J A Thomas
Affiliation: University of Texas Southwestern Medical Center
- IL-1 receptor-associated kinase modulates host responsiveness to endotoxinJ L Swantek
Departments of Pharmacology, Pediatrics, and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
J Immunol 164:4301-6. 2000..These findings, coupled with the critical role for IRAK in IL-1 and IL-18 signal transduction, demonstrate the importance of this kinase and the IL-1/Toll signaling cassette in sensing and responding to Gram-negative infection...
- Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinaseJ A Thomas
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Immunol 163:978-84. 1999..These results demonstrate that although IRAK participates in IL-1 and IL-18 signal transduction, residual cytokine responsiveness operates through an IRAK-independent pathway...
- Toll-like receptor cross-hyporesponsiveness is functional in interleukin-1-receptor-associated kinase-1 (IRAK-1)-deficient macrophages: differential role played by IRAK-1 in regulation of tumour necrosis factor and interleukin-10 productionM Berglund
Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Scand J Immunol 67:473-9. 2008..Our results demonstrate that IRAK-1 is not necessary for induction of TLR cross-tolerance as judged by TNF production...
- Changes in chemical signature and host specificity from larval retrieval to full social integration in the myrmecophilous butterfly Maculinea rebeliK Schonrogge
Centre for Ecology and Hydrology, Winfrith Technology Centre, Dorchester DT2 8ZD, United Kingdom
J Chem Ecol 30:91-107. 2004..The ability to synthesize or suppress additional compounds once adopted explains the pattern of mortalities found among fully integrated caterpillars in Myrmica colonies of different species and physiological states...
- Host propagation permits extreme local adaptation in a social parasite of antsK Schonrogge
Centre for Ecology and Hydrology, CEH Dorset, Winfrith Technology Centre, Dorchester DT2 8XE, UK
Ecol Lett 9:1032-40. 2006..The consequences of such extreme host specificity for insect conservation are discussed...