Research Topics
| Herve TettelinSummaryAffiliation: University of Maryland Country: USA Publications
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Detail Information
Publications
Genomic insights into the emerging human pathogen Mycobacterium massilienseHerve Tettelin
Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Bacteriol 194:5450. 2012..Mycobacterium massiliense (Mycobacterium abscessus group) is an emerging pathogen causing pulmonary disease and skin and soft tissue infections. We report the genome sequence of the type strain CCUG 48898...
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related speciesClaudio Donati
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
Genome Biol 11:R107. 2010..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group...
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity islandWillem van Schaik
Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
BMC Genomics 11:239. 2010..The Gram-positive bacterium Enterococcus faecium is an important cause of nosocomial infections in immunocompromized patients...
Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applicationsJorge Valdes
Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida, Facultad de Ciencias de la Salud, Universidad Andres Bello, Santiago, Chile
BMC Genomics 9:597. 2008..Also, confusion has been caused by prior metabolic models constructed based upon the examination of multiple, and sometimes distantly related, strains of the microorganism...
Improving pan-genome annotation using whole genome multiple alignmentSamuel V Angiuoli
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA
BMC Bioinformatics 12:272. 2011..Genome annotations can contain inconsistencies and errors that hinder comparative analysis even within a single species. Tools are needed to compare and improve annotation quality across sets of closely related genomes...
Comparative genomics: the bacterial pan-genomeHerve Tettelin
Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Curr Opin Microbiol 11:472-7. 2008..Different models exist for the analysis and their accuracy and applicability depend on the case at hand. Here we discuss current models and suggest a new model of broad applicability, including examples of its implementation...
Comparative genomics of emerging human ehrlichiosis agentsJulie C Dunning Hotopp
The Institute for Genomic Research, Rockville, Maryland, USA
PLoS Genet 2:e21. 2006..These discoveries provide significant insights into the biology of these obligate intracellular pathogens...
Using Sybil for interactive comparative genomics of microbes on the webDavid R Riley
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
Bioinformatics 28:160-6. 2012..In addition to scalability, comparative genomics tools must also provide user-friendly interfaces such that the research scientist can explore complex data with minimal technical expertise...
Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotesJulie C Dunning Hotopp
Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 317:1753-6. 2007..Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions...
Bacterial genome sequencingHerve Tettelin
Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Methods Mol Biol 551:231-47. 2009..We review a number of sequencing technologies and provide examples of applications. We also discuss the impact genomics and new DNA sequencing approaches have had on various fields of biological research...
Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath)Naomi Ward
The Institute for Genomic Research, Rockville, Maryland, USA
PLoS Biol 2:e303. 2004..We have gained evidence for greater metabolic flexibility than was previously known, and for genetic components that may have biotechnological potential...
Whole-genome association study on tissue tropism phenotypes in group A StreptococcusDebra E Bessen
New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
J Bacteriol 193:6651-63. 2011..This study employs a novel synthesis of tools to help delineate the major genetic changes associated with key adaptive shifts in an extensively recombined bacterial species...
Genome-wide identification of genes required for fitness of group A Streptococcus in human bloodYoann Le Breton
Department of Cell Biology and Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA
Infect Immun 81:862-75. 2013..Overall, this work represents the first use of TraSH in GAS to identify potential virulence genes...
