Nancy Thomas

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
  2. pmc Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 19:2932-41. 2010
  3. pmc Melanoma molecular subtypes: unifying and paradoxical results
    Nancy E Thomas
    Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 130:12-4. 2010
  4. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
  5. ncbi request reprint Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 126:1693-6. 2006
  6. ncbi request reprint BRAF somatic mutations in malignant melanoma and melanocytic naevi
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Melanoma Res 16:97-103. 2006
  7. ncbi request reprint Invasive superficial spreading melanomas arising from clinically normal skin
    Nancy E Thomas
    Department of Dermatology, University of North Carolina at Chapel Hill, NC 27599, USA
    J Am Acad Dermatol 51:466-70. 2004
  8. ncbi request reprint Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth
    Honglin Hao
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Ther 6:2220-9. 2007
  9. ncbi request reprint Indications for lymphatic mapping and sentinel lymphadenectomy in patients with thin melanoma (Breslow thickness < or =1.0 mm)
    Karyn B Stitzenberg
    Division of Surgical Oncology, Department of Surgery, 3010 Old Clinic Building, CB 7213, University of North Carolina, Chapel Hill, NC 27599 7213, USA
    Ann Surg Oncol 11:900-6. 2004
  10. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006

Detail Information

Publications24

  1. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
    ..The finding of tandem mutations in thin melanomas makes it more likely that they arise as a simultaneous rather than sequential event...
  2. pmc Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 19:2932-41. 2010
    ..Solar elastosis adjacent to melanomas in histologic sections is regarded as an indicator of sun exposure, although the associations of UV exposure and phenotype with solar elastosis are yet to be fully explored...
  3. pmc Melanoma molecular subtypes: unifying and paradoxical results
    Nancy E Thomas
    Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 130:12-4. 2010
    ..The authors did not find an association between somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status. We discuss this seeming paradox in light of previous studies demonstrating strong associations...
  4. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
    ..The association of BRAF mutations with early-life UV exposure provides evidence in support of childhood sun protection for melanoma prevention...
  5. ncbi request reprint Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 126:1693-6. 2006
    ..We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection...
  6. ncbi request reprint BRAF somatic mutations in malignant melanoma and melanocytic naevi
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Melanoma Res 16:97-103. 2006
    ....
  7. ncbi request reprint Invasive superficial spreading melanomas arising from clinically normal skin
    Nancy E Thomas
    Department of Dermatology, University of North Carolina at Chapel Hill, NC 27599, USA
    J Am Acad Dermatol 51:466-70. 2004
    ..Clinical, dermoscopic, and pathologic features of these "de novo" melanomas, which became invasive while small in diameter and had few clinical criteria for diagnosis, are reported...
  8. ncbi request reprint Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth
    Honglin Hao
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Ther 6:2220-9. 2007
    ..Our observations suggest that Raf and MEK inhibitors may be effective for the treatment of B-RAF mutation-positive colorectal carcinomas as well as melanomas...
  9. ncbi request reprint Indications for lymphatic mapping and sentinel lymphadenectomy in patients with thin melanoma (Breslow thickness < or =1.0 mm)
    Karyn B Stitzenberg
    Division of Surgical Oncology, Department of Surgery, 3010 Old Clinic Building, CB 7213, University of North Carolina, Chapel Hill, NC 27599 7213, USA
    Ann Surg Oncol 11:900-6. 2004
    ....
  10. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006
    ..ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant. The results provide further evidence for a role of XPD in the etiology of melanoma...
  11. pmc DNA-methylation profiling distinguishes malignant melanomas from benign nevi
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 24:352-60. 2011
    ..This first report of a DNA-methylation signature discriminating melanomas from nevi indicates that DNA methylation appears promising as an additional tool for enhancing melanoma diagnosis...
  12. pmc CD200 is induced by ERK and is a potential therapeutic target in melanoma
    Kimberly B Petermann
    Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7295, USA
    J Clin Invest 117:3922-9. 2007
    ....
  13. pmc Distance to diagnosing provider as a measure of access for patients with melanoma
    Karyn B Stitzenberg
    Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, 3010 Old Clinic Bldg, CB 7213, Chapel Hill, NC 27599 7213, USA
    Arch Dermatol 143:991-8. 2007
    ..To examine the effect of travel distance and other sociodemographic factors on access to a diagnosing provider for patients with melanoma...
  14. pmc Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Invest Dermatol 128:175-87. 2008
    ..The results suggest that defects in DNA damage checkpoints may be recognized in melanomas through analysis of gene expression...
  15. ncbi request reprint Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma
    Janiel M Shields
    Department of Biochemistry and Biophysics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cancer Res 67:1502-12. 2007
    ..These results show a molecularly distinct melanoma subtype that does not require ERK activation or epithelial-mesenchymal transformation for progression...
  16. ncbi request reprint Population-based analysis of lymphatic mapping and sentinel lymphadenectomy utilization for intermediate thickness melanoma
    Karyn B Stitzenberg
    Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 2755 7590, USA
    J Surg Oncol 93:100-7; discussion 107-8. 2006
    ..We hypothesize that a significant portion of these patients are not undergoing LM/SL. We explore factors that influence use of LM/SL...
  17. ncbi request reprint Influence of provider and practice characteristics on melanoma care
    Karyn B Stitzenberg
    Department of Surgery, University of North Carolina, 3010 Old Clinic Building, CB 7213, Chapel Hill, NC 27599 7213, USA
    Am J Surg 193:206-12. 2007
    ..The purpose of this study is to describe the structure of melanoma care in North Carolina by examining services provided by different providers and the overall coordination of care...
  18. doi request reprint Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program
    Anne M Lachiewicz
    Department of Dermatology, University of North Carolina, Chapel Hill, 3100 Thurston Bowles Bldg, Manning Drive, CB No 7287, Chapel Hill, NC 27599 7287, USA
    Arch Dermatol 144:515-21. 2008
    ..To compare the prognosis of patients with scalp or neck (scalp/neck) melanomas with that of patients with melanomas at other sites in a large, population-based national data set controlling for known prognostic factors...
  19. ncbi request reprint Consumption of the epidermis: a criterion in the differential diagnosis of melanoma and dysplastic nevi that is associated with increasing breslow depth and ulceration
    Ruth Fulghum Walters
    Department of Pathology, University of North Carolina Hospitals, Chapel Hill, NC 27599 7287, USA
    Am J Dermatopathol 29:527-33. 2007
    ..Furthermore, the process leading to COE may be the first step in a progression to ulceration...
  20. ncbi request reprint Eruptive post-chemotherapy in situ melanomas and dysplastic nevi
    Jason C Reutter
    Department of Pathology, University of North Carolina, Chapel Hill, NC, USA
    Pediatr Dermatol 24:135-7. 2007
    ..We report an occurrence of multiple eruptive dysplastic nevi and in situ melanomas appearing shortly after completion of chemotherapy...
  21. ncbi request reprint RNA expression analysis of formalin-fixed paraffin-embedded tumors
    Shannon K Penland
    Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Lab Invest 87:383-91. 2007
    ..Although only a minority of FFPE blocks could be analyzed, we show that informative RNA expression analysis can be derived from selected FFPE samples...
  22. doi request reprint Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program
    Anne M Lachiewicz
    J Invest Dermatol 128:1340-2. 2008
  23. ncbi request reprint Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results Program
    Anne M Lachiewicz
    J Invest Dermatol 128:243-5. 2008
  24. ncbi request reprint BRAF and NRAS mutations in melanoma and melanocytic nevi
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Melanoma Res 16:267-73. 2006
    ..We suggest that BRAF mutations contribute to benign melanocytic hyperplasia, but are likely to contribute to invasive melanoma only in conjunction with other mutations...

Research Grants8

  1. RAS/BRAF Melanoma Mutations: Precursors, Risk, Prognosis
    Nancy Thomas; Fiscal Year: 2004
    ..This study is also expected to lead to identification of new chemotherapeutic targets and more efficient testing of inhibitors for NRAS and BRAF signaling, which have recently been developed. ..
  2. Melanoma NRAS/BRAF Mutations: A Population-Based Study
    Nancy Thomas; Fiscal Year: 2007
    ..This study is also expected to lead to identification of new hemotherapeutic targets and more efficient testing of inhibitors for NRAS and BRAF signaling, which have recently been developed. ..
  3. Melanoma RAS/BRAF Mutation: Heterogeneity-Risk-Prognosis
    Nancy E Thomas; Fiscal Year: 2010
    ....
  4. Melanoma RAS/BRAF Mutation: Heterogeneity-Risk-Prognosis
    Nancy Thomas; Fiscal Year: 2009
    ..Understanding of the role of these somatic mutations in the etiology and progression of melanoma likely will be crucial for its prevention, improved diagnosis, and effective application of new clinical treatments. ..