Genomes and Genes
Affiliation: University of Arizona
- Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAsS Tharun
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, 1007 E Lowell, Tucson, AZ 85721, USA
Mol Cell 8:1075-83. 2001..These results define an important rearrangement in mRNP organization and suggest that deadenylation promotes mRNA decapping by both the loss of Pab1p and the recruitment of the Lsm1p-7p complex...
- Yeast Sm-like proteins function in mRNA decapping and decayS Tharun
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson 85721, USA
Nature 404:515-8. 2000..In addition, the Lsm complex that functions in mRNA decay appears to be distinct from the U6-associated Lsm complex, indicating that Lsm proteins form specific complexes that affect different aspects of mRNA metabolism...
- Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver developmentS Tharun
Centre for Cellular and Molecular Biology, Hyderabad, India
Nucleic Acids Res 23:641-6. 1995..Since accumulation of degradation intermediates is known to correlate with higher rate of mRNA turnover, our observations raise the possibility that the stability of albumin mRNA may be lower in fetal than in adult mouse liver...