DAN contact THEODORESCU

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma
    Hillary L Copp
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    Cancer 107:60-6. 2006
  2. ncbi request reprint Radical cystectomy with ileal conduit diversion: early prospective evaluation of the impact of robotic assistance
    Jonathan J Rhee
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    BJU Int 98:1059-63. 2006
  3. ncbi request reprint Atypical small acinar proliferation: biopsy artefact or distinct pathological entity?
    Sarah C Flury
    Department of Urology, University of Virginia Health System, Charlottesville, VA, USA
    BJU Int 99:780-5. 2007
  4. doi request reprint Predicting tumor outcomes in urothelial bladder carcinoma: turning pathways into clinical biomarkers of prognosis
    Behfar Ehdaie
    Department of Urology, Box 422, University of Virginia, Charlottesville, Virginia 22908, USA
    Expert Rev Anticancer Ther 8:1103-10. 2008
  5. pmc Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis
    Behfar Ehdaie
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Indian J Urol 24:61-7. 2008
  6. pmc Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts
    L R Karns
    1Upstate Biotechnology Inc, Charlottesville, Virginia, USA
    BMC Biotechnol 1:11. 2001
  7. ncbi request reprint Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression
    D Theodorescu
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Int J Cancer 78:775-82. 1998
  8. ncbi request reprint Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
    Dan Theodorescu
    Department of Molecular Physiology, Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA, USA
    Lancet Oncol 7:230-40. 2006
  9. ncbi request reprint The impact of prostate volume following neoadjuvant androgen deprivation on quality of life and voiding symptoms in patients undergoing permanent prostate brachytherapy
    Tracey Krupski
    Department of Urology, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    Eur Urol 43:467-72. 2003
  10. ncbi request reprint Molecular pathogenesis of urothelial bladder cancer
    D Theodorescu
    University of Virginia, Department of Urology, P O Box 800422, Charlottesville, Virginia 22908, USA
    Histol Histopathol 18:259-74. 2003

Research Grants

  1. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2006
  2. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2007
  3. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2005
  4. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2005
  5. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2004
  6. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2004
  7. RAl GTPases and partners in human bladder cancer metastasis
    Dan Theodorescu; Fiscal Year: 2009
  8. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2003
  9. Understanding the RhoGDI2 metastasis suppressor gene
    DAN contact THEODORESCU; Fiscal Year: 2010
  10. Signaling and Progression in Prostate Cancer
    Dan Theodorescu; Fiscal Year: 2007

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma
    Hillary L Copp
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    Cancer 107:60-6. 2006
    ....
  2. ncbi request reprint Radical cystectomy with ileal conduit diversion: early prospective evaluation of the impact of robotic assistance
    Jonathan J Rhee
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    BJU Int 98:1059-63. 2006
    ..To compare the performance of radical cystectomy with ileal conduit diversion by standard methods with that using the assistance of the daVinci robotic system (Intuitive Surgical, Sunnyvale, CA, USA)...
  3. ncbi request reprint Atypical small acinar proliferation: biopsy artefact or distinct pathological entity?
    Sarah C Flury
    Department of Urology, University of Virginia Health System, Charlottesville, VA, USA
    BJU Int 99:780-5. 2007
    ....
  4. doi request reprint Predicting tumor outcomes in urothelial bladder carcinoma: turning pathways into clinical biomarkers of prognosis
    Behfar Ehdaie
    Department of Urology, Box 422, University of Virginia, Charlottesville, Virginia 22908, USA
    Expert Rev Anticancer Ther 8:1103-10. 2008
    ....
  5. pmc Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis
    Behfar Ehdaie
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Indian J Urol 24:61-7. 2008
    ..The discovery of biomarkers has enabled the elucidation of targets for novel therapeutic agents to disrupt the deregulation underlying the development and progression of urothelial carcinogenesis...
  6. pmc Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts
    L R Karns
    1Upstate Biotechnology Inc, Charlottesville, Virginia, USA
    BMC Biotechnol 1:11. 2001
    ..The popularity of the ecdysone inducible gene switch system has led us to investigate whether such a system can successfully regulate gene expression in a syngeneic tumor system in vivo...
  7. ncbi request reprint Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression
    D Theodorescu
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Int J Cancer 78:775-82. 1998
    ..Our results would seem to corroborate the notion that a high dietary intake of isoflavones is a likely explanation for the decreased incidence of invasive bladder cancer...
  8. ncbi request reprint Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
    Dan Theodorescu
    Department of Molecular Physiology, Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA, USA
    Lancet Oncol 7:230-40. 2006
    ..We aimed to use mass spectrometry and bioinformatics to define and validate a cancer-specific proteomic pattern...
  9. ncbi request reprint The impact of prostate volume following neoadjuvant androgen deprivation on quality of life and voiding symptoms in patients undergoing permanent prostate brachytherapy
    Tracey Krupski
    Department of Urology, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    Eur Urol 43:467-72. 2003
    ..We sought to determine if data from patients treated with neoadjuvant androgen ablation followed by BT at our institution supported this notion using a cross-sectional study design...
  10. ncbi request reprint Molecular pathogenesis of urothelial bladder cancer
    D Theodorescu
    University of Virginia, Department of Urology, P O Box 800422, Charlottesville, Virginia 22908, USA
    Histol Histopathol 18:259-74. 2003
    ..The intent of this review is to provide the reader an overview of our current understanding of this tumor from the standpoint of its molecular biology as related to tumor development and progression...
  11. ncbi request reprint Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer
    Dan Theodorescu
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Clin Cancer Res 10:3800-6. 2004
    ....
  12. ncbi request reprint RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation
    Michael A Harding
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    Urol Oncol 25:401-6. 2007
    ..These targets, endothelin-1 and Neuromedin U are excellent potential targets for therapeutic intervention in the metastatic cascade...
  13. ncbi request reprint Why patients choose prostatectomy or brachytherapy for localized prostate cancer: results of a descriptive survey
    Joshua D Hall
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Urology 61:402-7. 2003
    ..Therefore, we carried out a descriptive pilot study to determine such motivations, sources of information, and other variables that influence how such patients choose between radical prostatectomy (RP) and brachytherapy (BT)...
  14. doi request reprint Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    Peter C Black
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:1478-86. 2008
    ..The aim of this study was to define molecular markers of response to cetuximab therapy in a panel of urothelial carcinoma cell lines...
  15. ncbi request reprint Tumor control outcomes of patients treated with trimodality therapy for locally advanced prostate cancer
    Hillary Copp
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Urology 65:1146-51. 2005
    ..We adopted trimodality therapy (neoadjuvant and adjuvant androgen ablation, external beam radiotherapy [RT], and a brachytherapy boost) to augment biochemical disease-free survival in this patient population...
  16. ncbi request reprint Undetectable prostate specific antigen at 6-12 months: a new marker for early success in hormonally treated patients after prostate brachytherapy
    Nicole Miller
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer 103:2499-506. 2005
    ..To address this, the authors sought to develop a new predictive marker in such patients after prostate brachytherapy (BT)...
  17. pmc Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy
    COURTNEY POLLARD
    Department of Molecular Physiology, University of Virginia, Charlottesville, 22908, USA
    Am J Pathol 175:1824-30. 2009
    ..Although these predictive results were obtained on tumor tissues, the presence of GGH and DBI in urine serves as a rationale for developing them as urinary markers of clinical outcomes for patients treated with neoadjuvant MVAC...
  18. pmc Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function
    Yimin Wu
    Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 106:5807-12. 2009
    ..Our findings also suggest caution in using Src inhibitors in the hope of delaying progression in patients with bladder cancer...
  19. doi request reprint Pathways of metastasis suppression in bladder cancer
    Neveen Said
    Department of Urology, University of Virginia, Box 800422, Charlottesville, VA 22908, USA
    Cancer Metastasis Rev 28:327-33. 2009
    ..In this review, we will discuss the established roles of c-Src and RhoGDI2 in bladder cancer and speculate on their therapeutic relevance...
  20. ncbi request reprint Gene profiling and promoter reporter assays: novel tools for comparing the biological effects of botanical extracts on human prostate cancer cells and understanding their mechanisms of action
    Dora Bigler
    Department of Molecular Physiology and Biological Physics and Cancer Center, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    Oncogene 22:1261-72. 2003
    ....
  21. ncbi request reprint Impact of a novel neoadjuvant and adjuvant hormone-deprivation approach on quality of life, voiding function, and sexual function after prostate brachytherapy
    Nicole L Miller
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Cancer 97:1203-10. 2003
    ..A cross-sectional study was undertaken to evaluate the impact on QOL, voiding function, and sexual function of an alternative hormone-deprivation approach...
  22. ncbi request reprint RhoGDI2 is an invasion and metastasis suppressor gene in human cancer
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 62:6418-23. 2002
    ..These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human cancer, and a promising target for therapy...
  23. ncbi request reprint Surgery or radiation: what is the optimal management for locally advanced prostate cancer?
    Sophie G Fletcher
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Can J Urol 12:58-61; discussion 101-2. 2005
    ..In this short review we highlight key studies that may provide interim answers while awaiting definitive results from randomized studies...
  24. pmc Complementary and alternative medicine modality use and beliefs among African American prostate cancer survivors
    Randy A Jones
    School of Nursing, University of Virginia, Charlottesville, VA, USA
    Oncol Nurs Forum 34:359-64. 2007
    ..To examine the cultural beliefs and attitudes of African American prostate cancer survivors regarding the use of complementary and alternative medicine (CAM) modalities...
  25. ncbi request reprint Robot-assisted radical cystectomy in the management of bladder cancer
    Jessica L Keim
    Paul Mellon Prostate Cancer Institute and Department of Urology, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    ScientificWorldJournal 6:2560-5. 2006
    ....
  26. pmc A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
    Jae K Lee
    Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 104:13086-91. 2007
    ..Furthermore, we used COXEN for in silico screening of 45,545 compounds and identify an agent with activity against human bladder cancer...
  27. doi request reprint RhoGDI signaling provides targets for cancer therapy
    Michael A Harding
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    Eur J Cancer 46:1252-9. 2010
    ..Several novel therapeutic strategies are proposed for intervening in RhoGDI signaling, and potential complications arising from their implementation are discussed...
  28. pmc Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas
    Helen P Cathro
    Department of Pathology, University of Virginia Health System, Charlottesville, 22908, USA
    Cancer Immunol Immunother 59:465-72. 2010
    ..The goal of this study was to analyze protein expression of antigen processing machinery (APM) components in bladder carcinoma (BC), and to assess the clinical significance of defects in their expression...
  29. doi request reprint Invasion and metastasis models for studying RhoGDI2 in bladder cancer
    Matthew D Nitz
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Methods Enzymol 439:219-33. 2008
    ....
  30. pmc Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer
    Dmytro M Havaleshko
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 11:1185-93. 2009
    ..These results have significant implications for the use of such tools in personalizing the approach to cancers treated with EGFR-directed targeted therapies...
  31. pmc Prospective comparison of clinical and genomic multivariate predictors of response to neoadjuvant chemotherapy in breast cancer
    Jae K Lee
    Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    Clin Cancer Res 16:711-8. 2010
    ..Our goal was to compare the performance of four conceptually different predictors in an independent cohort of patients...
  32. pmc Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis
    Zhong Wu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 11:66-76. 2009
    ..Our results suggest a hypothetical model whereby PTEN loss upregulates cell cycle genes such as cdc6 and cyclin E2 that in turn promote metastatic colonization at distant sites...
  33. doi request reprint Integrin agonists as adjuvants in chemotherapy for melanoma
    Martin A Schwartz
    Department of Microbiology, Robert M Berne Cardiovascular Research Center, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA
    Clin Cancer Res 14:6193-7. 2008
    ..Thus, reduced integrin-dependent adhesion to ECM could mediate therapy resistance. The goal of this study was to test whether stimulation of integrin signaling could increase chemotherapeutic efficacy...
  34. pmc Family interactions among African American prostate cancer survivors
    Randy A Jones
    School of Nursing, University of Virginia, Charlottesville, VA 22908, USA
    Fam Community Health 31:213-20. 2008
    ..Data analysis revealed that support from family members and friends plays an important role in how men cope with their treatment and recovery from prostate cancer...
  35. pmc Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination
    Steven Christopher Smith
    Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Pathol 174:371-9. 2009
    ..In summary, LAMC2 is a novel biomarker of bladder cancer metastasis that reflects the propensity of cells to metastasize via either lymphatic or hematogenous routes...
  36. ncbi request reprint When is a negative lymph node really negative? Molecular tools for the detection of lymph node metastasis from urological cancer
    Dan Theodorescu
    Department of Urology, Molecular Physiology, University of Virginia Health System, Charlottesville, VA 22908 0422, USA
    Urol Oncol 22:256-9. 2004
  37. ncbi request reprint Determinants of long-term quality of life and voiding function of patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer
    Emily B Bradley
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0422, USA
    BJU Int 94:1003-9. 2004
    ..To assess the long-term quality of life (QoL) outcomes of three treatments for localized prostate cancer: radical prostatectomy (RP); brachytherapy monotherapy (BTM); and BT combined with external beam radiotherapy (BTC)...
  38. ncbi request reprint Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine
    Dan Theodorescu
    Paul Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, VA 22908, USA
    Electrophoresis 26:2797-808. 2005
    ..In conclusion, this early pilot study suggests that CE-MS of urine warrants further investigation as a tool that can identify putative biomarkers for CaP...
  39. ncbi request reprint Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling
    Michael A Harding
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 62:6981-9. 2002
    ....
  40. ncbi request reprint Perioperative costs and charges of prostate brachytherapy and prostatectomy
    Antoine A Makhlouf
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Urology 60:656-60. 2002
    ..To compare the costs and charges incurred for transrectal ultrasound-guided brachytherapy (USBT) and radical prostatectomy (RP) at a single institution...
  41. pmc Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy
    Paul D Williams
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 69:8302-9. 2009
    ..Use of such in vitro-based GEMs may provide a robust and generalizable approach to personalized cancer therapy...
  42. ncbi request reprint Molecular markers of prognosis and novel therapeutic strategies for urothelial cell carcinomas
    Christopher Y Thomas
    Department of Hematology and Oncology, UVA HSC, P O Box 800716, Charlottesville, VA 22908, USA
    World J Urol 24:565-78. 2006
  43. ncbi request reprint Health-related quality of life after prostate brachytherapy
    Nicole L Miller
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    BJU Int 94:487-91. 2004
  44. pmc The COXEN principle: translating signatures of in vitro chemosensitivity into tools for clinical outcome prediction and drug discovery in cancer
    Steven C Smith
    Department of Molecular Physiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 70:1753-8. 2010
    ....
  45. ncbi request reprint Status of robotic cystectomy in 2005
    Nicole L Miller
    Department of Urology, Methodist Hospital Institute for Kidney Stone Disease and Indiana University School of Medicine, 1801 N Senate Blvd, Suite 220, Indianapolis, 46202, USA
    World J Urol 24:180-7. 2006
    ..We review the current experience with laparoscopic and robotic radical cystectomy and its role in the treatment of muscle invasive bladder cancer...
  46. pmc Molecular credentialing of rodent bladder carcinogenesis models
    Paul D Williams
    Department of Public Health Sciences, Division of Biostatistics, University of Virginia School of Medicine, Charlottesville, VA 22908 0717, USA
    Neoplasia 10:838-46. 2008
    ..Finally, we provide a list of genes that are likely candidates for driving this disease process by virtue of their concordant regulation in tumors of all three species...
  47. ncbi request reprint Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
    Brian Titus
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 65:7320-7. 2005
    ..The data also suggest that blockade of the ET-1 axis may prevent lung metastasis, a new therapeutic concept that warrants clinical evaluation...
  48. ncbi request reprint Rap2 regulates androgen sensitivity in human prostate cancer cells
    Dora Bigler
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Prostate 67:1590-9. 2007
    ..Here we ask if Rap proteins play a role in determining androgen sensitivity of human prostate cancer cells either alone or in the context of an activated Ras...
  49. ncbi request reprint The role of Ras superfamily proteins in bladder cancer progression
    Gary Oxford
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    J Urol 170:1987-93. 2003
    ..We reviewed the roles that members of the Ras superfamily of monomeric G proteins, an important class of cellular regulator, have in bladder cancer and its progression...
  50. pmc Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases
    Konstadinos Moissoglu
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 69:2838-44. 2009
    ..These data show that RhoGDI2 metastasis inhibition works through Rho GTPases but via a mechanism distinct from inhibition of membrane association...
  51. pmc Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cancer Ther 8:2470-7. 2009
    ....
  52. ncbi request reprint PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    Oncogene 23:6788-97. 2004
    ....
  53. ncbi request reprint Permanent interstitial brachytherapy for prostate cancer: a current review
    Jeffrey Woolsey
    Department of Urology, University of Virginia Health Sciences Center, Box 422, Charlottesville, VA 22908, USA
    World J Urol 21:209-19. 2003
    ..Results will be discussed both in terms of cancer control and health-related quality of life endpoints...
  54. ncbi request reprint Case-matched comparison of contemporary radiation therapy to surgery in patients with locally advanced prostate cancer
    Sophie G Fletcher
    Department of Urology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Int J Radiat Oncol Biol Phys 66:1092-9. 2006
    ..Our objective was to compare rates of biochemical relapse-free survival (BFS) and surrogates of disease specific survival among men with high risk adenocarcinoma of the prostate as a function of treatment modality...
  55. pmc Molecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC)
    COURTNEY POLLARD
    Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
    Expert Rev Mol Med 12:e10. 2010
    ..Since several of these driving changes are amenable to therapeutic targeting, understanding the signalling events in NMIUC may offer novel approaches to manage the recurrence and progression of this disease...
  56. ncbi request reprint Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: is there evidence for systematic upgrading?
    Emily B Smith
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer 94:2282-7. 2002
    ..In contrast, grade has shifted heavily toward moderate differentiation. The authors sought to test the hypothesis that such changes in grade in part may be because of trends among pathologists to upgrade similar specimens over time...
  57. ncbi request reprint The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer
    Steven C Smith
    Department of Molecular Physiology, University of Virginia, Charlottesville, Virginia, USA
    Cancer Res 66:1917-22. 2006
    ..We suggest that these insights may lead to future therapeutic approaches that seek to eliminate CD24 function in cancer cells...
  58. pmc A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer
    Mikael Herlevsen
    Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 352:549-55. 2007
    ..In conclusion, using a biologically relevant model system to dissect PTEN tumor suppressor function in human bladder cancer, we identified three molecules important for many cellular functions in complex with PTEN...
  59. pmc The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target
    Steven Christopher Smith
    Department of Urology, Molecular Physiology, Biological Physics, University of Virginia Health System, Charlottesville, VA 22908, USA
    Urol Oncol 27:42-7. 2009
    ..These findings are reviewed here and suggest that Ral GTPases and their downstream pathways constitute key mediators of bladder cancer progression and may include targets for future therapeutic strategies...
  60. ncbi request reprint Prospective outcomes associated with migration from preoperative to intraoperative planned brachytherapy: a single center report
    Jeffrey Woolsey
    Departments of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Urol 172:2528-31. 2004
    ..We report our experience with transition to IO planned BT after performing more than 600 PO planned implants since 1997...
  61. ncbi request reprint Ras superfamily monomeric G proteins in carcinoma cell motility
    Gary Oxford
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Cancer Lett 189:117-28. 2003
    ..Novel emerging mechanisms of migration in carcinoma cells involving RhoC and Ral are also discussed...
  62. ncbi request reprint Morbidity of modified prophylactic inguinal lymphadenectomy for squamous cell carcinoma of the penis
    Timothy R Coblentz
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    J Urol 168:1386-9. 2002
    ..Reports on saphenous vein preservation in men undergoing inguinal lymphadenectomy are limited and, therefore, we reviewed our experience...
  63. ncbi request reprint Mass spectrometry based proteomics in urine biomarker discovery
    Dan Theodorescu
    Department of Molecular Physiology, University of Virginia, Charlottesville, USA
    World J Urol 25:435-43. 2007
    ..The second part summarizes the recent progress in the definition and identification of clinically relevant polypeptide markers...
  64. ncbi request reprint Unusual case of recurrent low-grade invasive and endophytic squamous cell carcinoma of the penis
    Caroline D Ames
    Department of Urology, University of Virginia, Charlottesville, VA, USA
    Scand J Urol Nephrol 38:258-9. 2004
    ..We present a case of low-grade yet recurrent and invasive squamous cell carcinoma that may constitute a new biological variant of penile cancer...
  65. ncbi request reprint Cancer incidence after localized therapy for prostate cancer
    Kihyuck Moon
    Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer 107:991-8. 2006
    ..In this study, the authors examined the size and significance of the observed association between occurrences of secondary cancers 5 years after radiotherapy in a large population of men with incident prostate cancer...
  66. ncbi request reprint Expression of ral GTPases, their effectors, and activators in human bladder cancer
    Steven Christopher Smith
    Department of Molecular Physiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Clin Cancer Res 13:3803-13. 2007
    ....
  67. ncbi request reprint Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation
    Petra Zurbig
    Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany
    Electrophoresis 27:2111-25. 2006
    ..This uniqueness facilitates the independent entry of different sequencing platforms for peptide sequencing of CE-MS-defined biomarkers from highly complex mixtures...
  68. ncbi request reprint Brachytherapy for prostate cancer: follow-up and management of treatment failures
    Eric M Horwitz
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Urol Clin North Am 30:737-50, viii-ix. 2003
    ..Finally, a comprehensive review of the management of local recurrence following brachytherapy is offered...
  69. ncbi request reprint Brachytherapy of prostate cancer after colectomy for colorectal cancer: pilot experience
    Panos G Koutrouvelis
    URO Radiology Prostate Institute, 8320 Old Courthouse Road, Vienna, Virginia 22182, USA
    J Urol 173:82-5; discussion 85-6. 2005
    ..We present a method of brachytherapy for prostate cancer using a 3-dimensional stereotactic system and computerized tomography guidance in patients without a rectum due to previous treatment for colorectal cancer...
  70. ncbi request reprint Statistical identification of differentially labeled peptides from liquid chromatography tandem mass spectrometry
    HyungJun Cho
    Department of Statistics, Korea University, Seoul, Korea
    Proteomics 7:3681-92. 2007
    ....
  71. pmc Metastasis: a therapeutic target for cancer
    Patricia S Steeg
    Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Nat Clin Pract Oncol 5:206-19. 2008
    ..Here we discuss the similarity and differences between primary tumors and metastases, pathways controlling the colonization of a distant organ, and incorporation of antimetastatic therapies into clinical testing...
  72. doi request reprint Isolation and identification of potential urinary microparticle biomarkers of bladder cancer
    David M Smalley
    Mellon Medical Biomarker Discovery Laboratory, W M Keck Laboratory for Mass Spectrometry, Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Proteome Res 7:2088-96. 2008
    ..Further studies will be needed to validate these potential biomarkers...
  73. ncbi request reprint Combination antiangiogenic and androgen deprivation therapy for prostate cancer: a promising therapeutic approach
    Brian Nicholson
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA
    Clin Cancer Res 10:8728-34. 2004
    ..We examined combined androgen ablation and inhibition of VEGF signaling in an androgen-sensitive human prostate cancer xenograft model (LNCaP) that is known to develop androgen-independent growth after androgen ablation...
  74. pmc Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application
    Carrie W Rinker-Schaeffer
    Section of Urology, Department of Surgery, The University of Chicago, Chicago, Illinois, USA
    Clin Cancer Res 12:3882-9. 2006
  75. ncbi request reprint RalA and RalB: antagonistic relatives in cancer cell migration
    Gary Oxford
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 65:7111-20. 2005
    ..In summary, we present the first demonstration that despite their significant sequence homology, RalA and RalB have nonoverlapping and opposing functions in cancer cell migration but overlapping functions in cell growth...
  76. ncbi request reprint Adrenal tumor with caval extension--case report and review of the literature
    John P Chesson
    Department of Urology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Scand J Urol Nephrol 36:71-3. 2002
    ..Our review suggests that over half of all adrenal lesions with IVC extension will be clinically nonfunctional, including up to 17% of pheochromocytomas...
  77. ncbi request reprint Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis
    Christopher Y Thomas
    J Urol 176:1909-10. 2006
  78. ncbi request reprint Profiling the evolution of human metastatic bladder cancer
    Brian E Nicholson
    Department of Molecular Physiology and Biological Physics, Division of Biostatistics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 64:7813-21. 2004
    ....
  79. ncbi request reprint Radiation for prostate cancer issue
    Dan Theodorescu
    World J Urol 21:189. 2003
  80. ncbi request reprint Longitudinal comparison of sexual function after 3-dimensional conformal radiation therapy or prostate brachytherapy
    Richard K Valicenti
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Urol 168:2499-504; discussion 2504. 2002
    ..To estimate the risk from 2 popular radiotherapies we compared erectile function and overall satisfaction with sexual function after 3-dimensional (D) conformal radiation therapy and transperineal prostate brachytherapy...
  81. ncbi request reprint The role of Ral A in epidermal growth factor receptor-regulated cell motility
    John J Gildea
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Cancer Res 62:982-5. 2002
    ..This is the first demonstration of an essential role for Ral in EGF-mediated cell motility and its potential contribution to tumor metastasis in human cancer...

Research Grants17

  1. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2006
    ..abstract_text> ..
  2. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2007
    ..abstract_text> ..
  3. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2005
    ..abstract_text> ..
  4. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2005
    ..abstract_text> ..
  5. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2004
    ..abstract_text> ..
  6. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2004
    ..abstract_text> ..
  7. RAl GTPases and partners in human bladder cancer metastasis
    Dan Theodorescu; Fiscal Year: 2009
    ..The goal of this project is to understand the mechanisms that underlie lung metastasis in human bladder cancer and use this knowledge to predict and treat this condition in patients. ..
  8. Ral in human bladder cancer progression
    Dan Theodorescu; Fiscal Year: 2003
    ..abstract_text> ..
  9. Understanding the RhoGDI2 metastasis suppressor gene
    DAN contact THEODORESCU; Fiscal Year: 2010
    ..The goal of this project is to understand the mechanisms that underlie lung metastasis in human bladder cancer and use this knowledge to predict and treat this lethal condition in patients. ..
  10. Signaling and Progression in Prostate Cancer
    Dan Theodorescu; Fiscal Year: 2007
    ..abstract_text> ..
  11. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2001
    ..abstract_text> ..
  12. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2003
    ..abstract_text> ..
  13. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2002
    ..abstract_text> ..
  14. RAl GTPases and partners in human bladder cancer metastasis
    Dan Theodorescu; Fiscal Year: 2010
    ..The goal of this project is to understand the mechanisms that underlie lung metastasis in human bladder cancer and use this knowledge to predict and treat this condition in patients. ..