S L Thibeault

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc In vivo comparison of biomimetic approaches for tissue regeneration of the scarred vocal fold
    Susan L Thibeault
    Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792 7375, USA
    Tissue Eng Part A 15:1481-7. 2009
  2. pmc A method for identification of vocal fold lamina propria fibroblasts in culture
    Susan L Thibeault
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, WI, USA
    Otolaryngol Head Neck Surg 139:816-22. 2008
  3. pmc At the crossroads: mucosal immunology of the larynx
    S L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mucosal Immunol 2:122-8. 2009
  4. ncbi request reprint Gene expression changes of inflammatory mediators in posterior laryngitis due to laryngopharyngeal reflux and evolution with PPI treatment: a preliminary study
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    Laryngoscope 117:2050-6. 2007
  5. ncbi request reprint Histologic and rheologic characterization of vocal fold scarring
    Susan L Thibeault
    Department of Surgery, University of Utah, Primary Children s Hospital, Salt Lake City 84113, USA
    J Voice 16:96-104. 2002
  6. ncbi request reprint In vivo engineering of the vocal fold extracellular matrix with injectable hyaluronic acid hydrogels: early effects on tissue repair and biomechanics in a rabbit model
    Jennifer K Hansen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, The University of Utah, Salt Lake City, UT 84132 2301, USA
    Ann Otol Rhinol Laryngol 114:662-70. 2005
  7. pmc Characteristics of age-related changes in cultured human vocal fold fibroblasts
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792 7275, USA
    Laryngoscope 118:1700-4. 2008
  8. ncbi request reprint Characterization of chronic vocal fold scarring in a rabbit model
    Bernard Rousseau
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Voice 18:116-24. 2004
  9. ncbi request reprint Attitudes of children with dysphonia
    Nadine P Connor
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Voice 22:197-209. 2008
  10. pmc Role of tumor necrosis factor-alpha in wound repair in human vocal fold fibroblasts
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Laryngoscope 120:1819-25. 2010

Collaborators

Detail Information

Publications41

  1. pmc In vivo comparison of biomimetic approaches for tissue regeneration of the scarred vocal fold
    Susan L Thibeault
    Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792 7375, USA
    Tissue Eng Part A 15:1481-7. 2009
    ..Optimization of cell-scaffold interactions and subsequent cell behavior is necessary for utilization of scaffold and scaffold-cell approaches...
  2. pmc A method for identification of vocal fold lamina propria fibroblasts in culture
    Susan L Thibeault
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, WI, USA
    Otolaryngol Head Neck Surg 139:816-22. 2008
    ..We present an in vitro technique that allows for identification of fibroblasts by ruling out the possibility of the cells belonging to other lineages that are found in vocal fold tissue...
  3. pmc At the crossroads: mucosal immunology of the larynx
    S L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mucosal Immunol 2:122-8. 2009
    ....
  4. ncbi request reprint Gene expression changes of inflammatory mediators in posterior laryngitis due to laryngopharyngeal reflux and evolution with PPI treatment: a preliminary study
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    Laryngoscope 117:2050-6. 2007
    ....
  5. ncbi request reprint Histologic and rheologic characterization of vocal fold scarring
    Susan L Thibeault
    Department of Surgery, University of Utah, Primary Children s Hospital, Salt Lake City 84113, USA
    J Voice 16:96-104. 2002
    ..This animal model should allow for systematic future investigations of vocal fold scarring and its treatment...
  6. ncbi request reprint In vivo engineering of the vocal fold extracellular matrix with injectable hyaluronic acid hydrogels: early effects on tissue repair and biomechanics in a rabbit model
    Jennifer K Hansen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, The University of Utah, Salt Lake City, UT 84132 2301, USA
    Ann Otol Rhinol Laryngol 114:662-70. 2005
    ....
  7. pmc Characteristics of age-related changes in cultured human vocal fold fibroblasts
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792 7275, USA
    Laryngoscope 118:1700-4. 2008
    ..The purpose of this study was to compare the morphological and proliferation characteristics and gene expression of hVFFs from different aged donors...
  8. ncbi request reprint Characterization of chronic vocal fold scarring in a rabbit model
    Bernard Rousseau
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Voice 18:116-24. 2004
    ..Based on these results, a 6-month postoperative time frame is proposed for future studies of chronic vocal fold scarring using the rabbit animal model...
  9. ncbi request reprint Attitudes of children with dysphonia
    Nadine P Connor
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Voice 22:197-209. 2008
    ..Chronic dysphonia negatively affects the lives of children. This work will serve as the basis for development of a valid, reliable, and age-appropriate measure of voice-related quality of life in children...
  10. pmc Role of tumor necrosis factor-alpha in wound repair in human vocal fold fibroblasts
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Laryngoscope 120:1819-25. 2010
    ....
  11. ncbi request reprint Advances in our understanding of the Reinke space
    Susan L Thibeault
    The University of Utah, Division of Otolaryngology Head and Neck Surgery, Department of Surgery, School of Medicine, Salt Lake City, Utah 84132 2301, USA
    Curr Opin Otolaryngol Head Neck Surg 13:148-51. 2005
    ..In this article, the present literature on the Reinke space in normal and disease states is reviewed including publications in the multidisciplinary fields of biomechanics, histology, molecular biology, and tissue engineering...
  12. ncbi request reprint Characterization of vocal fold scarring in a canine model
    Bernard Rousseau
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Laryngoscope 113:620-7. 2003
    ..The objective was to assess the histological and viscoelastic shear tissue properties of the scarred vocal fold lamina propria at 2 and 6 months postoperatively in a canine model...
  13. ncbi request reprint Instability of extracellular matrix gene expression in primary cell culture of fibroblasts from human vocal fold lamina propria and tracheal scar
    Susan L Thibeault
    Department of Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 111:8-14. 2002
    ..Recommendations for use of primary cell cultures for further studies of gene expression are made...
  14. ncbi request reprint Hyaluronan levels in acute vocal fold scar
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah, USA
    Laryngoscope 114:760-4. 2004
    ..The objective was to measure the level of hyaluronan during the first 15 days after vocal fold biopsy in a rabbit model...
  15. ncbi request reprint Viscoelasticity of hyaluronan and nonhyaluronan based vocal fold injectables: implications for mucosal versus muscle use
    Trace Caton
    Division of Otolaryngology Head and Neck Surgery, The University of Utah, Salt Lake City, Utah, USA
    Laryngoscope 117:516-21. 2007
    ....
  16. ncbi request reprint Fine needle aspiration of the vocal fold lamina propria in an animal model
    Will Cobell
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, School of Medicine, University of Utah, Salt Lake City, USA
    Ann Otol Rhinol Laryngol 115:764-8. 2006
    ..The objective of this study was to determine whether FNA of the VF lamina propria is feasible and whether it causes injury to the VF...
  17. pmc Biocompatibility of a synthetic extracellular matrix on immortalized vocal fold fibroblasts in 3-D culture
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, 5136 WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
    Acta Biomater 6:2940-8. 2010
    ..This investigation demonstrates that Carbylan GSX may serve as a natural biomaterial for tissue-engineering of human vocal folds...
  18. ncbi request reprint Genotypic and phenotypic expression of vocal fold polyps and Reinke's edema: a preliminary study
    Susan L Thibeault
    Department of Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 111:302-9. 2002
    ..The study also gives clues as to the proteins responsible for the phenotype...
  19. ncbi request reprint DNA microarray gene expression analysis of a vocal fold polyp and granuloma
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, School of Medicine, University of Utah, Salt Lake City 84132 2301, USA
    J Speech Lang Hear Res 46:491-502. 2003
    ..Further investigation is needed on larger sample sizes to establish transcriptional gene expression patterns for VP and VG...
  20. pmc Inhibitory effects of hepatocyte growth factor and interleukin-6 on transforming growth factor-beta1 mediated vocal fold fibroblast-myofibroblast differentiation
    Bimal Vyas
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Ann Otol Rhinol Laryngol 119:350-7. 2010
    ..The objective of this investigation was to develop and characterize a myofibroblast in vitro model that could be utilized to investigate the molecular mechanism of myofibroblast differentiation and function in injured vocal fold tissue...
  21. ncbi request reprint Inflammatory cytokine responses to synthetic extracellular matrix injection to the vocal fold lamina propria
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison 53792 7375, USA
    Ann Otol Rhinol Laryngol 117:221-6. 2008
    ..We determined cytokine profiles for tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1alpha, and IL-1beta after injection of a synthetic extracellular matrix into the vocal fold lamina propria...
  22. pmc Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Tissue Eng Part C Methods 15:201-12. 2009
    ..This is the first report of immortalization and biochemical characterization of hVFFs, providing a novel and invaluable tool for tissue regeneration applications in the larynx...
  23. pmc Characterization of mesenchymal stem cells from human vocal fold fibroblasts
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    Laryngoscope 120:546-51. 2010
    ..We hypothesized that human vocal fold fibroblasts (hVFF) isolated from the lamina propria meet the criteria established to define MSCs and are functionally similar to MSCs derived from BM and adipose tissue...
  24. ncbi request reprint Microarray analysis of allergic fungal sinusitis and eosinophilic mucin rhinosinusitis
    Richard R Orlandi
    Division of Otolaryngology Head and Neck Surgery, University of Utah, Salt Lake City, UT 84132, USA
    Otolaryngol Head Neck Surg 136:707-13. 2007
    ..Our goal was to determine and compare the differential gene expression in allergic fungal sinusitis (AFS) and eosinophilic mucin rhinosinusitis (EMRS)...
  25. pmc Localization of label-retaining cells in murine vocal fold epithelium
    Ciara Leydon
    Brooklyn College, New York, NY, USA
    J Speech Lang Hear Res 54:1060-6. 2011
    ..As a known characteristic of stem cells is that they are slow-cycling in vivo, the purpose of this prospective controlled study was to identify and quantify slow-cycling cells or putative stem cells in murine vocal fold epithelium...
  26. ncbi request reprint Occupational risk factors associated with voice disorders among teachers
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Utah, Salt Lake City, UT 84132, USA
    Ann Epidemiol 14:786-92. 2004
    ..This study was designed to determine the occupational risk factors associated with voice disorders among schoolteachers, a high-risk population for developing voice problems...
  27. ncbi request reprint Differential gene expression profiling of vocal fold polyps and Reinke's edema by complementary DNA microarray
    Suzy M Duflo
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, School of Medicine, The University of Utah, Salt Lake City, Utah, USA
    Ann Otol Rhinol Laryngol 115:703-14. 2006
    ..Established transcript profiles can provide insight into the molecular and cellular processes involved in these diseases...
  28. ncbi request reprint Quality of life in children with velopharyngeal insufficiency
    Lucy Barr
    Division of Otolaryngology Head and Neck Surgery, The University of Utah, Salt Lake City, USA
    Arch Otolaryngol Head Neck Surg 133:224-9. 2007
    ..To determine if quality of life (QOL) is affected in children with velopharyngeal insufficiency (VPI)...
  29. ncbi request reprint Comparison of telomere length of vocal folds with different tissues: a physiological measurement of vocal senescence
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Utah, Salt Lake City, Utah 84132 2301, USA
    J Voice 20:165-70. 2006
    ..05, R2 = 0.624). Our findings indicate that surrogate tissue for measurement of telomere length of TVF includes FVF, bone marrow, skin, and aorta. These findings have implications for understanding vocal fold aging at the cellular level...
  30. ncbi request reprint Effect of a synthetic extracellular matrix on vocal fold lamina propria gene expression in early wound healing
    Suzy Duflo
    Fédération d Otorhinolaryngology, Head and Neck Surgery, Hopital de la Timone, Marseille, France
    Tissue Eng 12:3201-7. 2006
    ..This amplification provided an optimal environment for tissue regeneration and may lead to the recovery of the functional biomechanical properties of the vocal folds necessary for voice production...
  31. ncbi request reprint Current understanding and review of the literature: vocal fold scarring
    Jennifer K Hansen
    University of Utah, School of Medicine, Division of Otolaryngology Head and Neck Surgery, Salt Lake City, UT 84132, USA
    J Voice 20:110-20. 2006
    ..We present an up-to-date, thorough, and scholarly review of the literature in vocal fold scarring since 1996...
  32. ncbi request reprint Extracellular matrix gene expression after vocal fold injury in a rabbit model
    Bernard Rousseau
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Ann Otol Rhinol Laryngol 117:598-603. 2008
    ..We determined the expression of matrix metalloproteinase (MMP)-1, MMP-9, collagen types I and III, and fibronectin from rabbit vocal folds after injury...
  33. ncbi request reprint Hyaluronic acid: its role in voice
    P Daniel Ward
    School of Medicine, University of Utah, Salt Lake City 84113, USA
    J Voice 16:303-9. 2002
    ..This article provides an introduction to the structure and biological functions of HA and its importance in voice. In addition, an overview of the pharmaceutical applications of HA is discussed...
  34. pmc Experimentally induced phonation increases matrix metalloproteinase-1 gene expression in normal rabbit vocal fold
    Bernard Rousseau
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, TN 37232 4480, USA
    Otolaryngol Head Neck Surg 138:62-8. 2008
    ..An in vivo rabbit model was used to study the effect of 3 hours of experimentally induced phonation on messenger RNA expression of the normal vocal fold...
  35. ncbi request reprint Interstitial protein alterations in rabbit vocal fold with scar
    Susan L Thibeault
    Division of Otolaryngology, Head and Neck Surgery, Department of Communicative Disorders, University of Utah, Salt Lake City 84132, USA
    J Voice 17:377-83. 2003
    ..The implications of altered interstitial proteins levels and their affect on the fibrous proteins will be discussed in relation to increased vocal fold stiffness and viscosity, which characterizes vocal fold scar...
  36. ncbi request reprint Vocal fold tissue repair in vivo using a synthetic extracellular matrix
    Suzy Duflo
    Fédération d Otorhinolaryngology, Head and Neck Surgery, Hopital de la Timone, Marseille, France
    Tissue Eng 12:2171-80. 2006
    ..Both Carbylan-SX and Carbylan-GSX significantly improved tissue elasticity and viscosity. Carbylan-GSX containing 5% w/w gelatin showed the most promise as a scaffold material for vocal fold tissue regeneration...
  37. ncbi request reprint Fibronectin: an interesting vocal fold protein
    Scot D Hirschi
    University of Utah Medical School, Salt Lake City 84123, USA
    J Voice 16:310-6. 2002
    ..Lastly, it discusses preliminary microarray data that show gene expression for fibronectin to be upregulated in true vocal folds when compared to false vocal folds...
  38. ncbi request reprint Relationship between time of exposure of laryngopharyngeal reflux and gene expression in laryngeal fibroblasts
    Riitta Ylitalo
    Department of Otolaryngology Head and Neck Surgery, Karolinska Institute, Stockholm, Sweden
    Ann Otol Rhinol Laryngol 115:775-83. 2006
    ..The purpose of this study was to determine whether varying the exposure times at low pH with or without pepsin alters gene expression in laryngeal fibroblasts...
  39. ncbi request reprint Diversity in voice characteristics--interaction between genes and environment, use of microarray analysis
    Steven D Gray
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Utah, Salt Lake City 84132, USA
    J Commun Disord 35:347-54. 2002
    ..Some voice disorders have been treated successfully through using proteomic approaches...
  40. doi request reprint Does hyaluronic acid distribution in the larynx relate to the newborn's capacity for crying?
    John M Schweinfurth
    Department of Otolaryngology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Laryngoscope 118:1692-9. 2008
    ..Our objective was to examine the histological structure and the quantity and arrangement of HA within the lamina propria of the pediatric larynx and review the relevant physiology of hyaluronic acid and its impact on voice production...
  41. ncbi request reprint Injectable synthetic extracellular matrices for tissue engineering and repair
    Glenn D Prestwich
    Department of Medicinal Chemistry, The University of Utah, Salt Lake City, Utah, USA
    Adv Exp Med Biol 585:125-33. 2006

Research Grants14

  1. Fine Needle Aspiration of Benign Vocal Fold Lesions
    Susan Thibeault; Fiscal Year: 2004
    ..abstract_text> ..
  2. ENGINEERING THE VOCAL FOLD EXTRACELLULAR MATRIX
    Susan Thibeault; Fiscal Year: 2009
    ..The overarching hypothesis is that in vivo ECM manipulation with injectable HA agents will yield optimal tissue composition and biomechanically functional results. ..
  3. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan Thibeault; Fiscal Year: 2009
    ..This project will provide a comprehensive understanding of the interaction between the laryngeal mucosal immune system and inflammatory challenges as considered by the genome, proteome and bacteriome. ..
  4. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan L Thibeault; Fiscal Year: 2010
    ..This project will provide a comprehensive understanding of the interaction between the laryngeal mucosal immune system and inflammatory challenges as considered by the genome, proteome and bacteriome. ..
  5. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan Thibeault; Fiscal Year: 2009
    ..This project will provide a comprehensive understanding of the interaction between the laryngeal mucosal immune system and inflammatory challenges as considered by the genome, proteome and bacteriome. ..
  6. Safety & effectiveness of HA hydrogels in immortalized vocal fold fibroblast cell
    Susan Thibeault; Fiscal Year: 2007
    ..Efforts from this R21 will provide imminent directions for an R01 focusing on human clinical trials for treatment of ECM disorders. ..
  7. ENGINEERING THE VOCAL FOLD EXTRACELLULAR MATRIX
    Susan L Thibeault; Fiscal Year: 2010
    ..The proposed research defines a novel and fundamental tissue engineering approach to repair vocal folds with longstanding damage due to injury or disease ..