D C Thomas

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al
    Duncan C Thomas
    Ann Epidemiol 17:511-3. 2007
  2. doi request reprint Viewpoint: using gene-environment interactions to dissect the effects of complex mixtures
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, California 90089 9011, USA
    J Expo Sci Environ Epidemiol 17:S71-4. 2007
  3. pmc Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    Hum Genet 131:1565-89. 2012
  4. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
  5. pmc Genetic epidemiology with a capital E: where will we be in another 10 years?
    Duncan C Thomas
    Genet Epidemiol 36:179-82. 2012
  6. pmc Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome
    Duncan C Thomas
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Epidemiol 175:203-7; discussion 208-9. 2012
  7. pmc Bayesian hierarchical modeling of means and covariances of gene expression data within families
    Roger Pique Regi
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, California 90089, USA
    BMC Proc 1:S111. 2007
  8. pmc Design considerations in a sib-pair study of linkage for susceptibility loci in cancer
    Richard A Kerber
    Population Sciences Program, Hunstman Cancer Institute, Salt Lake City, UT, USA
    BMC Med Genet 9:64. 2008
  9. pmc Segregation and linkage analysis for longitudinal measurements of a quantitative trait
    Conway Gee
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, California, USA
    BMC Genet 4:S21. 2003
  10. pmc Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study
    Terri Kang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    BMC Genet 4:S43. 2003

Research Grants

  1. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1993
  2. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2000
  3. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2004
  4. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1992
  5. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1991
  6. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2005
  7. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2006
  8. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2003
  9. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2003
  10. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2002

Detail Information

Publications74

  1. ncbi request reprint Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al
    Duncan C Thomas
    Ann Epidemiol 17:511-3. 2007
  2. doi request reprint Viewpoint: using gene-environment interactions to dissect the effects of complex mixtures
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, California 90089 9011, USA
    J Expo Sci Environ Epidemiol 17:S71-4. 2007
    ..I explore a general hierarchical modeling framework that would allow such information as sources, genetic interactions, and toxicology to be included in the higher levels of the model...
  3. pmc Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    Hum Genet 131:1565-89. 2012
    ..We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena...
  4. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
    ..A subset of these SNPs, selected upon their main effects on contralateral breast cancer risk was further evaluated for interaction with treatment modalities and estrogen receptor (ER) status...
  5. pmc Genetic epidemiology with a capital E: where will we be in another 10 years?
    Duncan C Thomas
    Genet Epidemiol 36:179-82. 2012
    ..The basic principles of population-based research and the importance of taking account of the environment remain important to the field...
  6. pmc Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome
    Duncan C Thomas
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Epidemiol 175:203-7; discussion 208-9. 2012
    ....
  7. pmc Bayesian hierarchical modeling of means and covariances of gene expression data within families
    Roger Pique Regi
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, California 90089, USA
    BMC Proc 1:S111. 2007
    ..The approach appears to be a promising way to address the huge multiple comparisons problem for relating genome-wide genotype x expression data...
  8. pmc Design considerations in a sib-pair study of linkage for susceptibility loci in cancer
    Richard A Kerber
    Population Sciences Program, Hunstman Cancer Institute, Salt Lake City, UT, USA
    BMC Med Genet 9:64. 2008
    ..However, the sibpair design is still valuable because it requires few assumptions other than acceptably high penetrance to identify genetic loci...
  9. pmc Segregation and linkage analysis for longitudinal measurements of a quantitative trait
    Conway Gee
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, California, USA
    BMC Genet 4:S21. 2003
    ..5) for specific markers on chromosomes 1, 3, 5, 9, 10, and 17. For the slopes, however, the data did not support a Mendelian model, and thus no formal linkage analyses were conducted...
  10. pmc Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study
    Terri Kang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    BMC Genet 4:S43. 2003
    ..This suggests that if missingness patterns are correlated within families, then imputation methods that do not allow this correlation can yield biased results...
  11. pmc Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits
    E Warwick Daw
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 4:S3. 2003
    ....
  12. pmc Recent developments in genomewide association scans: a workshop summary and review
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Am J Hum Genet 77:337-45. 2005
    ....
  13. ncbi request reprint Bayesian model averaging in time-series studies of air pollution and mortality
    Duncan C Thomas
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9011, USA
    J Toxicol Environ Health A 70:311-5. 2007
    ..This paper examines recent attempts to use BMA in air pollution studies to illustrate the potential benefits and limitations of the method...
  14. ncbi request reprint High-volume "-omics" technologies and the future of molecular epidemiology
    Duncan C Thomas
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, CA 90089, USA
    Epidemiology 17:490-1. 2006
  15. pmc Genome-wide association studies for discrete traits
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9011, USA
    Genet Epidemiol 33:S8-12. 2009
    ..Other issues considered by this group included subgroup analysis, gene-gene interactions, and the use of biomarkers...
  16. pmc Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies
    Duncan Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, 90089 9011, USA
    Annu Rev Public Health 31:21-36. 2010
    ....
  17. ncbi request reprint Dissecting effects of complex mixtures: who's afraid of informative priors?
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Epidemiology 18:186-90. 2007
    ..In doing so - and by directly incorporating into our analyses information from other studies or allied fields - we can improve our ability to distinguish true causes of disease from noise and bias...
  18. pmc Use of pathway information in molecular epidemiology
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Hum Genomics 4:21-42. 2009
    ..The review concludes with some thoughts about potential uses of pathways in genome-wide association studies...
  19. ncbi request reprint Two-Stage sampling designs for gene association studies
    Duncan Thomas
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Genet Epidemiol 27:401-14. 2004
    ..2003; Nature 426:789-796] rapidly accumulates in public databases, such two-stage designs may soon become unnecessary...
  20. ncbi request reprint Multistage sampling for latent variable models
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Lifetime Data Anal 13:565-81. 2007
    ....
  21. pmc Gene--environment-wide association studies: emerging approaches
    Duncan Thomas
    Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, California 90089 9011, USA
    Nat Rev Genet 11:259-72. 2010
    ..I also explore methods for marrying hypothesis-driven pathway-based approaches with 'agnostic' GWA studies...
  22. ncbi request reprint Why do estimates of the acute and chronic effects of air pollution on mortality differ?
    Duncan Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    J Toxicol Environ Health A 68:1167-74. 2005
    ....
  23. ncbi request reprint Genetic epidemiology with a capital "E"
    D C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9011, USA
    Genet Epidemiol 19:289-300. 2000
    ..I believe that the Society should reach out more to the epidemiology community and that the journal should shift its emphasis from pure methodology to also include more substantive papers that illustrate these principles...
  24. ncbi request reprint Bayesian spatial modeling of haplotype associations
    Duncan C Thomas
    University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:32-40. 2003
    ..We conclude with a discussion of the implications of these methods for modeling cryptic relatedness, haplotype blocks, and haplotype tagging SNPs, and suggest a Bayesian framework for the HapMap project...
  25. ncbi request reprint A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function
    J M Peters
    Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, USA
    Am J Respir Crit Care Med 159:768-75. 1999
    ..For boys, significant associations were seen between peak O3 exposures and lower FVC and FEV1, but only in those spending more time outdoors. These findings underline the importance of follow-up of this cohort...
  26. pmc Bias and efficiency in family-based gene-characterization studies: conditional, prospective, retrospective, and joint likelihoods
    P Kraft
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90033, USA
    Am J Hum Genet 66:1119-31. 2000
    ..The efficiency gains of the mixed-model prospective, retrospective, and joint likelihoods relative to the efficiency of conditional likelihood are small in the situations presented here...
  27. ncbi request reprint Genome scan of complex traits by haplotype sharing correlation
    D Qian
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP-220, Los Angeles, CA 90089, USA
    Genet Epidemiol 21:S582-7. 2001
    ....
  28. pmc Testing linkage disequilibrium in sibships
    K D Siegmund
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Am J Hum Genet 67:244-8. 2000
    ..Finally, we concluded that although the standard analysis may lead to correct inference for practical purposes, the new test is valid, even under extreme residual familial correlation and with no cost in power at the causal locus...
  29. ncbi request reprint Bayes estimates of haplotype effects
    D C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP-220, Los Angeles, CA 90089-9011, USA
    Genet Epidemiol 21:S712-7. 2001
    ..When applied to the Genetic Analysis Workshop 12 data for trait Q1, we found highly significant variation between haplotypes, using either a structured or unstructured covariance matrix...
  30. ncbi request reprint Analysis of gene-smoking interaction in lung cancer
    W J Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90033, USA
    Genet Epidemiol 14:199-214. 1997
    ..Results from this analysis also support a nonsignificant gene-smoking interaction and an allele frequency of 2%, but a lower genetic relative risk (9.0) compared to the "complete case" analysis...
  31. ncbi request reprint A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity
    J M Peters
    Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, USA
    Am J Respir Crit Care Med 159:760-7. 1999
    ....
  32. pmc Discovery of complex pathways from observational data
    James W Baurley
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Stat Med 29:1998-2011. 2010
    ..Our method can correctly identify the risk factors and interactions involved in the simulated pathway. We apply our framework to an asthma case-control data set with polymorphisms in 12 genes...
  33. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  34. doi request reprint Using biological knowledge to discover higher order interactions in genetic association studies
    Gary K Chen
    Division of Biostatics, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9601, USA
    Genet Epidemiol 34:863-78. 2010
    ..We also apply the method to data from a GWAS for breast cancer, revealing a set of interactions enriched for the Gene Ontology terms growth, metabolic process, and biological regulation...
  35. doi request reprint Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
    ..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
  36. ncbi request reprint Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation
    Juan Pablo Lewinger
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9011, USA
    Genet Epidemiol 31:871-82. 2007
    ..We show that the ranking by posterior expectations performs better at selecting the true positive association than a simple ranking of p-values if at least some of the prior covariates have predictive value...
  37. ncbi request reprint Commentary: the concept of 'Mendelian Randomization'
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 9089 9011, USA
    Int J Epidemiol 33:21-5. 2004
  38. pmc Efficient genome-wide association testing of gene-environment interaction in case-parent trios
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Am J Epidemiol 172:116-22. 2010
    ..This 2-step scan for G x E interaction is independent of any prior scan that may have been conducted for genetic main effects, and thus has the potential to uncover new genes in a GWAS that have not been previously identified...
  39. pmc Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer
    Bryan Langholz
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA
    Biometrics 65:599-608. 2009
    ..The methods are illustrated and compared using the WECARE study of radiation and asynchronous contralateral breast cancer...
  40. pmc Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Cancer Causes Control 21:839-46. 2010
    ..In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers...
  41. pmc Sample size requirements to detect gene-environment interactions in genome-wide association studies
    Cassandra E Murcray
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9010, USA
    Genet Epidemiol 35:201-10. 2011
    ..15, and a binary exposure with prevalence 0.3, the Murcray, Kooperberg and hybrid methods are 1.90, 1.27, and 1.87 times as efficient, respectively, as the traditional case-control analysis to detect an interaction effect size of 2.0...
  42. ncbi request reprint BRCA1 variants in a family study of African-American and Latina women
    Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue MS 44, Los Angeles, CA 90089 9175, USA
    Hum Genet 116:497-506. 2005
    ..We believe this to be the largest study of high-risk African-American and Latina women sequenced for variants in the BRCA1 gene to date...
  43. ncbi request reprint Bayesian modeling of complex metabolic pathways
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:83-93. 2003
    ..The new analyses are structured in a manner that attempts to take advantage of prior knowledge of the metabolism of these classes of compounds and the various genes that regulate these pathways...
  44. ncbi request reprint Traffic density and the risk of childhood leukemia in a Los Angeles case-control study
    Bryan Langholz
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Ann Epidemiol 12:482-7. 2002
    ..To investigate the relationship between traffic density and the risk of childhood leukemia...
  45. ncbi request reprint Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Hered 55:179-90. 2003
    ..1]) the differences between the three methods are very small and in particular that the single imputation method may be expected to work extremely well...
  46. ncbi request reprint Ascertainment bias in rate ratio estimation from case-sibling control studies of variable age-at-onset diseases
    B Langholz
    Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles 90033, USA
    Biometrics 55:1129-36. 1999
    ..An important consequence of this work is that standard family-based case-control studies are subject to ascertainment bias if exchangeability of the covariates under investigation does not hold...
  47. ncbi request reprint Point: population stratification: a problem for case-control studies of candidate-gene associations?
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033 9987, USA
    Cancer Epidemiol Biomarkers Prev 11:505-12. 2002
  48. ncbi request reprint Optimal two-stage genotyping designs for genome-wide association scans
    Hansong Wang
    Division of Biostatistics and Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Genet Epidemiol 30:356-68. 2006
    ....
  49. ncbi request reprint The effects of ambient air pollution on school absenteeism due to respiratory illnesses
    F D Gilliland
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Epidemiology 12:43-54. 2001
    ..7)] compared with communities with high average levels [38.1% (95% CI = 8.5-75.8)]. Increased school absenteeism from O3 exposure in children is an important adverse effect of ambient air pollution worthy of public policy consideration...
  50. ncbi request reprint Evolution of the simulated data problem
    D C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP-220, Los Angeles, CA 90089-9011, USA
    Genet Epidemiol 21:S325-31. 2001
    ..We describe the process that was used to structure the problem and summarize the discussions about many of the scientific issues that were considered...
  51. doi request reprint Complex system approaches to genetic analysis Bayesian approaches
    Melanie A Wilson
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Adv Genet 72:47-71. 2010
    ..In particular, we highlight the ability of Bayesian methods to construct complex probability models via a hierarchical structure and to account for uncertainty in model specification by averaging over large spaces of alternative models...
  52. pmc Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985
    S Preston Martin
    Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, 90033
    Br J Cancer 59:783-6. 1989
    ..We propose that the findings in this study which identify noise as a risk factor support the hypothesis that mechanical trauma may contribute to tumorigenesis...
  53. pmc Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study
    J M Pogoda
    Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles CA 90089, USA
    Br J Cancer 104:1482-6. 2011
    ..High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography...
  54. ncbi request reprint A three-level model for binary time-series data: the effects of air pollution on school absences in the Southern California Children's Health Study
    Virginie Rondeau
    Institut National de la Sante et de la Recherche Medicale, Equipe Mixte INSERM E03 38 Biostatistique, Université Bordeaux2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Stat Med 24:1103-15. 2005
    ..We illustrate this proposed model via detailed analysis of the effect of air pollution on school absenteeism based on data from the Southern California Children's Health Study...
  55. ncbi request reprint An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna
    Duncan C Thomas
    Eur J Hum Genet 14:1238-9. 2006
  56. ncbi request reprint Case-sibling gene-association studies for diseases with variable age at onset
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Med 23:3697-712. 2004
    ....
  57. ncbi request reprint SNPs, haplotypes, and cancer: applications in molecular epidemiology
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, School of Medicine, Abramson Cancer Center, University of Pennsylvania, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 13:681-7. 2004
  58. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
    ..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated...
  59. ncbi request reprint Betting odds and genetic associations
    Duncan C Thomas
    J Natl Cancer Inst 96:421-3. 2004
  60. ncbi request reprint Summary report: Missing data and pedigree and genotyping errors
    Michael D Badzioch
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, 98195, USA
    Genet Epidemiol 25:S36-42. 2003
    ..Overall, more consideration needs to be given to the effects that missing data and data errors have on our ability to map complex traits efficiently and accurately...
  61. ncbi request reprint Breast cancer risks for BRCA1/2 carriers
    Douglas F Easton
    Science 306:2187-91; author reply 2187-91. 2004
  62. ncbi request reprint The need for a systematic approach to complex pathways in molecular epidemiology
    Duncan C Thomas
    Cancer Epidemiol Biomarkers Prev 14:557-9. 2005
  63. ncbi request reprint Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study
    Jonine L Berstein
    Radiat Res 163:698-9. 2005
  64. ncbi request reprint Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Natl Cancer Inst 100:32-40. 2008
    ..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...
  65. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
    ..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers...
  66. pmc The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma
    Marinela Capanu
    Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, New York, NY 10021, U S A
    Stat Med 27:1973-92. 2008
    ..However, further research is needed to validate the application of asymptotic methods to such sparse data...
  67. ncbi request reprint Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty
    Daniel O Stram
    Health Phys 93:326-7; author reply 327-8. 2007
  68. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
  69. pmc Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement
    Michael Jerrett
    School of Public Health, Division of Environmental Health Science, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 116:1433-8. 2008
    ..The question of whether air pollution contributes to asthma onset remains unresolved...
  70. ncbi request reprint Are we ready for genome-wide association studies?
    Duncan C Thomas
    Cancer Epidemiol Biomarkers Prev 15:595-8. 2006
  71. ncbi request reprint Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15
    Michael D Swartz
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Genet Epidemiol 31:S96-102. 2007
    ..These group contributions exhibit the value of framing genetic problems in terms of model selection, and highlight the impact of variable selection for gene mapping...
  72. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
  73. ncbi request reprint Lung cancer etiology: independent and joint effects of genetics, tobacco, and arsenic
    Habibul Ahsan
    JAMA 292:3026-9. 2004

Research Grants21

  1. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1993
    ....
  2. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2000
    ..Explore extensions of these designs for gene mapping studies aimed at finding genes that interact with environmental agents. ..
  3. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2004
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  4. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1992
    ....
  5. SURVIVAL MODEL FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1991
    ....
  6. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2005
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  7. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2006
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  8. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2003
    ..Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible. ..
  9. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2003
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  10. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2002
    ..Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible. ..
  11. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2001
    ..Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible. ..
  12. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2000
    ..Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible. ..
  13. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 1999
    ..Explore extensions of these designs for gene mapping studies aimed at finding genes that interact with environmental agents. ..
  14. Methods for Pathway Modeling with Application to Folate
    Duncan C Thomas; Fiscal Year: 2010
    ....
  15. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2002
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  16. DESIGN AND ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES
    Duncan Thomas; Fiscal Year: 2007
    ..We will then sample from these populations to simulate replicate case-control data sets under known phenotype models to investigate the statistical performance of alternative study designs and analysis methods. ..