A D Thor

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
    Aeree Kim
    Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
    Breast Cancer Res 7:R708-18. 2005
  2. ncbi request reprint Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers
    A D Thor
    Evanston Northwestern Hospital Research Institute and Northwestern University, Evanston, IL 60201, USA
    Clin Cancer Res 7:2415-24. 2001
  3. ncbi request reprint Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer
    A D Thor
    Department of Pathology, Evanston Hospital Northwestern University, Evanston, IL 60201, USA
    J Clin Oncol 18:3230-9. 2000
  4. ncbi request reprint Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer
    S Liu
    Research Institute, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Clin Cancer Res 7:1716-23. 2001
  5. ncbi request reprint Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy
    Xiao He Yang
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 26:1675-80. 2005
  6. ncbi request reprint Age-associated biomarker profiles of human breast cancer
    Serenella Eppenberger-Castori
    Stiftung Tumorbank Basel and Department of Research, University Clinics, Basel, Switzerland
    Int J Biochem Cell Biol 34:1318-30. 2002
  7. doi request reprint Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B
    Michael P Digiovanna
    Yale University School of Medicine, Section of Medical Oncology, 333 Cedar St, Room WWW 217, New Haven, CT 06510, USA
    J Clin Oncol 26:2364-72. 2008
  8. ncbi request reprint HER2 and response to paclitaxel in node-positive breast cancer
    Daniel F Hayes
    Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109, USA
    N Engl J Med 357:1496-506. 2007
  9. ncbi request reprint Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms
    Chaitali Tophkhane
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 31:867-74. 2007
  10. ncbi request reprint Caspase expression profile and functional activity in a panel of breast cancer cell lines
    Shihe Yang
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Oncol Rep 17:1229-35. 2007

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
    Aeree Kim
    Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
    Breast Cancer Res 7:R708-18. 2005
    ..We hypothesized that physical and functional interactions between the wt rat neu/ErbB2 transgene and mouse ErbB3-encoded proteins could occur, activating downstream signaling and promoting mammary oncogenesis...
  2. ncbi request reprint Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers
    A D Thor
    Evanston Northwestern Hospital Research Institute and Northwestern University, Evanston, IL 60201, USA
    Clin Cancer Res 7:2415-24. 2001
    ..A physical basis for this motility may depend on the coexpression of gelsolin, a M(r) 80,000 actin-binding protein...
  3. ncbi request reprint Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer
    A D Thor
    Department of Pathology, Evanston Hospital Northwestern University, Evanston, IL 60201, USA
    J Clin Oncol 18:3230-9. 2000
    ..This study was designed to compare the incidence and prognostic value of ErbB-2 (HER-2/neu) and P-ErbB-2 immunoexpression in archival breast cancer samples...
  4. ncbi request reprint Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer
    S Liu
    Research Institute, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Clin Cancer Res 7:1716-23. 2001
    ..The number of mitoses per 1000 was independently associated with DFS (P = 0.043) but not with DSS. Apoptosis data did not provide independent prognostic value in any, node-positive or node-negative, breast cancer patients...
  5. ncbi request reprint Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy
    Xiao He Yang
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 26:1675-80. 2005
    ..These data indicate that caspase-3 plays a critical role in radiotherapy-induced apoptosis, and suggest that caspase-3 deficiency may contribute to the radioresistance of breast cancers...
  6. ncbi request reprint Age-associated biomarker profiles of human breast cancer
    Serenella Eppenberger-Castori
    Stiftung Tumorbank Basel and Department of Research, University Clinics, Basel, Switzerland
    Int J Biochem Cell Biol 34:1318-30. 2002
    ..In particular, breast tumors arising in older patients have slower growth rates, are more likely to be ER-positive, and are less likely to be p53-positive, EGFR-positive or ErbB2-positive...
  7. doi request reprint Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B
    Michael P Digiovanna
    Yale University School of Medicine, Section of Medical Oncology, 333 Cedar St, Room WWW 217, New Haven, CT 06510, USA
    J Clin Oncol 26:2364-72. 2008
    ....
  8. ncbi request reprint HER2 and response to paclitaxel in node-positive breast cancer
    Daniel F Hayes
    Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109, USA
    N Engl J Med 357:1496-506. 2007
    ..We hypothesized that HER2 positivity predicts a benefit from adjuvant doxorubicin doses above standard levels, from the addition of paclitaxel after adjuvant chemotherapy with doxorubicin plus cyclophosphamide, or from both...
  9. ncbi request reprint Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms
    Chaitali Tophkhane
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 31:867-74. 2007
    ....
  10. ncbi request reprint Caspase expression profile and functional activity in a panel of breast cancer cell lines
    Shihe Yang
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Oncol Rep 17:1229-35. 2007
    ....
  11. ncbi request reprint Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells
    Bolin Liu
    Department of Pathology and College of Medicine, University of Colorado at Denver and Health Sciences Center UCDHSC, Aurora, CO, USA
    Int J Cancer 120:1874-82. 2007
    ..Furthermore, erbB3 also contributes to erbB2-mediated tamoxifen resistance and therefore may be a clinically relevant therapeutic target in addition to erbB2...
  12. ncbi request reprint Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    Sathish Kumar Mungamuri
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Res 66:4715-24. 2006
    ....
  13. ncbi request reprint Caspase 3 activation during herpes simplex virus 1 infection
    Rachel M Kraft
    Department of Microbiology, One Gustave L Levy Place, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Virus Res 120:163-75. 2006
    ..These results indicate that caspase 3 activation is a consequence of HSV-1 infection and have important implications in our understanding of the interactions of the virus with host cells...
  14. ncbi request reprint c-erbB-2 in breast cancer: development of a clinically useful marker
    Daniel F Hayes
    University of Michigan Comprehensive Cancer Center, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Semin Oncol 29:231-45. 2002
    ..Well-designed, prospective, randomized clinical trials (designed to test the value of c-erbB-2) or formal meta-analyses will help to better establish the predictive role of c-erbB-2 in breast cancer...
  15. ncbi request reprint Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization
    Ann D Thor
    Department of Pathology, University of Oklahoma Health Science Centers, Oklahoma City, USA
    Hum Pathol 33:628-31. 2002
    ..This region of chromosome 8 may contain 1 or more genes whose loss leads to this particular histology and/or the lymphotrophic phenotype associated with this histopathologic pattern...
  16. ncbi request reprint Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients
    Michael P Digiovanna
    Department of Internal Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 23:1152-60. 2005
    ..To examine the relationship of epidermal growth factor receptor (EGFR) expression to ErbB-2 signaling activity in breast cancer and the impact that this interaction has on the prognosis of patients with early-stage breast cancer...
  17. ncbi request reprint Perinucleolar compartment prevalence has an independent prognostic value for breast cancer
    Rajesh V Kamath
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Cancer Res 65:246-53. 2005
    ..These findings also show the potential of PNC prevalence as a prognostic marker for breast cancer...
  18. ncbi request reprint erbB-2 (HER-2) and breast cancer progression
    S M Edgerton
    Department of Pathology, School of Medicine, University of Oklahoma Health Sciences Centers, Oklahoma City, Oklahoma, U S A
    Appl Immunohistochem Mol Morphol 11:214-21. 2003
    ..The lack of complete concordance suggests clonal selection or genetic drift in some cases...
  19. pmc The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis
    Anjali Naresh
    Department of Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, Louisiana
    Cancer Res 68:6387-95. 2008
    ....

Research Grants3

  1. E2 MODULATION OF TUMORIGENESIS IN ERBB2 TRANSGENIC MICE
    Ann Thor; Fiscal Year: 2003
    ..Utilization of this model will provide developmental, expression and molecular data associated with estrogen/estrogen receptor and tyrosine kinase receptor/ligand growth promoted breast carcinogenesis. ..