G K Thaker

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Schizophrenia endophenotypes as treatment targets
    Gunvant K Thaker
    University of Maryland School of Medicine, Maryland Psychiatric Research Center, Department of Psychiatry, PO Box 21247, Baltimore, MD 21228, USA
    Expert Opin Ther Targets 11:1189-206. 2007
  2. ncbi request reprint Defining the schizophrenia phenotype
    G K Thaker
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    Curr Psychiatry Rep 2:398-403. 2000
  3. pmc A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Psychophysiology 40:277-84. 2003
  4. pmc Psychosis endophenotypes in schizophrenia and bipolar disorder
    Gunvant Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 34:720-1. 2008
  5. pmc Neurophysiological endophenotypes across bipolar and schizophrenia psychosis
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 34:760-73. 2008
  6. ncbi request reprint Functional deterioration in individuals with schizophrenia spectrum personality symptoms
    G Thaker
    Maryland Psychiatric Research Center, Baltimore, USA
    J Pers Disord 15:229-34. 2001
  7. ncbi request reprint Saccadic eye movement abnormalities in relatives of patients with schizophrenia
    G K Thaker
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 45:235-44. 2000
  8. ncbi request reprint Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia
    G K Thaker
    Schizophrenia Related Dis Program, Maryland Psychiatric Research Center, Baltimore 21228, USA
    Psychiatry Res 88:209-19. 1999
  9. ncbi request reprint Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report
    Gunvant K Thaker
    MPRC, PO Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 161:2320-2. 2004
  10. ncbi request reprint Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia
    G K Thaker
    Maryland Psychiatric Research Center, Baltimore 21228, USA
    Arch Gen Psychiatry 55:830-6. 1998

Detail Information

Publications65

  1. ncbi request reprint Schizophrenia endophenotypes as treatment targets
    Gunvant K Thaker
    University of Maryland School of Medicine, Maryland Psychiatric Research Center, Department of Psychiatry, PO Box 21247, Baltimore, MD 21228, USA
    Expert Opin Ther Targets 11:1189-206. 2007
    ..As endophenotypes are present during childhood and adolescence, novel drugs that are developed on the basis of this subgroup could have implications for preventive strategies in schizophrenia...
  2. ncbi request reprint Defining the schizophrenia phenotype
    G K Thaker
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    Curr Psychiatry Rep 2:398-403. 2000
    ..Subtle clinical signs and symptoms, cognitive impairment particularly in attention and memory, and neurophysiologic deficits such as in sensory gating and smooth-pursuit eye movements all define aspects of the schizophrenia phenotype...
  3. pmc A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Psychophysiology 40:277-84. 2003
    ....
  4. pmc Psychosis endophenotypes in schizophrenia and bipolar disorder
    Gunvant Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 34:720-1. 2008
    ..These alternative phenotypes are likely to aid search for liability genes in schizophrenia and bipolar disorders and likely to be informative regarding the extent to which the 2 disorders share etio-pathophysiology...
  5. pmc Neurophysiological endophenotypes across bipolar and schizophrenia psychosis
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 34:760-73. 2008
    ..And finally, the clinical and functional consequences of the neurophysiological deficits both in the probands and their relatives are not well described...
  6. ncbi request reprint Functional deterioration in individuals with schizophrenia spectrum personality symptoms
    G Thaker
    Maryland Psychiatric Research Center, Baltimore, USA
    J Pers Disord 15:229-34. 2001
    ..Further research is needed to identify subtle deficits underlying functional deterioration and to develop targets for treatment strategies...
  7. ncbi request reprint Saccadic eye movement abnormalities in relatives of patients with schizophrenia
    G K Thaker
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 45:235-44. 2000
    ..The relatively high prevalence rate of the abnormality in at-risk subjects may have relevance for use of these measures in linkage analysis...
  8. ncbi request reprint Smooth pursuit eye movements to extra-retinal motion signals: deficits in patients with schizophrenia
    G K Thaker
    Schizophrenia Related Dis Program, Maryland Psychiatric Research Center, Baltimore 21228, USA
    Psychiatry Res 88:209-19. 1999
    ....
  9. ncbi request reprint Catechol O-methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report
    Gunvant K Thaker
    MPRC, PO Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 161:2320-2. 2004
    ..This study examined associations between functional polymorphism (Val(108/158) Met) in the catechol O-methyltransferase (COMT) gene and eye tracking measures in schizophrenia...
  10. ncbi request reprint Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia
    G K Thaker
    Maryland Psychiatric Research Center, Baltimore 21228, USA
    Arch Gen Psychiatry 55:830-6. 1998
    ..Based on recent findings in schizophrenia, we hypothesize that subtle deficits in the ability to hold online and/or use extraretinal motion information underlie the pursuit abnormality in vulnerable individuals...
  11. ncbi request reprint The relationship between smooth pursuit eye movements and tardive dyskinesia in schizophrenia
    D E Ross
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, MD, USA
    Schizophr Res 31:141-50. 1998
    ..To examine the relationship between smooth pursuit eye movements and tardive dyskinesia (TD) in schizophrenia...
  12. ncbi request reprint Covert visual attention in schizophrenia spectrum personality disordered subjects: visuospatial cuing and alerting effects
    M J Moran
    Maryland Psychiatric Research Center, University of Maryland at Baltimore 21228, USA
    J Psychiatr Res 30:261-75. 1996
    ..The findings of an asymmetrical deficit in the disengagement and shift of covert visual attention in schizophrenia spectrum subjects are similar to the one's observed in patients with unilateral left hemisphere lesions...
  13. doi request reprint The psychoses: cluster 3 of the proposed meta-structure for DSM-V and ICD-11
    W T Carpenter
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychol Med 39:2025-42. 2009
    ..In an effort to group mental disorders on the basis of etiology, five clusters have been proposed. Here we consider the validity of the cluster comprising selected psychotic and related disorders...
  14. ncbi request reprint Nicotine improves delayed recognition in schizophrenic patients
    Carol S Myers
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 174:334-40. 2004
    ..Nicotine has been shown to enhance some aspects of memory, attention and cognition in normal subjects and in some patient populations such as Alzheimer's and Parkinson's disease groups...
  15. ncbi request reprint Spontaneous dyskinesia in subjects with schizophrenia spectrum personality
    S L Cassady
    Schizophrenia Related Disorders Program, Maryland Psychiatric Research Center, Baltimore 21228, USA
    Am J Psychiatry 155:70-5. 1998
    ..They also tested the hypothesis that dyskinetic-like movements would increase after repeated dextroamphetamine challenge to the dopaminergic system...
  16. ncbi request reprint Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 120:47-50. 2003
    ..These results provide support for a role of this variant in the etiopathophysiology of schizophrenia...
  17. ncbi request reprint The effects of nicotine on specific eye tracking measures in schizophrenia
    Jay D Sherr
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Catonsville, USA
    Biol Psychiatry 52:721-8. 2002
    ..The purpose of the current study was to examine the effects of acute administration of nicotine on specific measures of smooth pursuit eye movements and visual attention...
  18. ncbi request reprint Current progress in schizophrenia research: cognitive phenotypes of schizophrenia: attention
    James M Gold
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, MD 21228, USA
    J Nerv Ment Dis 190:638-9. 2002
  19. ncbi request reprint Association between eye tracking disorder in schizophrenia and poor sensory integration
    D E Ross
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland at Baltimore, USA
    Am J Psychiatry 155:1352-7. 1998
    ..The authors tested the hypothesis that eye tracking disorder in schizophrenia is associated with neurological signs...
  20. ncbi request reprint Naltrexone treatment of tardive dyskinesia in patients with schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 24:441-5. 2004
    ..The goal of the current study was to test whether moderately high doses of naltrexone, alone or in combination with a subtherapeutic dose of a gamma aminobutyric acid agonist, improve TD...
  21. ncbi request reprint Current progress in schizophrenia research. Eye movement abnormalities in schizophrenia: what is the nature of the deficit?
    Matthew T Avila
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Box 21247, Baltimore, Maryland 21228, USA
    J Nerv Ment Dis 190:479-80. 2002
  22. ncbi request reprint Tardive dyskinesia in children treated with atypical antipsychotic medications
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Mov Disord 22:1777-82. 2007
    ..Ethnicity might also be a risk factor for dyskinesia in children. Side-effect profile of the atypical antipsychotic drugs in children may be much different than that in adults...
  23. pmc Evidence-based therapeutics--introducing the Cochrane corner
    William T Carpenter
    Schizophr Bull 33:633-4. 2007
  24. ncbi request reprint Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 164:61-5. 2007
    ..The authors hypothesized that the relationship of the two measures may vary as a function of interstimulus intervals of stimulus presentations...
  25. pmc Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:17-23. 2008
    ..A widely used surrogate measure of psychosis in animal models, PPI is considered a schizophrenia endophenotype. We hypothesized that if NRG1 influences PPI in rodents, then it should have a similar effect on PPI in humans...
  26. pmc Refining the predictive pursuit endophenotype in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:458-64. 2008
    ..Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement...
  27. ncbi request reprint Deficits on the Continuous Performance Test within the schizophrenia spectrum and the mediating effects of family history of schizophrenia
    Matthew T Avila
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    J Abnorm Psychol 115:771-8. 2006
    ..Results suggest that SSPD in the absence of a family history of psychosis may be a phenocopy...
  28. pmc Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 66:431-41. 2009
    ..Imaging studies showed that nicotine challenges almost always involve the cingulate cortex, suggesting that this locus may be a key region associated with nicotine addiction and its treatment...
  29. pmc A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Proc Natl Acad Sci U S A 107:13509-14. 2010
    ..Identifying where and how brain circuits link genes to smoking provides practical neural circuitry targets for new treatment development...
  30. ncbi request reprint Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 33:2167-74. 2008
    ..002). In conclusion, the findings confirmed that nicotine transiently improves acoustic PPI in schizophrenia patients. Additionally, schizophrenia patients with more clinical symptoms may have benefited more from nicotinic effect on PPI...
  31. ncbi request reprint Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychophysiology 45:197-204. 2008
    ..The results suggested that beta oscillation indexed a neural process associated with the strength of sensory gating...
  32. pmc Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:632-40. 2010
    ..These electrical oscillatory indexes of subanesthetic ketamine can be potentially used to cross-examine glutamatergic pharmacological effects in translational animal and human studies...
  33. pmc Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009
    ..05), but higher expression in schizophrenia donors. Findings suggest regulatory effects of another gene(s) or etiological factor in schizophrenia, which modulate DAT1 gene function...
  34. pmc Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 65:1008-16. 2008
    ..Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to the direct genetic effects, and thus a more valid endophenotype...
  35. pmc Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 37:416-25. 2011
    ..These findings provide guidance for developing new treatment strategies for the sustained attention deficit in schizophrenia...
  36. pmc Is motion perception deficit in schizophrenia a consequence of eye-tracking abnormality?
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 65:1079-85. 2009
    ..However, eye movement closely interacts with motion perception. The known eye-tracking difficulties in schizophrenia patients may interact with their motion perception...
  37. ncbi request reprint Effects of repeated amphetamine administration on antisaccade in schizophrenia spectrum personality
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Psychiatry Res 141:237-45. 2006
    ..Findings from this preliminary study suggest SSP may be more receptive to the beneficial effects of repeated amphetamine on cognition than healthy controls...
  38. ncbi request reprint Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
    Arch Gen Psychiatry 63:259-64. 2006
    ..Recent studies have suggested that deficit in predictive pursuit, a specific component of the SPEMs, marks schizophrenia susceptibility...
  39. ncbi request reprint Effects of nicotine on leading saccades during smooth pursuit eye movements in smokers and nonsmokers with schizophrenia
    Matthew T Avila
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 28:2184-91. 2003
    ....
  40. ncbi request reprint Neurodevelopmental interactions conferring risk for schizophrenia: a study of dermatoglyphic markers in patients and relatives
    Matthew T Avila
    Schizophrenia Related Disorders Clinic, Maryland Psychiatric Research Center, Baltimore 21228, USA
    Schizophr Bull 29:595-605. 2003
    ..Rather, the data are consistent with a more complex model in which nonspecific genetic factors that increase susceptibility to developmental abnormalities interact with insults and specific genetic factors...
  41. ncbi request reprint Gamma/beta oscillation and sensory gating deficit in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University of Maryland, PO Box 21247, Baltimore, MD 21228, USA
    Neuroreport 15:155-9. 2004
    ..The results of the present study showed that post-SI beta frequency response was inversely correlated to the S2 P50 response in patients with schizophrenia...
  42. ncbi request reprint Evoked gamma band synchronization and the liability for schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 70:293-302. 2004
    ....
  43. ncbi request reprint Ethnicity and the course of tardive dyskinesia in outpatients presenting to the motor disorders clinic at the Maryland psychiatric research center
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychopharmacol 24:592-8. 2004
    ..The current study examines the anatomic distribution and course of TD in a cohort of schizophrenia patients of European and African descent with TD who were referred to the Motor Disorders Clinic (MDC)...
  44. ncbi request reprint Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging study
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
    Biol Psychiatry 57:726-32. 2005
    ....
  45. ncbi request reprint Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005
    ..2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia...
  46. ncbi request reprint Response to unexpected target changes during sustained visual tracking in schizophrenic patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Exp Brain Res 165:125-31. 2005
    ..Data suggest that at-risk individuals for schizophrenia depend less on extraretinal and more on retinal motion signals to maintain pursuit than healthy individuals...
  47. ncbi request reprint Components of the smooth pursuit function in deficit and nondeficit schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 63:39-48. 2003
    ..These findings suggest that predictive smooth pursuit abnormality is associated with positive symptoms in schizophrenia, and that initiation abnormalities may be associated with the deficit syndrome...
  48. ncbi request reprint Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia
    Matthew T Avila
    Maryland Psychiatric Research Center, Baltimore 21228, USA
    Am J Psychiatry 159:1490-6. 2002
    ..The authors examined the effects of ketamine on leading saccadic eye movements, a specific component of the smooth-pursuit response shown to be abnormal in schizophrenia patients and their relatives...
  49. ncbi request reprint Current progress in schizophrenia research: sensory gating deficit in schizophrenia: is the nicotinic alpha-7 receptor implicated?
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore 21228, USA
    J Nerv Ment Dis 190:550-1. 2002
  50. ncbi request reprint Reliability of a portable head-mounted eye tracking instrument for schizophrenia research
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
    Behav Res Methods 37:133-8. 2005
    ..96). This result suggests that the portable device is comparable with a lab-based system, which makes possible the collection of eye movement data in community-based and multicenter familial studies of schizophrenia...
  51. ncbi request reprint Neurophysiological markers of vulnerability to schizophrenia: sensitivity and specificity of specific quantitative eye movement measures
    Matthew T Avila
    Maryland Psychiatric Research Center, University of Maryland, Baltimore 21228, USA
    J Abnorm Psychol 111:259-67. 2002
    ..Combining specific measures provided greater predictive accuracy compared with single measures. Implications for the use of specific eye movement measures to define schizophrenia-related phenotypes in genetic studies are discussed...
  52. ncbi request reprint Using neurophysiological markers of genetic risk to define the boundaries of the schizophrenia spectrum phenotype
    Matthew T Avila
    Schizophrenia Related Disorders Clinic, Maryland Psychiatric Research Center, Baltimore 21228, USA
    Schizophr Bull 29:299-309. 2003
    ..Our results provide suggestive evidence that the use of clinical criteria in research may, in fact, underidentify at-risk individuals--potentially distorting genetic and neurophysiological findings...
  53. ncbi request reprint Current progress in schizophrenia research. Search for genes of schizophrenia: back to defining valid phenes
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore 21228, USA
    J Nerv Ment Dis 190:411-2. 2002
  54. ncbi request reprint Role of anticipation in schizophrenia-related pursuit initiation deficits
    Matthew T Avila
    Maryland Psychiatric Research Ctr, PO Box 21247, Baltimore, MD 21228, USA
    J Neurophysiol 95:593-601. 2006
    ....
  55. pmc A CHRNA5 allele related to nicotine addiction and schizophrenia
    L E Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Genes Brain Behav 10:530-5. 2011
    ....
  56. ncbi request reprint Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome
    C A Tamminga
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228
    Arch Gen Psychiatry 49:522-30. 1992
    ..These results suggest that the limbic system, especially the hippocampus, is functionally involved in schizophrenic psychosis and that different manifestations of schizophrenia may involve different neuronal circuits...
  57. doi request reprint Genetics and intermediate phenotypes of the schizophrenia--bipolar disorder boundary
    Elena I Ivleva
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235, USA
    Neurosci Biobehav Rev 34:897-921. 2010
    ..Overlapping and unique genetic and intermediate phenotypic signatures of the two psychoses are comprehensively recapitulated. Alternative strategies which may be implicated into genetic research are discussed...
  58. ncbi request reprint Current progress in schizophrenia research: application of emerging "gene chip" technologies in search of genes
    Gunvant K Thaker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, Maryland, USA
    J Nerv Ment Dis 190:781. 2002
  59. ncbi request reprint Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Motor Disorders Clinic, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Adv Neurol 96:336-49. 2005
    ..No effective treatments for TD are available. This lack of effective therapy is problematic, especially in the few patients in whom the disorder causes functional impairment and other complications, and in whom it may be irreversible...
  60. ncbi request reprint Schizophrenia, VII: defining the neurobiology of risk factors
    L Elliot Hong
    Am J Psychiatry 160:1929. 2003
  61. pmc Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction
    Alice M Saperstein
    Department of Psychology, University of Maryland, College Park, 20742, USA
    Schizophr Bull 32:498-506. 2006
    ..This is particularly relevant for research efforts to identify pathophysiological components of the disease...
  62. pmc Neurophysiological biomarkers for drug development in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Schizophrenia Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Nat Rev Drug Discov 7:68-83. 2008
    ..Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery...
  63. pmc Endophenotypic studies in schizophrenia: promise and challenges
    Gunvant K Thaker
    Schizophr Bull 33:1-2. 2007
  64. ncbi request reprint Schizophrenia, V: risk markers
    Gunvant K Thaker
    Am J Psychiatry 160:1578. 2003
  65. ncbi request reprint Association between polymorphism of the SNAP29 gene promoter region and schizophrenia
    Ikwunga Wonodi
    Schizophr Res 78:339-41. 2005

Research Grants22

  1. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2007
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. ..
  2. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2007
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  3. RESEARCH TRACK RESIDENCY TRAINING PROGRAM
    Gunvant Thaker; Fiscal Year: 2007
    ....
  4. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant Thaker; Fiscal Year: 2007
    ....
  5. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant Thaker; Fiscal Year: 2009
    ....
  6. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2001
    ..Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status. ..
  7. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant K Thaker; Fiscal Year: 2010
    ....