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Genomes and GenesSpecies | Paul ThompsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Sexual dimorphism of brain developmental trajectories during childhood and adolescenceRhoshel K Lenroot
Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
Neuroimage 36:1065-73. 2007..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development...
Computational anatomical methods as applied to ageing and dementiaP M Thompson
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Br J Radiol 80:S78-91. 2007..Finally, we indicate which computational methods are powerful enough to track dementia in clinical trials, on the basis of their efficiency and sensitivity to early change, and the detail in the measures they provide...- Three-dimensional mapping of the lateral ventricles in autismChristine N Vidal
Laboratory of Neuro Imaging, Brain Mapping Division, Department Neurology, UCLA School of Medicine, Los Angeles, California, USA
Psychiatry Res 163:106-15. 2008..These localized reductions in the lateral ventricles may result from exaggerated brain growth early in life... - Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 43:59-68. 2008..Our error metrics compare favorably with those previously reported for other automated hippocampal segmentations, suggesting the utility of the approach for large-scale studies... - Localized measures of callosal atrophy are associated with late-life hypertension: AGES-Reykjavik StudyPeter Harris
Department of Neurology, University of California, Davis, CA, USA
Neuroimage 43:489-96. 2008..The posterior CC may be differentially vulnerable to hypertension-associated atrophy, possibly due to its relatively tenuous vascularization... - Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophreniaMatej Oresic
VTT Technical Research Centre of Finland, Tietotie 2, Espoo, FI 02044 VTT, Finland
Genome Med 4:1. 2012..The 'prostaglandin deficiency' hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission... 
Mapping hippocampal and ventricular change in Alzheimer diseasePaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neuroimage 22:1754-66. 2004..These quantitative, dynamic visualizations of hippocampal atrophy and ventricular expansion rates in aging and AD may provide a promising measure to track AD progression in drug trials...- Structural abnormalities in the brains of human subjects who use methamphetaminePaul M Thompson
Laboratory of Neuroimaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
J Neurosci 24:6028-36. 2004..These brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury... - Time-lapse mapping of cortical changes in schizophrenia with different treatmentsPaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California Los Anges, School of Medicine, Los Angeles, CA 90095 7332, USA
Cereb Cortex 19:1107-23. 2009..These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions... - Mapping cortical change in Alzheimer's disease, brain development, and schizophreniaPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 23:S2-18. 2004..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages... - Abnormal cortical complexity and thickness profiles mapped in Williams syndromePaul M Thompson
Laboratory of Neuroimaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
J Neurosci 25:4146-58. 2005..03). These findings visualize cortical zones with altered anatomy in WS, which merit additional study with techniques to assess function and connectivity... - Tracking Alzheimer's diseasePaul M Thompson
Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Ann N Y Acad Sci 1097:183-214. 2007..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed... - Dynamics of gray matter loss in Alzheimer's diseasePaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
J Neurosci 23:994-1005. 2003..This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly populations and in those with dementia... - Mapping genetic influences on human brain structurePaul Thompson
Laboratory of Neuro Imaging and Brain Mapping Division, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Ann Med 34:523-36. 2002..Computational methods from brain imaging and genetics can be fruitfully merged, to shed light on the inheritance of personality differences and behavioral traits, and the genetic transmission of diseases that affect the human brain... - 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDSPaul M Thompson
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 31:12-23. 2006..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline... - Imaging genomicsPaul M Thompson
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
Curr Opin Neurol 23:368-73. 2010..Along with clinical diagnosis and cognitive testing, brain imaging offers highly reproducible measures that can be subjected to genetic analysis... - Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte declinePaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
Proc Natl Acad Sci U S A 102:15647-52. 2005..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy... - Genetic influences on brain structureP M Thompson
Laboratory of Neuro Imaging and Brain Mapping Division, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
Nat Neurosci 4:1253-8. 2001..05). These genetic brain maps reveal how genes determine individual differences, and may shed light on the heritability of cognitive and linguistic skills, as well as genetic liability for diseases that affect the human cortex... - Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophreniaP M Thompson
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, 4238 Reed Neurology, University of California School of Medicine, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 98:11650-5. 2001..The resulting mapping strategy reveals a shifting pattern of tissue loss in schizophrenia. Aspects of the anatomy and dynamics of disease are uncovered, in a changing profile that implicates genetic and nongenetic patterns of deficits... - Cortical change in Alzheimer's disease detected with a disease-specific population-based brain atlasP M Thompson
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping and Alzheimer s Disease Center, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Cereb Cortex 11:1-16. 2001..These deficits can therefore be (i) charted in a living population and (ii) compared across individuals and groups, facilitating longitudinal, genetic and interventional studies of dementia... - Growth patterns in the developing brain detected by using continuum mechanical tensor mapsP M Thompson
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Nature 404:190-3. 2000..Conversely, at ages 3-6 years, the fastest growth rates occurred in frontal networks that regulate the planning of new actions. Local rates, profiles, and principal directions of growth were visualized in each individual child... - Mathematical/computational challenges in creating deformable and probabilistic atlases of the human brainP M Thompson
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Hum Brain Mapp 9:81-92. 2000..Population-based maps of cortical variation reveal a mosaic of variability patterns that segregate sharply according to functional specialization and cytoarchitectonic boundaries... - Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effectsMartina Ballmaier
Laboratory of Neuroimaging, Department of Neurology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
Neuroimage 23:325-35. 2004..Further investigation of the influence of gender might provide a more comprehensive understanding of the pathophysiological differences underlying the two forms of dementia... - Genetic contributions to altered callosal morphology in schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Neuropsychiatric Institute, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA
J Neurosci 22:3720-9. 2002..An upward bowing of the callosum may thus provide an easily identifiable neuroanatomic marker to screen individuals possessing a biological vulnerability for schizophrenia... - Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Hum Brain Mapp 30:2766-88. 2009..Forty subjects were sufficient to discriminate AD from normal and correlate atrophy with CDR scores; 104, 200, and 304 subjects, respectively, were required to correlate MMSE with atrophy, to distinguish MCI from normal, and MCI from AD... - Information-theoretic analysis of brain white matter fiber orientation distribution functionsMing Chang Chiang
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Inf Process Med Imaging 20:172-82. 2007.... - Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophreniaChristine N Vidal
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, David Geffen School of Medicine at UCLA, 90095-1769, USA
Arch Gen Psychiatry 63:25-34. 2006..CONCLUSION: Frontal and limbic regions may not be equally vulnerable to gray matter attrition, which is consistent with the cognitive, metabolic, and functional vulnerability of the frontal cortices in schizophrenia... - A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly... - Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjectsXue Hua
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
Neuroimage 48:668-81. 2009..TBM offers high statistical power to track brain changes in large, multi-site neuroimaging studies and clinical trials of AD... - Detecting brain growth patterns in normal children using tensor-based morphometryXue Hua
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 7334, USA
Hum Brain Mapp 30:209-19. 2009..We demonstrate that a tensor-based Jacobian map is a sensitive and reliable method to detect regional tissue changes during development... - Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and ageKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Am J Psychiatry 160:2169-80. 2003..Cortical gray matter reductions show aging effects but are below the threshold of significance in schizophrenia... - Genetics of brain fiber architecture and intellectual performanceMing Chang Chiang
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 7334, USA
J Neurosci 29:2212-24. 2009..These genetic brain maps reveal heritable aspects of white matter integrity and should expedite the discovery of single-nucleotide polymorphisms affecting fiber connectivity and cognition... - Optimized conformal parameterization of cortical surfaces using shape based matching of landmark curvesLok Ming Lui
Department of Mathematics, UCLA, Los Angeles, CA 90095 1555, USA
Med Image Comput Comput Assist Interv 11:494-501. 2008..The utility of our model is demonstrated in experiments on cortical surfaces with landmarks delineated, which show that our computed maps give a shape-based alignment of the sulcal curves without significantly impairing conformality... - Automatic subcortical segmentation using a contextual modelJonathan H Morra
Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
Med Image Comput Comput Assist Interv 11:194-201. 2008.... - Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDSNatasha Lepore
Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 9:191-8. 2006..We apply a manifold version of Hotelling's T2 test to the strain matrices. Our results complement those found from the determinants of the Jacobians alone and provide greater power in detecting group differences in brain structure... - Mesh-based spherical deconvolution: a flexible approach to reconstruction of non-negative fiber orientation distributionsVishal Patel
Laboratory of Neuro Imaging, University of California, Los Angeles, USA
Neuroimage 51:1071-81. 2010..Finally, we provide a software tool for computing the FOD using our new formulation in hopes of simplifying and encouraging the adoption of spherical deconvolution techniques... - Regional specificity of hippocampal volume reductions in first-episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA
Neuroimage 21:1563-75. 2004..Targeting regional hippocampal abnormalities may help dissociate schizophrenia patients from other groups exhibiting global hippocampal volume changes, and better focus systems-level pathophysiological hypotheses... - Mean template for tensor-based morphometry using deformation tensorsNatasha Lepore
Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA
Med Image Comput Comput Assist Interv 10:826-33. 2007..These results are compared to the ones found using the 'best' control, B. Statistics on both shapes are evaluated using cumulative distribution functions of the p-values in maps of inter-group differences... - Cortical thinning in cingulate and occipital cortices in first episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
Biol Psychiatry 58:32-40. 2005.... - Abnormal gyral complexity in first-episode schizophreniaKatherine L Narr
Laboratory of Neuro-Imaging, Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA 90095-1769, USA
Biol Psychiatry 55:859-67. 2004.... - A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration methodCaroline Brun
Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA
Med Image Comput Comput Assist Interv 11:914-21. 2008..Power improvements were quantified by comparing the cumulative distribution functions of the p-values generated from both competing methods. The Riemannian algorithm outperformed the standard fluid registration... - Direct mapping of hippocampal surfaces with intrinsic shape contextYonggang Shi
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neuroimage 37:792-807. 2007..Spherical harmonics (SPHARM) analysis is then applied and it confirms our results on temporal changes of HC asymmetry in AD... - Localizing gray matter deficits in late-onset depression using computational cortical pattern matching methodsMartina Ballmaier
Laboratory of Neuro Imaging, Department of Neurology, Rm. 4238, Reed Neurological Research Center, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Am J Psychiatry 161:2091-9. 2004.... - A framework for registration, statistical characterization and classification of cortically constrained functional imaging dataAnand A Joshi
Signal and Image Processing Institute, University of Southern California, Los Angeles, CA 90089, USA
Inf Process Med Imaging 19:186-96. 2005.... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controlsJonathan H Morra
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 45:S3-15. 2009..They also reveal genetically greater atrophy in cognitively intact subjects... - Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervalsXue Hua
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 51:63-75. 2010..These statistics may facilitate clinical trial design using voxel-based brain mapping methods such as TBM... - Surface-constrained volumetric brain registration using harmonic mappingsAnand A Joshi
Image Processing Institute, University of Southern California, Los Angeles, CA 90089, USA
IEEE Trans Med Imaging 26:1657-69. 2007..We evaluate the performance of our proposed method relative to existing methods that use only intensity information; for this comparison we compute the intersubject alignment of expert-labeled subcortical structures after registration... - Increased volume of the amygdala and hippocampus in bipolar patients treated with lithiumLara C Foland
Laboratory of Neuroimaging, Department of Neurology, University of California, UCLA School of Medicine, Los Angeles, California, USA
Neuroreport 19:221-4. 2008..Our findings may help to explain previous inconsistencies in the bipolar literature... - Adaptive reproducing kernel particle method for extraction of the cortical surfaceMeihe Xu
Department of Neurology, University of California at Los Angeles School of Medicine, CA 90095, USA
IEEE Trans Med Imaging 25:755-67. 2006..We also show that the independence of the shape functions of the RKPM from the underlying mesh enhances the convergence speed of the deformable model... - Genetic influences on brain asymmetry: a DTI study of 374 twins and siblingsNeda Jahanshad
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
Neuroimage 52:455-69. 2010..These maps identify heritable DTI-derived features, and may empower genome-wide searches for genetic polymorphisms that influence brain asymmetry... - 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometryXue Hua
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
Neuroimage 41:19-34. 2008..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials... - Adaptive elastic segmentation of brain MRI via shape-model-guided evolutionary programmingAlain Pitiot
Reed Neurological Research Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
IEEE Trans Med Imaging 21:910-23. 2002..We focus on understanding the features of template matching that are most beneficial in terms of the achieved match. Examples from simulated and real image data are discussed, with considerations of algorithmic efficiency... - Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactionsTyrone D Cannon
Department of Psychology, University of California, Los Angeles, 90095, USA
Schizophr Bull 29:653-69. 2003.... - Agreement-based semi-supervised learning for skull strippingJuan Eugenio Iglesias
Medical Imaging Informatics, University of California, Los Angeles, USA
Med Image Comput Comput Assist Interv 13:147-54. 2010..Our system is practical, and it displays significant improvement over supervised approaches, BET and FreeSurfer in two datasets (60 test images)... - Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controlsYi Yu Chou
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
Neuroimage 46:394-410. 2009..Ventricular expansion maps correlate with pathological and cognitive measures in AD, and may be useful in future imaging-based clinical trials... - Age effects on hippocampal structural changes in old men: the HAASYuan Xu
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1721, USA
Neuroimage 40:1003-15. 2008..However, the sample sizes of disease groups are relatively low; further studies with more AD/VaD data are needed... - Mapping cerebellar degeneration in HIV/AIDSAndrea D Klunder
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 7332, USA
Neuroreport 19:1655-9. 2008..Profound cerebellar deficits in HIV/AIDS (P=0.007, corrected) were associated with depression, suggesting a surrogate disease marker for antiretroviral trials... - Brain fiber architecture, genetics, and intelligence: a high angular resolution diffusion imaging (HARDI) studyMing Chang Chiang
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
Med Image Comput Comput Assist Interv 11:1060-7. 2008..Our methods show promise for discovering genes affecting fiber connectivity in the brain... - Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometryApril J Ho
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Hum Brain Mapp 31:499-514. 2010..Overall, 1.5 and 3 T scans did not significantly differ in their power to detect neurodegenerative changes over a year. Hum Brain Mapp, 2010. (c) 2009 Wiley-Liss, Inc... - Mapping the regional influence of genetics on brain structure variability--a tensor-based morphometry studyCaroline C Brun
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South Suite 225, Los Angeles, CA 90095 7334, USA
Neuroimage 48:37-49. 2009.... - Thinning of sensorimotor cortices in children with Tourette syndromeElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, 635 Charles Young Drive South, Suite 225, Los Angeles, California 90095, USA
Nat Neurosci 11:637-9. 2008..Correlations of cortical thickness in sensorimotor regions with tic symptoms suggest that these brain regions are important in the pathogenesis of Tourette syndrome... - Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposureEric Kan
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California, USA
Neuroreport 16:1285-90. 2005..These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology... - Automated extraction of the cortical sulci based on a supervised learning approachZhuowen Tu
Laboratory of Neuro Imaging, University of California Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
IEEE Trans Med Imaging 26:541-52. 2007..The algorithm is tested on two groups of data, including some brains from patients with Williams Syndrome, and the results are very encouraging... - 3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometryAgatha D Lee
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 34:924-38. 2007..Investigation of how these anomalies emerge over time will accelerate our understanding of FraX and its treatment... - Lossless online ensemble learning (LOEL) and its application to subcortical segmentationJonathan H Morra
Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
Med Image Comput Comput Assist Interv 12:432-40. 2009.... - Mapping cortical thickness in children with 22q11.2 deletionsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Cereb Cortex 17:1889-98. 2007..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype... - Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposureElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California at Los Angeles, 90095, USA
Neuroimage 17:1807-19. 2002.... - Positive correlations between corpus callosum thickness and intelligenceEileen Luders
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, and Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Neuroimage 37:1457-64. 2007..Our findings emphasize the importance of incorporating posterior (callosal) regions into the theories and models proposed to explain the anatomical substrates of intelligence... - Regional cortical thinning in subjects with violent antisocial personality disorder or schizophreniaVeena M Narayan
Laboratory of Neuro Imaging, Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Am J Psychiatry 164:1418-27. 2007.... - Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiativeOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Arch Neurol 67:1370-8. 2010.... - HARDI denoising: variational regularization of the spherical apparent diffusion coefficient sADCYunho Kim
Mathematics Department, UCLA, Los Angeles, CA, USA
Inf Process Med Imaging 21:515-27. 2009..We use vectorial total variation regularization, an L1 data fidelity term and the logarithmic barrier function in the minimization. We present experiments of denoising synthetic and real HARDI data... - How does angular resolution affect diffusion imaging measures?Liang Zhan
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 49:1357-71. 2010..These plots may help in making trade-off decisions when designing diffusion imaging protocols... - Mapping cortical thickness and gray matter concentration in first episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA
Cereb Cortex 15:708-19. 2005..Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity... - Genetics of anisotropy asymmetry: registration and sample size effectsNeda Jahanshad
Laboratory of Neuro Imaging, Department of Neurology, UCLA, CA, USA
Med Image Comput Comput Assist Interv 12:498-505. 2009..All methods consistently found that genetic factors strongly determined the lateralization of fiber anisotropy, facilitating the quest for specific genes that might influence brain asymmetry and fiber integrity... - 3D pattern of brain abnormalities in Williams syndrome visualized using tensor-based morphometryMing Chang Chiang
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
Neuroimage 36:1096-109. 2007..We used tensor-based morphometry (TBM) to visualize the complex pattern of gray/white matter reductions in WS, based on fluid registration of structural brain images... - A novel measure of fractional anisotropy based on the tensor distribution functionLiang Zhan
Laboratory of Neuroimaging, Dept of Neurology, University of California, Los Angeles, USA
Med Image Comput Comput Assist Interv 12:845-52. 2009..By contrast, mean diffusivity (MD) as defined in standard DTI appears to be more accurate. Overall, we argue that novel measures derived from the TDF approach may yield more sensitive and accurate information than DTI-derived measures... - Inverse consistent mapping in 3D deformable image registration: its construction and statistical propertiesAlex Leow
Rm 4238, 710 Westwood Plaza, Loni, UCLA School of Medicine, USA
Inf Process Med Imaging 19:493-503. 2005..Statistically significant differences were detected between consistent versus inconsistent matching when permutation tests were performed on the resulting deformation maps... - Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trialsLon S Schneider
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Alzheimers Dement 6:367-77. 2010.... - Voxelwise genome-wide association study (vGWAS)Jason L Stein
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 53:1160-74. 2010..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure... - Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: data from the Osteoarthritis InitiativeHussain Z Tameem
Biomedical Engineering Department, University of California, Los Angeles, California, USA
J Magn Reson Imaging 34:372-83. 2011..To create an average atlas of knee femoral cartilage morphology, to apply the atlas for quantitative assessment of osteoarthritis (OA), and to study localized sex differences... - Dynamic mapping of hippocampal development in childhood onset schizophreniaTom F Nugent
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
Schizophr Res 90:62-70. 2007.... - Cortical mapping of genotype-phenotype relationships in schizophreniaCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
Hum Brain Mapp 28:519-32. 2007.... - Computer-assisted imaging to assess brain structure in healthy and diseased brainsJohn Ashburner
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
Lancet Neurol 2:79-88. 2003.... - Genus zero surface conformal mapping and its application to brain surface mappingXianfeng Gu
Department of Computer and Information Science and Engineering, University of Florida, FL 32611, USA
IEEE Trans Med Imaging 23:949-58. 2004..Compared with other brain surface conformal mapping algorithms, our algorithm is more stable and has good extensibility... - Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairmentOwen T Carmichael
Radiology Department, University of Pittsburgh, B 938 PUH, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neuroimage 27:979-90. 2005..The use of fully deformable registration methods, cohort atlases, and user-defined manual tracings are recommended for highest performance in fully automated hippocampus segmentation... - Three-dimensional patterns of hippocampal atrophy in mild cognitive impairmentJames T Becker
Alzheimer s Disease Research Center, University of Pittsburgh, PA 15213, USA
Arch Neurol 63:97-101. 2006.... - Extrapolation of sparse tensor fields: application to the modeling of brain variabilityPierre Fillard
INRIA Sophia Antipolis, Epidaure Project, France
Inf Process Med Imaging 19:27-38. 2005..Interestingly, such an asymmetry in anatomical variance could explain why there may be greater power to detect group activation in one hemisphere than the other in fMRI studies... - Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementiaOwen T Carmichael
Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
Alzheimer Dis Assoc Disord 21:14-24. 2007..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes... - The topography of grey matter involvement in early and late onset Alzheimer's diseaseGiovanni B Frisoni
Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
Brain 130:720-30. 2007..These findings indicate that EOAD and LOAD differ in their typical topographic patterns of brain atrophy, suggesting different predisposing or aetiological factors... - Relationship among neuroimaging indices of cerebral health during normal agingPeter Kochunov
Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas 78284, USA
Hum Brain Mapp 29:36-45. 2008..34). These findings are of interest in designing quantitative measures of brain aging for monitoring individual patients and in large-scale clinical trials... - Increased local gyrification mapped in Williams syndromeChristian Gaser
Department of Psychiatry, University of Jena, Jena, Germany
Neuroimage 33:46-54. 2006..The observed gyrification abnormalities in individuals with WS might be related to dysfunctions in neuronal circuits and consequently contribute to the distinct cognitive and behavioral profile accompanying the disorder... - Ventricular volume and dementia progression in the Cardiovascular Health StudyOwen T Carmichael
Neurology Department, University of California, Davis, CA 95616, USA
Neurobiol Aging 28:389-97. 2007..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology... - Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matchingPaul E Rasser
Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD, Australia
Neuroimage 26:941-51. 2005.... - Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivityMartina Ballmaier
Department of Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
Neuropsychopharmacology 33:1528-36. 2008..Patients with a late onset of depression may be at higher risk of illness progression and eventually dementia conversion than early-onset depression, with potentially important implications for research and therapy... - Learning object correspondences with the observed transport shape measureAlain Pitiot
Epidaure, INRIA, 2004 Route des Lucioles BP 93, 06 902 Sophia-Antipolis, France
Inf Process Med Imaging 18:25-37. 2003..We present two learning strategies that rely on the distance matrix and discuss their applications to the matching of a variety of 1-D, 2-D and 3-D objects, including the corpus callosum and ventricular surfaces... - Genus zero surface conformal mapping and its application to brain surface mappingXianfeng Gu
Division of Engineering and Applied Science, Harvard University, USA
Inf Process Med Imaging 18:172-84. 2003..Compared with other brain surface conformal mapping algorithms, our algorithm is more stable and has good extensibility... - Hippocampal morphology and distinguishing late-onset from early-onset elderly depressionMartina Ballmaier
Department of Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin
Am J Psychiatry 165:229-37. 2008..This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated... - Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's diseaseYi Yu Chou
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA, USA
Neuroimage 40:615-30. 2008..This high-throughput method for morphometric studies further motivates the combination of genetic and neuroimaging strategies in predicting AD progression and treatment response... - Detection and mapping of hippocampal abnormalities in autismRob Nicolson
Department of Psychiatry, The University of Western Ontario, London, Ontario, Canada
Psychiatry Res 148:11-21. 2006..The increased statistical and spatial power of computational mapping methods provided the ability to detect these differences, which were not found with traditional volumetric methods... - Genetics of brain structure and intelligenceArthur W Toga
Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Annu Rev Neurosci 28:1-23. 2005..We argue that these genetic links are partly mediated by brain structure that is likewise under strong genetic control. Other factors, such as the environment, obviously play a role, but the predominant determinant appears to be genetic...
Research Grants
- A Multidimensional Alzheimer's Disease Brain AtlasPaul M Thompson; Fiscal Year: 2010..We will share all images, protocols, and algorithms with our 100+ collaborating laboratories. ..
- Computational Modeling of High-Field MR ImagesPaul M Thompson; Fiscal Year: 2010..We will share all images, protocols, and algorithms with our network of 100+ collaborating laboratories. ..
- HARDI Mapping of Disease Effects on the BrainPaul Thompson; Fiscal Year: 2009..5 million individuals in the U.S. alone. ..
- A Multidimensional Alzheimer's Disease Brain AtlasPaul Thompson; Fiscal Year: 2009..We will share all images, protocols, and algorithms with our 100+ collaborating laboratories. ..
- A Multidimensional Alzheimer's Disease Brain AtlasPaul Thompson; Fiscal Year: 2007..We will share all images, protocols, and algorithms with our 100+ collaborating laboratories. ..
- Computational Modeling of High-Field MR ImagesPaul Thompson; Fiscal Year: 2007..We will share all images, protocols, and algorithms with our network of 100+ collaborating laboratories. ..
- Algorithms to Map Disease & Genetic Effects on the BrainPaul Thompson; Fiscal Year: 2005..Validated on unique datasets, these tools will greatly empower biomedical studies that bridge imaging and genetics. They will help investigate the genetic transmission, triggers, and dynamics of disease in whole human populations. ..
- Novel PDEs for Cortical Mapping and Analysis in DiseasePaul Thompson; Fiscal Year: 2004..abstract_text> ..
- HARDI Mapping of Disease Effects on the BrainPaul M Thompson; Fiscal Year: 2010..5 million individuals in the U.S. alone. ..