Dafydd G Thomas

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Clin Cancer Res 8:788-93. 2002
  2. ncbi request reprint Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
  3. pmc Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:12507-12. 2005
  4. ncbi request reprint Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
  5. pmc Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:1062-71. 2006
  6. ncbi request reprint Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Cancer 103:830-8. 2005
  7. pmc Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 11:388-96. 2009
  8. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
  9. pmc Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity
    Amy L Silvers
    Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2009-21. 2010
  10. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002

Detail Information

Publications55

  1. ncbi request reprint Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Clin Cancer Res 8:788-93. 2002
    ..Several reports have claimed expression of the HER2/neu (c-erbB-2) gene in a high percentage of OSs and that its expression is a poor prognostic factor and have advocated monoclonal antibody therapy in those cases...
  2. ncbi request reprint Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
    ....
  3. pmc Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:12507-12. 2005
    ....
  4. ncbi request reprint Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
    ..Although most are sporadic, some tumors occur in association with prior radiation therapy. The purpose of the current study was to compare clinicopathologic and prognostic features of primary and radiation-associated osteosarcoma...
  5. pmc Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:1062-71. 2006
    ..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme...
  6. ncbi request reprint Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Cancer 103:830-8. 2005
    ..Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu...
  7. pmc Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 11:388-96. 2009
    ..The expression, mechanisms of regulation, and functional impact of INHBA (activin A) in lung adenocarcinoma (AD) have not been fully elucidated...
  8. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
    ..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy...
  9. pmc Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity
    Amy L Silvers
    Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2009-21. 2010
    ....
  10. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002
    ..Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas...
  11. ncbi request reprint Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  12. ncbi request reprint RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
    ..The purpose of this study was to identify differences in global gene expression profiles between stage I NSCLC tumors with ALR (ALR+) and those without ALR (ALR-)...
  13. ncbi request reprint Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
    ..Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas...
  14. ncbi request reprint Proteomic analysis of eIF-5A in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
    Proteomics 3:496-504. 2003
    ..Moreover, the investigation on agents that inhibit eIF-5A function is encouraged...
  15. pmc Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
    Thomas J Giordano
    Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, Ann Arbor, MI 48109 0669, USA
    Clin Cancer Res 15:668-76. 2009
    ..For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance?..
  16. ncbi request reprint Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mapping
    Jia Zhao
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 6:987-99. 2007
    ..These differentially expressed proteins may have utility as useful candidate markers of esophageal adenocarcinoma...
  17. pmc Stromal LRP1 in lung adenocarcinoma predicts clinical outcome
    He Meng
    Departments of Neurology, University of Michigan and Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:2426-33. 2011
    ..It is expressed in numerous cancers, but its role in lung cancer has not been characterized. Here, we investigate the relationship between LRP1 and lung cancer...
  18. pmc Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma
    Lin Lin
    Department of Surgery, Department of Pathology, and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:4251-6. 2012
    ..We conclude that selective gene amplification of GATA6 during EAC development sustains oncogenic lineage-survival of esophageal adenocarcinoma...
  19. pmc Protein profiles associated with survival in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:13537-42. 2003
    ..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer...
  20. ncbi request reprint Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
    ..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers...
  21. doi request reprint INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Thorac Oncol 4:455-62. 2009
    ..The expression, mechanisms of regulation, and functional impact of activin (INHBA) in esophageal adenocarcinoma (EAC) have not been fully defined...
  22. pmc Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
    Joanne H Heaton
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Pathol 181:1017-33. 2012
    ..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis...
  23. pmc Characterization of vitamin D receptor (VDR) in lung adenocarcinoma
    So Hee Kim
    Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Lung Cancer 77:265-71. 2012
    ..In the present study, we characterized VDR expression in lung adenocarcinoma (AC)...
  24. doi request reprint Efficacy of imatinib in aggressive fibromatosis: Results of a phase II multicenter Sarcoma Alliance for Research through Collaboration (SARC) trial
    Rashmi Chugh
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 5843, USA
    Clin Cancer Res 16:4884-91. 2010
    ..Here, we report specifically on the outcome of patients with AF as well as evaluations undertaken to examine the mechanism of imatinib...
  25. ncbi request reprint Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma
    Dennis P M Hughes
    Department of Pediatrics and Infectious Diseases, Division of Pediatric Hematology Oncology, University of Michigan Medical Center, L2110 Women s Hospital, 0238, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0238, USA
    Cancer Res 64:2047-53. 2004
    ..Therapy directed against this family of receptors may be beneficial for patients with osteosarcoma...
  26. ncbi request reprint Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 12:1983-93. 2006
    ..These results have implications for the neoplastic mechanism of these follicular carcinomas...
  27. ncbi request reprint Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    Lin Lin
    Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
    Genes Chromosomes Cancer 45:319-31. 2006
    ..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development...
  28. pmc L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 6:74-84. 2004
    ..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1...
  29. ncbi request reprint Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 67:3461-7. 2007
    ..These studies indicate that autoantibody profiles, as well as individual candidates, may be useful for the noninvasive detection of lung adenocarcinoma...
  30. pmc Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma
    Wibisono Hartojo
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Transl Oncol 3:99-108. 2010
    ....
  31. ncbi request reprint Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  32. doi request reprint p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
    Histopathology 60:597-608. 2012
    ..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ...
  33. pmc CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma
    Guoan Chen
    Section of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:817-26. 2011
    ..The purpose of our study was to assess CYP24A1 as a prognostic marker and to study its relevance to antiproliferative activity of 1,25-D(3) in lung AC cells...
  34. doi request reprint Histologic alterations from neoadjuvant chemotherapy in high-grade extremity soft tissue sarcoma: clinicopathological correlation
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Oncologist 13:451-8. 2008
    ....
  35. pmc Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines
    Edith J Mensah-Osman
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Cancer 109:957-65. 2007
    ....
  36. pmc Differential protein mapping of ovarian serous adenocarcinomas: identification of potential markers for distinct tumor stage
    Yanfei Wang
    Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109, Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Proteome Res 8:1452-63. 2009
    ..To further confirm the stage-dependent protein identifications, Lamin A/C and Vimentin expression in ovarian serous carcinomas was assessed by immunohistochemistry using ovarian tumor tissue microarrays for 66 samples...
  37. pmc Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma
    Ferdous M Barlaskar
    Department of Internal Medicine Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    J Clin Endocrinol Metab 94:204-12. 2009
    ..Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious...
  38. pmc Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104 5054, USA
    Am J Clin Pathol 139:771-9. 2013
    ..In summary, EPR3864 may be useful in detecting EWSR1:FLI1 and EWSR1:ERG rearranged EFTs in addition to prostate carcinomas...
  39. doi request reprint Ewing sarcoma of the kidney: case series and literature review of an often overlooked entity in the diagnosis of primary renal tumors
    R Grant Rowe
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5848, USA
    Urology 81:347-53. 2013
    ..To evaluate our own experience with primary Ewing sarcoma family tumors (ESFTs) of the kidney and to review cases of this in published reports...
  40. pmc Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
    Thomas J Giordano
    Departments of Pathology, Pediatrics, Surgery, and Biostatistics, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 162:521-31. 2003
    ..Moreover, we identified several genes that represent potential diagnostic markers and may play a role in the pathogenesis of ACC...
  41. ncbi request reprint Neoadjuvant docetaxel and capecitabine and the use of thymidine phosphorylase as a predictive biomarker in breast cancer
    Rachel M Layman
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0848, USA
    Clin Cancer Res 13:4092-7. 2007
    ..We evaluated whether TP protein expression is increased by docetaxel and correlates with pathologic complete response (pCR) in breast cancer patients...
  42. pmc Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice
    Ericka Diallo-Krou
    University of Michigan, 5560 MSRB 2, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5678, USA
    Endocrinology 150:5181-90. 2009
    ..However, the mice develop thyroid hyperplasia, not carcinoma, suggesting that additional events are required to cause follicular thyroid cancer...
  43. doi request reprint Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0054, USA
    Cancer 115:4186-95. 2009
    ..The differential expression of smooth muscle markers, estrogen receptor (ER), progesterone receptor (PR), and Wilms tumor-1 protein (WT1) by anatomic subtype and gender was explored...
  44. doi request reprint Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimics
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA
    Histopathology 58:169-79. 2011
    ....
  45. ncbi request reprint Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma
    Rashmi Chugh
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer 109:2315-22. 2007
    ..The pharmacokinetics of ifosfamide and CYP3A measurements observed are reported...
  46. doi request reprint Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas
    Cohra C Mankey
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Histopathology 56:364-71. 2010
    ..The aim was to investigate further lymphatic antigen expression, and to explore the relation of immunohistochemistry to morphological and clinical findings...
  47. doi request reprint Phase II multicenter trial of imatinib in 10 histologic subtypes of sarcoma using a bayesian hierarchical statistical model
    Rashmi Chugh
    1500 E Medical Center Dr, C407 Med Inn, SPC 5843, Ann Arbor, MI 48109 5843, USA
    J Clin Oncol 27:3148-53. 2009
    ..Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes...
  48. pmc HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab
    Suthinee Ithimakin
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Cancer Res 73:1635-46. 2013
    ..Furthermore, these studies support a CSC model in which maximal clinical benefit is achieved when CSC targeting agents are administered in the adjuvant setting. Cancer Res; 73(5); 1635-46. ©2012 AACR...
  49. pmc Distinct gene expression profiles of viral- and nonviral-associated merkel cell carcinoma revealed by transcriptome analysis
    Paul W Harms
    1 Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, USA 2 Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Invest Dermatol 133:936-45. 2013
    ..Functional and clinical validation studies are needed to determine whether this tumor-suppressor pathway represents an avenue for targeted therapy...
  50. doi request reprint Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 34:844-51. 2010
    ..Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm...
  51. pmc An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer
    Xiao Song Wang
    Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
    Nat Biotechnol 27:1005-11. 2009
    ..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery...
  52. ncbi request reprint Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors
    Guoan Chen
    Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:2298-305. 2002
    ..The goal of this study was to identify potential protein markers in lung adenocarcinomas...
  53. ncbi request reprint Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma
    Stephen H Olsen
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109 0054, USA
    Mod Pathol 19:659-68. 2006
    ..Cluster analysis also highlighted aberrant staining reactions and diagnostic pitfalls in these tumors. Hierarchical cluster analysis is an effective method for analyzing high-volume immunohistochemical data...
  54. ncbi request reprint Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma
    Hassan R Dhaini
    Department of Environmental Health Sciences, Toxicology Program, University of Michigan, Ann Arbor 48109, USA
    J Clin Oncol 21:2481-5. 2003
    ..One of these, CYP3A4/5 is involved in metabolic activation and detoxification of a wide number of carcinogens and chemotherapeutic agents, including many drugs that are useful in the treatment of osteosarcomas...
  55. ncbi request reprint Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition
    Dennis P M Hughes
    Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 46:614-23. 2006
    ..We wished to determine if erbB kinases in osteosarcoma were phosphorylated, and if this was required for growth...