Sufi Mary Thomas

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models
    Sufi M Thomas
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    ACS Chem Biol 8:345-52. 2013
  2. ncbi request reprint Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck
    Sufi Mary Thomas
    University of Pittsburgh, 200 Lothrop St, W915 BST, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:627-38. 2008
  3. ncbi request reprint Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Res 66:11831-9. 2006
  4. pmc Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:426-31. 2005
  5. ncbi request reprint Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 63:5629-35. 2003
  6. ncbi request reprint Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor
    Vivian Wai Yan Lui
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 22:6183-93. 2003
  7. ncbi request reprint Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Treat Rev 30:255-68. 2004
  8. pmc The current state of head and neck cancer gene therapy
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Hum Gene Ther 20:1565-75. 2009

Collaborators

Detail Information

Publications8

  1. pmc Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models
    Sufi M Thomas
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    ACS Chem Biol 8:345-52. 2013
    ..Our data reveals that GPNA is just as effective as a molecular platform for treating cetuximab resistant cells, demonstrating its utility in the treatment of cancer...
  2. ncbi request reprint Antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck
    Sufi Mary Thomas
    University of Pittsburgh, 200 Lothrop St, W915 BST, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:627-38. 2008
    ..05). Combination of EGFR antisense oligonucleotides with low doses of docetaxel has antitumor efficacy, and it may be an effective treatment strategy for SCCHN...
  3. ncbi request reprint Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Res 66:11831-9. 2006
    ..Combined blockade of both EGFR and GPCRs may be a rational strategy to treat cancers, including HNSCC that shows cross-talk between GPCR and EGFR signaling pathways...
  4. pmc Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:426-31. 2005
    ..Because a major effect of GRPR appears to be promoting the release of EGFR ligand, this study suggests that a greater inhibition of cell proliferation may occur by abrogating EGFR ligand release in consort with inhibition of EGFR...
  5. ncbi request reprint Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 63:5629-35. 2003
    ..Tumors expressed higher levels of phosphorylated PLCgamma-1 compared with normal adjacent mucosa (P = 0.05). Thus, PLCgamma-1 may mediate invasion and metastasis downstream of EGFR in HNSCC...
  6. ncbi request reprint Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor
    Vivian Wai Yan Lui
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Oncogene 22:6183-93. 2003
    ..These results imply that the mitogenic effects of GRP in HNSCC are mediated by extracellular release of TGF-alpha and require the activation of an EGFR-dependent MEK/MAPK-dependent pathway...
  7. ncbi request reprint Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Treat Rev 30:255-68. 2004
    ..These data should enable the clinician to select the most suitable EGFR targeting agent based on objective data...
  8. pmc The current state of head and neck cancer gene therapy
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Hum Gene Ther 20:1565-75. 2009
    ..This review discusses promising preclinical and clinical approaches and new directions for HNSCC gene therapy...