Alun Thomas

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Towards linkage analysis with markers in linkage disequilibrium by graphical modelling
    Alun Thomas
    Department of Biomedical Informatics, Genetic Epidemiology, University of Utah, Salt Lake City, Utah 84108, USA
    Hum Hered 64:16-26. 2007
  2. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
  3. pmc Case-control association testing by graphical modeling for the Genetic Analysis Workshop 17 mini-exome sequence data
    Haley J Abel
    Division of Genetic Epidemiology, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84105, USA
    BMC Proc 5:S62. 2011
  4. ncbi request reprint GMCheck: Bayesian error checking for pedigree genotypes and phenotypes
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Bioinformatics 21:3187-8. 2005
  5. pmc Assessment of SNP streak statistics using gene drop simulation with linkage disequilibrium
    Alun Thomas
    Department of Biomedical Informatics, University of Utah, USA
    Genet Epidemiol 34:119-24. 2010
  6. ncbi request reprint Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting
    Alun Thomas
    Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, 84108, USA
    Bioinformatics 22:771-2. 2006
  7. pmc The conditional independences between variables derived from two independent identically distributed Markov random fields when pairwise order is ignored
    Alun Thomas
    Genetic Epidemiology, University of Utah, Salt Lake City, UT 84108, USA
    Math Med Biol 27:283-8. 2010
  8. ncbi request reprint Characterizing allelic associations from unphased diploid data by graphical modeling
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah, Salt Lake City, Utah 84108, USA
    Genet Epidemiol 29:23-35. 2005
  9. pmc Effect of linkage disequilibrium on the identification of functional variants
    Alun Thomas
    Division of Genetic Epidemiology, University of Utah, Salt Lake City, UT 84108, USA
    Genet Epidemiol 35:S115-9. 2011
  10. pmc Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays
    A Thomas
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    Ann Hum Genet 72:279-87. 2008

Detail Information

Publications53

  1. ncbi request reprint Towards linkage analysis with markers in linkage disequilibrium by graphical modelling
    Alun Thomas
    Department of Biomedical Informatics, Genetic Epidemiology, University of Utah, Salt Lake City, Utah 84108, USA
    Hum Hered 64:16-26. 2007
    ..We conclude with a discussion of how this still experimental approach might be further developed...
  2. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
    ....
  3. pmc Case-control association testing by graphical modeling for the Genetic Analysis Workshop 17 mini-exome sequence data
    Haley J Abel
    Division of Genetic Epidemiology, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84105, USA
    BMC Proc 5:S62. 2011
    ..We found that our approach was able to describe the relationships between the outcomes and covariates and that it could correctly detect associations of disease with several loci and with a reasonable false-positive detection rate...
  4. ncbi request reprint GMCheck: Bayesian error checking for pedigree genotypes and phenotypes
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Bioinformatics 21:3187-8. 2005
    ..GMCheck uses graphical modeling to find the posterior probabilities of data errors given genotypes or phenotypes in a specified pedigree structure...
  5. pmc Assessment of SNP streak statistics using gene drop simulation with linkage disequilibrium
    Alun Thomas
    Department of Biomedical Informatics, University of Utah, USA
    Genet Epidemiol 34:119-24. 2010
    ..This is illustrated by reanalysis of a previously reported linkage of prostate cancer to chromosome 1p23...
  6. ncbi request reprint Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting
    Alun Thomas
    Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, 84108, USA
    Bioinformatics 22:771-2. 2006
    ..Genotypes may be missing or partially observed, and error rates can be simultaneously estimated...
  7. pmc The conditional independences between variables derived from two independent identically distributed Markov random fields when pairwise order is ignored
    Alun Thomas
    Genetic Epidemiology, University of Utah, Salt Lake City, UT 84108, USA
    Math Med Biol 27:283-8. 2010
    ..It explains why, in terms of the conditional independence structure, it sometimes does not matter whether you consider haplotypes or genotypes...
  8. ncbi request reprint Characterizing allelic associations from unphased diploid data by graphical modeling
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah, Salt Lake City, Utah 84108, USA
    Genet Epidemiol 29:23-35. 2005
    ..The graphical model approach is shown to have some advantages in terms of tractability and can be used to select informative subsets of loci and to map loci influencing phenotypes...
  9. pmc Effect of linkage disequilibrium on the identification of functional variants
    Alun Thomas
    Division of Genetic Epidemiology, University of Utah, Salt Lake City, UT 84108, USA
    Genet Epidemiol 35:S115-9. 2011
    ..The second unexpected result was that applying principal components analysis to genome-wide genotype data can apparently control not only for population structure but also for linkage disequilibrium...
  10. pmc Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays
    A Thomas
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    Ann Hum Genet 72:279-87. 2008
    ....
  11. ncbi request reprint GCHap: fast MLEs for haplotype frequencies by gene counting
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Bioinformatics 19:2002-3. 2003
    ..A second program, ApproxGCHap, is provided to give alternate estimates for data sets with large numbers of loci or large amounts of missing genotypes...
  12. ncbi request reprint Accelerated gene counting for haplotype frequency estimation
    Alun Thomas
    Department of Medical Informatics and the Center for High Performance Computing, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
    Ann Hum Genet 67:608-12. 2003
    ..The method is illustrated by haplotype frequency estimation from a sample of 45 individuals genotyped at 26 single nucleotide polymorphisms in the PIK3R1 gene...
  13. pmc Graphical modeling of the joint distribution of alleles at associated loci
    Alun Thomas
    Department of Medical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    Am J Hum Genet 74:1088-101. 2004
    ..Graphical models provide more flexibility to express these features of the joint distribution of alleles than do monotonic functions connecting physical and genetic maps...
  14. pmc A method and program for estimating graphical models for linkage disequilibrium that scale linearly with the number of loci, and their application to gene drop simulation
    Alun Thomas
    Department of Biomedical Informatics, Division of Genetic Epidemiology, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Bioinformatics 25:1287-92. 2009
    ..Efficient models for genetic linkage disequilibrium (LD) are needed to enable appropriate statistical analysis of the dense, genome-wide single nucleotide polymorphism assays currently available...
  15. ncbi request reprint Simulating realistic zero loop pedigrees using a bipartite Prufer code and graphical modelling
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Math Med Biol 21:335-45. 2004
    ..Summary statistics from pedigrees generated in this way can be used to check real pedigrees for anomalies due to biased sampling or phenotypic effects on the pedigree structure...
  16. pmc Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in mice
    Yuanyuan Wang
    Blood and Marrow Transplantation Program, Department of Medicine, University of Utah, 30 North 1900 East, SOM5C402, Salt Lake City, UT 84132, USA
    Immunogenetics 65:585-96. 2013
    ..This may lead to new approaches for overcoming the problem of graft rejection in clinical hematopoietic cell transplantation...
  17. pmc Pathways analysis of differential gene expression induced by engrafting doses of total body irradiation for allogeneic bone marrow transplantation in mice
    Xinjian Chen
    Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Immunogenetics 65:597-607. 2013
    ..These exploratory results highlight gene pathways that may be important in mediating BM engraftment resistance. ..
  18. pmc Pairwise shared genomic segment analysis in three Utah high-risk breast cancer pedigrees
    Zheng Cai
    Department of Biomedical Informatics, University of Utah Medical School, Health Sciences Education Building, Salt Lake City, UT 84112, USA
    BMC Genomics 13:676. 2012
    ..We applied a new weighted pairwise shared genomic segment (pSGS) analysis for susceptibility gene localization to high-density genomewide SNP data in three extended high-risk breast cancer pedigrees...
  19. pmc Haplotype association analyses in resources of mixed structure using Monte Carlo testing
    Ryan Abo
    Department of Biomedical Informatics, University of Utah, Salt Lake City, USA
    BMC Bioinformatics 11:592. 2010
    ..Both traditional association statistics and transmission/disequilibrium statistics can be performed. The method includes a phasing algorithm that can be used in large pedigrees and optional use of pseudocontrols...
  20. pmc Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based study
    Nicola J Camp
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 18:1290-4. 2009
    ..We also nominally replicated the association of prostate cancer with rs5945619 (Xp11). In particular, it seems that the susceptibility locus at 10q11 maybe involved in familial, early-onset disease...
  21. ncbi request reprint Identification of specific Y chromosomes associated with increased prostate cancer risk
    Lisa A Cannon-Albright
    Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah George E Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah Huntsman Cancer Institute, Salt Lake City, Utah
    Prostate 74:991-8. 2014
    ..Evidence supports the possibility of a role of the Y chromosome in prostate cancer, but controversy exists...
  22. pmc Shared genomic segment analysis: the power to find rare disease variants
    Stacey Knight
    Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Ann Hum Genet 76:500-9. 2012
    ..96 Mb region containing the known causal APC gene with genome-wide significance. SGS is a powerful method for detecting rare variants and a valuable complement to genome-wide association studies and linkage analysis...
  23. ncbi request reprint Estimating the parameters of a model for protein-protein interaction graphs
    Vikrant Deshmukh
    Department of Biomedical Informatics, University of Utah, 26 South 2000 East, Room 5775, Salt Lake City, UT 84112 5750, USA
    Math Med Biol 23:279-95. 2006
    ..Characterization of this model lays the foundation for its use as a prior distribution in a Bayesian analysis of yeast two-hybrid networks that can potentially aid in identifying false-positive and false-negative results...
  24. doi request reprint A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q
    Craig Teerlink
    Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hum Genet 131:77-85. 2012
    ..Our approach illustrates an example of using high-risk pedigrees for the identification of new melanoma predisposition variants...
  25. ncbi request reprint Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer
    Nicola J Camp
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Genet Epidemiol 28:232-43. 2005
    ....
  26. ncbi request reprint A multivariate time series approach to modeling and forecasting demand in the emergency department
    Spencer S Jones
    Department of Biomedical Informatics, University of Utah, Health Sciences Education Building, 26 S 2000 E, Salt Lake City, UT 84112 5750, USA
    J Biomed Inform 42:123-39. 2009
    ..The goals of this investigation were to study the temporal relationships between the demands for key resources in the emergency department (ED) and the inpatient hospital, and to develop multivariate forecasting models...
  27. ncbi request reprint Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Hum Hered 60:220-6. 2005
    ..No variants likely to contribute to autism were found in the coding sequence, exon-intron boundaries, or the promoter region of this gene...
  28. pmc Identification of regions of positive selection using Shared Genomic Segment analysis
    Zheng Cai
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Eur J Hum Genet 19:667-71. 2011
    ..Others are suggested to be novel regions. Our finding illustrates the utility of SGS as a method for identifying regions of selection, and some of these regions have been proposed to be candidate regions for harboring disease genes...
  29. pmc A chromosome 16 quantitative trait locus regulates allogeneic bone marrow engraftment in nonmyeloablated mice
    Thai M Cao
    Department of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 114:202-10. 2009
    ..K strain, that are permissive for allogeneic BM engraftment. Further identification of Bmgr5 genes by positional cloning may reveal new and effective approaches for overcoming BM engraftment obstacles...
  30. pmc Automated construction and testing of multi-locus gene-gene associations
    Ryan Abo
    Department of Biomedical Informatics, University of Utah School of Medicine, UT, USA
    Bioinformatics 27:134-6. 2011
    ..This tool provides a flexible data-mining approach to identifying gene-gene effects that otherwise is currently unavailable...
  31. pmc A parallel genetic algorithm to discover patterns in genetic markers that indicate predisposition to multifactorial disease
    Tobias Rausch
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Comput Biol Med 38:826-36. 2008
    ..In particular, the correlation analysis of IBD expression patterns might hint to possible gene-gene interactions and the filtering might be a fruitful approach to distinguish true correlation signals from noise...
  32. pmc Accuracy and computational efficiency of a graphical modeling approach to linkage disequilibrium estimation
    Haley J Abel
    University of Utah, Utah, USA
    Stat Appl Genet Mol Biol 10:Article 5. 2011
    ..While the times for fitting and imputation are both O(nm), the imputation process is considerably faster; thus, once a model is estimated from a reference data set, the marginal cost of phasing and imputing further samples is very low...
  33. ncbi request reprint Creation of a national resource with linked genealogy and phenotypic data: the Veterans Genealogy Project
    Lisa A Cannon-Albright
    Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Genet Med 15:541-7. 2013
    ..When complete, this US genealogy will be record linked to the National Veteran's Health Administration medical data representing more than 8 million US veterans...
  34. pmc Evaluation of record linkage between a large healthcare provider and the Utah Population Database
    Scott L DuVall
    VA Salt Lake City Health Care System, Salt Lake City, Utah, USA
    J Am Med Inform Assoc 19:e54-9. 2012
    ..Innovative approaches for creating research infrastructure beyond a traditional data system are necessary...
  35. pmc Pairwise shared genomic segment analysis in high-risk pedigrees: application to Genetic Analysis Workshop 17 exome-sequencing SNP data
    Zheng Cai
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    BMC Proc 5:S9. 2011
    ..7 false positives were identified per pedigree. In conclusion, we have demonstrated the potential of our new pSGS method for localizing rare disease causal variants in common disease using high-risk pedigrees and exome sequence data...
  36. doi request reprint Forecasting daily patient volumes in the emergency department
    Spencer S Jones
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA
    Acad Emerg Med 15:159-70. 2008
    ..There are few studies that explore the use of forecasting methods to predict patient volumes in the ED...
  37. pmc Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Hum Hered 72:258-63. 2011
    ..The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP...
  38. ncbi request reprint The impact of a growing minority population on identification of duplicate records in an enterprise data warehouse
    Scott L DuVall
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA
    Stud Health Technol Inform 160:1122-6. 2010
    ....
  39. pmc Identification of a major susceptibility locus for lethal graft-versus-host disease in MHC-matched mice
    Thai M Cao
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, 84132, USA
    J Immunol 183:462-9. 2009
    ..Further identification of Gvh genes by positional cloning may yield new insight into genetic control mechanisms regulating GVHD and potentially reveal novel approaches for effective GVHD therapy...
  40. ncbi request reprint Population-based risk assessment for other cancers in relatives of hereditary prostate cancer (HPC) cases
    Lisa A Cannon Albright
    Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Prostate 64:347-55. 2005
    ....
  41. doi request reprint Extending the Fellegi-Sunter probabilistic record linkage method for approximate field comparators
    Scott L DuVall
    Department of Biomedical Informatics, University of Utah, Utah, USA
    J Biomed Inform 43:24-30. 2010
    ..Given the ubiquity of linkage in both clinical and research settings, the incremental improvement of the extension has the potential to make a considerable impact...
  42. pmc Analysis of high-density single-nucleotide polymorphism data: three novel methods that control for linkage disequilibrium between markers in a linkage analysis
    Kristina Allen Brady
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, Utah 84108, USA
    BMC Proc 1:S160. 2007
    ..Additional work is required to further understand the effects of LD on linkage results and explore LD control methodology...
  43. pmc Extracting disease risk profiles from expression data for linkage analysis: application to prostate cancer
    G Bryce Christensen
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, Utah 84108 1266, USA
    BMC Proc 1:S82. 2007
    ..Our results do indicate there exists potential to augment our current knowledge about the relationships among genes associated with complex diseases using expression data...
  44. ncbi request reprint Use of strain typing data to estimate bacterial transmission rates in healthcare settings
    Brian R Jackson
    Department of Medical Informatics, University of Utah, Salt Lake City, Utah, USA
    Infect Control Hosp Epidemiol 26:638-45. 2005
    ..To create an affordable and accurate method for continuously monitoring bacterial transmission rates in healthcare settings...
  45. pmc Pedigree association: assigning individual weights to pedigree members for genetic association analysis
    Stacey Knight
    Biomedical Informatics Department, University of Utah, 26 South 2000 East Room 5775 HSEB, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S121. 2009
    ..We compare this new method with an existing weighting algorithm, a naïve analysis (relatedness is ignored), and an empirical method that appropriately accounts for all relationships (the gold standard)...
  46. ncbi request reprint Enumeration and simulation of marriage node graphs on zero-loop pedigrees
    Alun Thomas
    Department of Medical Informatics and Center for High Performance Computing, 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA
    Math Med Biol 20:261-75. 2003
    ..The enumeration method leads naturally to a scheme for simulating from a uniform distribution on such pedigrees. This is extended to simulating pedigrees for which the underlying marriage node graph is a tree of any particular size...
  47. pmc An application of the latent p value method to assess linkage in asthma pedigrees
    Craig C Teerlink
    Department of Internal Medicine, University of Utah School of Medicine, University of Utah, Salt Lake City, Utah 84108 1266, USA craig teerlink utah edu
    Hum Hered 70:1-8. 2010
    ..It is particularly applicable to genome-wide genetic linkage analysis for test statistics with poorly defined analytical distributions...
  48. ncbi request reprint The P2X7 receptor gene polymorphism 1513 A-->C has no effect on clinical prognostic markers, in vitro sensitivity to fludarabine, Bcl-2 family protein expression or survival in B-cell chronic lymphocytic leukaemia
    Jane Starczynski
    Department of Haematology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
    Br J Haematol 123:66-71. 2003
    ..These results indicate that the 1513 A-->C polymorphism of the P2X7 gene is unlikely to play a significant role in the pathogenesis or disease progression of B-CLL...
  49. ncbi request reprint Effect of linkage disequilibrium between markers in linkage and association analyses
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Epidemiol 31:S139-48. 2007
    ....
  50. ncbi request reprint A draft sequence of the rice genome (Oryza sativa L. ssp. japonica)
    Stephen A Goff
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA
    Science 296:92-100. 2002
    ..Assignment of candidate rice orthologs to Arabidopsis genes is possible in many cases. The rice genome sequence provides a foundation for the improvement of cereals, our most important crops...
  51. ncbi request reprint Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated
    Jane Starczynski
    Department of Haematology, Heartlands Hospital, Bordesley Green E, Birmingham, UK B91 1JR
    J Clin Oncol 23:1514-21. 2005
    ..This retrospective study assessed the clinical impact of a common single nucleotide polymorphism of the pro-apoptotic bax gene in patients with chronic lymphocytic leukemia...
  52. ncbi request reprint An analysis of unclassified missense substitutions in human BRCA1
    Sean V Tavtigian
    International Agency for Research on Cancer, Lyon, France
    Fam Cancer 5:77-88. 2006
    ....
  53. ncbi request reprint Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells
    Alun Thomas
    Department of Haematology, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan, CF64 2XX, UK
    Leuk Lymphoma 45:997-1008. 2004
    ....

Research Grants5

  1. ASSOCIATION BETWEEN PHENOTYPES AND DISEQUALIBRIATE LOCI
    Alun Thomas; Fiscal Year: 2006
    ..This proposal is to extend graphical modeling methods already developed by the investigators for haploid data to diploid data, larger genomic regions, admixed populations and family data. ..
  2. Graphical models for linkage disequilibrium in genetic mapping
    Alun Thomas; Fiscal Year: 2007
    ..For this aim of the project we intend to apply the methods developed to dense genotype assays obtained for distantly related breast cancer cases in extended Utah pedigrees. ..
  3. Graphical models for linkage disequilibrium in genetic mapping
    Alun Thomas; Fiscal Year: 2009
    ..For this aim of the project we intend to apply the methods developed to dense genotype assays obtained for distantly related breast cancer cases in extended Utah pedigrees. ..
  4. Graphical models for linkage disequilibrium in genetic mapping
    Alun Thomas; Fiscal Year: 2010
    ..For this aim of the project we intend to apply the methods developed to dense genotype assays obtained for distantly related breast cancer cases in extended Utah pedigrees. ..