P Thomas

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone
    Per Erik Olsson
    Department of Natural Science, Unit of Molecular Biology, Orebro University, SE 701 82 Orebro, Sweden
    Reprod Biol Endocrinol 3:37. 2005
  2. ncbi Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor
    A Håkan Berg
    The University of Texas, Austin Marine Science Institute, Port Aransas, Texas, USA
    Reprod Biol Endocrinol 3:64. 2005
  3. ncbi Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings
    Peter Thomas
    University of Texas at Austin Marine Science Institute, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Steroids 67:511-7. 2002
  4. ncbi Progestin, estrogen and androgen G-protein coupled receptors in fish gonads
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, Port Aransas, 78374, USA
    Steroids 71:310-6. 2006
  5. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
  6. ncbi Interference by atrazine and bisphenol-A with progestin binding to the ovarian progestin membrane receptor and induction of oocyte maturation in Atlantic croaker
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Mar Environ Res 66:1-2. 2008
  7. ncbi Binding characteristics, hormonal regulation and identity of the sperm membrane progestin receptor in Atlantic croaker
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373 5015, USA
    Steroids 70:427-33. 2005
  8. ncbi Reproductive endocrine dysfunction in Atlantic croaker exposed to hypoxia
    Peter Thomas
    The University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Mar Environ Res 62:S249-52. 2006
  9. ncbi Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Proc Biol Sci 274:2693-701. 2007
  10. ncbi Multiple rapid progestin actions and progestin membrane receptor subtypes in fish
    Peter Thomas
    University of Texas at Austin Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Steroids 69:567-73. 2004

Collaborators

Detail Information

Publications88

  1. ncbi Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone
    Per Erik Olsson
    Department of Natural Science, Unit of Molecular Biology, Orebro University, SE 701 82 Orebro, Sweden
    Reprod Biol Endocrinol 3:37. 2005
    ..These findings demonstrate the presence of a receptor preferentially activated by 11-ketotestosterone in the three-spined stickleback, so far the only one known in any animal...
  2. ncbi Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor
    A Håkan Berg
    The University of Texas, Austin Marine Science Institute, Port Aransas, Texas, USA
    Reprod Biol Endocrinol 3:64. 2005
    ....
  3. ncbi Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings
    Peter Thomas
    University of Texas at Austin Marine Science Institute, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Steroids 67:511-7. 2002
    ..Current evidence suggests this G-protein-coupled receptor-like protein is the long sought after MIS receptor mediating meiotic maturation of teleost oocytes...
  4. ncbi Progestin, estrogen and androgen G-protein coupled receptors in fish gonads
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, Port Aransas, 78374, USA
    Steroids 71:310-6. 2006
    ....
  5. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
    ..The results indicate that nontraditional estrogen actions mediated through GPR30 are potentially susceptible to disruption by a variety of environmental estrogens...
  6. ncbi Interference by atrazine and bisphenol-A with progestin binding to the ovarian progestin membrane receptor and induction of oocyte maturation in Atlantic croaker
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Mar Environ Res 66:1-2. 2008
    ..The results suggest that diverse classes of environmental chemicals can disrupt nongenomic progestin actions via receptor-mediated mechanisms...
  7. ncbi Binding characteristics, hormonal regulation and identity of the sperm membrane progestin receptor in Atlantic croaker
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373 5015, USA
    Steroids 70:427-33. 2005
    ..The results suggest that the mechanism of progestin action on fish sperm involving mPRs is basically similar to that in mammals and has been evolutionarily conserved amongst vertebrates...
  8. ncbi Reproductive endocrine dysfunction in Atlantic croaker exposed to hypoxia
    Peter Thomas
    The University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Mar Environ Res 62:S249-52. 2006
    ..The results indicate that reproductive morphometric and endocrine biomarkers in croaker are sensitive to moderate hypoxia, and are potentially useful as early warning indicators of reproductive failure...
  9. ncbi Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Proc Biol Sci 274:2693-701. 2007
    ....
  10. ncbi Multiple rapid progestin actions and progestin membrane receptor subtypes in fish
    Peter Thomas
    University of Texas at Austin Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Steroids 69:567-73. 2004
    ..However, mPRbeta antisense experiments in zebrafish oocytes suggest the beta-subtype also participates in the control of oocyte maturation in zebrafish...
  11. ncbi Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    P Thomas
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Endocrinology 146:624-32. 2005
    ..The identification of a second distinct class of GPCR-like steroid membrane receptors suggests a widespread role for GPCRs in nonclassical steroid hormone actions...
  12. ncbi Disruption of rapid, nongenomic steroid actions by environmental chemicals: interference with progestin stimulation of sperm motility in Atlantic croaker
    Peter Thomas
    The University of Texas at Austin Marine Science Institute, Port Aransas, Texas 78373, USA
    Environ Sci Technol 38:6328-32. 2004
    ..The finding that low concentrations of a wide range of organic environmental contaminants can interfere with a rapid, nongenomic steroid action suggests that this mechanism of endocrine disturbance is of toxicological importance...
  13. ncbi Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins
    Peter Thomas
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Endocrinology 148:705-18. 2007
    ..Thus, mPRs arose from Eubacteria independently from members of the GPCR superfamily, which arose from Archeabacteria, suggesting convergent evolution of seven-transmembrane hormone receptors coupled to G proteins...
  14. ncbi Upregulation of the maturation-inducing steroid membrane receptor in spotted seatrout ovaries by gonadotropin during oocyte maturation and its physiological significance
    P Thomas
    Department of Marine Science, Marine Science Institute, University of Texas at Austin, Port Aransas, Texas 78373 5015, USA
    Biol Reprod 64:21-9. 2001
    ....
  15. ncbi Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
    Yong Zhu
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Proc Natl Acad Sci U S A 100:2231-6. 2003
    ..These characteristics suggest the fish protein is a membrane progestin receptor mediating a "nonclassical" action of progestins to induce oocyte maturation in fish...
  16. ncbi Estrogen signaling characteristics of Atlantic croaker G protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest
    Yefei Pang
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Endocrinology 149:3410-26. 2008
    ..These findings further support our previous suggestion that GPR30 is a vertebrate mER. In addition, the results suggest GRP30 may play a critical role in regulating reentry into the meiotic cell cycle in fish oocytes...
  17. ncbi Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
    Yong Zhu
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Proc Natl Acad Sci U S A 100:2237-42. 2003
    ..These results suggest this is a new family of steroid receptors unrelated to nuclear steroid receptors, but instead having characteristics of G protein-coupled receptors...
  18. ncbi Binding characteristics of estrogen receptor (ER) in Atlantic croaker (Micropogonias undulatus) testis: different affinity for estrogens and xenobiotics from that of hepatic ER
    A K Loomis
    Department of Marine Science, Marine Science Institute, University of Texas at Austin, Port Aransas, Texas 78373, USA
    Biol Reprod 61:51-60. 1999
    ..The identification of a testicular ER and evidence that estradiol is produced by the testes in croaker suggest that estrogens participate in the hormonal control of testicular function in teleosts...
  19. ncbi Correlation between binding affinities of C21 steroids for the maturation-inducing steroid membrane receptor in spotted seatrout ovaries and their agonist and antagonist activities in an oocyte maturation bioassay
    P Thomas
    The University of Texas at Austin, Marine Science Institute, Port Aransas 78373 5015, USA
    Biol Reprod 57:999-1007. 1997
    ..These findings strongly support the concept that induction of FOM by the MIS in spotted seatrout is mediated solely through the ovarian plasma membrane 20beta-S receptor...
  20. ncbi Characterization of two nuclear androgen receptors in Atlantic croaker: comparison of their biochemical properties and binding specificities
    T S Sperry
    Department of Marine Science, University of Texas Marine Science Institute, University of Texas, Port Aransas 78373, USA
    Endocrinology 140:1602-11. 1999
    ..This is the first report of the presence of two different nuclear ARs displaying markedly different steroid binding specificities within a single vertebrate species...
  21. ncbi Characterization of membrane receptor activity for 17 alpha, 20 beta, 21-trihydroxy-4-pregnen-3-one in ovaries of spotted seatrout (Cynoscion nebulosus)
    R Patino
    University of Texas, Marine Science Institute, Port Aransas, Austin 78373 1267
    Gen Comp Endocrinol 78:204-17. 1990
    ..A distinct, soluble binding site for 17 alpha, 20 beta-P was also identified in seatrout ovaries, but its biological function remains unclear. A hypothesis is presented for the significance of this 17 alpha,20 beta-P binding site...
  22. ncbi Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia
    M S Rahman
    University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Neuroscience 158:751-65. 2009
    ..Moreover, they provide the first evidence that hypoxia decreases the expression of TPH transcripts in vertebrate brains...
  23. ncbi Disruption of neuroendocrine control of luteinizing hormone secretion by aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity
    I A Khan
    The University of Texas at Austin, Marine Science Institute, Port Aransas, Texas 78373, USA
    Biol Reprod 64:955-64. 2001
    ..These results demonstrate that TPH is one of the targets of PCB neurotoxicity and indicate that a decrease in 5-HT availability in PCB-exposed croaker results in disruption of the stimulatory 5-HT/GnRH pathway controlling LH secretion...
  24. ncbi Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility
    Christopher Tubbs
    Marine Science Institute, The University of Texas at Austin, Port Aransas, Texas 78373, USA
    Endocrinology 150:473-84. 2009
    ..Taken together these findings provide a plausible mechanism by which progestins stimulate sperm hypermotility in croaker and provide the first evidence of hormonal activation of Golf in any species...
  25. ncbi Functional characteristics of membrane progestin receptor alpha (mPRalpha) subtypes: a review with new data showing mPRalpha expression in seatrout sperm and its association with sperm motility
    Christopher Tubbs
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Steroids 73:935-41. 2008
    ..These results suggest that st-mPRalpha is an intermediary in progestin stimulation of sperm motility in seatrout by an unknown mechanism involving G protein activation...
  26. ncbi Expression and gonadotropin regulation of membrane progestin receptor alpha in Atlantic croaker (Micropogonias undulatus) gonads: role in gamete maturation
    Christopher Tubbs
    The University of Texas at Austin, Marine Science Institute, Port Aransas, 78373 TX, USA
    Gen Comp Endocrinol 165:144-54. 2010
    ..Taken together, these data strongly support the hypothesis that mPRalpha mediates progestin induction of oocyte maturation and upregulation of sperm motility in teleosts...
  27. ncbi Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility
    P Thomas
    Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA
    Steroids 74:614-21. 2009
    ..These results suggest that, similar to its proposed function in fishes, mPRalpha is an intermediary in progestin stimulation of sperm motility in humans by a mechanism involving G-protein activation...
  28. ncbi Gonadal stage-dependent effects of gonadal steroids on gonadotropin II secretion in the Atlantic croaker (Micropogonias undulatus)
    I A Khan
    The University of Texas at Austin, Marine Science Institute, Port Aransas, Texas 78373, USA
    Biol Reprod 61:834-41. 1999
    ....
  29. ncbi Effects of the maturation-inducing steroid on LH secretion and the GnRH system at different stages of the gonadal cycle in Atlantic croaker
    Sonya Mathews
    Marine Science Institute, The University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 126:287-97. 2002
    ..Moreover, the fact that concurrent changes occur in POAH and pituitary sbGnRH contents suggests that the actions of 20beta-S on LH secretion are at least partly mediated via the GnRH system...
  30. ncbi Changes in ovarian steroidogenesis in vitro associated with final maturation of Atlantic croaker oocytes
    J M Trant
    Marine Science Institute, University of Texas at Austin, Port Aransas 78373
    Gen Comp Endocrinol 75:405-12. 1989
    ..The timely synthesis of 20 beta-S in croaker at the onset of oocyte maturation provides further evidence for a physiological role of 20 beta-S in the induction of FOM in this species...
  31. ncbi GABA exerts stimulatory and inhibitory influences on gonadotropin II secretion in the Atlantic croaker (Micropogonias undulatus)
    I A Khan
    The University of Texas at Austin, Marine Science Institute, Port Aransas, Tex, USA
    Neuroendocrinology 69:261-8. 1999
    ..Thus, GABAergic pathways may be important in mediating seasonal influences on GTH II secretion in this species...
  32. ncbi Lead and Aroclor 1254 disrupt reproductive neuroendocrine function in Atlantic croaker
    I A Khan
    Marine Science Institute, University of Texas at Austin, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Mar Environ Res 50:119-23. 2000
    ..The decline in 5-HT availability due to reduced 5-HT synthesis in the PCB-exposed fish may result in disruption of the stimulatory 5-HT-GnRH pathway controlling GTH II secretion leading to impairment of gonadal growth...
  33. ncbi Biochemical characterization of a membrane androgen receptor in the ovary of the atlantic croaker (Micropogonias undulatus)
    Alyssa M Braun
    University of Texas at Austin, Marine Science Institute, Port Aransas, Texas 78373, USA
    Biol Reprod 71:146-55. 2004
    ..It is concluded that the androgen-binding moiety identified in the plasma membrane fraction of Atlantic croaker ovarian tissue fulfils all the criteria for its designation as a steroid receptor...
  34. ncbi Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts
    M B Hawkins
    University of Texas at Austin Marine Science Institute, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Proc Natl Acad Sci U S A 97:10751-6. 2000
    ..The presence of three functional ERs in one species expands the role of ER multiplicity in estrogen signaling systems and provides a unique opportunity to investigate the dynamics and mechanisms of ER evolution...
  35. ncbi Chemical interference with genomic and nongenomic actions of steroids in fishes: role of receptor binding
    P Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373 5015, USA
    Mar Environ Res 50:127-34. 2000
    ..These various factors that influence chemical/steroid receptor interactions are likely to significantly modify steroid hormone actions at target tissues and consequently the toxicological effects of chemical exposure...
  36. ncbi Isolation of a novel maturation-inducing steroid produced in vitro by ovaries of Atlantic croaker
    J M Trant
    Marine Science Institute, University of Texas at Austin, Port Aransas 78373
    Gen Comp Endocrinol 75:397-404. 1989
    ..These results provide further evidence that 20 beta-S is a major maturation-inducing steroid in Atlantic croaker...
  37. ncbi Involvement of calcium and calmodulin in the regulation of ovarian steroidogenesis in Atlantic croaker (Micropogonias undulatus) and modulation by Aroclor 1254
    Abby D Benninghoff
    Department of Marine Science, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 144:211-23. 2005
    ....
  38. ncbi Role of G protein-coupled estrogen receptor 1, GPER, in inhibition of oocyte maturation by endogenous estrogens in zebrafish
    Yefei Pang
    University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Dev Biol 342:194-206. 2010
    ..A model is proposed for the dual control of the onset of oocyte maturation in teleosts by estrogens and progestins acting through GPER and mPRalpha, respectively, at different stages of oocyte development...
  39. ncbi Gonadotropin regulation of testosterone production by primary cultured theca and granulosa cells of Atlantic croaker: II. Involvement of a mitogen-activated protein kinase pathway
    Abby D Benninghoff
    Department of Marine Science, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 147:288-96. 2006
    ....
  40. ncbi Gonadotropin regulation of testosterone production by primary cultured theca and granulosa cells of Atlantic croaker: I. Novel role of CaMKs and interactions between calcium- and adenylyl cyclase-dependent pathways
    Abby D Benninghoff
    Department of Marine Science, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 147:276-87. 2006
    ....
  41. ncbi Androgen binding profiles of two distinct nuclear androgen receptors in Atlantic croaker (Micropogonias undulatus)
    T S Sperry
    Department of Marine Science, The University of Texas Marine Science Institute, The University of Texas at Austin, 78373, USA
    J Steroid Biochem Mol Biol 73:93-103. 2000
    ..Widely different androgen binding affinities of AR1 and AR2 suggest that these two nuclear androgen receptors may mediate the physiological actions of different androgens in teleosts...
  42. ncbi Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish
    P Thomas
    University of Texas at Austin Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Steroids 75:595-602. 2010
    ....
  43. ncbi Diversity of sexual dimorphism in electrocommunication signals and its androgen regulation in a genus of electric fish, Apteronotus
    K D Dunlap
    Department of Zoology, University of Texas, Austin 78712, USA
    J Comp Physiol A 183:77-86. 1998
    ....
  44. ncbi Involvement of estradiol-17beta and its membrane receptor, G protein coupled receptor 30 (GPR30) in regulation of oocyte maturation in zebrafish, Danio rario
    Yefei Pang
    University of Texas at Austin, Marine Science Institute, 750 Channel View Dr, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 161:58-61. 2009
    ..These results suggest that endogenous estrogens acting through GPR30 are involved in maintaining meiotic arrest of zebrafish oocytes...
  45. ncbi Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions
    Peter Thomas
    University of Texas at Austin, Marine Science, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Front Neuroendocrinol 29:292-312. 2008
    ....
  46. ncbi Characterization of putative ligands for a fish gonadal androgen receptor in a pulp mill effluent
    D G Joakim Larsson
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, 78373 Texas, USA
    Environ Toxicol Chem 25:419-27. 2006
    ..The detection of multiple fractions with significant binding activity indicates that a variety of compounds in effluents have the potential to masculinize fish near pulp mills via an androgen receptor-mediated mechanism...
  47. ncbi Region-wide impairment of Atlantic croaker testicular development and sperm production in the northern Gulf of Mexico hypoxic dead zone
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Mar Environ Res 69:S59-62. 2010
    ..The results suggest that reproductive impairment can occur over regional scales in marine fish populations exposed to extensive seasonal hypoxia in dead zones with potential long-term impacts on population abundance...
  48. ncbi PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker
    Izhar A Khan
    The University of Texas at Austin, Marine Science Institute, Port Aransas, TX 78373, USA
    Mar Environ Res 62:S25-8. 2006
    ..The results provide the first evidence for PCB congener-specific disruption of reproductive neuroendocrine function in a vertebrate species...
  49. ncbi Chronic hypoxia impairs gamete maturation in Atlantic croaker induced by progestins through nongenomic mechanisms resulting in reduced reproductive success
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Environ Sci Technol 43:4175-80. 2009
    ..The results suggestthat nongenomic progestin signaling controlling the final stages of the reproductive cycle in fish is impaired under hypoxic conditions...
  50. ncbi Molecular cloning, characterization and expression of two hypoxia-inducible factor alpha subunits, HIF-1alpha and HIF-2alpha, in a hypoxia-tolerant marine teleost, Atlantic croaker (Micropogonias undulatus)
    Md Saydur Rahman
    Marine Science Institute, The University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Gene 396:273-82. 2007
    ..suggest that the upregulation of both HIF-1alpha and HIF-2alpha subunits at the transcriptional level is an important component of adaptation of croaker to chronic hypoxia and HIF-alphas are potentially useful molecular indicators of..
  51. ncbi Vitamin E co-treatment reduces Aroclor 1254-induced impairment of reproductive neuroendocrine function in Atlantic croaker
    Izhar A Khan
    Marine Science Institute, The University of Texas at Austin, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Mar Environ Res 58:333-6. 2004
    ..The vitamin E co-treatments (1 and 10 mg/100 g BW/day) with PCB significantly reduced the effects of PCB on TPH activity and gonadal growth. These results suggest possible involvement of oxidative processes in PCB neurotoxicity...
  52. ncbi Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout
    Margaret C Pace
    The University of Texas at Austin Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Dev Biol 285:70-9. 2005
    ..These results support a mechanism of MIS action involving binding to a novel, G-protein coupled receptor and activation of an inhibitory G-protein, the most comprehensive and plausible model of MIS initiation of OM proposed to date...
  53. ncbi Steroid-induced oocyte maturation in Atlantic croaker (Micropogonias undulatus) is dependent on activation of the phosphatidylinositol 3-kinase/Akt signal transduction pathway
    Margaret C Pace
    The University of Texas at Austin Marine Science Institute, Port Aransas, Texas 78373, USA
    Biol Reprod 73:988-96. 2005
    ..These results demonstrate that activation of cAMP-independent signaling pathways, especially the Pik3/Akt pathway, is necessary for 20beta-S-induced GVBD in Atlantic croaker oocytes...
  54. ncbi Isolation, cloning, and expression of three prepro-GnRH mRNAs in Atlantic croaker brain and pituitary
    J Shaik Mohamed
    Marine Science Institute, The University of Texas at Austin, Port Aransas, Texas 78373, USA
    J Comp Neurol 488:384-95. 2005
    ..Moreover, localization of sbGnRH mRNA in a teleost pituitary points to sbGnRH synthesis, and its potential role as a local regulator, within the pituitary, similar to the role of GnRH-I in mammals...
  55. ncbi Alterations in the GnRH-LH system in relation to gonadal stage and Aroclor 1254 exposure in Atlantic croaker
    I A Khan
    The University of Texas at Austin, Marine Science Institute, 750 Channelview Drive, 78373, Port Aransas, TX, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:251-9. 2001
    ..This impairment may be due to a direct action of PCB on GnRH neurons and/or indirectly via interference with other neurotransmitter pathways that modulate GnRH function...
  56. ncbi Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain
    Izhar A Khan
    Marine Science Institute, The University of Texas at Austin, 750 Channelview Drive, Port Aransas, TX 78373, USA
    Arch Toxicol 78:316-20. 2004
    ....
  57. ncbi Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol
    D G Joakim Larsson
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    Gen Comp Endocrinol 128:224-30. 2002
    ..These results suggest that gonadal factors, including both androgens and estrogens, are involved in the physiological regulation of brain androgen receptors in a teleost species during the reproductive cycle...
  58. ncbi Thyroid hormone status of Atlantic croaker exposed to Aroclor 1254 and selected PCB congeners
    Kimberly D LeRoy
    The University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Comp Biochem Physiol C Toxicol Pharmacol 144:263-71. 2006
    ....
  59. ncbi The distributions of the duplicate oestrogen receptors ER-beta a and ER-beta b in the forebrain of the Atlantic croaker (Micropogonias undulatus): evidence for subfunctionalization after gene duplication
    M B Hawkins
    Marine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA
    Proc Biol Sci 272:633-41. 2005
    ....
  60. ncbi Identification of membrane progestin receptors in human breast cancer cell lines and biopsies and their potential involvement in breast cancer
    Gwen E Dressing
    University of Texas at Austin Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, United States
    Steroids 72:111-6. 2007
    ..Taken together these results suggest a potential involvement of mPRs during the development or progression of breast cancer...
  61. ncbi Role of arachidonic acid and protein kinase C during maturation-inducing hormone-dependent meiotic resumption and ovulation in ovarian follicles of Atlantic croaker
    Reynaldo Patino
    U S Geological Survey, Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock, Texas 79409 2120, USA
    Biol Reprod 68:516-23. 2003
    ..LOX and COX metabolites of AA are both required for ovulation, but at upstream and downstream sites of the pathway, respectively, relative to PKC, and 2). PKC is downstream of genomic activation...
  62. ncbi Interactions of diethylstilbestrol (DES) and DES analogs with membrane progestin receptor-alpha and the correlation with their nongenomic progestin activities
    Toshinobu Tokumoto
    Department of Biology, Faculty of Science, National University Corporation Shizuoka University, Shizuoka 422 8529, Japan
    Endocrinology 148:3459-67. 2007
    ....
  63. ncbi Identification of 17,20beta,21-trihydroxy-4-pregnen-3-one as an oocyte maturation-inducing steroid in black porgy, Acanthopagrus schlegeli
    Wen Shiun Yueh
    Department of Aquaculture, National Kaohsiung Marine University, Kaohsiung 811, Taiwan
    Gen Comp Endocrinol 140:184-91. 2005
    ..Plasma 20beta-S concentrations increased significantly during the oocyte maturation after injection with a LHRH analog. The present data suggest that 20beta-S is the MIS in black porgy...
  64. ncbi Reproductive seasonality of the male Florida gar, Lepisosteus platyrhincus
    Edward F Orlando
    Department of Zoology, University of Florida, 223 Bartram Hall, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 131:365-71. 2003
    ..Furthermore, it increases our understanding of the reproductive biology of semitropical fishes...
  65. ncbi Androgens inhibit estradiol-17beta synthesis in Atlantic croaker (Micropogonias undulatus) ovaries by a nongenomic mechanism initiated at the cell surface
    Alyssa M Braun
    Department of Biological Sciences, University of Nevada, Las Vegas, NV 89154, USA
    Biol Reprod 69:1642-50. 2003
    ..These studies suggest that androgens can down-regulate estrogen production in croaker ovaries via a rapid, cell surface-mediated, nongenomic mechanism...
  66. ncbi Cloning and identification of a membrane progestin receptor in goldfish ovaries and evidence it is an intermediary in oocyte meiotic maturation
    Mika Tokumoto
    Department of Biology and Geosciences, Faculty of Science, National University Corporation, Shizuoka University, Shizuoka 422 8529, Japan
    Gen Comp Endocrinol 145:101-8. 2006
    ....
  67. ncbi Surface expression of heterogeneous nuclear RNA binding protein M4 on Kupffer cell relates to its function as a carcinoembryonic antigen receptor
    Olga Bajenova
    Department of Surgery, Boston University School of Medicine, 801 Albany Street, Boston, MA 02118, USA
    Exp Cell Res 291:228-41. 2003
    ....
  68. ncbi GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Trends Endocrinol Metab 16:362-7. 2005
    ..Thus, estrogen can signal by the same mechanism as various other hormones, through a specific 7TM receptor...
  69. ncbi The role of Xenopus membrane progesterone receptor beta in mediating the effect of progesterone on oocyte maturation
    Liat Josefsberg Ben Yehoshua
    Howard Hughes Medical Institute, Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Mol Endocrinol 21:664-73. 2007
    ..These results suggest that XmPRbeta is a physiological progesterone receptor involved in initiating the resumption of meiosis during maturation of Xenopus oocytes...
  70. ncbi Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube
    Magdalena Nutu
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Reprod Dev 74:843-50. 2007
    ..The presence of mPRgamma in lung and liver of mice suggests that the receptor mediates the actions of progesterone outside the reproductive tract as well...
  71. ncbi Modeling vitellogenesis in female fish exposed to environmental stressors: predicting the effects of endocrine disturbance due to exposure to a PCB mixture and cadmium
    Cheryl A Murphy
    Department of Oceanography and Coastal Sciences, Energy, Coast and Environment Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Reprod Toxicol 19:395-409. 2005
    ..Simulations illustrate the potential utility of our model for interpreting reproductive endocrine biomarkers measured in fish collected from degraded environments...
  72. ncbi Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term
    Emmanouil Karteris
    Division of Clinical Science, University of Warwick, Coventry, UK
    Mol Endocrinol 20:1519-34. 2006
    ..Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a quiescent state to one of contraction...
  73. ncbi Effects of external pH on hormonally regulated ovarian follicle maturation and ovulation in Atlantic croaker
    Reynaldo Patino
    U S Geological Survey Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock, TX 79409 2120, USA
    Gen Comp Endocrinol 141:126-34. 2005
    ..Further, an understanding of the physiological significance of the enhancing effect of alkaline pH on maturation and ovulation will require determination of the intrafollicular pH around the oocyte during the periovulatory period...
  74. ncbi Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells
    Richard Hanna
    Department of Biology, East Carolina University, 1000 E 5th Street, Greenville, North Carolina 27858 4553, USA
    J Endocrinol 190:247-60. 2006
    ..The results of this study suggest that zebrafish mPRalpha and mPRbeta signal similarly upon progestin binding resulting in rapid activation of MAPK and downregulation of adenylyl cyclase activity...
  75. ncbi Molecular characterization of three forms of putative membrane-bound progestin receptors and their tissue-distribution in channel catfish, Ictalurus punctatus
    Yukinori Kazeto
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, Maryland 21202, USA
    J Mol Endocrinol 34:781-91. 2005
    ..Additionally, regulatory features of the 5'-flanking regions and the differences in tissue-specific expression of each IpmPR gene suggest that they are involved in different endocrine functions in catfish...
  76. ncbi Changes in homologous and heterologous gap junction contacts during maturation-inducing hormone-dependent meiotic resumption in ovarian follicles of Atlantic croaker
    Digbo Bolamba
    Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock, TX 79409-2120, USA
    Gen Comp Endocrinol 131:291-5. 2003
    ..The significance of the changes in homologous and heterologous GJ is uncertain and deserves further study...
  77. ncbi Expression profiling and interferon-beta regulation of liver metastases in colorectal cancer cells
    Regis Zimmer
    Department of Surgery, Boston University, School of Medicine, Laboratory of Surgical Biology, Massachusetts 02119 2511, USA
    Clin Exp Metastasis 19:541-50. 2002
    ..This information may help identifying new markers for colorectal cancer prognosis as well as aid the development of new therapeutic approaches...
  78. ncbi Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
    ..Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes...
  79. ncbi Regulation of cytokine production in carcinoembryonic antigen stimulated Kupffer cells by beta-2 adrenergic receptors: implications for hepatic metastasis
    Peter Thomas
    Laboratory of Surgical Biology, Department of Surgery, Boston University School of Medicine, 801 Albany St, S310, Boston, MA 02118, USA
    Cancer Lett 209:251-7. 2004
    ..Control of TNF-alpha production is negatively affected by terbutaline, while that of IL-6 and IL-10 is positively controlled suggesting that very different beta-adrenergic receptor signaling pathways are involved...
  80. ncbi Biomechanical and allergological characteristics of a biodegradable poly(D,L-lactic acid) coating for orthopaedic implants
    Hans Gollwitzer
    Klinik und Poliklinik für Orthopädie und Sportorthopädie, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    J Orthop Res 23:802-9. 2005
    ..PDLLA coating proved high mechanical stability on different orthopaedic implants and did not influence in vitro T-cell reactivity towards specific biomaterials...
  81. ncbi Cross-sensitization between poppy seed and buckwheat in a food-allergic patient with poppy seed anaphylaxis
    Tilmann Oppel
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Int Arch Allergy Immunol 140:170-3. 2006
    ..Allergological workup revealed a poppy seed anaphylaxis and led to the identification of a novel cross-sensitization with buckwheat...
  82. ncbi Surface expression and CEA binding of hnRNP M4 protein in HT29 colon cancer cells
    Luciana Laguinge
    Department of Oncology and Surgery, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    Anticancer Res 25:23-31. 2005
    ..Future experiments will elucidate whether the CEA-CEAR interaction is involved in CEA's antiapoptotic role and mediates the prometastatic properties of CEA in colon cancer cells...
  83. ncbi Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease
    El-Nasir Lalani
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
    Int J Mol Med 15:811-7. 2005
    ..Thus, up-regulation of HGF and c-met occurred in the presence of the necrosis and inflammation suggesting that HGF may be acting to protect against liver injury or accelerate the regenerative process...
  84. ncbi Experimental immunotherapy of colorectal carcinoma by monoclonal antibody ND4
    Timothy M Kelly
    Department of Surgery, Laboratory of Cancer Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Hybridoma (Larchmt) 26:10-6. 2007
    ..p. injections at 7-day intervals. The MAb ND4 may be useful as a therapeutic reagent for colorectal tumors...
  85. ncbi Hepatic colorectal cancer metastases: imaging initial steps of formation in mice
    Jonathan B Kruskal
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, West Clinical Center CC302B, 1 Deaconess Rd, Boston, MA 02215, USA
    Radiology 243:703-11. 2007
    ..To prospectively use optical imaging to study the cell-specific mechanisms of entrapment and subsequent growth of two human colon cancer cell lines differing in their propensity to form hepatic metastases...
  86. ncbi Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells
    John Milburn Jessup
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    Int J Cancer 111:332-7. 2004
    ..Thus, CEA stimulates production of IL-10 that may enhance metastasis by promoting the ability of circulating CRC cells to survive the I/R injury of implantation...
  87. ncbi Preventing childhood obesity: two year follow-up results from the Christchurch obesity prevention programme in schools (CHOPPS)
    Janet James
    Bournemouth Diabetes and Endocrine Centre, Royal Bournemouth Hospital, Bournemouth, BH7 7DW
    BMJ 335:762. 2007
    ..To assess the long term effects of an obesity prevention programme in schools...
  88. ncbi Comparative immunotoxicity evaluation of amphotericin B and ABELCET, an amphotericin B lipid complex (ABLC)
    Zhihua Zhang
    Enzon Pharmaceuticals, Inc, Piscataway, New Jersey 08854, USA
    Int J Toxicol 25:487-92. 2006
    ..Based on the results of this study, it was concluded that neither ABLC at dose up to 10 mg/kg nor AmBd at dose up to 1.0 mg/kg produce biologically significant immunologic changes in B6C3F1 mice...