P M Thomas

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston, USA
    Am J Hum Genet 59:510-8. 1996
  2. ncbi Genetic mutations as a cause of hyperinsulinemic hypoglycemia in children
    P M Thomas
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA
    Endocrinol Metab Clin North Am 28:647-56, viii. 1999
  3. ncbi Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Science 268:426-9. 1995
  4. ncbi Homozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030
    Am J Hum Genet 56:416-21. 1995
  5. ncbi A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene
    N Wohllk
    Section of Endocrinology, The University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Mol Genet Metab 65:187-90. 1998
  6. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999
  7. ncbi Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes
    P M Thomas
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    DNA Seq 12:131-5. 2001
  8. ncbi A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
    T Otonkoski
    Transplantation Laboratory, Haartman Institute, and University of Helsinki, Finland
    Diabetes 48:408-15. 1999

Collaborators

Detail Information

Publications8

  1. ncbi Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston, USA
    Am J Hum Genet 59:510-8. 1996
    ..These data suggest that both nucleotide-binding-fold regions of the sulfonylurea receptor are required for normal regulation of beta-cell ATP-dependent potassium channel activity and insulin secretion...
  2. ncbi Genetic mutations as a cause of hyperinsulinemic hypoglycemia in children
    P M Thomas
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, USA
    Endocrinol Metab Clin North Am 28:647-56, viii. 1999
    ..This article reviews recent progress that has elucidated several beta-cell molecular defects responsible for the pathogenesis of this disorder...
  3. ncbi Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Science 268:426-9. 1995
    ..Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene...
  4. ncbi Homozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030
    Am J Hum Genet 56:416-21. 1995
    ..Identification of this gene may allow a better understanding of other disorders of glucose homeostasis, by providing insight into the regulation of insulin release...
  5. ncbi A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene
    N Wohllk
    Section of Endocrinology, The University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Mol Genet Metab 65:187-90. 1998
    ..The second gene CII-3b is expressed at a low level and contains a 102-bp internal deletion compared to CII-3 cDNA. These genes should prove valuable in the characterization of Complex II disorders...
  6. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999
    ..The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach...
  7. ncbi Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes
    P M Thomas
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    DNA Seq 12:131-5. 2001
    ..The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function...
  8. ncbi A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
    T Otonkoski
    Transplantation Laboratory, Haartman Institute, and University of Helsinki, Finland
    Diabetes 48:408-15. 1999
    ..This unique SUR1 mutation explains the majority of PHHI cases in Finland and is strongly associated with a severe form of the disease. These findings provide diagnostic and prognostic utility for suspected PHHI patients...