Research Topics
Species | GULGUN TEZELSummaryAffiliation: University of Louisville Country: USA Publications
Research Grants
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Publications
A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegenerationGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA Electronic address
Prog Retin Eye Res 35:18-43. 2013....- Immunoproteomic analysis of potential serum biomarker candidates in human glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 53:8222-31. 2012..This study using an antibody-based proteomics approach aimed to identify disease-related antigens as candidate biomarkers of glaucoma... - Immune regulation toward immunomodulation for neuroprotection in glaucomaGULGUN TEZEL
Departments of Ophthalmology and Visual Sciences and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA
Curr Opin Pharmacol 13:23-31. 2013..This review highlights the current knowledge of molecular mechanisms regulating neuroinflammation in glaucoma... - An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Invest Ophthalmol Vis Sci 53:4220-33. 2012..To delineate astrocyte-mediated inflammatory processes in glaucoma, we analyzed proteomic responses of retinal astrocytes in an experimental rat model using a cell-specific approach... 
Comparative gene array analysis of TNF-alpha-induced MAPK and NF-kappaB signaling pathways between retinal ganglion cells and glial cellsGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
Exp Eye Res 81:207-17. 2005....- Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
Invest Ophthalmol Vis Sci 46:3177-87. 2005.... - Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequencesGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
Prog Retin Eye Res 25:490-513. 2006..By discussing current evidence, this review provides a broad perspective on cellular mechanisms and potential consequences of oxidative stress in glaucoma... - Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head gliaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
Invest Ophthalmol Vis Sci 48:705-14. 2007..This study aimed to determine the in vitro effects of reactive oxygen species (ROS) on the phenotype and antigen-presenting function of the retina and optic nerve head glia... - GlaucomaGULGUN TEZEL
Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
Chem Immunol Allergy 92:221-7. 2007.... - TNF-alpha signaling in glaucomatous neurodegenerationGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
Prog Brain Res 173:409-21. 2008..This review focuses on the present evidence supporting the involvement of TNF-alpha signaling in glaucomatous neurodegeneration and possible treatment targets to provide neuroprotection... - Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenationGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 51:907-19. 2010..To determine expression, cellular distribution, and regulation of hemoglobin (Hb) in normal and glaucomatous tissues... - Oxidative stress and the regulation of complement activation in human glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 51:5071-82. 2010..As part of ongoing studies on proteomic alterations during glaucomatous neurodegeneration, this study focused on the complement system... - The immune response in glaucoma: a perspective on the roles of oxidative stressGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
Exp Eye Res 93:178-86. 2011.... - Caspase-independent component of retinal ganglion cell death, in vitroGULGUN TEZEL
Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, KY 40202, USA
Invest Ophthalmol Vis Sci 45:4049-59. 2004.... - Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve headGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Arch Ophthalmol 122:1348-56. 2004..To examine tissue hypoxia in the retina and optic nerve head of glaucomatous eyes by the assessment of a transcription factor, hypoxia-inducible factor 1alpha (HIF-1alpha), which is tightly regulated by the cellular oxygen concentration... - Alterations in the morphology of lamina cribrosa pores in glaucomatous eyesG Tezel
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky Lions Eye Center, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
Br J Ophthalmol 88:251-6. 2004..To determine alterations which occur in the size and shape of lamina cribrosa (LC) pores in glaucomatous eyes over a period of time... - Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in miceGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 E Muhammad Ali Boulevard, Louisville, KY 40202, USA
Brain Res 996:202-12. 2004..Since secondarily degenerating neurons are viable targets for neuroprotection, inhibition of TNF death receptor signaling may be an effective strategy to protect RGCs in several neurodegenerative injuries... - Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 44:3025-33. 2003..To determine whether retinal glial cells exhibit an activated phenotype in glaucomatous human eyes and whether the mitogen-activated protein kinases (MAPKs) are associated with glial activation in glaucoma... - Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signalingCheng Luo
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 51:5697-707. 2010..To determine the regulation of immune system activity associated with Toll-like receptor (TLR) signaling in glaucoma... - Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cellsXiangjun Yang
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 49:2483-94. 2008..To focus on the proteomic analysis of 14-3-3 proteins and to determine their cellular localization and functional role during glaucomatous neurodegeneration... - Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retinaXiangjun Yang
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 52:8442-54. 2011..This study aimed to determine retinal proteomic alterations in human glaucoma, with particular focus on links to TNF-α/TNFR1 signaling... - Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve headGULGUN TEZEL
Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 48:1201-11. 2007.... - Glial modulation of retinal ganglion cell death in glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky, USA
J Glaucoma 12:63-8. 2003 - Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rageJulie A Kiland
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA
Trans Am Ophthalmol Soc 107:146-58. 2009.... 
Immunoregulation of retinal ganglion cell fate in glaucomaMartin B Wax
Department of Ophthalmology and Visual Sciences, University of Texas, Southwestern Medical School, Dallas, TX 75390 9057, USA
Exp Eye Res 88:825-30. 2009....- The immune system and glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
Curr Opin Ophthalmol 15:80-4. 2004..Compelling evidence obtained from studies over the last decade strongly suggests the involvement of immune system regulation in cell fate decisions in glia and retinal ganglion cells that lead to glaucomatous optic nerve degeneration... - Heat shock proteins, immunity and glaucomaGULGUN TEZEL
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA
Brain Res Bull 62:473-80. 2004.... - Clinical factors associated with progression of glaucomatous optic disc damage in treated patientsG Tezel
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8096, 660 S Euclid Ave, St Louis, MO 63110, USA
Arch Ophthalmol 119:813-8. 2001..Reducing intraocular pressure (IOP) in glaucomatous eyes does not always prevent disease progression... - Clinical and ocular histopathological findings in a patient with normal-pressure glaucomaM B Wax
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
Arch Ophthalmol 116:993-1001. 1998..To study the histopathological changes of eyes from a patient with normal-pressure glaucoma whose clinical and laboratory findings were well documented... - Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United StatesM B Wax
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA
Ophthalmology 108:296-302. 2001.... - In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve headG Tezel
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, 63110, USA
Glia 34:178-89. 2001..These in vitro findings provide a clearer understanding of the pathophysiologic mechanisms of characteristic tissue remodeling events that occur, in vivo, in the glaucomatous optic nerve head... - Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucomaM B Wax
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Ophthalmol 125:145-57. 1998.... - Serum autoantibody against glutathione S-transferase in patients with glaucomaJ Yang
Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Invest Ophthalmol Vis Sci 42:1273-6. 2001..013; POAG versus control, P = 0.0006). CONCLUSIONS. These findings indicate that GST is one of the retinal antigens targeted by the serum antibodies detected in some patients with glaucoma... - TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyesG Tezel
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Invest Ophthalmol Vis Sci 42:1787-94. 2001..To determine the expression and localization of tumor necrosis factor (TNF)-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes...
Research Grants
- Proteomic Analysis of Retinal Ganglion Cell Death in GlaucomaGULGUN TEZEL; Fiscal Year: 2010..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
- TNF-alpha in cell death & neuroprotection in glaucomaGULGUN TEZEL; Fiscal Year: 2009....
- TNF-alpha in cell death & neuroprotection in glaucomaGULGUN TEZEL; Fiscal Year: 2007....
- TNF-alpha in cell death & neuroprotection in glaucomaGULGUN TEZEL; Fiscal Year: 2006..abstract_text> ..
- TNF-alpha in cell death & neuroprotection in glaucomaGULGUN TEZEL; Fiscal Year: 2010....