evidence of toxicity was observed... - Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsisKevin C Doerschug
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA
Crit Care Med 32:489-94. 2004..CONCLUSIONS: In this model of sepsis, antibiotics delay but do not prevent acute lung injury and mortality. Even in the presence of antibiotics, acute lung injury is strongly associated with bacteremia and bacteria within the lungs... - Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessmentIlka Noss
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
Appl Environ Microbiol 74:5621-7. 2008..We therefore conclude that measuring endotoxin levels with the EDC is a valid measure of average airborne endotoxin exposure, while reproducibility over time is at least equivalent to that of reservoir dust analyses... - Health-based occupational exposure limits for high molecular weight sensitizers: how long is the road we must travel?Dick Heederik
Institute for Risk Assessment Sciences, Division of Environmental and Occupational Health, Utrecht University, PO Box 80176, The Netherlands
Ann Occup Hyg 46:439-46. 2002..The major practical constraint at this moment seems to be the absence of well-standardized measurement techniques (immunoassays) for the evaluation of allergen exposure in the field... - Exposure to multiple indoor allergens in US homes and its relationship to asthmaPäivi M Salo
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Allergy Clin Immunol 121:678-684.e2. 2008..The National Survey of Lead and Allergens in Housing was the first population-based study to measure indoor allergen levels in US homes... - First National Survey of Lead and Allergens in Housing: survey design and methods for the allergen and endotoxin componentsPatrick J Vojta
Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 110:527-32. 2002..S. households, their distribution by various housing characteristics, and their associations with allergic diseases such as asthma and rhinitis... - Optimization of airborne endotoxin exposure assessment: effects of filter type, transport conditions, extraction solutions, and storage of samples and extractsSuzanne Spaan
Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
Appl Environ Microbiol 73:6134-43. 2007..05% Tween 20 in the assay solution had an additive effect. Thus, this study investigated gaps in the CEN protocol and provides data with which to fully specify a protocol for standardization of endotoxin exposure assessment... - Impact of the home indoor environment on adult asthma and rhinitisPaul D Blanc
Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94117, USA
J Occup Environ Med 47:362-72. 2005..We sought to study the combined effects of multiple home indoor environmental exposures in adult asthma and rhinitis... - History and results of the two inter-laboratory round robin endotoxin assay studies on cotton dustDavid T W Chun
Cotton Quality Research Station, Agricultural Research Service, U S Department of Agriculture, Clemson, South Carolina 29633, USA
Am J Ind Med 49:301-6. 2006..When different laboratories assay identical samples, the levels differ. The objective of this research was to evaluate the intra- and inter-laboratory variability for 13 laboratories measuring endotoxin in cotton dust... - Inter- and intraindividual variation of endotoxin- and beta(1 --> 3)-glucan-induced cytokine responses in a whole blood assayInge M Wouters
Institute for Risk Assessment Sciences, Division of Environmental and Occupational Health, Utrecht University, The Netherlands
Toxicol Ind Health 18:15-27. 2002.... - Interlaboratory evaluation of endotoxin analyses in agricultural dusts--comparison of LAL assay and mass spectrometryStephen J Reynolds
Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, CO 80523 1681, USA
J Environ Monit 7:1371-7. 2005..GC-MS may be of use when comparing across heterogeneous environments and should be considered for inclusion in future studies of human health outcomes... - Airborne endotoxin predicts symptoms in non-mouse-sensitized technicians and research scientists exposed to laboratory miceKarin A Pacheco
Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Crit Care Med 167:983-90. 2003..8, p = 0.003). We conclude that airborne endotoxin is associated with respiratory symptoms to mice in non-mouse-sensitized scientists and technicians... - Endotoxin in inner-city homes: associations with wheeze and eczema in early childhoodMatthew S Perzanowski
Columbia's Center for Children's Environmental Health, Columbia University, New York, NY 10032, USA
J Allergy Clin Immunol 117:1082-9. 2006.... - Characterization of endotoxin and mouse allergen exposures in mouse facilities and research laboratoriesKarin A Pacheco
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Ann Occup Hyg 50:563-72. 2006..Endotoxin and mouse allergen are derived from the same animal source, but have different physicochemical attributes. It is not known if airborne exposures to these agents are correlated in the laboratory animal workplace... - Dog ownership enhances symptomatic responses to air pollution in children with asthmaRob McConnell
Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
Environ Health Perspect 114:1910-5. 2006..Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence... - Personal exposures to inorganic and organic dust in manual harvest of California citrus and table grapesKiyoung Lee
Department of Epidemiology and Preventive Medicine, Western Center for Agricultural Health and Safety, University of California, Davis, Calif, USA
J Occup Environ Hyg 1:505-14. 2004..The degree of vigorous contact with foliage appeared to be a significant determining factor of exposures in manual harvesting... - Impacts of waste from concentrated animal feeding operations on water qualityJoAnn Burkholder
North Carolina State University, Raleigh, North Carolina, USA
Environ Health Perspect 115:308-12. 2007..Last, there is a need to promote and enforce best practices to minimize inputs of nutrients and toxicants from CAFOs into freshwater and marine ecosystems... - Monitoring and modeling of emissions from concentrated animal feeding operations: overview of methodsBryan Bunton
Iowa Department of Natural Resources, Des Moines, Iowa, USA
Environ Health Perspect 115:303-7. 2007..Additional data are needed to obtain reliable emission rates from CAFOs... - Health effects of airborne exposures from concentrated animal feeding operationsDick Heederik
University of Utrecht, Utrecht, The Netherlands
Environ Health Perspect 115:298-302. 2007.... - Characterization of airborne molds, endotoxins, and glucans in homes in New Orleans after Hurricanes Katrina and RitaCarol Y Rao
Epidemic Intelligence Service, Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS C09, Atlanta, GA 30333, USA
Appl Environ Microbiol 73:1630-4. 2007..The species and concentrations were different from those previously reported for non-water-damaged buildings in the southeastern United States... - Second inter-laboratory study comparing endotoxin assay results from cotton dustDavid T W Chun
Cotton Quality Research Station, Agricultural Research Service, US Department of Agriculture, P O Box 792, Clemson, SC 29633, USA
Ann Agric Environ Med 9:49-53. 2002..The results of this second round robin endotoxin assay study indicate that differences between laboratories are still high, but most of the laboratories could discern the cotton dusts with the different levels of endotoxin... - Effect of extraction and assay media on analysis of airborne endotoxinSuzanne Spaan
Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
Appl Environ Microbiol 74:3804-11. 2008..In conclusion, of the media tested, only Tween enhances the efficiency of endotoxin extraction from airborne dust samples in a consistent manner. We recommend extraction in PFW-Tween combined with dilution and LAL analysis in PFW... - Six month tracking of microbial growth in a metalworking fluid after system cleaning and rechargingMarc Veillette
Centre de Recherche, , , 2725 Chemin Ste-Foy, , Ste-Foy, G1V 4G5, Canada
Ann Occup Hyg 48:541-6. 2004..This study demonstrates that standard methods for cleaning MWF systems are inadequate since residual bacteria in the system can rapidly repopulate the newly charged MWF... - Toenail arsenic content and cutaneous melanoma in IowaLaura E Beane Freeman
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
Am J Epidemiol 160:679-87. 2004..03). The arsenic-melanoma findings in this study are not known to have been previously reported in observational epidemiologic studies involving incident cutaneous melanoma. Therefore, the findings warrant confirmation... - Mold and endotoxin levels in the aftermath of Hurricane Katrina: a pilot project of homes in New Orleans undergoing renovationGinger L Chew
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10034 4206, USA
Environ Health Perspect 114:1883-9. 2006..After Hurricane Katrina, many New Orleans homes remained flooded for weeks, promoting heavy microbial growth...
Research Grants
- Exposure Intervention in a Rural Pediatric Asthma CohortPeter Thorne; Fiscal Year: 2005..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
- ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTERPeter Thorne; Fiscal Year: 2007..During that time it has had two Directors, Dr. James Merchant (1993-2003) and Dr. Peter Thorne (2003-present)...