John Jg Tesmer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Guanylyl cyclase sees the light
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    J Biol 7:31. 2008
  2. pmc Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Med Chem 53:1867-70. 2010
  3. pmc The quest to understand heterotrimeric G protein signaling
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Struct Mol Biol 17:650-2. 2010
  4. ncbi request reprint In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers
    Xiaoyun Chen
    Department of Chemistry, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Chem Soc 129:12658-9. 2007
  5. pmc Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation
    Puja Singh
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:14053-62. 2008
  6. pmc Molecular basis for activation of G protein-coupled receptor kinases
    Cassandra A Boguth
    Life Sciences Institute, The University of Michigan, Ann Arbor, MI, USA
    EMBO J 29:3249-59. 2010
  7. pmc Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors
    Mohamed Aittaleb
    University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Mol Pharmacol 77:111-25. 2010
  8. pmc A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases
    Chih Chin Huang
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 284:17206-15. 2009
  9. pmc Structural analysis of thermostabilizing mutations of cocaine esterase
    Diwahar Narasimhan
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    Protein Eng Des Sel 23:537-47. 2010
  10. pmc Assembly of high order G alpha q-effector complexes with RGS proteins
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:34923-34. 2008

Collaborators

Detail Information

Publications12

  1. pmc Guanylyl cyclase sees the light
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    J Biol 7:31. 2008
    ....
  2. pmc Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol
    John J G Tesmer
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Med Chem 53:1867-70. 2010
    ..The selectivity of balanol among human GRKs is assessed...
  3. pmc The quest to understand heterotrimeric G protein signaling
    John J G Tesmer
    Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Struct Mol Biol 17:650-2. 2010
    ..Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs...
  4. ncbi request reprint In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers
    Xiaoyun Chen
    Department of Chemistry, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Chem Soc 129:12658-9. 2007
  5. pmc Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation
    Puja Singh
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:14053-62. 2008
    ..Co-localization of the N terminus and the C-terminal extension near the hinge of the kinase domain suggests that activated GPCRs stimulate kinase activity by binding to this region to facilitate full closure of the kinase domain...
  6. pmc Molecular basis for activation of G protein-coupled receptor kinases
    Cassandra A Boguth
    Life Sciences Institute, The University of Michigan, Ann Arbor, MI, USA
    EMBO J 29:3249-59. 2010
    ..Our structural and biochemical results thus provide an explanation for how receptor recognition, phospholipid binding, and kinase activation are intimately coupled in GRKs...
  7. pmc Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors
    Mohamed Aittaleb
    University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Mol Pharmacol 77:111-25. 2010
    ..This review covers what is currently known about the structure, function, and regulation of these recently recognized effectors of heterotrimeric G proteins...
  8. pmc A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases
    Chih Chin Huang
    Life Sciences Institute, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 284:17206-15. 2009
    ..Receptor binding is proposed to promote this interaction, thereby enhancing GRK activity...
  9. pmc Structural analysis of thermostabilizing mutations of cocaine esterase
    Diwahar Narasimhan
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    Protein Eng Des Sel 23:537-47. 2010
    ..The improved stability of these engineered CocE enzymes will have a profound influence on the use of this protein to combat cocaine-induced toxicity and addiction in humans...
  10. pmc Assembly of high order G alpha q-effector complexes with RGS proteins
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:34923-34. 2008
    ....
  11. pmc Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell Signal 22:1114-23. 2010
    ....
  12. pmc Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent
    Jeffery N Talbot
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    J Neurochem 112:1026-34. 2010
    ....