GULGUN TEZEL

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
    Prog Retin Eye Res 35:18-43. 2013
  2. pmc Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 53:8222-31. 2012
  3. pmc Immune regulation toward immunomodulation for neuroprotection in glaucoma
    GULGUN TEZEL
    Departments of Ophthalmology and Visual Sciences and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA
    Curr Opin Pharmacol 13:23-31. 2013
  4. pmc An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 53:4220-33. 2012
  5. ncbi request reprint Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cells
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Eye Res 81:207-17. 2005
  6. ncbi request reprint Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 46:3177-87. 2005
  7. pmc Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Prog Retin Eye Res 25:490-513. 2006
  8. pmc Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 48:705-14. 2007
  9. pmc Glaucoma
    GULGUN TEZEL
    Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Chem Immunol Allergy 92:221-7. 2007
  10. pmc TNF-alpha signaling in glaucomatous neurodegeneration
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
    Prog Brain Res 173:409-21. 2008

Collaborators

Detail Information

Publications35

  1. pmc A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
    Prog Retin Eye Res 35:18-43. 2013
    ....
  2. pmc Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 53:8222-31. 2012
    ..This study using an antibody-based proteomics approach aimed to identify disease-related antigens as candidate biomarkers of glaucoma...
  3. pmc Immune regulation toward immunomodulation for neuroprotection in glaucoma
    GULGUN TEZEL
    Departments of Ophthalmology and Visual Sciences and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA
    Curr Opin Pharmacol 13:23-31. 2013
    ..This review highlights the current knowledge of molecular mechanisms regulating neuroinflammation in glaucoma...
  4. pmc An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 53:4220-33. 2012
    ..To delineate astrocyte-mediated inflammatory processes in glaucoma, we analyzed proteomic responses of retinal astrocytes in an experimental rat model using a cell-specific approach...
  5. ncbi request reprint Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cells
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Eye Res 81:207-17. 2005
    ....
  6. ncbi request reprint Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 46:3177-87. 2005
    ....
  7. pmc Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Prog Retin Eye Res 25:490-513. 2006
    ..By discussing current evidence, this review provides a broad perspective on cellular mechanisms and potential consequences of oxidative stress in glaucoma...
  8. pmc Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Invest Ophthalmol Vis Sci 48:705-14. 2007
    ..This study aimed to determine the in vitro effects of reactive oxygen species (ROS) on the phenotype and antigen-presenting function of the retina and optic nerve head glia...
  9. pmc Glaucoma
    GULGUN TEZEL
    Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Chem Immunol Allergy 92:221-7. 2007
    ....
  10. pmc TNF-alpha signaling in glaucomatous neurodegeneration
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
    Prog Brain Res 173:409-21. 2008
    ..This review focuses on the present evidence supporting the involvement of TNF-alpha signaling in glaucomatous neurodegeneration and possible treatment targets to provide neuroprotection...
  11. pmc Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 51:907-19. 2010
    ..To determine expression, cellular distribution, and regulation of hemoglobin (Hb) in normal and glaucomatous tissues...
  12. pmc Oxidative stress and the regulation of complement activation in human glaucoma
    Gülgün Tezel
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 51:5071-82. 2010
    ..As part of ongoing studies on proteomic alterations during glaucomatous neurodegeneration, this study focused on the complement system...
  13. pmc The immune response in glaucoma: a perspective on the roles of oxidative stress
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
    Exp Eye Res 93:178-86. 2011
    ....
  14. ncbi request reprint Caspase-independent component of retinal ganglion cell death, in vitro
    GULGUN TEZEL
    Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA
    Invest Ophthalmol Vis Sci 45:4049-59. 2004
    ....
  15. ncbi request reprint Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Arch Ophthalmol 122:1348-56. 2004
    ..To examine tissue hypoxia in the retina and optic nerve head of glaucomatous eyes by the assessment of a transcription factor, hypoxia-inducible factor 1alpha (HIF-1alpha), which is tightly regulated by the cellular oxygen concentration...
  16. pmc Alterations in the morphology of lamina cribrosa pores in glaucomatous eyes
    G Tezel
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Br J Ophthalmol 88:251-6. 2004
    ..To determine alterations which occur in the size and shape of lamina cribrosa (LC) pores in glaucomatous eyes over a period of time...
  17. ncbi request reprint Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    Brain Res 996:202-12. 2004
    ..Since secondarily degenerating neurons are viable targets for neuroprotection, inhibition of TNF death receptor signaling may be an effective strategy to protect RGCs in several neurodegenerative injuries...
  18. ncbi request reprint Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 44:3025-33. 2003
    ..To determine whether retinal glial cells exhibit an activated phenotype in glaucomatous human eyes and whether the mitogen-activated protein kinases (MAPKs) are associated with glial activation in glaucoma...
  19. pmc Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling
    Cheng Luo
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 51:5697-707. 2010
    ..To determine the regulation of immune system activity associated with Toll-like receptor (TLR) signaling in glaucoma...
  20. pmc Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells
    Xiangjun Yang
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 49:2483-94. 2008
    ..To focus on the proteomic analysis of 14-3-3 proteins and to determine their cellular localization and functional role during glaucomatous neurodegeneration...
  21. pmc Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina
    Xiangjun Yang
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Invest Ophthalmol Vis Sci 52:8442-54. 2011
    ..This study aimed to determine retinal proteomic alterations in human glaucoma, with particular focus on links to TNF-α/TNFR1 signaling...
  22. pmc Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head
    GULGUN TEZEL
    Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 48:1201-11. 2007
    ....
  23. ncbi request reprint Autoantibodies in glaucoma
    Martin Wax
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Eye Res 25:113-6. 2002
  24. pmc Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage
    Julie A Kiland
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
    Trans Am Ophthalmol Soc 107:146-58. 2009
    ....
  25. ncbi request reprint Glial modulation of retinal ganglion cell death in glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky, USA
    J Glaucoma 12:63-8. 2003
  26. doi request reprint Immunoregulation of retinal ganglion cell fate in glaucoma
    Martin B Wax
    Department of Ophthalmology and Visual Sciences, University of Texas, Southwestern Medical School, Dallas, TX 75390 9057, USA
    Exp Eye Res 88:825-30. 2009
    ....
  27. ncbi request reprint The immune system and glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Curr Opin Ophthalmol 15:80-4. 2004
    ..Compelling evidence obtained from studies over the last decade strongly suggests the involvement of immune system regulation in cell fate decisions in glia and retinal ganglion cells that lead to glaucomatous optic nerve degeneration...
  28. ncbi request reprint Heat shock proteins, immunity and glaucoma
    GULGUN TEZEL
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
    Brain Res Bull 62:473-80. 2004
    ....
  29. ncbi request reprint Clinical factors associated with progression of glaucomatous optic disc damage in treated patients
    G Tezel
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8096, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 119:813-8. 2001
    ..Reducing intraocular pressure (IOP) in glaucomatous eyes does not always prevent disease progression...
  30. ncbi request reprint Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma
    M B Wax
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Arch Ophthalmol 116:993-1001. 1998
    ..To study the histopathological changes of eyes from a patient with normal-pressure glaucoma whose clinical and laboratory findings were well documented...
  31. ncbi request reprint Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States
    M B Wax
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA
    Ophthalmology 108:296-302. 2001
    ....
  32. ncbi request reprint In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head
    G Tezel
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Glia 34:178-89. 2001
    ..These in vitro findings provide a clearer understanding of the pathophysiologic mechanisms of characteristic tissue remodeling events that occur, in vivo, in the glaucomatous optic nerve head...
  33. ncbi request reprint Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma
    M B Wax
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 125:145-57. 1998
    ....
  34. ncbi request reprint Serum autoantibody against glutathione S-transferase in patients with glaucoma
    J Yang
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
    Invest Ophthalmol Vis Sci 42:1273-6. 2001
    ..013; POAG versus control, P = 0.0006). CONCLUSIONS. These findings indicate that GST is one of the retinal antigens targeted by the serum antibodies detected in some patients with glaucoma...
  35. ncbi request reprint TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes
    G Tezel
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Invest Ophthalmol Vis Sci 42:1787-94. 2001
    ..To determine the expression and localization of tumor necrosis factor (TNF)-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes...

Research Grants11

  1. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  2. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2009
    ....
  3. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2007
    ....
  4. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2006
    ..abstract_text> ..
  5. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ....