Affiliation: University of New Mexico
- Perturbation of the glutamate-glutamine system in alcohol dependence and remissionRobert Thoma
MIND Research Network, Albuquerque, NM, USA
Neuropsychopharmacology 36:1359-65. 2011..The absence of differences in mean Glu and Gln between the AUD and AUD-R groups suggests that altered Glu-Gln metabolism may either predate the onset of abuse or persist during prolonged abstinence...
- Impaired secondary somatosensory gating in patients with schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
Psychiatry Res 151:189-99. 2007..Patients demonstrated no impairment in SI gating, but a robust gating deficit in SII, supporting the presence of cross modal gating deficits in schizophrenia...
- Hippocampus volume and episodic memory in schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA
J Int Neuropsychol Soc 15:182-95. 2009..In this sample of adults with schizophrenia, atypical relationships between regional hippocampus volumes and episodic memory ability were found, as was an atypical negative association between hippocampus volume and age...
- Developmental instability and the neural dynamics of the speed-intelligence relationshipRobert J Thoma
Center for Neuropsychological Services, Department of Psychiatry, 915 Vassar NE, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
Neuroimage 32:1456-64. 2006..These observations suggest that fluid intelligence is primarily related to speed during processing associated with decision time, while fluctuating asymmetry predicted slower processing across all stages of information processing...
- Neuropsychological and sensory gating deficits related to remote alcohol abuse history in schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
J Int Neuropsychol Soc 12:34-44. 2006....
- Schizophrenia diagnosis and anterior hippocampal volume make separate contributions to sensory gatingRobert J Thoma
Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
Psychophysiology 45:926-35. 2008..Schizophrenia diagnosis predicted M50 gating independent of hippocampal volume. These results are consistent with the finding that hippocampus is a critical part of a fronto-temporal circuit involved in auditory gating...
- Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performanceRobert J Thoma
Department of Psychiatry, University of New Mexico, Albuquerque, 87131, USA
Alcohol Clin Exp Res 35:39-46. 2011....
- Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophreniaRobert J Thoma
Psychiatry Service, Department of Radiology, New Mexico VA Health Care System, VAMC 116A, 1501 San Pedro SE, Albuquerque, NM 87108, USA
Am J Psychiatry 160:1595-605. 2003....
- Visual processing of facial affectStephen Lewis
Department of Psychiatry, University of New Mexico, School of Medicine, Albuquerque, NM 87131, USA
Neuroreport 14:1841-5. 2003..These findings are considered in the context of a specialized neural face-dependent information system...
- Cognitive abilities and 50- and 100-msec paired-click processes in schizophreniaAshley K Smith
Center for Functional Brain Imaging, New Mexico VA Health Care System, 1501 San Pedro Drive S E, Albuquerque, NM 87108, USA
Am J Psychiatry 167:1264-75. 2010..In addition, the functional implications remain unclear. In the present study, EEG and magnetoencephalography (MEG) were used to examine paired-click measures and cognitive correlates of paired-click activity...
- A specific test of hippocampal deficit in schizophreniaFaith M Hanlon
Department of Psychiatry, New Mexico Veterans Affairs Health Care System, University of New Mexico, Albuquerque, NM 87131, USA
Behav Neurosci 119:863-75. 2005..Patients' abnormal hippocampal lateralization may play a role in the hippocampal-dependent behavioral deficit...
- Resting state and task-induced deactivation: A methodological comparison in patients with schizophrenia and healthy controlsMaggie V Mannell
The MIND Research Network, Albuquerque, New Mexico, USA
Hum Brain Mapp 31:424-37. 2010..The increased posterior and reduced anterior connectivity may partially explain some of the cognitive dysfunction and clinical symptoms that are frequently associated with schizophrenia...
- Efficacy of olanzapine and risperidone in schizophrenia: a randomized double-blind crossover designJose M Canive
Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
Psychopharmacol Bull 39:105-16. 2006..Despite the small number of subjects, this study shows the potential of a within-subject design to elucidate differences in efficacy...
- Dynamic neural activity recorded from human amygdala during fear conditioning using magnetoencephalographySandra N Moses
Department of Psychology, University of New Mexico, Albuquerque, NM 87109, USA
Brain Res Bull 71:452-60. 2007..The amygdala also shows stimulus omission-related activation that could potentially provide feedback about experienced stimulus contingencies to modify future responding during learning and extinction...
- The impact of developmental instability on Voxel-Based Morphometry analyses of neuroanatomical abnormalities in schizophreniaMatthew Euler
Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA
Schizophr Res 115:1-7. 2009..These results support the DI approach and suggest that the unique etiologic factors associated with schizophrenia lead to widespread gray matter volume reductions...
- Distinct M50 and M100 auditory gating deficits in schizophreniaFaith M Hanlon
Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, New Mexico 87108, USA
Psychophysiology 42:417-27. 2005..In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating...
- Impairment on the hippocampal-dependent virtual Morris water task in schizophreniaFaith M Hanlon
The Mental Illness and Neuroscience Discovery MIND Institute, 1101 Yale Blvd NE, Albuquerque, New Mexico 87106, USA
Schizophr Res 87:67-80. 2006..There was no deficit in the visible-platform condition. These findings identify a behavioral impairment on a hippocampal-dependent task in schizophrenia and support using the MWT in testing animal models of schizophrenia...
- Abnormal stimulus-response intensity functions in posttraumatic stress disorder: an electrophysiological investigationJeffrey David Lewine
Departments of Psychology and Psychiatry, University of New Mexico, Albuquerque, NM, USA
Am J Psychiatry 159:1689-95. 2002....
- Superior temporal gyrus spectral abnormalities in schizophreniaJ Christopher Edgar
Department of Psychology, Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Psychophysiology 45:812-24. 2008..Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure...
- A parietal-frontal network studied by somatosensory oddball MEG responses, and its cross-modal consistencyMing Xiong Huang
Department of Radiology, University of California, San Diego, 92103 8756, USA
Neuroimage 28:99-114. 2005....
- M50 sensory gating predicts negative symptoms in schizophreniaRobert J Thoma
Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
Schizophr Res 73:311-8. 2005..This finding is compatible with information processing theories of negative symptoms and with more recent findings of fronto-temporal abnormality in patients with predominantly negative symptoms...
- Cross-modal generality of the gating deficitJ Christopher Edgar
Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, IL 61820, USA
Psychophysiology 42:318-27. 2005..Patients showed abnormal auditory M50 gating but normal somatosensory M20 gating. Results argue against a cross-modal gating deficit in primary somatosensory cortex...
- A non-invasive method for observing hippocampal functionFaith M Hanlon
New Mexico VA Health Care System, 1501 San Pedro Drive, SE Albuquerque, NM 87108, USA
Neuroreport 14:1957-60. 2003..Patients with unilateral hippocampal damage showed activation in undamaged hippocampus. MEG during transverse patterning performance is a promising, non-invasive tool for assessing hippocampal function...
- Brain and Behavioral Impairment in Alcohol Dependence and SchizophreniaRobert Thoma; Fiscal Year: 2007..It is relevant public health research in that it will help to develop new tools and biomarkers sensitive to alcohol-related cognitive dysfunction, and will expand our knowledge of cognitive recovery. ..
- Adolescent Neurodevelopment and AlcoholRobert Thoma; Fiscal Year: 2007..This interdisciplinary project closely follows the guidelines set out in the 2005 NIH Roadmap. ..