Thomas H Thatcher

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
  2. ncbi Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
  3. ncbi The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
  4. ncbi Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
  5. ncbi Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006
  6. ncbi Transglutaminase 2 and its role in pulmonary fibrosis
    Keith C Olsen
    University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 184:699-707. 2011
  7. ncbi Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Pathol 179:125-33. 2011
  8. ncbi PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ. of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
  9. ncbi High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function
    Thomas H Thatcher
    Department of Medicine, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L412-21. 2008
  10. ncbi Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 170:855-64. 2007

Collaborators

  • Richard K Barth
  • Simona Bancos
  • Gail V W Johnson
  • Jacqueline P Williams
  • PATRICIA JANET SIME
  • Anthony Gaspari
  • Richard P Phipps
  • Heather E Ferguson
  • Heather F Lakatos
  • Carolyn J Baglole
  • Sesquile Ramon
  • Ajit A Kulkarni
  • Keith C Olsen
  • Heather A Burgess
  • David H McMillan
  • Christopher M Hogan
  • Ramil E Sapinoro
  • R M Kottmann
  • Tatiana M Garcia-Bates
  • Stephen E Feldon
  • Collynn F Woeller
  • Thomas I Murant
  • Andrea Bottaro
  • Julie M Sahler
  • Safiehkhatoon Moshkani
  • Stephen J Pollock
  • Sanjay Maggirwar
  • Michael N Gurell
  • Siiri E Iismaa
  • Carolyn Jones
  • Ajit Kulkarni
  • Geniece M Lehmann
  • Krystel R Huxlin
  • Emily R Strong
  • Thomas A Gasiewicz
  • Sanjay B Maggirwar
  • Tatiana M Garcia
  • R Matthew Kottmann
  • Michelle R Redonnet
  • Eric Hernady
  • Michelle Redonnet
  • John Van Kirk
  • Beth A Graf
  • D J John Park
  • Vu T Nguyen
  • Louis Eugene Daugherty
  • Denise M Ray
  • Shira Landskroner-Eiger
  • Donald Chang

Detail Information

Publications17

  1. ncbi Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
    ..In fact, there is no difference in the inflammatory or fibrotic response to bleomycin between TCRbeta transgenic and control mice. Thus, if T cells are required for fibrogenesis, it must involve an antigen-independent mechanism...
  2. ncbi Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
    ..As the inhibitory concentration causing a 50% decrease in aSMA for CDDO is 400-fold lower than that in rosiglitazone, the translational potential of CDDO for treatment of fibrotic diseases is high...
  3. ncbi The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
    ..The association between RelB and AhR may represent a new therapeutic and more selective target with which to combat inflammation-associated diseases...
  4. ncbi Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
    ....
  5. ncbi Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006
    ..Oropharyngeal aspiration should be considered as an alternative to intratracheal instillation of silica and other particulates in studies of respiratory toxicity and lung disease...
  6. ncbi Transglutaminase 2 and its role in pulmonary fibrosis
    Keith C Olsen
    University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 184:699-707. 2011
    ..Idiopathic pulmonary fibrosis (IPF) is a deadly progressive disease with few treatment options. Transglutaminase 2 (TG2) is a multifunctional protein, but its function in pulmonary fibrosis is unknown...
  7. ncbi Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Pathol 179:125-33. 2011
    ..Therefore, increased expression and/or activation of RelB could be a novel therapeutic strategy against acute lung inflammation caused by respirable agents and possibly against chronic injury, such as COPD...
  8. ncbi PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ. of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
    ..Thus PPARgamma agonists have novel and potent antifibrotic effects in human lung fibroblasts and may have potential for therapy of fibrotic diseases in the lung and other tissues...
  9. ncbi High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function
    Thomas H Thatcher
    Department of Medicine, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L412-21. 2008
    ....
  10. ncbi Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 170:855-64. 2007
    ....
  11. ncbi Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response
    Sesquile Ramon
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 189:4740-7. 2012
    ..This is the first report, to our knowledge, to show that, under physiological conditions, PPARγ expression in B cells is required for an efficient B cell-mediated immune response as it regulates B cell differentiation and Ab production...
  12. ncbi Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
    Ajit A Kulkarni
    Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 692, Rochester, NY 14642, USA
    PPAR Res 2012:705352. 2012
    ....
  13. ncbi The Role of PPARs in Lung Fibrosis
    Heather F Lakatos
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    PPAR Res 2007:71323. 2007
    ..The clinical availability of potent and selective PPARalpha and PPARgamma agonists should facilitate rapid development of successful treatment strategies based on current and ongoing research...
  14. ncbi Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy
    Stephen E Feldon
    Department of Ophthalmology, University of Rochester, NY 14642, USA
    Invest Ophthalmol Vis Sci 46:3913-21. 2005
    ..Thus, therapies that interfere with CD40-CD40L signaling, antigen expression by fibroblasts, or T-cell function may be effective in preventing progression of GO symptoms...
  15. ncbi Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism
    Christopher M Hogan
    Division of Pulmonary and Critical Care Medicine, University of Rochester, 601 Elmwood Avenue, P O Box 692, Rochester, NY 14642, USA
    PPAR Res 2011:318134. 2011
    ....
  16. ncbi Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis
    Richard P Phipps
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1010-6. 2005
    ..Moreover, they suggest a mechanism to explain the differing fibrogenic potential of CS and AS. The molecules COX-2, PGE synthase, and PGE2 are identified as effectors in silicosis...
  17. ncbi Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance
    Thomas H Thatcher
    Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    J Invest Dermatol 126:821-31. 2006
    ....