Thomas H Thatcher

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc The Role of PPARs in Lung Fibrosis
    Heather F Lakatos
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    PPAR Res 2007:71323. 2007
  2. ncbi request reprint Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
  3. pmc Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
  4. pmc The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis
    Ajit A Kulkarni
    The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e63798. 2013
  5. pmc A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation
    Hsi Min Hsiao
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA
    PLoS ONE 8:e58258. 2013
  6. pmc The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
  7. pmc Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 305:L165-74. 2013
  8. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
  9. pmc Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 304:L774-81. 2013
  10. ncbi request reprint Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006

Collaborators

  • Richard K Barth
  • Marc A Williams
  • Terry W Wright
  • Simona Bancos
  • Jacqueline P Williams
  • Gail V W Johnson
  • PATRICIA JANET SIME
  • Anthony Gaspari
  • Richard P Phipps
  • Amanda Croasdell
  • Collynn F Woeller
  • Hsi Min Hsiao
  • Ajit A Kulkarni
  • Keith C Olsen
  • Heather E Ferguson
  • Stephen J Pollock
  • Sesquile Ramon
  • David H McMillan
  • Heather F Lakatos
  • Carolyn J Baglole
  • Amali P Epa
  • Robert Matthew Kottmann
  • Ramil E Sapinoro
  • R M Kottmann
  • Nina Kim
  • Lindsay A Wahl
  • Kristina M Owens
  • Charles N Serhan
  • Elizabeth P Levy
  • Robert A Fulton
  • Heather A Burgess
  • Christopher M Hogan
  • R Matthew Kottmann
  • Sanjay B Maggirwar
  • Charles W O'Loughlin
  • Tatiana M Garcia-Bates
  • Stephen E Feldon
  • Katherine M A O'Reilly
  • Shannon H Lacy
  • Jennifer L Judge
  • Steven E Feldon
  • Emma Trawick
  • Romain A Colas
  • Jesmond Dalli
  • Elizabeth Lyda
  • Sherry L Spinelli
  • Jason Morrissette
  • Safiehkhatoon Moshkani
  • Andrea Bottaro
  • Thomas I Murant
  • Julie M Sahler
  • Carolyn Jones
  • Siiri E Iismaa
  • Michael N Gurell
  • Sanjay Maggirwar
  • Ajit Kulkarni
  • Krystel R Huxlin
  • Geniece M Lehmann
  • Emily R Strong
  • Thomas A Gasiewicz
  • Tatiana M Garcia
  • Michelle R Redonnet
  • Eric Hernady
  • Michelle Redonnet
  • Shira Landskroner-Eiger
  • John Van Kirk
  • Beth A Graf
  • Denise M Ray
  • Louis Eugene Daugherty
  • Donald Chang
  • D J John Park
  • Vu T Nguyen

Detail Information

Publications29

  1. pmc The Role of PPARs in Lung Fibrosis
    Heather F Lakatos
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    PPAR Res 2007:71323. 2007
    ..The clinical availability of potent and selective PPARalpha and PPARgamma agonists should facilitate rapid development of successful treatment strategies based on current and ongoing research...
  2. ncbi request reprint Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire
    Thomas H Thatcher
    Department of Microbiology and Immunology, Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 31:685-700. 2005
    ..In fact, there is no difference in the inflammatory or fibrotic response to bleomycin between TCRbeta transgenic and control mice. Thus, if T cells are required for fibrogenesis, it must involve an antigen-independent mechanism...
  3. pmc Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 41:722-30. 2009
    ..As the inhibitory concentration causing a 50% decrease in aSMA for CDDO is 400-fold lower than that in rosiglitazone, the translational potential of CDDO for treatment of fibrotic diseases is high...
  4. pmc The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis
    Ajit A Kulkarni
    The Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e63798. 2013
    ..g. chemotherapy and radiation) and by systemic autoimmune diseases...
  5. pmc A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation
    Hsi Min Hsiao
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA
    PLoS ONE 8:e58258. 2013
    ..We hypothesize that resolvin D1 (RvD1) has potent anti-inflammatory and pro-resolving effects in a model of cigarette smoke-induced lung inflammation...
  6. pmc The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
    ..The association between RelB and AhR may represent a new therapeutic and more selective target with which to combat inflammation-associated diseases...
  7. pmc Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 305:L165-74. 2013
    ..These compounds may have promise in preventing or treating lung disease associated with chronic smoke exposure, including COPD. ..
  8. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
    ....
  9. pmc Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 304:L774-81. 2013
    ..RelB and miRNA-146a may therefore be new therapeutic targets in the treatment of lung inflammation caused by various agents and conditions...
  10. ncbi request reprint Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006
    ..Oropharyngeal aspiration should be considered as an alternative to intratracheal instillation of silica and other particulates in studies of respiratory toxicity and lung disease...
  11. pmc Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Pathol 179:125-33. 2011
    ..Therefore, increased expression and/or activation of RelB could be a novel therapeutic strategy against acute lung inflammation caused by respirable agents and possibly against chronic injury, such as COPD...
  12. pmc Transglutaminase 2 and its role in pulmonary fibrosis
    Keith C Olsen
    University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 184:699-707. 2011
    ..Idiopathic pulmonary fibrosis (IPF) is a deadly progressive disease with few treatment options. Transglutaminase 2 (TG2) is a multifunctional protein, but its function in pulmonary fibrosis is unknown...
  13. ncbi request reprint PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
    ..Thus PPARgamma agonists have novel and potent antifibrotic effects in human lung fibroblasts and may have potential for therapy of fibrotic diseases in the lung and other tissues...
  14. pmc Pharmacologic inhibition of lactate production prevents myofibroblast differentiation
    Robert Matthew Kottmann
    University of Rochester Department of Medicine, Rochester, New York University of Rochester Lung Biology and Disease Program, Rochester, New York
    Am J Physiol Lung Cell Mol Physiol 309:L1305-12. 2015
    ..These data support the hypothesis that pharmacologic inhibition of LDH may play an important role in the treatment of pulmonary fibrosis. ..
  15. pmc Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages
    Amanda Croasdell
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York
    Am J Physiol Lung Cell Mol Physiol 309:L888-901. 2015
    ..These data show that resolvins act on human macrophages to attenuate cigarette smoke-induced inflammatory effects through proresolving mechanisms and provide new evidence of the therapeutic potential of SPMs. ..
  16. pmc Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1
    Hsi Min Hsiao
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642
    J Immunol 193:4980-7. 2014
    ..In this article, we present the idea that RvD1 has the potential to be used as an anti-inflammatory and proresolving agent, possibly in the context of exuberant host responses to damaging respirable agents such as viruses. ..
  17. pmc Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response
    Sesquile Ramon
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 189:4740-7. 2012
    ..This is the first report, to our knowledge, to show that, under physiological conditions, PPARγ expression in B cells is required for an efficient B cell-mediated immune response as it regulates B cell differentiation and Ab production...
  18. pmc High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function
    Thomas H Thatcher
    Department of Medicine, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L412-21. 2008
    ....
  19. pmc Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae
    Amanda Croasdell
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 and
    J Immunol 196:2742-52. 2016
    ..This research highlights the beneficial role of SPMs in pulmonary bacterial infections and provides the groundwork for further investigation into SPMs as alternatives to immunosuppressive therapies like steroids. ..
  20. pmc Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production
    Nina Kim
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA
    Eur J Immunol 46:81-91. 2016
    ....
  21. pmc Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2
    Amali P Epa
    Department of Pathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, United States of America
    PLoS ONE 10:e0135266. 2015
    ..To investigate this hypothesis, we employed a novel co-culture model with primary human lung epithelial cells and fibroblasts to investigate whether epithelial cells inhibit myofibroblast differentiation...
  22. pmc Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn
    Collynn F Woeller
    Department of Environmental Medicine and Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    FASEB J 29:920-31. 2015
    ..Thus, these studies reveal Thy1 blocks adipogenesis and PPARγ by inhibiting Fyn and support the idea that Thy1 is a novel therapeutic target in obesity...
  23. pmc Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 170:855-64. 2007
    ....
  24. pmc Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function
    Thomas H Thatcher
    Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, NY, USA
    Immunology 147:41-54. 2016
    ..Therefore, the AhR may represent an important target for therapeutic intervention in allergic airways inflammation. ..
  25. ncbi request reprint Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis
    Katherine M A O'Reilly
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1010-6. 2005
    ..Moreover, they suggest a mechanism to explain the differing fibrogenic potential of CS and AS. The molecules COX-2, PGE synthase, and PGE2 are identified as effectors in silicosis...
  26. pmc Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
    Ajit A Kulkarni
    Division of Pulmonary and Critical Care, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 692, Rochester, NY 14642, USA
    PPAR Res 2012:705352. 2012
    ....
  27. ncbi request reprint Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy
    Stephen E Feldon
    Department of Ophthalmology, University of Rochester, NY 14642, USA
    Invest Ophthalmol Vis Sci 46:3913-21. 2005
    ..GO is also characterized by autoimmune inflammation of orbital connective tissue with mononuclear cell infiltration, including T cells...
  28. pmc Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism
    Christopher M Hogan
    Division of Pulmonary and Critical Care Medicine, University of Rochester, 601 Elmwood Avenue, P O Box 692, Rochester, NY 14642, USA
    PPAR Res 2011:318134. 2011
    ....
  29. ncbi request reprint Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance
    Thomas H Thatcher
    Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    J Invest Dermatol 126:821-31. 2006
    ....