Research Topics
Genomes and Genes
| Dafydd G ThomasSummaryAffiliation: University of Michigan Country: USA Publications
| Collaborators
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Detail Information
Publications
Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcomaDafydd G Thomas
Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
Clin Cancer Res 8:788-93. 2002..Several reports have claimed expression of the HER2/neu (c-erbB-2) gene in a high percentage of OSs and that its expression is a poor prognostic factor and have advocated monoclonal antibody therapy in those cases...- Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysisThomas J Giordano
Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
Oncogene 24:6646-56. 2005.... 
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomasGuoan Chen
Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:12507-12. 2005....- Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisonsJonathan B McHugh
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-0054, USA
Cancer 107:554-62. 2006..In addition, they demonstrate higher expression rates of adverse prognostic indicators, further highlighting the distinction... - Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinomaJules Lin
Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 8:1062-71. 2006..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme... - Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcomaDafydd G Thomas
Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
Cancer 103:830-8. 2005..Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu... - Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinomaChristopher W Seder
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 11:388-96. 2009..The expression, mechanisms of regulation, and functional impact of INHBA (activin A) in lung adenocarcinoma (AD) have not been fully elucidated... - Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivityAmy L Silvers
Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Cancer Res 16:2009-21. 2010.... - Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variantsJules Lin
Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Clin Cancer Res 10:5708-16. 2004..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy... - Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinomaTarek G Gharib
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Neoplasia 4:440-8. 2002..Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas... - Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomasGuoan Chen
Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 2:107-16. 2003.... - RANTES expression is a predictor of survival in stage I lung adenocarcinomaChristopher J Moran
Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 8:3803-12. 2002..002). CONCLUSION: When tested in the Cox univariate proportional hazards model, RANTES expression by lung adenocarcinoma cells is a predictor of survival in stage I NSCLC patients and may be useful as a prognostic factor in lung cancer... - Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomasGuoan Chen
Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Pathol 202:321-9. 2004..Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas... - Proteomic analysis of eIF-5A in lung adenocarcinomasGuoan Chen
Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
Proteomics 3:496-504. 2003..Moreover, the investigation on agents that inhibit eIF-5A function is encouraged... - Molecular classification and prognostication of adrenocortical tumors by transcriptome profilingThomas J Giordano
Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, Ann Arbor, MI 48109 0669, USA
Clin Cancer Res 15:668-76. 2009..For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance?.. - Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mappingJia Zhao
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 6:987-99. 2007..These differentially expressed proteins may have utility as useful candidate markers of esophageal adenocarcinoma... - Stromal LRP1 in lung adenocarcinoma predicts clinical outcomeHe Meng
Departments of Neurology, University of Michigan and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 17:2426-33. 2011..It is expressed in numerous cancers, but its role in lung cancer has not been characterized. Here, we investigate the relationship between LRP1 and lung cancer... - Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinomaLin Lin
Department of Surgery, Department of Pathology, and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 109:4251-6. 2012..We conclude that selective gene amplification of GATA6 during EAC development sustains oncogenic lineage-survival of esophageal adenocarcinoma... 
INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinomaChristopher W Seder
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Thorac Oncol 4:455-62. 2009..The expression, mechanisms of regulation, and functional impact of activin (INHBA) in esophageal adenocarcinoma (EAC) have not been fully defined...- Protein profiles associated with survival in lung adenocarcinomaGuoan Chen
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:13537-42. 2003..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer... - Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomasCharles T Miller
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Oncogene 22:7950-7. 2003..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers... - Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-cateninJoanne H Heaton
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Am J Pathol 181:1017-33. 2012..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis... - Characterization of vitamin D receptor (VDR) in lung adenocarcinomaSo Hee Kim
Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Lung Cancer 77:265-71. 2012..In the present study, we characterized VDR expression in lung adenocarcinoma (AC)... - Efficacy of imatinib in aggressive fibromatosis: Results of a phase II multicenter Sarcoma Alliance for Research through Collaboration (SARC) trialRashmi Chugh
Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 5843, USA
Clin Cancer Res 16:4884-91. 2010..Here, we report specifically on the outcome of patients with AF as well as evaluations undertaken to examine the mechanism of imatinib... - Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcomaDennis P M Hughes
Department of Pediatrics and Infectious Diseases, Division of Pediatric Hematology Oncology, University of Michigan Medical Center, L2110 Women s Hospital, 0238, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0238, USA
Cancer Res 64:2047-53. 2004..Therapy directed against this family of receptors may be beneficial for patients with osteosarcoma... - Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinomaLin Lin
Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
Genes Chromosomes Cancer 45:319-31. 2006..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development... - Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocationThomas J Giordano
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Clin Cancer Res 12:1983-93. 2006..These results have implications for the neoplastic mechanism of these follicular carcinomas... - L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinomaJules Lin
Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 6:74-84. 2004..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1... - Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinomaGuoan Chen
Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer Res 67:3461-7. 2007..These studies indicate that autoantibody profiles, as well as individual candidates, may be useful for the noninvasive detection of lung adenocarcinoma... - Gene-expression profiles predict survival of patients with lung adenocarcinomaDavid G Beer
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Nat Med 8:816-24. 2002..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy... - Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinomaWibisono Hartojo
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
Transl Oncol 3:99-108. 2010.... - p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting systemJason C Carvalho
Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
Histopathology 60:597-608. 2012..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ... - CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinomaGuoan Chen
Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 17:817-26. 2011..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells... - Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell linesEdith J Mensah-Osman
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Cancer 109:957-65. 2007.... - Histologic alterations from neoadjuvant chemotherapy in high-grade extremity soft tissue sarcoma: clinicopathological correlationDavid R Lucas
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
Oncologist 13:451-8. 2008.... - Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stageYanfei Wang
Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Proteome Res 8:1452-63. 2009..To further confirm the stage-dependent protein identifications, Lamin A/C and Vimentin expression in ovarian serous carcinomas was assessed by immunohistochemistry using ovarian tumor tissue microarrays for 66 samples... - Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinomaFerdous M Barlaskar
Department of Internal Medicine Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
J Clin Endocrinol Metab 94:204-12. 2009..Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious... - Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysisThomas J Giordano
Departments of Pathology, Pediatrics, Surgery, and Biostatistics, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
Am J Pathol 162:521-31. 2003..Moreover, we identified several genes that represent potential diagnostic markers and may play a role in the pathogenesis of ACC... - Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic miceEricka Diallo-Krou
University of Michigan, 5560 MSRB 2, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5678, USA
Endocrinology 150:5181-90. 2009..However, the mice develop thyroid hyperplasia, not carcinoma, suggesting that additional events are required to cause follicular thyroid cancer... - Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroupsJason C Carvalho
Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0054, USA
Cancer 115:4186-95. 2009..The differential expression of smooth muscle markers, estrogen receptor (ER), progesterone receptor (PR), and Wilms tumor-1 protein (WT1) by anatomic subtype and gender was explored... - Neoadjuvant docetaxel and capecitabine and the use of thymidine phosphorylase as a predictive biomarker in breast cancerRachel M Layman
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0848, USA
Clin Cancer Res 13:4092-7. 2007..We evaluated whether TP protein expression is increased by docetaxel and correlates with pathologic complete response (pCR) in breast cancer patients... - Phase II multicenter trial of imatinib in 10 histologic subtypes of sarcoma using a bayesian hierarchical statistical modelRashmi Chugh
1500 E Medical Center Dr, C407 Med Inn, SPC 5843, Ann Arbor, MI 48109 5843, USA
J Clin Oncol 27:3148-53. 2009..Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes... - Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomasCohra C Mankey
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
Histopathology 56:364-71. 2010..The aim was to investigate further lymphatic antigen expression, and to explore the relation of immunohistochemistry to morphological and clinical findings... - Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcomaRashmi Chugh
Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer 109:2315-22. 2007..The pharmacokinetics of ifosfamide and CYP3A measurements observed are reported... - Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimicsJason C Carvalho
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA
Histopathology 58:169-79. 2011.... - Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumorsGuoan Chen
Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 8:2298-305. 2002..The association of specific isoforms of these proteins with clinical variables and understanding the regulation of their expression will aid in determination of their potential use as biomarkers in this cancer... - Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcomaStephen H Olsen
Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109-0054, USA
Mod Pathol 19:659-68. 2006..Cluster analysis also highlighted aberrant staining reactions and diagnostic pitfalls in these tumors. Hierarchical cluster analysis is an effective method for analyzing high-volume immunohistochemical data... - An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancerXiao Song Wang
Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
Nat Biotechnol 27:1005-11. 2009..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery... - Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like featuresDavid R Lucas
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 34:844-51. 2010..Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm... - Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcomaHassan R Dhaini
Department of Environmental Health Sciences, Toxicology Program, University of Michigan, Ann Arbor 48109, USA
J Clin Oncol 21:2481-5. 2003..0004). CONCLUSION: High cytochrome P450 CYP3A4/5 expression may predict metastasis and poor prognosis in osteosarcomas. Its use as a biomarker of therapeutic response will have implications for the treatment of these tumors... - Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibitionDennis P M Hughes
Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA
Pediatr Blood Cancer 46:614-23. 2006..We wished to determine if erbB kinases in osteosarcoma were phosphorylated, and if this was required for growth...