Cory Teuscher

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice
    K M Spach
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Genes Immun 11:649-59. 2010
  2. pmc Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis
    Naresha Saligrama
    1Immunobiology Program, C331 Given Medical Building, University of Vermont, Burlington, VT 05405, USA
    FASEB J 28:1898-909. 2014
  3. pmc Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis
    Dionne P Robinson
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biol Sex Differ 2:8. 2011
  4. pmc Evidence that the Y chromosome influences autoimmune disease in male and female mice
    Cory Teuscher
    Department of Medicine and Pathology and Medical Biostatistics, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 103:8024-9. 2006
  5. pmc eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter
    Cory Teuscher
    Department of Medicine and Pathology, University of Vermont, Burlington 05405, USA
    Genetics 172:1147-53. 2006
  6. pmc Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells
    Cory Teuscher
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 164:883-92. 2004
  7. pmc Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis
    Cory Teuscher
    Immunobiology Program, C317 Given Medical Building, University of Vermont, Burlington, VT 05405, USA
    Am J Pathol 165:1593-602. 2004
  8. pmc Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
    Cory Teuscher
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:10146-51. 2007
  9. pmc Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 180:7471-9. 2008
  10. pmc The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease
    Laure K Case
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Genome Res 23:1474-85. 2013

Research Grants

  1. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2007
  2. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2004
  3. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
  4. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2007
  5. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2005
  6. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2000
  7. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2001
  8. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2009
  9. Histamine Receptor Signaling in CNS Autoimmune Disease
    Cory Teuscher; Fiscal Year: 2009
  10. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2009

Collaborators

Detail Information

Publications56

  1. pmc Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice
    K M Spach
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Genes Immun 11:649-59. 2010
    ..These results indicate that multiple quantitative trait loci (QTLs) within the Tmevd2/Eae3 interval influence EAE severity, one of which includes a homology region for a QTL found in MS by admixture mapping...
  2. pmc Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis
    Naresha Saligrama
    1Immunobiology Program, C331 Given Medical Building, University of Vermont, Burlington, VT 05405, USA
    FASEB J 28:1898-909. 2014
    ..Saligrama, N., Case, L. K., Krementsov, D. N., Teuscher, C. Histamine H2 receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. ..
  3. pmc Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis
    Dionne P Robinson
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biol Sex Differ 2:8. 2011
    ..abstract:..
  4. pmc Evidence that the Y chromosome influences autoimmune disease in male and female mice
    Cory Teuscher
    Department of Medicine and Pathology and Medical Biostatistics, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 103:8024-9. 2006
    ..Importantly, these data provide experimental evidence supporting the existence of a Y-chromosome polymorphism capable of modifying autoimmune disease susceptibility in both males and females...
  5. pmc eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter
    Cory Teuscher
    Department of Medicine and Pathology, University of Vermont, Burlington 05405, USA
    Genetics 172:1147-53. 2006
    ....
  6. pmc Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells
    Cory Teuscher
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 164:883-92. 2004
    ..Because MCP-1 is known to inhibit IL-12 production, the failure of H2RKO mice to generate encephalitogenic Th1 effector cell responses is consistent with inhibition of negative regulation of MCP-1 secretion by H2R signaling in APCs...
  7. pmc Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis
    Cory Teuscher
    Immunobiology Program, C317 Given Medical Building, University of Vermont, Burlington, VT 05405, USA
    Am J Pathol 165:1593-602. 2004
    ..These results indicate that age and seasonal effects are capable of overriding eae5-dependent genetic control of susceptibility to clinical EAE and have significant implications for the genetics of MS...
  8. pmc Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
    Cory Teuscher
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:10146-51. 2007
    ..Our data suggest that pharmacological targeting of the H3R may be useful in preventing the development and formation of new lesions in multiple sclerosis, thereby significantly limiting the progression of the disease...
  9. pmc Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 180:7471-9. 2008
    ..These data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility...
  10. pmc The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease
    Laure K Case
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Genome Res 23:1474-85. 2013
    ..Thus, as in Drosophila, these data establish the mammalian ChrY as a member of the regulatory genome due to its ability to epigenetically regulate genome-wide gene expression in immune cells. ..
  11. pmc Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis
    Changming Lu
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 107:18967-72. 2010
    ..Thus, contrary to prevailing assumptions, our results show that endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity...
  12. pmc Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis
    Naresha Saligrama
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 191:614-22. 2013
    ..Understanding and exploiting this pathway has the potential to lead to new disease-modifying therapies in multiple sclerosis and other autoimmune and allergic diseases...
  13. pmc Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, Vermont, USA
    PLoS ONE 8:e62743. 2013
    ..Pharmacological targeting of H(3)R may therefore be useful in preventing the development and formation of new lesions in MS, thereby limiting disease progression...
  14. pmc The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice
    Laure K Case
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Immunol 260:119-27. 2010
    ..These data suggest that there are maternally derived postnatal factors that influence the development of autoimmune disease in A/J mice...
  15. pmc Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C
    Roxana del Rio
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, Vermont, United States of America
    PLoS Genet 8:e1003140. 2012
    ..These findings may provide mechanistic insight into how polymorphism in other kinesins such as KIF21B and KIF5A influence susceptibility and resistance to human autoimmune diseases...
  16. pmc H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis
    Naresha Saligrama
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Immunol 278:27-34. 2012
    ....
  17. pmc von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Pathol 173:892-900. 2008
    ..Taken together, these data indicate that VWF and/or Weibel-Palade bodies negatively regulate BBB permeability changes and autoimmune inflammatory lesion formation within the brain elicited by peripheral inflammatory stimuli...
  18. pmc Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    J Clin Invest 117:3507-18. 2007
    ..These data suggest that the presence of H1R in CD4+ T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease...
  19. pmc Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system
    Roxana del Rio
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Immunol 188:541-7. 2012
    ..Moreover, the lack of H(4)R leads to an impairment of an anti-inflammatory response due to fewer T(R) cells in the CNS during the acute phase of the disease and an increase in the proportion of Th17 cells...
  20. pmc Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system
    Naresha Saligrama
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Eur J Immunol 42:1536-46. 2012
    ..These findings support the concept that combined pharmacological targeting of HRs may be an appropriate ancillary DMT in MS and other immunopathologic diseases...
  21. pmc Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice
    Karen M Spach
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 182:1789-93. 2009
    ..EAE was significantly more severe in young male SJL.Y(B10.S) mice compared with young male SJL/J mice. These studies show that a Y chromosome-linked polymorphism controls the age-dependent EAE sexual dimorphism observed in SJL/J mice...
  22. pmc G proteins Gαi1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization
    SEAN A DIEHL
    Department of Medicine Infectious Diseases, University of Vermont College of Medicine, Burlington, Vermont, USA
    Infect Immun 82:773-82. 2014
    ..Finally, by using mice deficient in individual Gαi/o G-protein subunits, we demonstrate that Gαi1 and Gαi3 are the critical in vivo targets of ADP-ribosylation underlying VAAS elicited by PTX exposure. ..
  23. pmc Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT
    Ann Neurol 75:50-66. 2014
    ..Investigators have described p38 mitogen-activated protein kinase (MAPK) as a key regulator of inflammatory responses in autoimmunity, but its role in the sexual dimorphism in MS or MS models remains unexplored...
  24. pmc Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
    Rajkumar Noubade
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT, USA
    Blood 118:3290-300. 2011
    ..Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell-mediated diseases...
  25. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
    ..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
  26. pmc H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease
    Roxana del Rio
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 186:382-9. 2011
    ..These data support the existence of an LN-specific, H2-controlled mechanism regulating the prevalence of nTregs in autoimmune disease susceptibility...
  27. pmc A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis
    Karen M Spach
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 182:7776-83. 2009
    ..Single nucleotide polymorphisms like the one that distinguishes Tyk2 alleles are of considerable significance given the potential role of gene-by-environment interactions in autoimmune disease susceptibility...
  28. ncbi request reprint Pertussis toxin induces angiogenesis in brain microvascular endothelial cells
    Changming Lu
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Neurosci Res 86:2624-40. 2008
    ..Taken together, these findings are consistent with the concept that PTX may lead to increased BBB permeability by altering endothelial plasticity and angiogenesis...
  29. pmc Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin
    Jian Feng Gao
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Infect Immun 71:1281-7. 2003
    ..These results indicate that the phenotypic variation in responsiveness to PTX reflects the genetic control of distinct intermediate phenotypes rather than allelic variation in genes controlling overall susceptibility to intoxication...
  30. pmc Histamine H(1) receptor signaling regulates effector T cell responses and susceptibility to coxsackievirus B3-induced myocarditis
    Laure K Case
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cell Immunol 272:269-74. 2012
    ..These data establish a critical role for histamine and H(1)R signaling in regulating T cell responses and susceptibility to CVB3-induced myocarditis in B6 mice...
  31. pmc Resistance to lipopolysaccharide-induced preterm delivery mediated by regulatory T cell function in mice
    Peyman Bizargity
    Department of Obstetrics, University of Vermont College of Medicine, Burlington, Vermont, USA
    Biol Reprod 80:874-81. 2009
    ....
  32. pmc Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus
    Emma H Wall
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    FASEB J 27:1874-86. 2013
    ..Our novel insights into the mechanisms underlying the genetic control of tissue sensitivity to estrogen have great potential to advance understanding of individualized effects in physiological and disease states...
  33. pmc Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function
    Idil Aktan
    Department of Surgery, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Immunol 185:144-56. 2010
    ..These data suggest that the polymorphisms that distinguish two Slam haplotypes significantly modulate the innate immune response in vivo through their effect on NKT cells...
  34. doi request reprint G Proteins Gαi1/3 Are Critical Targets for Bordetella pertussis Toxin-Induced Vasoactive Amine Sensitization
    SEAN A DIEHL
    Department of Medicine Infectious Diseases, University of Vermont College of Medicine, Burlington, Vermont, USA
    Infect Immun 82:773-82. 2014
    ..Finally, by using mice deficient in individual Gαi/o G-protein subunits, we demonstrate that Gαi1 and Gαi3 are the critical in vivo targets of ADP-ribosylation underlying VAAS elicited by PTX exposure. ..
  35. pmc The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, Vermont, USA
    Mol Cell Biol 33:3728-34. 2013
    ....
  36. pmc Studies in experimental autoimmune encephalomyelitis do not support developmental bisphenol a exposure as an environmental factor in increasing multiple sclerosis risk
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, Vermont 05405, USA
    Toxicol Sci 135:91-102. 2013
    ..Overall, our results do not support gestational BPA exposure as a significant contributor to the increasing female MS risk. ..
  37. pmc Environmental factors acting during development to influence MS risk: insights from animal studies
    Dimitry N Krementsov
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Mult Scler 19:1684-9. 2013
    ..Nonetheless, studies in this area so far are few. In this review, we summarize the insights gleaned from studies that test environmental influences in animal models of MS, with a particular focus on gestational and early life exposures. ..
  38. ncbi request reprint Identification of Bphs, an autoimmune disease locus, as histamine receptor H1
    Runlin Z Ma
    Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101
    Science 297:620-3. 2002
    ..Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization...
  39. ncbi request reprint Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility
    Randall J Roper
    Department of Veterinary Pathobiology, University of Illinois, Urbana, IL 61802, USA
    J Immunol 170:5886-91. 2003
    ..Given the roles of cathepsins in Ag processing and presentation, Stfa1 and Stfa2 alleles have the potential to control susceptibility to autoimmune disease at the level of both CD4(+)CD25(+) suppressor and CD4(+)CD25(-) effector T cells...
  40. pmc The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am J Pathol 163:1599-605. 2003
    ..These results indicate that the immunomodulatory effects of E2 in EAE are dependent on Esr1 and not Esr2 signaling...
  41. pmc Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis
    Parley D Fillmore
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Am J Pathol 163:1623-32. 2003
    ..These results reinforce the importance of gene-environment interactions in initiating and propagating autoimmune disease of the central nervous system, particularly in the context of susceptibility to MS and disease heterogeneity...
  42. pmc Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis
    Parley D Fillmore
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Am J Pathol 164:167-75. 2004
    ..Thus, additional mechanisms must play a role in regulating gender differences in autoimmune disease of the CNS...
  43. pmc Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Pathol 164:1915-24. 2004
    ..These results indicate that the heterotic effect at Esr2 is a function of the nonhematopoietic compartment...
  44. pmc IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 S W U S Veterans Hospital Road, Portland, OR 97239, USA
    J Immunol 180:2679-85. 2008
    ....
  45. ncbi request reprint Identification of quantitative trait loci for chemical/inflammatory nociception in mice
    Sonya G Wilson
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Pain 96:385-91. 2002
    ..Identification of the genes underlying these QTLs may illuminate the basis of individual differences in inflammatory pain, and lead to novel analgesic treatment strategies...
  46. ncbi request reprint Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases
    Marko Mihelic
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 580:4195-9. 2006
    ..In contrast, the inhibitory activities of Stfa2-a and Stfa2-b were found to be roughly equivalent for all targets peptidases...
  47. ncbi request reprint Cutting edge: Autoimmune disease in day 3 thymectomized mice is actively controlled by endogenous disease-specific regulatory T cells
    Eileen T Samy
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 180:4366-70. 2008
    ..Thus, d3tx mice possess disease-relevant Treg of presumed neonatal origin. They accumulate in the regional LN and actively inhibit concurrent autoimmune disease; however, they cannot fully prevent autoimmune disease development...
  48. pmc Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase
    Hillary Crandall
    Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132
    Am J Pathol 167:775-85. 2005
    ..Together, these results argue that Ncf1 is not a candidate gene for regulation of Lyme arthritis and reveal Lyme arthritis to be independent of NADPH oxidase activity, distinguishing it from other models of rheumatoid arthritis...
  49. ncbi request reprint Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice
    Randall J Roper
    Department of Veterinary Pathobiology, University of Illinois, Urbana, IL 61802, USA
    J Immunol 169:1640-6. 2002
    ....
  50. ncbi request reprint Identification of alternate splice variants for murine SmX5
    Yi Zhang
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Yi Chuan Xue Bao 30:515-20. 2003
    ....
  51. pmc Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression
    Scott W Rogers
    SLC VA GRECC and University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hippocampus 18:750-7. 2008
    ..These finding suggest that this chromosomal segment harbors genes that regulate strain distinct hippocampal morphology that is revealed by nAChR alpha 4 expression...
  52. pmc Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi
    Melissa R Potter
    Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, Salt Lake City, Utah 84132 2501, USA
    Infect Immun 70:1372-81. 2002
    ..Interestingly, there was no alteration in the B. burgdorferi-specific antibody isotypes in OPN-deficient mice, indicating that its effect on helper T-cell responses is not relevant to the host response to B. burgdorferi...
  53. pmc Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination
    Russell J Butterfield
    Department of Veterinary Pathobiology, University of Illinois, Urbana, Illinois 61802, USA
    Genetics 163:1041-6. 2003
    ..Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice...
  54. pmc Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci
    Ryan D McAllister
    Department of Microbiology, University of Illinois, Urbana, IL, USA
    Am J Pathol 163:1735-41. 2003
    ..Additionally, to recapitulate dominant resistance to mortality as seen in (BALB/c x DBA/2) F(1) hybrids, DBA/2 alleles are required at all three QTL...
  55. pmc From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
    Sangwon F Kim
    The Solomon H Snyder Department of Neuroscience, Departments of Pharmacology and Molecular Sciences and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3456-9. 2007
    ..These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake...

Research Grants35

  1. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2007
    ....
  2. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2004
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  3. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
    ....
  4. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2007
    ..abstract_text> ..
  5. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2005
    ..abstract_text> ..
  6. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2000
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  7. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2001
    ....
  8. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2009
    ..abstract_text> ..
  9. Histamine Receptor Signaling in CNS Autoimmune Disease
    Cory Teuscher; Fiscal Year: 2009
    ..In this regard, GPCRs are one of the most tractable set of targets for the development of clinically effective, small molecule pharmaceuticals. Of the drugs used clinically in man ~50% target GPCRs. ..
  10. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2009
    ....
  11. Histamine Receptor Signaling in CNS Autoimmune Disease
    Cory Teuscher; Fiscal Year: 2010
    ..In this regard, GPCRs are one of the most tractable set of targets for the development of clinically effective, small molecule pharmaceuticals. Of the drugs used clinically in man ~50% target GPCRs. ..
  12. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2007
    ..abstract_text> ..
  13. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2006
    ....
  14. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2006
    ..abstract_text> ..
  15. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2000
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  16. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2001
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  17. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2002
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  18. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2001
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  19. IMMUNOREGULATORY LOCI IN ORGAN SPECIFIC AUTOIMMUNITY
    Cory Teuscher; Fiscal Year: 2001
    ..D2Orch3CT3 recombinant congenic mice to narrow down the support interval encoding the locus to a size amenable to positional cloning (less than 1 cM), and 2) construct a yeast artificial chromosome (YAC) contig encompassing Orch3. ..
  20. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2003
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  21. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2004
    ..abstract_text> ..
  22. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2005
    ..abstract_text> ..
  23. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2005
    ....
  24. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2006
    ..abstract_text> ..
  25. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2010
    ....