Genomes and Genes
Affiliation: University of Iowa
- Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd)Stewart Thompson
Department of Cell and Systems Biology, The University of Toronto, Toronto, Ontario, Canada
Invest Ophthalmol Vis Sci 49:2737-42. 2008..A novel assay of vision was used to determine how the form and extent of retinal disease affects visual phenotype in mice...
- Visual function testing: a quantifiable visually guided behavior in miceStewart Thompson
Howard Hughes Medical Institute and The Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Sciences, 4111 MERF, 375 Newton Road, The University of Iowa, Iowa City, IA 52242, USA
Vision Res 48:346-52. 2008..This suggests that where visual guidance is performance enhancing but not essential, loss of the contribution of visual guidance to the tasks might be compensated for by experience or training...
- Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by lightStewart Thompson
Howard Hughes Medical Institute, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242, USA
Eur J Neurosci 27:1973-9. 2008..Together the evidence demonstrates a pronounced and sustained classical photoreceptor input to irradiance detection for negative masking, and suggests one role of classical photoreceptor input is to constrain dynamic range...
- Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in miceStewart Thompson
Howard Hughes Medical Institute, Universityof Iowa, Iowa City, Iowa 52242, USA
Invest Ophthalmol Vis Sci 52:618-23. 2011....
- Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during agingN Mrosovsky
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ont, Canada M5S 3G5
Vision Res 48:1270-3. 2008....
- Photoreceptor cells with profound structural deficits can support useful vision in miceStewart Thompson
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa
Invest Ophthalmol Vis Sci 55:1859-66. 2014..The purpose of this study was to determine whether photoreceptor cells that lack a fully formed outer segment could usefully contribute to vision...
- Light aversion in mice depends on nonimage-forming irradiance detectionStewart Thompson
Department of Ophthalmology and Visual Sciences and The Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
Behav Neurosci 124:821-7. 2010..Further, the differing effects of disease suggest that negative masking and light aversion are distinct responses with specialized nonimage-forming irradiance detection pathways...
- Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsiaAdisa Kuburas
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, United States
Invest Ophthalmol Vis Sci 55:6878-85. 2014..The purpose of this study was to determine whether lack of Rgs9 also caused photophobia-like behavior in Rgs9 knockout (Rgs9-/-) mice and to identify useful diagnostic measures of Rgs9 dysfunction...
- Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degenerationElliott H Sohn
Stephen A Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa Departments of Ophthalmology and Visual Sciences, and Biostatistics, University of Iowa, Iowa City, Iowa and The Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa
Retina 35:48-57. 2015..Drusen in an exceedingly rare ADRD human donor eye was compared with eyes affected with age-related macular degeneration (AMD). This study also elucidated whether variations in high-risk AMD genotypes modify phenotypic severity of ADRD...
- Effects of hereditary retinal degeneration due to a CEP290 mutation on the feline pupillary light reflexStewart Thompson
Howard Hughes Medical Institute and Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52242, USA
Vet Ophthalmol 13:151-7. 2010..To understand how progressive rod cone degeneration due to a mutation in CEP290 affects the pupillary light reflex (PLR) in domestic cats...
- A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesityRoger E Davis
Department of Pediatrics, Anatomy and Cell Biology, Radiology, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 104:19422-7. 2007....
- The effects of rod and cone loss on the photic regulation of locomotor activity and heart rateStewart Thompson
Nuffield Laboratory of Ophthalmology, The John Radcliffe Hospital, Headley Way, University of Oxford, Roosevelt Drive, Oxford OX3 9DU, UK
Eur J Neurosci 28:724-9. 2008..Surprisingly, this irradiance detection response is dependent upon rod and cone photoreceptors, with no apparent contribution from melanopsin pRGCs...
- Non-rod, non-cone photoreception in rodents and teleost fishRussell G Foster
Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Novartis Found Symp 253:3-23; discussion 23-30, 52-5, 102-9. 2003..We compare non-rod, non-cone ocular photoreceptors in mammals and fish, and examine the criteria used to place candidate photopigment molecules into a functional context...