Peter Thomas


Affiliation: University of Texas
Country: USA


  1. Tan W, Pang Y, Tubbs C, Thomas P. Induction of sperm hypermotility through membrane progestin receptor alpha (mPRα): a teleost model of rapid, multifaceted, nongenomic progestin signaling. Gen Comp Endocrinol. 2018;: pubmed publisher
    ..As teleosts lack CatSper, the model described here is a non-CatSper mediated one and may therefore be applicable to a wide variety of nonmammalian vertebrates. ..
  2. Cheng S, Dong J, Pang Y, LaRocca J, Hixon M, Thomas P, et al. Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 2014;382:950-9 pubmed publisher
  3. Ondricek K, Thomas P. Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPR?, and GPER in Atlantic croaker ovaries. Comp Biochem Physiol A Mol Integr Physiol. 2018;: pubmed publisher
    ..The finding that ZIP9 expression was increased in ovaries of croaker exposed to hypoxia provides in vivo evidence supporting ZIP9's proposed function in mediating ovarian follicle cell apoptosis. ..
  4. Aizen J, Pang Y, Harris C, Converse A, Zhu Y, Aguirre M, et al. Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. Gen Comp Endocrinol. 2018;263:51-61 pubmed publisher
  5. Pang Y, Thomas P. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Gen Comp Endocrinol. 2018;265:180-187 pubmed publisher
    ..Collectively, the results suggest that Nppc through Npr2 cooperates with E2 through Gper in upregulation of cGMP levels to inhibit phosphodiesterase activity resulting in maintenance of oocyte meiotic arrest in zebrafish. ..
  6. Tan W, Thomas P. Involvement of epidermal growth factor receptors and mitogen-activated protein kinase in progestin-induction of sperm hypermotility in Atlantic croaker through membrane progestin receptor-alpha. Mol Cell Endocrinol. 2015;414:194-201 pubmed publisher
    ..These results demonstrate that progestin-mediated hypermotility via mPRα in croaker sperm involves activation of the Egfr, ErbB2 and Mapk pathways. ..
  7. Thomas P, Pang Y. Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells. Neuroendocrinology. 2012;96:162-71 pubmed publisher
  8. Thomas P, Rahman M, Picha M, Tan W. Impaired gamete production and viability in Atlantic croaker collected throughout the 20,000 km(2) hypoxic region in the northern Gulf of Mexico. Mar Pollut Bull. 2015;101:182-192 pubmed publisher
    ..The finding that environmental hypoxia exposure reduces oocyte viability in addition to decreasing oocyte production in croaker suggests that fecundity estimates need to be adjusted to account for the decrease in oocyte maturation. ..
  9. Pang Y, Thomas P. Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPR? (PAQR7). Mol Cell Endocrinol. 2018;474:20-34 pubmed publisher
    ..These results demonstrate progesterone directly relaxes human VSMCs through mPR?/Gi and MAP kinase/ERK-, Akt/PI3K-, and cAMP-dependent pathways. ..

More Information


  1. Fitzgerald A, Peyton C, Dong J, Thomas P. Bisphenol A and Related Alkylphenols Exert Nongenomic Estrogenic Actions Through a G Protein-Coupled Estrogen Receptor 1 (Gper)/Epidermal Growth Factor Receptor (Egfr) Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes. Biol Reprod. 2015;93:135 pubmed publisher
    ..The results suggest that BPA and related alkylphenols disrupt zebrafish OM by a novel nongenomic estrogenic mechanism involving activation of the Gper/Egfr/Mapk3/1 pathway. ..
  2. Chourasia T, Pang Y, Thomas P. The catecholestrogen, 2-hydroxyestradiol-17beta, acts as a G protein-coupled estrogen receptor 1 (GPER/GPR30) antagonist to promote the resumption of meiosis in zebrafish oocytes. Biol Reprod. 2015;92:69 pubmed publisher
    ..Collectively, the results suggest that 2-OHE2 functions as a GPER antagonist and promotes OM in zebrafish through blocking GPER-dependent E2 inhibition of the resumption of OM. ..
  3. Pang Y, Thomas P. Additive effects of low concentrations of estradiol-17? and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways. J Steroid Biochem Mol Biol. 2017;165:258-267 pubmed publisher
    ..These in vitro findings suggest that low doses of E2 and P4 may also have some beneficial cardiovascular effects in vivo when administered as hormone replacement therapy (HRT) for post-menopausal women. ..
  4. Thomas P. Role of G-protein-coupled estrogen receptor (GPER/GPR30) in maintenance of meiotic arrest in fish oocytes. J Steroid Biochem Mol Biol. 2017;167:153-161 pubmed publisher
    ..GPER is also present on murine oocytes but there are no reports of studies investigating its possible involvement in maintaining meiotic arrest in mammals. ..
  5. Thomas P, Pang Y, Dong J. Membrane androgen receptor characteristics of human ZIP9 (SLC39A) zinc transporter in prostate cancer cells: Androgen-specific activation and involvement of an inhibitory G protein in zinc and MAP kinase signaling. Mol Cell Endocrinol. 2017;447:23-34 pubmed publisher
    ..The results show ZIP9 is a specific Gi coupled-mAR mediating testosterone-induced MAP kinase and zinc signaling in PC3-ZIP9 cells. ..
  6. Thomas P, Converse A, Berg H. ZIP9, a novel membrane androgen receptor and zinc transporter protein. Gen Comp Endocrinol. 2018;257:130-136 pubmed publisher
    ..ZIP9 has a very broad tissue distribution and is predicted to mediate numerous and diverse nonclassical androgen actions in vertebrates. ..
  7. Thomas P. Reprint of "Role of G protein-coupled estrogen receptor (GPER/GPR30) in maintenance of meiotic arrest in fish oocytes". J Steroid Biochem Mol Biol. 2018;176:23-30 pubmed publisher
    ..GPER is also present on murine oocytes but there are no reports of studies investigating its possible involvement in maintaining meiotic arrest in mammals. ..
  8. Aizen J, Thomas P. Role of Pgrmc1 in estrogen maintenance of meiotic arrest in zebrafish oocytes through Gper/Egfr. J Endocrinol. 2015;225:59-68 pubmed publisher
    ..These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper. ..