M E Thase

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Efficacy of mirtazapine for prevention of depressive relapse: a placebo-controlled double-blind trial of recently remitted high-risk patients
    M E Thase
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 62:782-8. 2001
  2. ncbi Effectiveness of antidepressants: comparative remission rates
    Michael E Thase
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-7. 2003
  3. ncbi Achieving remission and managing relapse in depression
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-7. 2003
  4. ncbi Methodology to measure onset of action
    M E Thase
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 62:18-21. 2001
  5. ncbi Management of treatment-resistant depression: psychotherapeutic perspectives
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:18-24. 2001
  6. ncbi Evaluating antidepressant therapies: remission as the optimal outcome
    Michael E Thase
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Clin Psychiatry 64:18-25. 2003
  7. ncbi Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatr Clin North Am 26:495-518. 2003
  8. ncbi Citalopram treatment of fluoxetine nonresponders
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:683-7. 2001
  9. ncbi New approaches to managing difficult-to-treat depressions
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-4. 2003
  10. ncbi What role do atypical antipsychotic drugs have in treatment-resistant depression?
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:95-103. 2002

Collaborators

Detail Information

Publications162 found, 100 shown here

  1. ncbi Efficacy of mirtazapine for prevention of depressive relapse: a placebo-controlled double-blind trial of recently remitted high-risk patients
    M E Thase
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 62:782-8. 2001
    ..The current study was performed to evaluate the efficacy and safety of up to 1 year of mirtazapine therapy, using a more rigorous, randomized, placebo-controlled discontinuation design...
  2. ncbi Effectiveness of antidepressants: comparative remission rates
    Michael E Thase
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-7. 2003
    ..Given the better tolerability of newer antidepressants relative to tricyclics, both logic and an increasing amount of data support a greater role for multiaction antidepressants...
  3. ncbi Achieving remission and managing relapse in depression
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-7. 2003
    ..Ensuring that patients are indeed adherent with treatment is also worthwhile before assuming that a treatment has failed...
  4. ncbi Methodology to measure onset of action
    M E Thase
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 62:18-21. 2001
    ..In this article, the above-mentioned approaches will be explained with the help of some clinical examples to achieve a further understanding of the methodology of measuring onset of action...
  5. ncbi Management of treatment-resistant depression: psychotherapeutic perspectives
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:18-24. 2001
    ..Also discussed are modifications in treatment planning necessary to take into account the complexity of treatment-resistant depression...
  6. ncbi Evaluating antidepressant therapies: remission as the optimal outcome
    Michael E Thase
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Clin Psychiatry 64:18-25. 2003
    ..e., quantitative and pooled) suggest that both psychotherapy-pharmacotherapy combinations and use of antidepressants that enhance serotonergic and noradrenergic neurotransmission increase the likelihood of remission...
  7. ncbi Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatr Clin North Am 26:495-518. 2003
    ....
  8. ncbi Citalopram treatment of fluoxetine nonresponders
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:683-7. 2001
    ..We assessed the tolerability and utility of switching fluoxetine nonresponders to citalopram the day that fluoxetine therapy was stopped...
  9. ncbi New approaches to managing difficult-to-treat depressions
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 64:3-4. 2003
    ..Challenging subtypes of illness, including psychotic and bipolar subtypes of depression, are not necessarily inherently refractory but must be met with modified treatment approaches...
  10. ncbi What role do atypical antipsychotic drugs have in treatment-resistant depression?
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:95-103. 2002
    ..Although more studies will be required to confirm and extend these findings, the results suggest that there may be a clinical benefit to combining atypical antipsychotics with SSRIs in nonpsychotic TRD...
  11. ncbi Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:233-9. 2002
    ..Although various strategies have been proposed to treat antidepressant nonresponders, little controlled research has been published that examines prospectively the use of switching to an alternate antidepressant...
  12. ncbi Optimizing treatment outcomes for patients with depression and generalized anxiety disorder
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2593, USA
    Psychopharmacol Bull 36:93-102. 2002
    ....
  13. ncbi Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  14. ncbi Venlafaxine and treatment-resistant depression
    M E Thase
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pennsylvania, USA
    Depress Anxiety 12:55-62. 2000
    ..The relative merits of switching from a SSRI to venlafaxine versus adding a norepinephrine reuptake inhibitor also warrant careful study...
  15. ncbi Citalopram treatment of paroxetine-intolerant depressed patients
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Depress Anxiety 16:128-33. 2002
    ....
  16. ncbi Cardiovascular profile of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:132-40. 2005
    ..The cardiovascular effects of duloxetine appear to be comparable with medications considered to be first-line options for depression...
  17. ncbi Is psychotherapy an effective treatment for melancholia and other severe depressive states?
    M E Thase
    University of Pittsburgh School of Medicine, Western Psychiatric Institute, PA 15213, USA
    J Affect Disord 54:1-19. 1999
    ..We discuss the practical implications of the literature reviewed...
  18. ncbi When are psychotherapy and pharmacotherapy combinations the treatment of choice for major depressive disorder?
    M E Thase
    University of Pittsburgh School of Medicine, PA, USA
    Psychiatr Q 70:333-46. 1999
    ..By focusing attention on the patient subgroups most likely to show a true additive response to combined treatment, it may be possible to obtain maximum benefits from dwindling resources...
  19. ncbi Studying new antidepressants: if there were a light at the end of the tunnel, could we see it?
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, S 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    J Clin Psychiatry 63:24-8. 2002
    ....
  20. ncbi Treatment of severe depression
    M E Thase
    University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 61:17-25. 2000
    ..g., melancholia or psychotic depression) as well as various comorbid presentations. This article reviews the classification, phenomenology, pathophysiology, and treatment of severe depression...
  21. ncbi Is cognitive behavior therapy just a 'nonspecific' intervention for depression? A retrospective comparison of consecutive cohorts treated with cognitive behavior therapy or supportive counseling and pill placebo
    M E Thase
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 57:63-71. 2000
    ..Arch. Gen. Psychiatry 46 (1989) 971-982), failed to find a significant difference between CBT and a clinical management plus placebo condition...
  22. ncbi Gender differences in treatment response to sertraline versus imipramine in chronic depression
    S G Kornstein
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:1445-52. 2000
    ..The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor (SSRI), and to imipramine, a tricyclic antidepressant, in chronic depression...
  23. ncbi Natural history and preventative treatment of recurrent mood disorders
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pennsylvania 15213 2593, USA
    Annu Rev Med 50:453-68. 1999
    ..Finally, the chapter describes recent advances in the treatment of bipolar disorder...
  24. ncbi Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depression
    W H Denton
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, TX 75390 9121, USA
    Psychol Med 40:415-24. 2010
    ..This study investigated pretreatment dyadic discord as a predictor of non-remission and its relationship to depressive symptom change during acute treatment for chronic depression...
  25. ncbi Bupropion SR reduces periodic limb movements associated with arousals from sleep in depressed patients with periodic limb movement disorder
    E A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 61:858-62. 2000
    ..Given the role of dopamine in PLMD and the effects of bupropion sustained-release (SR) on central dopaminergic function, we hypothesized that bupropion SR would not be associated with antidepressant-induced PLMD...
  26. ncbi Medication augmentation after the failure of SSRIs for depression
    Madhukar H Trivedi
    Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    N Engl J Med 354:1243-52. 2006
    ..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach...
  27. ncbi An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depression
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 70:387-96. 2009
    ..To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant depression sponsored by Eli Lilly and Company...
  28. ncbi Training in cognitive, supportive-expressive, and drug counseling therapies for cocaine dependence
    P Crits-Christoph
    Department of Psychiatry, University of Pennsylvania, USA
    J Consult Clin Psychol 66:484-92. 1998
    ..Training in SE and CT did not have a negative impact on the therapeutic alliance, although alliance scores for trainees in drug counseling initially decreased but then rebounded to initial levels...
  29. ncbi Therapeutic alliance as a predictor of outcome and retention in the National Institute on Drug Abuse Collaborative Cocaine Treatment Study
    J P Barber
    Department of Psychiatry, University of Pennsylvania, USA
    J Consult Clin Psychol 69:119-24. 2001
    ..In CT, higher levels of alliance were associated with decreased retention...
  30. ncbi Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 161:1864-71. 2004
    ..Minor depressive disorder is both common and associated with significant psychosocial impairment. This study examined antidepressant treatment efficacy in a large group of patients with minor depressive disorder...
  31. ncbi Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  32. ncbi The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Am J Psychiatry 165:370-7; quiz 410. 2008
    ..In a naturalistic follow-up of adult bipolar patients, the authors examined the contributions of demographic, phenomenological, and clinical variables, including antidepressant use, to prospectively observed mood episode frequency...
  33. ncbi Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
    ..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established...
  34. ncbi Acceptability of second-step treatments to depressed outpatients: a STAR*D report
    Stephen R Wisniewski
    Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 164:753-60. 2007
    ..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches...
  35. ncbi What predicts attrition in second step medication treatments for depression?: a STAR*D Report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    Int J Neuropsychopharmacol 12:459-73. 2009
    ..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes...
  36. ncbi Selecting appropriate treatments for maintenance therapy for bipolar disorder
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Clin Psychiatry 69:28-35. 2008
    ..Additionally, several forms of psychotherapy specifically tailored to the needs of people with bipolar disorder should be considered as an adjunct to medication...
  37. ncbi Differential effects of treatments for chronic depression: a latent growth model reanalysis
    Niklaus Stulz
    Department of Psychiatry, University of Pennsylvania Philadelphia, PA 19104, USA
    J Consult Clin Psychol 78:409-19. 2010
    ....
  38. ncbi Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 71:296-303. 2010
    ..Poor medication adherence is common among bipolar patients...
  39. ncbi Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    Philip T Ninan
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Clin Psychiatry 63:434-41. 2002
    ..Among patients with a concurrent anxiety disorder, nefazodone. either alone or in combination with CBASP, improves anxiety symptoms faster than CBASP alone, independent of depressive symptom reduction...
  40. ncbi Update on partial response in depression
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, and Pittsburgh Medical Center, Philadelphia and Pittsburgh, USA
    J Clin Psychiatry 70:4-9. 2009
    ..Although studies on predictive factors have not yielded definitive results, clinicians in practice often select adjunctive agents that target patients' persistent symptoms...
  41. ncbi Comorbid alcoholism and depression: treatment issues
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:32-41. 2001
    ..Improved recognition and treatment will save lives, and the benefits are likely to extend across generations...
  42. ncbi Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisit
    C F Reynolds
    Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 12:368-73. 1989
    ..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample...
  43. ncbi Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  44. ncbi Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  45. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
    ..After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another...
  46. ncbi Income and attrition in the treatment of depression: a STAR*D report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9086, USA
    Depress Anxiety 26:622-33. 2009
    ..This report assessed whether attrition rates and predictors of attrition differed among depressed outpatients with different income levels...
  47. ncbi Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724-5002, USA
    Biol Psychiatry 54:806-17. 2003
    ..8%). Somnolence was significantly greater among the patients taking active medication (15.4%), compared with placebo (4.6%). CONCLUSIONS: Nefazodone is well-tolerated and is an effective maintenance therapy for chronic forms of MDD...
  48. ncbi Impact of substance abuse on the course and treatment of bipolar disorder
    I M Salloum
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Bipolar Disord 2:269-80. 2000
    ..The objectives of this article are to review the prevalence, natural history, pathophysiology, and treatment of comorbid bipolar disorder with alcoholism and other psychoactive substance use disorders (PSUDs)...
  49. ncbi A prospective test of criteria for response, remission, relapse, recovery, and recurrence in depressed patients treated with cognitive behavior therapy
    L P Riso
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Affect Disord 43:131-42. 1997
    ..Several of the findings suggest that continued refinement of the outcome definitions may enhance validity even further...
  50. ncbi Augmentation strategies for depression: history and concepts
    Michael E Thase
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    CNS Spectr 12:3-5. 2007
  51. ncbi Effect of age at onset on the course of major depressive disorder
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Am J Psychiatry 164:1539-46. 2007
    ..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
  52. ncbi Modafinil augmentation of selective serotonin reuptake inhibitor therapy in MDD partial responders with persistent fatigue and sleepiness
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, and Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Ann Clin Psychiatry 19:153-9. 2007
    ..This study evaluated modafinil in patients with major depressive disorder (MDD) who were partial responders to adequate selective serotonin reuptake inhibitor (SSRI) therapy and excessive sleepiness and fatigue...
  53. ncbi Management of patients with treatment-resistant depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Clin Psychiatry 69:e8. 2008
    ....
  54. ncbi Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  55. ncbi Brief report: paroxetine in younger and adult individuals at high risk for suicide
    Mark S Bauer
    Department of Psychiatry, Brown University, USA
    Psychopharmacol Bull 39:31-7. 2006
    ..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals...
  56. ncbi Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Affect Disord 110:55-61. 2008
    ..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment...
  57. ncbi Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination
    John Zajecka
    Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Suite 955, Chicago, IL 60612, USA
    J Clin Psychiatry 63:709-16. 2002
    ..Treatment with nefazodone, CBASP, and combined treatment improved sexual interest/satisfaction, with greatest improvement observed with combined treatment...
  58. ncbi Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Am J Psychiatry 166:599-607. 2009
    ....
  59. ncbi The state of knowledge of chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Arizona Health Sciences Center, Tucson, AZ, USA
    J Clin Psychiatry 67:179-84. 2006
  60. ncbi A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  61. ncbi Diagnostic certainty of a voluntary bipolar disorder case registry
    P A Cluss
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    J Affect Disord 52:93-9. 1999
    ..The development and implementation of a bipolar disorder case registry and the assessment of diagnostic certainty of the resulting sample are described...
  62. ncbi Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality
    E Frank
    Department of Psychiatry, University of Pittsburgh 15213, USA
    J Abnorm Psychol 108:579-87. 1999
    ..This finding, consistent with the authors' philosophy that bipolar patients benefit from stable routines, suggests that disruptions in the psychosocial treatment plan contribute to worse outcomes...
  63. ncbi Are buckling force measurements reliable in nocturnal penile tumescence studies?
    E A Nofzinger
    Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 16:156-62. 1993
    ....
  64. ncbi Effectiveness of St John's wort in major depression: a randomized controlled trial
    R C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville Tennessee, USA
    JAMA 285:1978-86. 2001
    ..Extracts of St John's wort are widely used to treat depression. Although more than 2 dozen clinical trials have been conducted with St John's wort, most have significant flaws in design and do not enable meaningful interpretation...
  65. ncbi Efficacy of duloxetine and selective serotonin reuptake inhibitors: comparisons as assessed by remission rates in patients with major depressive disorder
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:672-6. 2007
    ....
  66. ncbi A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:482-8. 2006
    ..In conclusion, in this patient population (ie, relatively young, sexually active outpatients), bupropion XL was at least as effective as venlafaxine XR and had a significantly more favorable sexual side effect profile...
  67. ncbi Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants
    Mark D Fossey
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
    Am J Addict 15:138-43. 2006
    ..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics...
  68. ncbi Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  69. ncbi Focus on bipolar disorder treatment
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
    J Clin Psychiatry 66:1598-609. 2005
  70. ncbi Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  71. ncbi Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 30:405-16. 2005
    ..Global patient ratings such as the PGI-I, as opposed to specific item-based ratings, provide less valid findings...
  72. ncbi Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D study
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
    J Affect Disord 117:63-73. 2009
    ..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI...
  73. ncbi Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remission
    Ripu D Jindal
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 51:230-6. 2002
    ..Resolution of this issue requires longitudinal and family studies...
  74. ncbi Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, N Y, USA
    J Clin Psychiatry 70:354-61. 2009
    ..We hypothesized that patient preference at baseline would interact with treatment group to differentially affect treatment outcome...
  75. ncbi Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  76. ncbi A randomized, double-blind, placebo-controlled study of the effect of sustained-release bupropion on blood pressure in individuals with mild untreated hypertension
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 28:302-7. 2008
    ..28 vs -0.64 beats/min; Delta = 2.92, P = 0.004). Although only minor effects on blood pressure were observed in this trial, an infrequent association of bupropion therapy and treatment-emergent hypertension cannot be ruled out...
  77. ncbi Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors
    M E Thase
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213-2593, USA
    Br J Psychiatry 178:234-41. 2001
    ..Results were not dependent on any one study or the definition of remission. CONCLUSIONS: Remission rates were significantly higher with venlafaxine than with an SSRI...
  78. ncbi Response to placebo among bipolar I disorder patients experiencing their first manic episode
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Special Studies Center at Mayview State Hospital, PA 15213 2593, USA
    Bipolar Disord 2:332-5. 2000
    ..Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999; 156: 702-709)...
  79. ncbi Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Trials 6:637-48. 2009
    ..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
  80. ncbi Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  81. ncbi A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes: a STAR*D report
    Charlene J Bryan
    School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Affect Disord 108:113-20. 2008
    ....
  82. ncbi Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
    Bipolar Disord 11:391-400. 2009
    ..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
  83. ncbi Primary care patients' personal illness models for depression: a preliminary investigation
    C Brown
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Fam Pract 18:314-20. 2001
    ..Knowledge about primary care patients' personal illness models will aid in the development of adherence interventions, self-management training and support services appropriate to patients' needs in the primary care setting...
  84. ncbi Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using
    E A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:95-111. 2001
    ..REM sleep are discussed...
  85. ncbi Research issues in the study of difficult-to-treat depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9086, USA
    Biol Psychiatry 53:743-53. 2003
    ..augmentation studies). Careful consideration of these issues should improve the interpretability and generalizability of findings obtained in trials with treatment-resistant major depressive disorder...
  86. ncbi Evaluating atypical antipsychotics in the treatment of refractory depression
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, and University of Pittsburgh Medical Center, Philadelphia and Pittsburgh, PA, USA
    J Clin Psychiatry 70:e14. 2009
    ..Atypical antipsychotics need to be compared for efficacy against specific target symptoms, as well as for differences in safety and tolerability...
  87. ncbi Modafinil augmentation of SSRI therapy in patients with major depressive disorder and excessive sleepiness and fatigue: a 12-week, open-label, extension study
    Michael E Thase
    Division of Adult Academic Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    CNS Spectr 11:93-102. 2006
    ..Placebo-controlled studies indicate that modafinil, a wake-promoting agent, may relieve residual symptoms...
  88. ncbi Heart rate variability in depressed elderly
    Ripu D Jindal
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Am J Geriatr Psychiatry 16:861-6. 2008
    ..Because aging is associated with decreased cardiac vagal activity, it is possible that autonomic abnormalities are even more pronounced in the older depressed patients...
  89. ncbi Recognition and diagnosis of atypical depression
    Michael E Thase
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19380, USA
    J Clin Psychiatry 68:11-6. 2007
    ..Although introduction of safer MAOIs has fostered renewed interest in atypical depression, the validity and importance of the DSM-IV definition of atypical depression for the nosology of affective illness remains an open question...
  90. ncbi Maintenance treatment of insomnia: what can we learn from the depression literature?
    Ripu D Jindal
    Mental Health Intervention Research Center, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 161:19-24. 2004
    ..This article compares and contrasts the current state of research in the maintenance therapy of depression and insomnia and highlights gaps in the insomnia literature...
  91. ncbi Primary care patients' personal illness models for depression: relationship to coping behavior and functional disability
    Charlotte Brown
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gen Hosp Psychiatry 29:492-500. 2007
    ..The intercorrelations of illness beliefs and the mediational effects of coping behavior on these beliefs were also evaluated. Moderating effects of coping behaviors were explored...
  92. ncbi Bipolar depression: diagnostic and treatment considerations
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15123 2593, USA
    Dev Psychopathol 18:1213-30. 2006
    ..Studies of adults indicate that several forms of focused psychotherapy may improve longer term outcomes...
  93. ncbi Pharmacotherapy of bipolar depression: an update
    Michael E Thase
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Curr Psychiatry Rep 8:478-88. 2006
    ..Antidepressants--particularly selective serotonin reuptake inhibitors and bupropion--are indicated when mood stabilizers are ineffective and for "breakthrough" depressions...
  94. ncbi Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    J Clin Psychopharmacol 26:600-9. 2006
    ..This study demonstrates that quetiapine monotherapy is an effective and well-tolerated treatment for depressive episodes in bipolar disorder, confirming the results observed from a previous study (BipOLar DEpRession [BOLDER] I)...
  95. ncbi Preventing relapse and recurrence of depression: a brief review of therapeutic options
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania 15213 2593, USA
    CNS Spectr 11:12-21. 2006
    ....
  96. ncbi Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  97. ncbi How can you improve antidepressant adherence?
    Charlotte Brown
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Fam Pract 56:356-63. 2007
  98. ncbi The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  99. ncbi Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  100. ncbi A randomized, double-blind comparison of olanzapine/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:224-36. 2007
    ..Two parallel, 8-week double-blind studies compared olanzapine/fluoxetine combination, olanzapine, and fluoxetine in outpatients with treatment-resistant depression (TRD)...
  101. ncbi Introduction: new directions in the treatment of atypical depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center School of Medicine, and the Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 68:4-9. 2007