Richard L Thompson

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0524, USA
    J Virol 75:6660-75. 2001
  2. ncbi Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0524, USA
    J Virol 77:12319-30. 2003
  3. ncbi The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections
    Richard L Thompson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Neurovirol 17:552-8. 2011
  4. ncbi VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
    Nancy M Sawtell
    Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Neurovirol 17:546-51. 2011
  5. ncbi De novo synthesis of VP16 coordinates the exit from HSV latency in vivo
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    PLoS Pathog 5:e1000352. 2009
  6. ncbi Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0524, USA
    Future Med Chem 2:1099-105. 2010
  7. ncbi Determination, by inductively coupled plasma mass spectrometry, of changes in cellular metal content resulting from herpes simplex virus-1 (HSV-1) infection
    Katie DeNicola Cafferky
    Department of Chemistry, University of Cincinnati, Mail Location 0172, Cincinnati, OH 45221, USA
    Anal Bioanal Chem 387:2037-43. 2007

Research Grants

  1. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2009
  2. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2006
  3. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2002
  4. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard L Thompson; Fiscal Year: 2010

Collaborators

Detail Information

Publications7

  1. ncbi Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0524, USA
    J Virol 75:6660-75. 2001
    ..Thus, one function of the LAT gene is to protect sensory neurons and enhance the establishment of latency in the PNS...
  2. ncbi Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0524, USA
    J Virol 77:12319-30. 2003
    ..These last results strongly suggest that there is a posttranscriptional constraint on the expression of ICP0 protein during reactivation from latency and that this constraint is mediated by LAT...
  3. ncbi The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections
    Richard L Thompson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Neurovirol 17:552-8. 2011
    ..Here, we report that the latency associated transcript locus of HSV-1 is required for long-term maintenance of reactivation competent latent infections...
  4. ncbi VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
    Nancy M Sawtell
    Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Neurovirol 17:546-51. 2011
    ....
  5. ncbi De novo synthesis of VP16 coordinates the exit from HSV latency in vivo
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    PLoS Pathog 5:e1000352. 2009
    ..HSV reactivation from latency conforms to a model in which stochastic derepression of the VP16 promoter and expression of VP16 initiates entry into the lytic cycle...
  6. ncbi Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0524, USA
    Future Med Chem 2:1099-105. 2010
    ..Blocking VP16 transactivation would reduce the spread of the virus in the population and, importantly, presumably reduce or prevent the pathological long term chronic inflammation in the nervous system...
  7. ncbi Determination, by inductively coupled plasma mass spectrometry, of changes in cellular metal content resulting from herpes simplex virus-1 (HSV-1) infection
    Katie DeNicola Cafferky
    Department of Chemistry, University of Cincinnati, Mail Location 0172, Cincinnati, OH 45221, USA
    Anal Bioanal Chem 387:2037-43. 2007
    ..This work is the first step in the identification of metals pertinent to HSV-1 infection and lays the foundation for future studies concentrating on characterization of these metal-associated or containing molecules...

Research Grants10

  1. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2009
    ..We plan to determine how this mechanism operates, and this knowledge will lead directly to improved vaccine design and preventative therapies. ..
  2. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2006
    ..abstract_text> ..
  3. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard Thompson; Fiscal Year: 2002
    ..The information gained in these studies will permit the design of more effective vaccines and interventive drug therapies. ..
  4. OCULAR HSV INFECTION-LATENCY AND PATHOGENESIS
    Richard L Thompson; Fiscal Year: 2010
    ..We plan to determine how this mechanism operates, and this knowledge will lead directly to improved vaccine design and preventative therapies. ..