JOHN TESMER

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer
    Valerie M Tesmer
    Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Structure 20:1300-9. 2012
  2. ncbi Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:622-5. 2012
  3. ncbi Pharmacology. Hitting the hot spots of cell signaling cascades
    John Joseph Grubb Tesmer
    Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    Science 312:377-8. 2006
  4. ncbi Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors
    David M Thal
    Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Room 3425, Ann Arbor, MI 48109, USA
    Mol Pharmacol 80:294-303. 2011
  5. ncbi The quest to understand heterotrimeric G protein signaling
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Struct Mol Biol 17:650-2. 2010
  6. ncbi Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Med Chem 53:1867-70. 2010
  7. ncbi A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins
    Barry Kreutz
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Biochemistry 45:167-74. 2006
  8. ncbi Guanylyl cyclase sees the light
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    J Biol 7:31. 2008
  9. ncbi In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers
    Xiaoyun Chen
    Department of Chemistry, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Chem Soc 129:12658-9. 2007
  10. ncbi Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation
    Puja Singh
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:14053-62. 2008

Research Grants

  1. Structural Studies of Galphaq and Its Complexes at the Cell Membrane
    John J G Tesmer; Fiscal Year: 2010
  2. Structural Studies of Galphaq and Its Complexes at the Cell Membrane
    JOHN TESMER; Fiscal Year: 2007
  3. Activation of G Protein-Coupled Kinase 2
    JOHN TESMER; Fiscal Year: 2007
  4. Molecular basis for the regulation of G protein-coupled receptor kinases
    John J G Tesmer; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer
    Valerie M Tesmer
    Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Structure 20:1300-9. 2012
    ..Constraints imposed on the RNA by the terminal stem of the aptamer also play a role. These results highlight how a high-affinity aptamer can be used to selectively trap a novel conformational state of a protein kinase...
  2. ncbi Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:622-5. 2012
    ....
  3. ncbi Pharmacology. Hitting the hot spots of cell signaling cascades
    John Joseph Grubb Tesmer
    Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    Science 312:377-8. 2006
  4. ncbi Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors
    David M Thal
    Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Room 3425, Ann Arbor, MI 48109, USA
    Mol Pharmacol 80:294-303. 2011
    ..However, our results indicate that these residues are not major determinants of selectivity among GRK subfamilies. Rather, selectivity is achieved by the stabilization of a unique inactive conformation of the GRK2 kinase domain...
  5. ncbi The quest to understand heterotrimeric G protein signaling
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Struct Mol Biol 17:650-2. 2010
    ..Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs...
  6. ncbi Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Med Chem 53:1867-70. 2010
    ..The selectivity of balanol among human GRKs is assessed...
  7. ncbi A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins
    Barry Kreutz
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Biochemistry 45:167-74. 2006
    ....
  8. ncbi Guanylyl cyclase sees the light
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    J Biol 7:31. 2008
    ....
  9. ncbi In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers
    Xiaoyun Chen
    Department of Chemistry, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Chem Soc 129:12658-9. 2007
  10. ncbi Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation
    Puja Singh
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:14053-62. 2008
    ..Co-localization of the N terminus and the C-terminal extension near the hinge of the kinase domain suggests that activated GPCRs stimulate kinase activity by binding to this region to facilitate full closure of the kinase domain...
  11. ncbi Molecular basis for activation of G protein-coupled receptor kinases
    Cassandra A Boguth
    Life Sciences Institute, The University of Michigan, Ann Arbor, MI, USA
    EMBO J 29:3249-59. 2010
    ..Our structural and biochemical results thus provide an explanation for how receptor recognition, phospholipid binding, and kinase activation are intimately coupled in GRKs...
  12. ncbi Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors
    Mohamed Aittaleb
    University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Mol Pharmacol 77:111-25. 2010
    ..This review covers what is currently known about the structure, function, and regulation of these recently recognized effectors of heterotrimeric G proteins...
  13. ncbi Assembly of high order G alpha q-effector complexes with RGS proteins
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:34923-34. 2008
    ....
  14. ncbi Structural analysis of thermostabilizing mutations of cocaine esterase
    Diwahar Narasimhan
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    Protein Eng Des Sel 23:537-47. 2010
    ..The improved stability of these engineered CocE enzymes will have a profound influence on the use of this protein to combat cocaine-induced toxicity and addiction in humans...
  15. ncbi A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases
    Chih Chin Huang
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 284:17206-15. 2009
    ..Receptor binding is proposed to promote this interaction, thereby enhancing GRK activity...
  16. ncbi Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell Signal 22:1114-23. 2010
    ....
  17. ncbi Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent
    Jeffery N Talbot
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    J Neurochem 112:1026-34. 2010
    ....

Research Grants12

  1. Structural Studies of Galphaq and Its Complexes at the Cell Membrane
    John J G Tesmer; Fiscal Year: 2010
    ..abstract_text> ..
  2. Structural Studies of Galphaq and Its Complexes at the Cell Membrane
    JOHN TESMER; Fiscal Year: 2007
    ..GRK2 and G?q /n are essential for proper heart development and function, RGS2 regulates blood pressure via attenuation of G?q signaling, and p63RhoGEF induces changes in myocytes that are characteristic of cardiac hypertrophy. ..
  3. Activation of G Protein-Coupled Kinase 2
    JOHN TESMER; Fiscal Year: 2007
    ..abstract_text> ..
  4. Molecular basis for the regulation of G protein-coupled receptor kinases
    John J G Tesmer; Fiscal Year: 2010
    ....