G D Thomas

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Flow-mediated dilation and biological variability
    Gail D Thomas
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    J Appl Physiol 99:1626. 2005
  2. ncbi request reprint Neural control of muscle blood flow during exercise
    Gail D Thomas
    Hypertension Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8586, USA
    J Appl Physiol 97:731-8. 2004
  3. ncbi request reprint Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress
    G D Thomas
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circ Res 88:816-23. 2001
  4. ncbi request reprint Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase
    Gail D Thomas
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Tex 75390 8586, USA
    Circ Res 92:554-60. 2003
  5. pmc ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
    G D Thomas
    Department of Internal Medicine, Molecular Cardiology Laboratories, The University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 99:2602-9. 1997
  6. pmc Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
    G D Thomas
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Physiol 506:817-26. 1998
  7. pmc Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle
    J Hansen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Clin Invest 98:584-96. 1996
  8. ncbi request reprint Noninvasive assessment of sympathetic vasoconstriction in human and rodent skeletal muscle using near-infrared spectroscopy and Doppler ultrasound
    Paul J Fadel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8586, USA
    J Appl Physiol 96:1323-30. 2004
  9. pmc Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle
    Bahman Chavoshan
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Physiol 540:377-86. 2002
  10. pmc Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
    G D Thomas
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 95:15090-5. 1998

Detail Information

Publications24

  1. ncbi request reprint Flow-mediated dilation and biological variability
    Gail D Thomas
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    J Appl Physiol 99:1626. 2005
  2. ncbi request reprint Neural control of muscle blood flow during exercise
    Gail D Thomas
    Hypertension Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8586, USA
    J Appl Physiol 97:731-8. 2004
    ..Understanding how these control systems interact to govern muscle blood flow during exercise leads to a clear set of specific aims for future research...
  3. ncbi request reprint Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress
    G D Thomas
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circ Res 88:816-23. 2001
    ..These data suggest that impaired metabolic modulation of sympathetic vasoconstriction in contracting skeletal muscle of MI rats is a consequence of superoxide-mediated disruption of the NO pathway...
  4. ncbi request reprint Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase
    Gail D Thomas
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Tex 75390 8586, USA
    Circ Res 92:554-60. 2003
    ....
  5. pmc ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
    G D Thomas
    Department of Internal Medicine, Molecular Cardiology Laboratories, The University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 99:2602-9. 1997
    ..We conclude that contraction-induced activation of KATP channels is a major mechanism underlying metabolic inhibition of sympathetic vasoconstriction in exercising skeletal muscle...
  6. pmc Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle
    G D Thomas
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Physiol 506:817-26. 1998
    ..Although the underlying mechanism is not known, it may involve NO-induced activation of vascular KATP channels...
  7. pmc Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle
    J Hansen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Clin Invest 98:584-96. 1996
    ..These events are different from those involved in either metaboreceptor muscle afferent activation or reactive hyperemia...
  8. ncbi request reprint Noninvasive assessment of sympathetic vasoconstriction in human and rodent skeletal muscle using near-infrared spectroscopy and Doppler ultrasound
    Paul J Fadel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8586, USA
    J Appl Physiol 96:1323-30. 2004
    ..92, P < 0.0001). These data indicate that, during steady-state metabolic conditions, changes in tissue oxygenation can be used to reliably assess sympathetic vasoconstriction in both resting and exercising skeletal muscle...
  9. pmc Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle
    Bahman Chavoshan
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Physiol 540:377-86. 2002
    ..These data advance the hypothesis that NO plays an important role in modulating sympathetic vasoconstriction in the microcirculation of exercising muscle, because such modulation is abrogated by NO synthase inhibition with L-NAME...
  10. pmc Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
    G D Thomas
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 95:15090-5. 1998
    ..Similar results were obtained in mutant mice that lack the gene encoding nNOS. Together these data suggest a specific role for nNOS in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle...
  11. pmc Impaired vasomodulation is associated with reduced neuronal nitric oxide synthase in skeletal muscle of ovariectomized rats
    Paul J Fadel
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390, USA
    J Physiol 549:243-53. 2003
    ....
  12. ncbi request reprint Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension
    Weiying Zhao
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390 8586, USA
    Hypertension 48:637-43. 2006
    ..These findings may have implications for muscle oxidative stress and sympathetic vasoregulation when the renin-angiotensin system is chronically activated...
  13. doi request reprint Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity
    W Zhang
    Department of Internal Medicine Hypertension Division, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Neuroendocrinol 22:175-80. 2010
    ..This is the first study to demonstrate that further increases in circulating leptin levels by leptin gene transfer during obesity could reduce blood pressure...
  14. ncbi request reprint Sympathetic neural mechanisms of cyclosporine-induced hypertension
    M Sander
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573, USA
    Am J Hypertens 9:121S-138S. 1996
    ..The elucidation of novel CsA-sensitive cellular signaling pathways has lead to the search for the ideal immunosuppressant drug, one which retains CsA's immunosuppressive efficacy but without its toxicity...
  15. pmc Reflex sympathetic activation during static exercise is severely impaired in patients with myophosphorylase deficiency
    Paul J Fadel
    Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, Dallas, USA
    J Physiol 548:983-93. 2003
    ..Together these data indicate that appropriate activation of glycogenolytic pathways is obligatory for normal metaboreflex-mediated sympathoexcitation during static exercise in humans...
  16. pmc Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy
    Paul J Fadel
    Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8586, USA
    J Physiol 561:893-901. 2004
    ..The effect of short-term unopposed oestrogen replacement to correct this impairment implicates a role for oestrogen in the sympathetic neural control of muscle haemodynamics during exercise...
  17. pmc {alpha}-Adrenoceptor constrictor responses and their modulation in slow-twitch and fast-twitch mouse skeletal muscle
    David G Lambert
    Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8586, USA
    J Physiol 563:821-9. 2005
    ..Based on the similar findings in soleus and EDL muscles, fibre type does not appear to determine the innate vascular response to alpha(1)- or alpha(2)-adrenoceptor activation...
  18. ncbi request reprint FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase
    Chieko Mineo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circ Res 97:1124-31. 2005
    ..Thus FcgammaRIIB mediates CRP inhibition of eNOS via PP2A, providing a mechanistic link between CRP and endothelial dysfunction...
  19. ncbi request reprint C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice
    Wanpen Vongpatanasin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Circulation 115:1020-8. 2007
    ..Chronic elevations in circulating C-reactive protein (CRP) are associated with a greater risk of hypertension. Whether elevations in CRP cause hypertension is unknown...
  20. ncbi request reprint Skin blood flow influences near-infrared spectroscopy-derived measurements of tissue oxygenation during heat stress
    Scott L Davis
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Suite 435, Dallas, Texas 75231, USA
    J Appl Physiol 100:221-4. 2006
    ..g., high-intensity and/or prolonged exercise)...
  21. pmc Having it both ways? Vasoconstriction in contracting muscles
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 550:333. 2003
  22. ncbi request reprint Nitric oxide pathway as new drug targets for refractory hypertension
    Robert A Augustyniak
    The Donald W Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 8586, USA
    Curr Pharm Des 11:3307-15. 2005
    ..The purpose of this article is to show how emerging basic research on the NO pathway is elucidating novel antihypertensive drug targets that are on the cusp of clinical application...
  23. ncbi request reprint Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice
    Kaori Ito
    Department of Child Development, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School, Kumamoto 860 0811, Japan
    Hum Mol Genet 15:2266-75. 2006
    ..In addition, the elevated serum creatine kinase levels observed in mdx mice were significantly reduced in SMTg/mdx mice. This is the first report of a functional role of dystrophin in vascular smooth muscle...
  24. ncbi request reprint In favor of a role of lactic acid on the generation of the exercise pressor reflex
    Gail D Thomas
    Clin Auton Res 13:5-6. 2003