Fernando D Testai

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA
    Stroke 43:2066-70. 2012
  2. doi Acute hemorrhagic stroke pathophysiology and medical interventions: blood pressure control, management of anticoagulant-associated brain hemorrhage and general management principles
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, 912 South Wood Street, Room 855N, Chicago, IL 60612, USA
    Neurol Clin 26:963-85, viii-ix. 2008
  3. doi Proof of concept: endogenous antiangiogenic factors predict the occurrence of symptomatic vasospasm post subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology of the University of Illinois at Chicago, 912 S Wood Street MC 796, Chicago, IL 60612 7330, USA
    Neurocrit Care 15:416-20. 2011
  4. doi Inherited metabolic disorders and stroke part 1: Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 S Wood St, Room 855N NPI
    Arch Neurol 67:19-24. 2010
  5. doi Inherited metabolic disorders and stroke part 2: homocystinuria, organic acidurias, and urea cycle disorders
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, 912 S Wood Street, Chicago, IL 60612, USA
    Arch Neurol 67:148-53. 2010
  6. pmc Effect of sex on outcome after recurrent stroke in African Americans: results from the African American Antiplatelet Stroke Prevention Study
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    J Stroke Cerebrovasc Dis 19:321-5. 2010
  7. ncbi New approaches to stroke prevention in atrial fibrillation
    Fernando D Testai
    Section of Cerebrovascular Disease and Neurologic Critical Care, Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 South Wood Street, Room 855N, Chicago, IL, 60612, USA
    Curr Treat Options Cardiovasc Med 12:261-73. 2010
  8. doi Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats
    Benjarat Changyaleket
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, United States
    Brain Res 1634:171-8. 2016
  9. pmc Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurochem 131:530-40. 2014
  10. pmc Changes in the metabolism of sphingolipids after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois
    J Neurosci Res 93:796-805. 2015

Collaborators

Detail Information

Publications19

  1. doi Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA
    Stroke 43:2066-70. 2012
    ..The purpose of this study was to investigate changes in the cerebrospinal fluid sphingolipid profile in patients with subarachnoid hemorrhage in relation to the occurrence of symptomatic vasospasm and outcome at hospital discharge...
  2. doi Acute hemorrhagic stroke pathophysiology and medical interventions: blood pressure control, management of anticoagulant-associated brain hemorrhage and general management principles
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, 912 South Wood Street, Room 855N, Chicago, IL 60612, USA
    Neurol Clin 26:963-85, viii-ix. 2008
    ....
  3. doi Proof of concept: endogenous antiangiogenic factors predict the occurrence of symptomatic vasospasm post subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology of the University of Illinois at Chicago, 912 S Wood Street MC 796, Chicago, IL 60612 7330, USA
    Neurocrit Care 15:416-20. 2011
    ..The authors hypothesize that circulating antiangiogenic factors play an important role in brain injury post SAH and that elevated levels predict the occurrence of symptomatic vasospasm...
  4. doi Inherited metabolic disorders and stroke part 1: Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 S Wood St, Room 855N NPI
    Arch Neurol 67:19-24. 2010
    ..In part 1, we concentrate on Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. In part 2 we will review homocystinuria, organic acidurias, and urea cycle disorders...
  5. doi Inherited metabolic disorders and stroke part 2: homocystinuria, organic acidurias, and urea cycle disorders
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, 912 S Wood Street, Chicago, IL 60612, USA
    Arch Neurol 67:148-53. 2010
    ..In part 2, we overview homocystinuria, organic acidurias, and urea cycle disorders...
  6. pmc Effect of sex on outcome after recurrent stroke in African Americans: results from the African American Antiplatelet Stroke Prevention Study
    Fernando D Testai
    Department of Neurology and Rehabilitation, Section of Cerebrovascular Disease and Neurological Critical Care, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    J Stroke Cerebrovasc Dis 19:321-5. 2010
    ..Our objective was to investigate the effect of sex on the outcome of recurrent nonfatal stroke in the African American Antiplatelet Stroke Prevention Study (AAASPS)...
  7. ncbi New approaches to stroke prevention in atrial fibrillation
    Fernando D Testai
    Section of Cerebrovascular Disease and Neurologic Critical Care, Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 South Wood Street, Room 855N, Chicago, IL, 60612, USA
    Curr Treat Options Cardiovasc Med 12:261-73. 2010
    ..However, the use of warfarin may be challenging in some patients, and there is a need for alternative treatments. We describe alternative treatments for AF and provide an overview on emerging therapies...
  8. doi Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats
    Benjarat Changyaleket
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, United States
    Brain Res 1634:171-8. 2016
    ..These findings indicate that S100B regulates neuronal and endothelial dependent cerebral arteriolar dilation and suggest that this phenomenon is mediated through RAGE-associated pathways. ..
  9. pmc Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurochem 131:530-40. 2014
    ..These changes reverse by inhibiting the de novo sphingolipid synthesis, which worsens hypoxia-induced endothelial barrier dysfunction and apoptosis, suggesting that the identified sphingolipids may be vasculoprotective. ..
  10. pmc Changes in the metabolism of sphingolipids after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois
    J Neurosci Res 93:796-805. 2015
    ..Additional studies are needed to determine the effect of modulators of the pathways described here in SAH...
  11. pmc Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
    Hao Liang Xu
    Neuroanesthesia Research Laboratory, University of Illinois College of Medicine, Chicago, IL, USA
    J Neuroinflammation 12:16. 2015
    ..Inflammation is increasingly recognized as a key pathogenic contributor to brain injury in this condition. In the present study, we examined the neuroprotective effects of the immunomodulatory agent, fingolimod, in rats subjected to SAH...
  12. pmc Oxidized phosphatidylcholine formation and action in oligodendrocytes
    Jingdong Qin
    Departments of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Neurochem 110:1388-99. 2009
    ..We concluded that OxPC initially activated NSMase and converted sphingomyelin into ceramide to mediate a series of downstream pro-apoptotic events in oligodendrocytes...
  13. pmc Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons
    John P Kilkus
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Neurochem 106:1745-57. 2008
    ..Thus, SMS rather than SMases may be more important for sphingolipid homeostasis in oligodendrocytes, whereas the reverse may be true for neurons...
  14. doi Correction of coagulopathy in warfarin associated cerebral hemorrhage
    Venkatesh Aiyagari
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Curr Opin Crit Care 15:87-92. 2009
    ..Traditional methods of reversal of the anticoagulant effect of warfarin involving the use of vitamin K and fresh frozen plasma are slow and relatively ineffective and there is a need for alternative treatment approaches...
  15. doi VAP-1 blockade prevents subarachnoid hemorrhage-associated cerebrovascular dilating dysfunction via repression of a neutrophil recruitment-related mechanism
    Haoliang Xu
    Neuroanesthesia Research Laboratory, Department of Anesthesiology, University of Illinois Chicago, Chicago, IL, United States Electronic address
    Brain Res 1603:141-9. 2015
    ..The present findings suggest that attenuating SAH-linked elevation in neutrophil trafficking will protect against the development of microvascular dysfunction and subsequent neurological impairment...
  16. doi The dementia of cardiac disease
    Hurmina Muqtadar
    Section of Stroke and Neurocritical Care, Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 60612, USA
    Curr Cardiol Rep 14:732-40. 2012
    ..In this article, the authors discuss the association between cognitive impairment and atrial fibrillation, coronary artery disease, congestive heart failure, and cardiovascular procedures...
  17. ncbi Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines
    John Kilkus
    Departments of Pediatrics, Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 30637, USA
    J Neurosci Res 72:65-75. 2003
    ..Most of the neutral sphingomyelinase activity is in the Raft fraction, suggesting that the conversion of sphingomyelin to ceramide in Rafts is an important event in neural cell apoptosis...
  18. ncbi Recurrent posterior reversible encephalopathy syndrome in a sickle cell patient
    Anjana Nair
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Illinois 60612, USA
    J Natl Med Assoc 103:170-2. 2011
    ..Here, we report a rare and unusual case of recurrent PRES in a young adult sickle cell patient without any obvious precipitating factors...