WALLACE BRUCE THORESON
Affiliation: University of Nebraska Medical Center
Van Hook M, Thoreson W. Unconventional Transmission at Conventional Synapses of an Inhibitory Interneuron. Neuron. 2015;87:463-5 pubmed publisher
..In this issue, Balakrishnan etÂ al. (2015) use capacitance recordings to unravel mechanisms of inhibitory synaptic transmission by AIIs. ..
Thoreson W, Stella S. Anion modulation of calcium current voltage dependence and amplitude in salamander rods. Biochim Biophys Acta. 2000;1464:142-50 pubmed
..Because of the overlap between the physiological voltage range and the lower part of the I(Ca) activation curve, anion effects on amplitude and activation may influence synaptic transmission at the first retinal synapse. ..
Thoreson W, Mangel S. Lateral interactions in the outer retina. Prog Retin Eye Res. 2012;31:407-41 pubmed publisher
..Finally, we examine the mechanisms and functions of two other forms of lateral interaction in the outer retina: negative feedback from horizontal cells to rods and positive feedback from horizontal cells to cones. ..
Chen M, Van Hook M, Thoreson W. Ca2+ Diffusion through Endoplasmic Reticulum Supports Elevated Intraterminal Ca2+ Levels Needed to Sustain Synaptic Release from Rods in Darkness. J Neurosci. 2015;35:11364-73 pubmed publisher
..Free diffusion of Ca(2+) within the ER may also communicate synaptic Ca(2+) changes back to the soma to influence other critical cell processes. ..
Wen X, Van Hook M, Grassmeyer J, Wiesman A, Rich G, Cork K, et al
. Endocytosis sustains release at photoreceptor ribbon synapses by restoring fusion competence. J Gen Physiol. 2018;150:591-611 pubmed publisher
..Unlike conventional synapses in which endocytic restoration of release sites is evident only at high frequencies, endocytosis is needed to maintain release from rod ribbon synapses even at modest frequencies. ..
Warren T, Van Hook M, Tranchina D, Thoreson W. Kinetics of Inhibitory Feedback from Horizontal Cells to Photoreceptors: Implications for an Ephaptic Mechanism. J Neurosci. 2016;36:10075-88 pubmed publisher
..By eliminating the proposed ephaptic mechanism for HC feedback regulation of photoreceptor Ca(2+) channels, our data support earlier proposals that synaptic cleft pH changes are more likely responsible. ..
Thoreson W, Miller R. Removal of extracellular chloride suppresses transmitter release from photoreceptor terminals in the mudpuppy retina. J Gen Physiol. 1996;107:631-42 pubmed
..Thus, it is possible that control of [Cl-] in and around photoreceptors may regulate glutamate release from these cells...
Thoreson W, Nitzan R, Miller R. Chloride efflux inhibits single calcium channel open probability in vertebrate photoreceptors: chloride imaging and cell-attached patch-clamp recordings. Vis Neurosci. 2000;17:197-206 pubmed
..Examination of the open and closed time distributions suggests that the reduction in open probability arises from increases in closed-state dwell times. Changes in intracellular [Cl-] may thus modulate photoreceptor Ca2+ channels...
Thoreson W, Bryson E, Rabl K. Reciprocal interactions between calcium and chloride in rod photoreceptors. J Neurophysiol. 2003;90:1747-53 pubmed
..These findings support the hypothesis that feedback interactions between Ca2+- and Ca2+-activated Cl- channels may contribute to the regulation of presynaptic Ca2+ currents involved in synaptic transmission from rod photoreceptors...