L V Thompson

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training
    O A Sanchez
    Division of Pathophysiology, Department of Physiological Sciences, School of Medicine, Universidad de Oriente, Cd Bolivar, Edo Bolivar, Venezuela
    Exp Diabetes Res 2009:737686. 2009
  2. pmc C57BL/6 neuromuscular healthspan scoring system
    Ted G Graber
    University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455
    J Gerontol A Biol Sci Med Sci 68:1326-36. 2013
  3. ncbi request reprint Age-related muscle dysfunction
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    Exp Gerontol 44:106-11. 2009
  4. pmc Oxidative stress, mitochondria and mtDNA-mutator mice
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    Exp Gerontol 41:1220-2. 2006
  5. ncbi request reprint Myosin and actin expression and oxidation in aging muscle
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Appl Physiol (1985) 101:1581-7. 2006
  6. ncbi request reprint Electron paramagnetic resonance: a high-resolution tool for muscle physiology
    L V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota, USA
    Exerc Sport Sci Rev 29:3-6. 2001
  7. ncbi request reprint Contractile function of single muscle fibers after hindlimb unweighting in aged rats
    L V Thompson
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    J Appl Physiol (1985) 84:229-35. 1998
  8. ncbi request reprint The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats
    Sheng Zhong
    Dept of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Cell Physiol 293:C723-8. 2007
  9. ncbi request reprint Age-related differences in the adaptive potential of type I skeletal muscle fibers
    Aimee D Husom
    Department of Physical Medicine and Rehabilitation, Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Gerontol 40:227-35. 2005
  10. pmc Age-dependent effects of treadmill exercise during a period of inactivity
    P Arora
    Department of Physical Medicine and Rehabilitation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Exp Gerontol 43:668-73. 2008

Research Grants

Collaborators

  • DEBORAH FERRINGTON
  • LEANN SNOW
  • DAWN LOWE
  • David D Thomas
  • Linda McLoon
  • Chuanning Tang
  • Hongwei Xie
  • P Arora
  • D R Dengel
  • Jong Hee Kim
  • J R Mickelson
  • M Brown
  • S J Valberg
  • Gordon L Warren
  • Andrew R Harrison
  • Holly M Brown-Borg
  • Edgar A Arriaga
  • Juan Feng
  • Ewa Prochniewicz
  • Chiao nan Joyce Chen
  • Sheng Zhong
  • Hossein Ahmadzadeh
  • Aimee D Husom
  • Marian Navratil
  • Timothy J Griffin
  • Danni L Meany
  • Nicole A Fugere
  • Ted G Graber
  • D L Templeton
  • Xin Xu
  • Mikel R Roe
  • Sharlene G Rakoczy
  • O A Sanchez
  • Chiao nan Chen
  • Otto A Sanchez
  • Alissa Guildner Gehrke
  • Jennifer Fox
  • Jon J Groskreutz
  • Lisa Ferguson-Stegall
  • N M Herrera
  • K H H Mosser
  • C N Chen
  • M D Stone
  • R John
  • J A Mlekoday
  • Thomas F McGowan
  • R C Serfass
  • T F Walseth
  • LeeAnn Higgins
  • Daniel J Spakowicz
  • Kate O'Conor
  • Dmitry Andreyev
  • Robert C Serfass
  • Robin Shotwell McDonald
  • Sara Willen Troje
  • Margaret Sheie Krull
  • Jaime ZumBerge
  • Elizabeth A Peters
  • Tracy Sparby
  • L Carney-Anderson
  • Jessica Thoele
  • Erin A Kolling
  • Peter Garber
  • Julie Vien
  • Monica Hoffman
  • Paul Schaefer
  • David Johnson
  • Christine Zeaton
  • E M Gallant
  • A N Zimmerman
  • D D Dykstra
  • J H Horton
  • D A Huetteman
  • S K Donaldson

Detail Information

Publications51

  1. pmc Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training
    O A Sanchez
    Division of Pathophysiology, Department of Physiological Sciences, School of Medicine, Universidad de Oriente, Cd Bolivar, Edo Bolivar, Venezuela
    Exp Diabetes Res 2009:737686. 2009
    ..Endurance exercise did not influence intramuscular sorbitol values as strongly as insulin...
  2. pmc C57BL/6 neuromuscular healthspan scoring system
    Ted G Graber
    University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455
    J Gerontol A Biol Sci Med Sci 68:1326-36. 2013
    ..In comparison with individual determinants, the NMHSS reduced the effect of individual variability within age groups, thus potentially providing an enhanced ability to detect treatment effects in future studies. ..
  3. ncbi request reprint Age-related muscle dysfunction
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    Exp Gerontol 44:106-11. 2009
    ..The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction...
  4. pmc Oxidative stress, mitochondria and mtDNA-mutator mice
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    Exp Gerontol 41:1220-2. 2006
    ..The purpose of this short review is to highlight several studies that provide direct evidence that accelerated aging is linked to mtDNA mutations, without an increase in oxidative damage...
  5. ncbi request reprint Myosin and actin expression and oxidation in aging muscle
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Appl Physiol (1985) 101:1581-7. 2006
    ..Additionally, age-dependent changes in myofibrillar stoichiometry do not contribute to the decline in force production in the soleus, but may play a role in the semimembranosus with advanced age...
  6. ncbi request reprint Electron paramagnetic resonance: a high-resolution tool for muscle physiology
    L V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota, USA
    Exerc Sport Sci Rev 29:3-6. 2001
    ..Electron paramagnetic resonance (EPR) paired with site-directed spin labeling has been used to study the relationships between (a) muscle force and myosin structure and (b) muscle relaxation and Ca-ATPase motion and structure...
  7. ncbi request reprint Contractile function of single muscle fibers after hindlimb unweighting in aged rats
    L V Thompson
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    J Appl Physiol (1985) 84:229-35. 1998
    ..The decline in the functional properties of single skeletal muscle fibers in the older animals appears to be more pronounced than what has been reported in younger animal populations...
  8. ncbi request reprint The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats
    Sheng Zhong
    Dept of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Cell Physiol 293:C723-8. 2007
    ..However, this reduction in V(o) is independent of myosin ATPase activity...
  9. ncbi request reprint Age-related differences in the adaptive potential of type I skeletal muscle fibers
    Aimee D Husom
    Department of Physical Medicine and Rehabilitation, Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Gerontol 40:227-35. 2005
    ..These results suggest aged skeletal muscle has an attenuated ability to adapt to inactivity by altering its size in response to inactivity...
  10. pmc Age-dependent effects of treadmill exercise during a period of inactivity
    P Arora
    Department of Physical Medicine and Rehabilitation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Exp Gerontol 43:668-73. 2008
    ..In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing-induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle...
  11. ncbi request reprint Electron paramagnetic resonance reveals age-related myosin structural changes in rat skeletal muscle fibers
    D A Lowe
    Department of Biochemistry, Molecular Biology, and Biophysics, Minnesota 55455, USA
    Am J Physiol Cell Physiol 280:C540-7. 2001
    ..We conclude that myosin structural changes can provide a molecular explanation for age-related decline in skeletal muscle force generation...
  12. ncbi request reprint Age-related changes in contractile properties of single skeletal fibers from the soleus muscle
    L V Thompson
    Program in Physical Therapy, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Appl Physiol (1985) 86:881-6. 1999
    ..Age-related changes in the molecular dynamics of myosin may be the underlying mechanism for altered force production. The presence of more than one beta/slow MHC isoform may be the mechanism for the altered Vo with age...
  13. ncbi request reprint Single soleus muscle fiber function after hindlimb unweighting in adult and aged rats
    L V Thompson
    Program in Physical Therapy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Appl Physiol (1985) 84:1937-42. 1998
    ....
  14. ncbi request reprint Effects of hindlimb unweighting and aging on rat semimembranosus muscle and myosin
    Sheng Zhong
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    J Appl Physiol 101:873-80. 2006
    ..Furthermore, the age of the rat has an influence on some parameters of changes in muscle contractility that are induced by unweighting...
  15. ncbi request reprint Adult and developmental myosin heavy chain isoforms in soleus muscle of aging Fischer Brown Norway rat
    LeAnn M Snow
    Department of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Anat Rec A Discov Mol Cell Evol Biol 286:866-73. 2005
    ..The developmental MHC-positive fibers provide evidence of ongoing myofiber remodeling in the oldest rats in the midst of the fiber degeneration of aging...
  16. ncbi request reprint Myosin heavy chain isoform immunolabelling in diabetic rats with peripheral neuropathy
    LeAnn M Snow
    Department of Physical Medicine and Rehabilitation, University of Minnesota Medical School, MMC 388, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Acta Histochem 107:221-9. 2005
    ..Insulin appeared to influence muscle fiber cross-sectional area and possibly fiber-type grouping frequency; the potential mechanism for these effects was not elucidated...
  17. ncbi request reprint Altered proteasome function and subunit composition in aged muscle
    Aimee D Husom
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Arch Biochem Biophys 421:67-76. 2004
    ..These results suggest significant alterations in the intrinsic activity, the percentage of immunoproteasome, and the regulation of the 20S proteasome by PA28 and PA700 in aged muscle...
  18. pmc Protein nitration with aging in the rat semimembranosus and soleus muscles
    Nicole A Fugere
    University of Minnesota, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 61:806-12. 2006
    ..However, significant levels of 3-NT modification were present at an earlier age in the semimembranosus muscle...
  19. ncbi request reprint Effects of age and training on skeletal muscle physiology and performance
    L V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis 55455
    Phys Ther 74:71-81. 1994
    ..Resistance and endurance training appear to attenuate the age-related alterations in skeletal muscle properties if the stimulus is of a sufficient intensity and duration...
  20. ncbi request reprint Effects of endurance exercise-training on single-fiber contractile properties of insulin-treated streptozotocin-induced diabetic rats
    Otto A Sanchez
    School of Kinesiology, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA
    J Appl Physiol 99:472-8. 2005
    ....
  21. pmc Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading
    Chiao nan Chen
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    J Appl Physiol (1985) 105:1554-61. 2008
    ..In summary, the data suggest that the muscle unloading-related changes of protein oxidation are more significant in specific proteins and that the changes are age related...
  22. ncbi request reprint Age-related decline in actomyosin function
    Ewa Prochniewicz
    Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 60:425-31. 2005
    ..We conclude that aging results in chemical changes in myosin (probably oxidation of cysteines) that have inhibitory effects on the actin-activated myosin ATPase...
  23. pmc Influence of insulin and muscle fiber type in nepsilon-(carboxymethyl)-lysine accumulation in soleus muscle of rats with streptozotocin-induced diabetes mellitus
    LeAnn M Snow
    Departmentof Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Pathobiology 76:227-34. 2009
    ..Skeletal muscle in diabetes demonstrates altered function, and increased accumulation of CML has been found in several fast-twitch muscles of diabetic animals...
  24. pmc Estimating relative carbonyl levels in muscle microstructures by fluorescence imaging
    Juan Feng
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Anal Bioanal Chem 391:2591-8. 2008
    ..This approach could easily be extended to the investigation of carbonyl levels in other muscles (composed of mixed skeletal muscle fiber types) or other tissues in which protein carbonyls are present...
  25. ncbi request reprint Skeletal muscle adaptations with age, inactivity, and therapeutic exercise
    LaDora V Thompson
    Department of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, USA
    J Orthop Sports Phys Ther 32:44-57. 2002
    ..Special emphasis will be placed on how alterations in muscle structure affect function and on the cellular and molecular mechanisms of the age-related and inactivity-induced muscle changes...
  26. ncbi request reprint Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers
    Dawn A Lowe
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Cell Physiol 283:C187-92. 2002
    ..This is in agreement with our previous electron paramagnetic resonance experiments that showed a reduced fraction of myosin heads in the strong-binding state during a maximal isometric contraction in fibers from older rats...
  27. ncbi request reprint Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers
    Ewa Prochniewicz
    Department of Biochemistry, University of Minnesota, Jackson Hall 6 155, 321 Church St, Minneapolis, MN 55455, USA
    Am J Physiol Cell Physiol 294:C613-26. 2008
    ....
  28. ncbi request reprint Advanced glycation end-product accumulation and associated protein modification in type II skeletal muscle with aging
    LeAnn M Snow
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis 55455, USA
    J Gerontol A Biol Sci Med Sci 62:1204-10. 2007
    ..Moreover, there is a significant increase in AGE modification of beta-enolase with age. These results identify a common subset of proteins that contain AGE and suggest that metabolic proteins are targets for glycation with aging...
  29. pmc Age-related decline in actomyosin structure and function
    Ewa Prochniewicz
    Department of Biochemistry, University of Minnesota, Minneapolis MN 55455, USA
    Exp Gerontol 42:931-8. 2007
    ..Therefore, understanding the aging process requires systematic, multidisciplinary studies on physiological, biochemical, structural, and chemical changes in specific muscles...
  30. ncbi request reprint Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry
    Danni L Meany
    Department of Chemistry, University of Minnesota, Minneapolis, MN, USA
    Proteomics 7:1150-63. 2007
    ..The results also demonstrate the utility of PQD operation on the LTQ instrument for quantitative analysis of iTRAQ reagent-labeled peptide mixtures, as well as the quantitative reproducibility of the avidin-affinity enrichment method...
  31. ncbi request reprint Advanced glycation end product in diabetic rat skeletal muscle in vivo
    LeAnn M Snow
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    Pathobiology 73:244-51. 2006
    ..Skeletal muscle contractile parameters have also been found to be altered in diabetes. Glycation has not been extensively studied in skeletal muscle, but AGE-modified proteins may influence contractility...
  32. ncbi request reprint Muscle activity and aging affect myosin structural distribution and force generation in rat fibers
    Dawn A Lowe
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Appl Physiol (1985) 96:498-506. 2004
    ..01). These data support the hypothesis that changes in muscle activity affect muscle strength, at least in part through alterations in myosin structure and function...
  33. ncbi request reprint Altered proteasome structure, function, and oxidation in aged muscle
    Deborah A Ferrington
    Department of Ophthalmology, 380 Lions Research Bldg, 2001 6th Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    FASEB J 19:644-6. 2005
    ..These results demonstrate significant age-related changes in proteasome structure, function, and oxidation state that could inhibit removal of oxidized proteins...
  34. ncbi request reprint Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats
    Dawn A Lowe
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis 55455, USA
    Mech Ageing Dev 125:619-27. 2004
    ....
  35. pmc Muscle disuse: adaptation of antioxidant systems is age dependent
    Chiao nan Joyce Chen
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 63:461-6. 2008
    ..The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage...
  36. ncbi request reprint Enzymatic alterations in single type IIB skeletal muscle fibers with inactivity and exercise in 12- and 30-month-old rats
    Jon J Groskreutz
    Program in Physical Therapy, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Aging Clin Exp Res 14:347-53. 2002
    ..The results demonstrate that the total LDH enzyme activities of the Type IIB fibers decrease with age, suggesting an age-related shift in the biochemical profile. Further, single skeletal muscle fiber adaptation is age-dependent...
  37. pmc Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress
    Chiao nan Joyce Chen
    Department of Physical Medicine and Rehabilitation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 65:129-37. 2010
    ..The results suggest that the regulation of GCL, especially the catalytic subunit, with stress may be compromised in aging muscles...
  38. ncbi request reprint The effects of non-weight bearing on skeletal muscle in older rats: an interrupted bout versus an uninterrupted bout
    Alissa Guildner Gehrke
    Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Res Nurs 5:195-202. 2004
    ..This study shows that initial weight bearing after an episode of non-weight bearing may be damaging to type II fibers of the EDL...
  39. pmc Quantitative proteomic profiling of muscle type-dependent and age-dependent protein carbonylation in rat skeletal muscle mitochondria
    Juan Feng
    University of Minnesota, 321 Church St SE, 6 155 Jackson Hall, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 63:1137-52. 2008
    ....
  40. ncbi request reprint Clenbuterol in the prevention of muscle atrophy: a study of hindlimb-unweighted rats
    N M Herrera
    Department of Physical Medicine and Rehabilitation, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Arch Phys Med Rehabil 82:930-4. 2001
    ..Thus, the administration of clenbuterol may lead to a more rapid rate of rehabilitation...
  41. ncbi request reprint GTP gammaS removal of D-600 block of skeletal muscle excitation-contraction coupling
    L Carney-Anderson
    Department of Physiology, School of Medicine, University of Minnesota, Minneapolis 55455, USA
    Am J Physiol 272:C572-81. 1997
    ..These data suggest that the molecular binding site for GTP gammaS and GDP betaS is likely to be in the TT near the DHPR, perhaps on a G protein...
  42. ncbi request reprint Effect of endurance exercise on myosin heavy chain isoform expression in diabetic rats with peripheral neuropathy
    LeAnn M Snow
    Department of Physical Medicine and Rehabilitation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Am J Phys Med Rehabil 84:770-9. 2005
    ..This study evaluated the effect of endurance exercise on myosin heavy chain (MHC) isoform expression in soleus muscle of diabetic rats with peripheral neuropathy...
  43. pmc Principal component analysis reveals age-related and muscle-type-related differences in protein carbonyl profiles of muscle mitochondria
    Juan Feng
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 63:1277-88. 2008
    ..In addition, PCA was used to predict that most age-related or muscle-type-related changes in carbonyl levels occur in proteins with a molecular weight between 9.8 and 11.7 kD...
  44. ncbi request reprint Morphological characteristics of skeletal muscles in relation to gender
    Jennifer Fox
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis 55455, USA
    Aging Clin Exp Res 15:264-9. 2003
    ..The aim of this study was to ascertain whether there are gender-related differences in the morphological characteristics of the soleus and tibialis anterior muscles in young adult and old Fischer 344/Brown Norway F1 rats...
  45. ncbi request reprint Calcium sensitivity of force production and myofibrillar ATPase activity in muscles from Thoroughbreds with recurrent exertional rhabdomyolysis
    J A Mlekoday
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA
    Am J Vet Res 62:1647-52. 2001
    ..Recurrent exertional rhabdomyolysis in Thoroughbreds may represent a novel heritable defect in the regulation of muscle excitation-contraction coupling or myoplasmic calcium concentration...
  46. doi request reprint Effects of left ventricular assist device (LVAD) placement on myocardial oxidative stress markers
    D L Templeton
    School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, United States
    Heart Lung Circ 21:586-97. 2012
    ..The primary purpose of this study was to examine the changes in myocardial oxidative stress during the support of a left ventricular assist device (LVAD)...
  47. pmc Myofiber length and three-dimensional localization of NMJs in normal and botulinum toxin treated adult extraocular muscles
    Andrew R Harrison
    Departments of Ophthalmology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Invest Ophthalmol Vis Sci 48:3594-601. 2007
    ..To demonstrate average myofiber length, randomly selected individual myofibers were reconstructed and compared with total muscle length...
  48. ncbi request reprint Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry
    Mikel R Roe
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Soc Mass Spectrom 21:1190-203. 2010
    ..Collectively, our method and software should provide valuable new tools for investigators studying protein carbonylation via mass spectrometry-based proteomics...
  49. ncbi request reprint On-column labeling for capillary electrophoretic analysis of individual mitochondria directly sampled from tissue cross sections
    Hossein Ahmadzadeh
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Anal Bioanal Chem 384:169-74. 2006
    ....
  50. pmc Analysis of superoxide production in single skeletal muscle fibers
    Xin Xu
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anal Chem 82:4570-6. 2010
    ..Future uses of the method include parallel single-fiber measurements aiming at comparing pharmacological treatments on the same set of fibers and investigating ROS production in response to muscle disease, disuse, exercise, and aging...
  51. ncbi request reprint Capillary electrophoresis reveals changes in individual mitochondrial particles associated with skeletal muscle fiber type and age
    Hossein Ahmadzadeh
    Department of Chemistry, California State Polytechnic University, Pomona, CA, USA
    J Gerontol A Biol Sci Med Sci 61:1211-8. 2006
    ..The CE-LIF results of individual mitochondrial particles are the first of their kind in that they reveal fiber type-specific and age-specific differences that are not obviously noticed in bulk measurements of heterogeneous tissues...

Research Grants13

  1. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2001
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  2. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora V Thompson; Fiscal Year: 2010
    ..This proposal investigates two key skeletal muscle proteins, Troponin C and myosin light chains, which are candidates to explain age-related muscle dysfunction. ..
  3. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2009
    ..This proposal investigates two key skeletal muscle proteins, Troponin C and myosin light chains, which are candidates to explain age-related muscle dysfunction. ..
  4. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2007
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  5. 2007 Aging, Biology of Gordon Conference
    LaDora Thompson; Fiscal Year: 2007
    ..We fully anticipate that progress in this field will pave the way for interventions and quality of life for the older adult. ..
  6. Myosin Modifications in Aged Muscle
    LaDora Thompson; Fiscal Year: 2007
    ..abstract_text> ..
  7. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2005
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  8. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2004
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  9. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2003
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  10. Structural and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2002
    ..The results will be invaluable for understanding the molecular mechanisms of cellular aging. ..
  11. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2009
    ..This proposal investigates two key skeletal muscle proteins, Troponin C and myosin light chains, which are candidates to explain age-related muscle dysfunction. ..